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Tag Content
UUCD2 ID IUUC-Gga-040524
UUCD1 version UUC-GaG-00053
Ensembl Protein ID ENSGALP00000044502.1
UniProt Accession E1BWY8; E1BWY8_CHICK
Genbank Protein ID ENSGALP00000006925
Protein Name Uncharacterized protein
Genbank Nucleotide ID AADN04000459
Gene Name NEDD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000004347.5 ENSGALT00000055021.1 ENSGALP00000044502.1
ENSGALG00000004347.5 ENSGALT00000053271.1 ENSGALP00000046551.1
ENSGALG00000004347.5 ENSGALT00000078142.1 ENSGALP00000048991.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 9.30e-134 446.4 570 899
Active Site
Position(s) Description Evidence
869 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
    lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 570 FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 658
    5899************************************************************************************* PP
   S: 93 sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
    ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en d ++ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 659 IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DP--AELDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 742
    *********************************99...44..558******************************************** PP
   S: 182 lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
    + +++++q++af+eGf e+ip++l+++F+e+elell+cG ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 743 FVSRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 831
    ***************************************************************************************** PP
   S: 271 ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
    +sr+P++Gfael p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 832 TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 899
    *******************************************************************8 PP
   

Organism Gallus gallus
Protein Sequence
(Fasta)
MAASPVEVFG LPGEEENTRI VRVKVIAGIG LAKKDILGAS DPYVKVTVYD PVNGVLSSVQ 60
TKTIRKSLNP KWNEELLFRV NPQKHRLLFE VFDENRLTRD DFLGQVDIPL YQLPTEHPSM 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Gga-040524|E3,HECT|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGCCGGGG GCGGGGCGCG GCCGTGGCGG GCGGCGCGCG GCATGGCGGC CTCTCCTGTG 60
GAGGTGTTCG GGCTGCCCGG CGAGGAGGTG AGGCCCGCGG ACCGCTCGGC TCGCGCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Gga-040524|E3,HECT|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001201 Ailuropoda melanoleuca 82.63 0.00e+00 1334.00
IUUC-Apl-003886 Anas platyrhynchos 89.55 0.00e+00 1591.00
IUUC-Ame-011138 Astyanax mexicanus 84.34 0.00e+00 847.00
IUUC-Bgr-012148 Blumeria graminis 47.60 7.00e-153 534.00
IUUC-Bta-012453 Bos taurus 81.26 0.00e+00 1298.00
IUUC-Bci-013785 Botrytis cinerea 47.25 8.00e-155 540.00
IUUC-Cja-019034 Callithrix jacchus 81.88 0.00e+00 1220.00
IUUC-Cfa-020258 Canis familiaris 83.25 0.00e+00 1315.00
IUUC-Cpo-021648 Cavia porcellus 79.29 0.00e+00 1420.00
IUUC-Csa-023334 Chlorocebus sabaeus 82.95 0.00e+00 1470.00
IUUC-Cin-025157 Ciona intestinalis 57.17 0.00e+00 968.00
IUUC-Dre-027924 Danio rerio 67.93 0.00e+00 1026.00
IUUC-Dno-029159 Dasypus novemcinctus 80.25 0.00e+00 1183.00
IUUC-Ete-032409 Echinops telfairi 75.89 0.00e+00 1068.00
IUUC-Eca-033441 Equus caballus 82.08 0.00e+00 1453.00
IUUC-Eeu-034546 Erinaceus europaeus 70.57 0.00e+00 1043.00
IUUC-Fca-036384 Felis catus 83.17 0.00e+00 1345.00
IUUC-Fal-037547 Ficedula albicollis 93.80 0.00e+00 1609.00
IUUC-Gmo-039679 Gadus morhua 68.21 0.00e+00 1204.00
IUUC-Gac-042607 Gasterosteus aculeatus 66.49 0.00e+00 1205.00
IUUC-Hsa-046479 Homo sapiens 82.38 0.00e+00 1328.00
IUUC-Itr-048383 Ictidomys tridecemlineatus 73.54 0.00e+00 1073.00
IUUC-Lch-050445 Latimeria chalumnae 73.09 0.00e+00 1182.00
IUUC-Loc-052645 Lepisosteus oculatus 74.37 0.00e+00 1325.00
IUUC-Mcc-055585 Macaca mulatta 82.88 0.00e+00 1325.00
IUUC-Meu-056897 Macropus eugenii 93.03 3.00e-166 579.00
IUUC-Mga-059362 Meleagris gallopavo 91.79 0.00e+00 1650.00
IUUC-Mmr-061061 Microcebus murinus 83.13 0.00e+00 1382.00
IUUC-Mmu-063318 Mus musculus 73.62 0.00e+00 1287.00
IUUC-Mpu-066567 Mustela putorius furo 83.22 0.00e+00 1508.00
IUUC-Mlu-068148 Myotis lucifugus 83.62 0.00e+00 1336.00
IUUC-Ncr-068918 Neurospora crassa 48.70 2.00e-155 542.00
IUUC-Nle-069225 Nomascus leucogenys 81.89 0.00e+00 1321.00
IUUC-Ont-071664 Oreochromis niloticus 67.09 0.00e+00 1194.00
IUUC-Oan-073019 Ornithorhynchus anatinus 84.44 0.00e+00 1412.00
IUUC-Ocu-074409 Oryctolagus cuniculus 82.13 0.00e+00 1327.00
IUUC-Oga-088241 Otolemur garnettii 76.11 0.00e+00 1186.00
IUUC-Oar-089797 Ovis aries 82.16 0.00e+00 1404.00
IUUC-Ptr-091629 Pan troglodytes 82.43 0.00e+00 1216.00
IUUC-Psi-093618 Pelodiscus sinensis 90.93 0.00e+00 1410.00
IUUC-Pno-095118 Phaeosphaeria nodorum 49.57 3.00e-161 561.00
IUUC-Pfo-097145 Poecilia formosa 69.28 0.00e+00 1192.00
IUUC-Pab-098394 Pongo abelii 81.60 0.00e+00 1450.00
IUUC-Pca-100568 Procavia capensis 72.17 0.00e+00 1053.00
IUUC-Pte-104016 Pyrenophora teres 49.66 2.00e-160 559.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 49.66 2.00e-160 559.00
IUUC-Rno-106095 Rattus norvegicus 73.17 0.00e+00 1272.00
IUUC-Sha-107370 Sarcophilus harrisii 77.89 0.00e+00 1273.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 50.09 2.00e-153 536.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 47.50 1.00e-155 543.00
IUUC-Sre-114929 Sporisorium reilianum 48.38 3.00e-155 541.00
IUUC-Tgu-117474 Taeniopygia guttata 93.90 0.00e+00 1643.00
IUUC-Tru-117675 Takifugu rubripes 65.71 0.00e+00 1176.00
IUUC-Tni-119993 Tetraodon nigroviridis 65.16 0.00e+00 1156.00
IUUC-Tbe-127408 Tupaia belangeri 78.03 0.00e+00 1038.00
IUUC-Ttr-128437 Tursiops truncatus 75.04 0.00e+00 1046.00
IUUC-Vpa-130503 Vicugna pacos 78.05 0.00e+00 1139.00
Created Date 25-Jun-2017

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