iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132474

UUCD1 version

UUC-XeT-00914

Ensembl Protein ID

ENSXETP00000046653.3

UniProt Accession

Q566M6; Q566M6_XENTR

Genbank Protein ID

AAH93450.1; AAI21225.1

Protein Name

Cbl-prov protein

Genbank Nucleotide ID

AAMC01039999; BC121224

Gene Name

cbl; cbl-prov

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021588.3	ENSXETT00000046653.3	ENSXETP00000046653.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	31.7	398	437

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 398  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 437
           99********.******************....5.555555****8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

ISPSQPGAHR EGCVRGPRVH QPQEFHPAAP RSLVTMATNL RKGGGLIGLV KDAFQPHHHH 60
PTAQPGAVDR KTVEKCWKLM DKVVRLCQNQ RLALKNSPPY ILDLLPDTYQ HLRTIMSRYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTCTCGCT TGAGAAAAGG CGGAAGTGAC GGCGGCGGCG CGGTGCTCGG CCCCGGGAGA 60
ATCATCTCCC CCTCCCAGCC CGGCGCACAC AGGGAGGGCT GTGTCCGGGG GCCCCGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	74.74	0.00e+00	1142.00
IUUC-Apl-004041	Anas platyrhynchos	75.00	0.00e+00	1162.00
IUUC-Aca-004899	Anolis carolinensis	73.18	0.00e+00	1113.00
IUUC-Bta-012759	Bos taurus	72.54	0.00e+00	1160.00
IUUC-Cja-019207	Callithrix jacchus	74.17	0.00e+00	1174.00
IUUC-Cfa-020897	Canis familiaris	73.71	0.00e+00	1157.00
IUUC-Cpo-021453	Cavia porcellus	72.64	0.00e+00	1155.00
IUUC-Csa-023136	Chlorocebus sabaeus	74.00	0.00e+00	1167.00
IUUC-Cho-024282	Choloepus hoffmanni	65.85	0.00e+00	967.00
IUUC-Cin-025574	Ciona intestinalis	70.32	4.00e-179	620.00
IUUC-Csv-025938	Ciona savignyi	69.37	1.00e-172	598.00
IUUC-Dre-027644	Danio rerio	86.75	0.00e+00	817.00
IUUC-Dno-030025	Dasypus novemcinctus	73.17	0.00e+00	1141.00
IUUC-Dme-032213	Drosophila melanogaster	73.60	0.00e+00	639.00
IUUC-Eca-033900	Equus caballus	74.65	0.00e+00	1158.00
IUUC-Eeu-035142	Erinaceus europaeus	75.17	0.00e+00	791.00
IUUC-Fca-035455	Felis catus	73.72	0.00e+00	1172.00
IUUC-Fal-037182	Ficedula albicollis	91.77	0.00e+00	857.00
IUUC-Gmo-038698	Gadus morhua	87.16	0.00e+00	860.00
IUUC-Gga-040438	Gallus gallus	74.74	0.00e+00	1190.00
IUUC-Gac-042166	Gasterosteus aculeatus	65.98	0.00e+00	914.00
IUUC-Ggo-045618	Gorilla gorilla	74.08	0.00e+00	1170.00
IUUC-Hsa-046177	Homo sapiens	74.08	0.00e+00	1169.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	81.00	0.00e+00	809.00
IUUC-Lch-050095	Latimeria chalumnae	71.63	0.00e+00	1106.00
IUUC-Loc-052570	Lepisosteus oculatus	67.08	0.00e+00	1055.00
IUUC-Laf-054008	Loxodonta africana	73.99	0.00e+00	1179.00
IUUC-Mcc-054676	Macaca mulatta	74.00	0.00e+00	1167.00
IUUC-Mga-059239	Meleagris gallopavo	74.37	0.00e+00	1202.00
IUUC-Mmr-060907	Microcebus murinus	72.83	0.00e+00	1160.00
IUUC-Mdo-062595	Monodelphis domestica	75.20	0.00e+00	1176.00
IUUC-Mmu-063725	Mus musculus	73.92	0.00e+00	1211.00
IUUC-Mpu-066771	Mustela putorius furo	73.13	0.00e+00	1166.00
IUUC-Mlu-067206	Myotis lucifugus	92.58	0.00e+00	801.00
IUUC-Nle-069285	Nomascus leucogenys	71.84	0.00e+00	1109.00
IUUC-Opr-071026	Ochotona princeps	73.08	0.00e+00	1145.00
IUUC-Ont-071954	Oreochromis niloticus	68.00	0.00e+00	1001.00
IUUC-Ocu-074657	Oryctolagus cuniculus	73.69	0.00e+00	1120.00
IUUC-Ola-087165	Oryzias latipes	87.08	0.00e+00	843.00
IUUC-Oga-088198	Otolemur garnettii	91.21	0.00e+00	844.00
IUUC-Oar-090258	Ovis aries	73.22	0.00e+00	1118.00
IUUC-Ptr-090710	Pan troglodytes	74.08	0.00e+00	1169.00
IUUC-Pan-092785	Papio anubis	74.00	0.00e+00	1166.00
IUUC-Pfo-096990	Poecilia formosa	86.99	0.00e+00	813.00
IUUC-Pab-098526	Pongo abelii	74.28	0.00e+00	1169.00
IUUC-Pva-102352	Pteropus vampyrus	89.91	0.00e+00	836.00
IUUC-Rno-105876	Rattus norvegicus	73.84	0.00e+00	1196.00
IUUC-Sha-107588	Sarcophilus harrisii	73.23	0.00e+00	1020.00
IUUC-Sar-112959	Sorex araneus	72.95	0.00e+00	1124.00
IUUC-Ssc-115261	Sus scrofa	73.72	0.00e+00	1178.00
IUUC-Tgu-116580	Taeniopygia guttata	73.11	0.00e+00	1127.00
IUUC-Tru-118731	Takifugu rubripes	66.38	0.00e+00	987.00
IUUC-Tsy-118982	Tarsius syrichta	63.57	0.00e+00	739.00
IUUC-Tni-120725	Tetraodon nigroviridis	66.70	0.00e+00	980.00
IUUC-Tbe-128018	Tupaia belangeri	81.52	0.00e+00	947.00
IUUC-Ttr-128927	Tursiops truncatus	74.55	0.00e+00	1200.00
IUUC-Vpa-130369	Vicugna pacos	73.68	0.00e+00	1097.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence