iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120442

UUCD1 version

UUC-TeN-00755

Ensembl Protein ID

ENSTNIP00000016282.1

UniProt Accession

H3D6Z1; H3D6Z1_TETNG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000013292.1	ENSTNIT00000016494.1	ENSTNIP00000016282.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-76	255.9	2374	2697

Active Site

Position(s)	Description	Evidence
2667	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 16   EegldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           +e+ + +G+tr ++++ +++  + +  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k 
   Q: 2374 QENRKRHGSTRSVVDMELDDPDDGEdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKV 2456
           5667777888888888777777766667788233333666666666554....89******************************** PP
   S: 100  llgkklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
           llg+k++++d++ +dp +y+sl ++ ++    e+d   +++dl+f ++ ++ + + ++eL++gG n+pVt  N +eYv++++e+r+ 
   Q: 2457 LLGRKVNWHDFAFFDPVMYESLRQLIRHSqagEADAVFAAMDLAFAIDLCKEEGAGQVELLSGGVNMPVTPLNVYEYVRKYAEHRML 2543
           *********************777766654777799999************************************************ PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLq 266
              ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er++++ 
   Q: 2544 VVAEQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDLVY 2630
           ****************************************************9999999888888999******************* PP
   S: 267  FvTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2631 FWTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2697
           **********999******..799999.99**********************************9.99875 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

NKYSYNSHPH LGLLEQATLK QCVVGPNHAG FLLEDGRVCR ISFAVQPDRL ELSKPDGSDG 60
SKLSSGSGTG RSSRPGRTSD PPWFLSGSDT LGRLAGNTLG SRWSSGVTSG RSSTAARDSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACAAATACA GCTATAACAG GTGTGTTCAT TTTACGTGTA TTTTAAGCTG CGAATGACCT 60
AGCATCGTTT ATGCTGTTAT TTATCTTTGA GTGTGTGTTT TCCCCATCGC AGTCACCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	84.61	0.00e+00	3776.00
IUUC-Apl-004165	Anas platyrhynchos	84.61	0.00e+00	3771.00
IUUC-Aca-004577	Anolis carolinensis	86.50	0.00e+00	2458.00
IUUC-Ame-010702	Astyanax mexicanus	84.92	0.00e+00	2372.00
IUUC-Bta-012313	Bos taurus	84.39	0.00e+00	3783.00
IUUC-Cel-018165	Caenorhabditis elegans	31.62	2.00e-80	295.00
IUUC-Cja-019858	Callithrix jacchus	84.36	0.00e+00	3801.00
IUUC-Cfa-020973	Canis familiaris	84.43	0.00e+00	3786.00
IUUC-Cpo-022108	Cavia porcellus	87.82	0.00e+00	1668.00
IUUC-Csa-023985	Chlorocebus sabaeus	84.21	0.00e+00	3806.00
IUUC-Cho-025034	Choloepus hoffmanni	77.36	0.00e+00	832.00
IUUC-Cin-025715	Ciona intestinalis	39.77	0.00e+00	893.00
IUUC-Csv-026131	Ciona savignyi	53.50	7.00e-152	531.00
IUUC-Dre-027730	Danio rerio	88.75	0.00e+00	3904.00
IUUC-Dno-029123	Dasypus novemcinctus	82.24	0.00e+00	3630.00
IUUC-Dor-030757	Dipodomys ordii	86.49	0.00e+00	1264.00
IUUC-Dme-032192	Drosophila melanogaster	51.60	3.00e-161	563.00
IUUC-Ete-032292	Echinops telfairi	82.56	0.00e+00	1744.00
IUUC-Eca-034347	Equus caballus	84.25	0.00e+00	3749.00
IUUC-Eeu-034873	Erinaceus europaeus	80.47	0.00e+00	3580.00
IUUC-Fca-036485	Felis catus	83.51	0.00e+00	3691.00
IUUC-Fal-037071	Ficedula albicollis	84.57	0.00e+00	3770.00
IUUC-Gmo-039589	Gadus morhua	89.83	0.00e+00	3952.00
IUUC-Gga-041195	Gallus gallus	83.42	0.00e+00	3685.00
IUUC-Gac-042538	Gasterosteus aculeatus	90.18	0.00e+00	3934.00
IUUC-Ggo-045351	Gorilla gorilla	84.51	0.00e+00	3837.00
IUUC-Hsa-045941	Homo sapiens	84.36	0.00e+00	3825.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	84.32	0.00e+00	3780.00
IUUC-Lch-050480	Latimeria chalumnae	84.70	0.00e+00	3745.00
IUUC-Loc-052664	Lepisosteus oculatus	86.20	0.00e+00	2922.00
IUUC-Laf-053935	Loxodonta africana	88.32	0.00e+00	1395.00
IUUC-Mcc-054703	Macaca mulatta	84.18	0.00e+00	3803.00
IUUC-Meu-056431	Macropus eugenii	77.85	0.00e+00	689.00
IUUC-Mga-059289	Meleagris gallopavo	84.21	0.00e+00	2987.00
IUUC-Mmr-061737	Microcebus murinus	84.11	0.00e+00	3729.00
IUUC-Mdo-062499	Monodelphis domestica	84.21	0.00e+00	3749.00
IUUC-Mmu-063273	Mus musculus	83.78	0.00e+00	3726.00
IUUC-Mpu-066907	Mustela putorius furo	84.23	0.00e+00	3504.00
IUUC-Mlu-067942	Myotis lucifugus	84.31	0.00e+00	3800.00
IUUC-Nle-069527	Nomascus leucogenys	84.29	0.00e+00	3825.00
IUUC-Opr-070626	Ochotona princeps	76.66	0.00e+00	1233.00
IUUC-Ont-071951	Oreochromis niloticus	90.85	0.00e+00	3979.00
IUUC-Oan-072958	Ornithorhynchus anatinus	84.43	0.00e+00	3496.00
IUUC-Ocu-074503	Oryctolagus cuniculus	83.00	0.00e+00	3714.00
IUUC-Ola-086757	Oryzias latipes	90.36	0.00e+00	4001.00
IUUC-Oga-088781	Otolemur garnettii	84.29	0.00e+00	3772.00
IUUC-Oar-089274	Ovis aries	84.11	0.00e+00	3771.00
IUUC-Ptr-090669	Pan troglodytes	84.32	0.00e+00	3319.00
IUUC-Pan-092226	Papio anubis	84.78	0.00e+00	3798.00
IUUC-Psi-093502	Pelodiscus sinensis	84.84	0.00e+00	3761.00
IUUC-Pma-094454	Petromyzon marinus	79.52	0.00e+00	696.00
IUUC-Pfo-096173	Poecilia formosa	91.14	0.00e+00	3752.00
IUUC-Pab-098355	Pongo abelii	85.04	0.00e+00	3768.00
IUUC-Pca-100570	Procavia capensis	86.09	0.00e+00	964.00
IUUC-Pva-102572	Pteropus vampyrus	83.07	0.00e+00	1122.00
IUUC-Rno-104916	Rattus norvegicus	82.41	0.00e+00	3258.00
IUUC-Sha-106653	Sarcophilus harrisii	84.80	0.00e+00	3764.00
IUUC-Sar-113517	Sorex araneus	81.16	0.00e+00	1139.00
IUUC-Ssc-115470	Sus scrofa	82.87	0.00e+00	2053.00
IUUC-Tgu-116932	Taeniopygia guttata	84.23	0.00e+00	3746.00
IUUC-Tru-117682	Takifugu rubripes	92.88	0.00e+00	2632.00
IUUC-Tsy-119417	Tarsius syrichta	79.51	0.00e+00	1993.00
IUUC-Tbe-127456	Tupaia belangeri	76.18	0.00e+00	1779.00
IUUC-Ttr-128606	Tursiops truncatus	85.06	0.00e+00	1345.00
IUUC-Vpa-130112	Vicugna pacos	81.49	0.00e+00	3061.00
IUUC-Xtr-131929	Xenopus tropicalis	82.09	0.00e+00	3689.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence