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Tag Content
UUCD2 ID IUUC-Itr-047951
UUCD1 version UUC-SpT-00745
Ensembl Protein ID ENSSTOP00000006256.2
UniProt Accession I3M8X9; I3M8X9_ICTTR
Genbank Protein ID ENSSTOP00000006256
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AGTP01030681
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000006982.2 ENSSTOT00000007001.2 ENSSTOP00000006256.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.80e-88 296.9 195 824
Active Site
Position(s) Description Evidence
204 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
760 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.............kkkeklneenp.........kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ ++ ++++e++++kk+ 
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppD---------LalteplevnLEPPGPLTLAMSQFLNEMQETKKGI 274
           5******************************86666666654441.........04444455558899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 275  VTPKELFAQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 363
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec +vs  +e+fldlslpv ++++ kk+                                                       
   Q: 364  STIMCDECSTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdndsyikerhdipsgtskhlqkkakkqakkqakn 452
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  qrrqqkiqgkvlhlndictidhpedneceaemslqeeveiksnhisqeevthkefcvnqkdlngqekmienitdnqksieeidiknidm 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  dndleelasstsectrnlngtflkegsngevdissgfknlnlnavlqpdeidieilndshtsgtkvyevvnedpetafctlanrdtlnt 630
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 631  decSVQYCLYQFTRNEKLRDANKLLCEVCTRRQYngpkantkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 717
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 718  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlilhgdipqdfemesTKGQWFHISDTHVQA 806
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 807  VPTAKVLN---SQAYLLFYER 824
           ********...********98 PP
   
Organism Ictidomys tridecemlineatus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKT VPTDDSSESS EPICRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYMIPRS EPHCLVLSLD NWSVWCYLCD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Itr-047951|DUB,USP|Ictidomys tridecemlineatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAAGGGGCAC GGTGGATTCG GCTCTGTTGC TCTCTATTCG TCACCGAGAG GAAGACGGAG 60
CCGGCCGCCT AGCCCAAAGG CCCATTAGGG GATGCAGTTA TGGGCGCTGT CACCGTGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Itr-047951|DUB,USP|Ictidomys tridecemlineatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 35.75 6.00e-29 122.00
IUUC-Aml-001931 Ailuropoda melanoleuca 90.68 0.00e+00 1411.00
IUUC-Atr-003015 Amborella trichopoda 31.90 3.00e-37 150.00
IUUC-Apl-004145 Anas platyrhynchos 62.99 0.00e+00 914.00
IUUC-Aca-004314 Anolis carolinensis 59.57 0.00e+00 902.00
IUUC-Aly-006422 Arabidopsis lyrata 28.62 5.00e-30 126.00
IUUC-Ath-006732 Arabidopsis thaliana 32.82 8.00e-34 139.00
IUUC-Ame-011659 Astyanax mexicanus 48.86 2.00e-109 389.00
IUUC-Bta-013362 Bos taurus 90.81 0.00e+00 1407.00
IUUC-Bdi-014465 Brachypodium distachyon 31.40 7.00e-32 132.00
IUUC-Bol-015941 Brassica oleracea 29.52 1.00e-33 138.00
IUUC-Bra-016751 Brassica rapa 28.81 3.00e-31 130.00
IUUC-Cja-019177 Callithrix jacchus 92.14 0.00e+00 1461.00
IUUC-Cfa-020051 Canis familiaris 90.81 0.00e+00 1419.00
IUUC-Cpo-021886 Cavia porcellus 82.05 0.00e+00 1304.00
IUUC-Csa-024103 Chlorocebus sabaeus 92.38 0.00e+00 1471.00
IUUC-Cho-024315 Choloepus hoffmanni 77.43 8.00e-132 464.00
IUUC-Cin-025775 Ciona intestinalis 52.48 3.00e-41 160.00
IUUC-Csv-026075 Ciona savignyi 54.08 1.00e-58 220.00
IUUC-Cme-027348 Cyanidioschyzon merolae 38.51 4.00e-20 92.80
IUUC-Dre-028388 Danio rerio 50.77 3.00e-119 422.00
IUUC-Dno-029409 Dasypus novemcinctus 88.15 0.00e+00 1398.00
IUUC-Dor-030443 Dipodomys ordii 78.96 0.00e+00 653.00
IUUC-Ete-032807 Echinops telfairi 83.73 0.00e+00 680.00
IUUC-Eca-033479 Equus caballus 91.54 0.00e+00 1451.00
IUUC-Eeu-034835 Erinaceus europaeus 84.10 0.00e+00 676.00
IUUC-Fca-036320 Felis catus 91.29 0.00e+00 1462.00
IUUC-Fal-037029 Ficedula albicollis 59.88 0.00e+00 850.00
IUUC-Gmo-039480 Gadus morhua 52.35 6.00e-114 404.00
IUUC-Gga-040527 Gallus gallus 63.92 0.00e+00 923.00
IUUC-Gac-042343 Gasterosteus aculeatus 50.34 2.00e-113 403.00
IUUC-Gma-044402 Glycine max 28.21 2.00e-33 137.00
IUUC-Ggo-045598 Gorilla gorilla 92.02 0.00e+00 1462.00
IUUC-Hsa-046598 Homo sapiens 91.66 0.00e+00 1449.00
IUUC-Hvu-047146 Hordeum vulgare 29.14 3.00e-29 124.00
IUUC-Lch-050536 Latimeria chalumnae 52.15 0.00e+00 758.00
IUUC-Lpe-050703 Leersia perrieri 30.03 6.00e-29 122.00
IUUC-Loc-051814 Lepisosteus oculatus 56.65 9.00e-128 450.00
IUUC-Laf-053732 Loxodonta africana 86.63 0.00e+00 1402.00
IUUC-Mcc-054661 Macaca mulatta 92.74 0.00e+00 1472.00
IUUC-Meu-055967 Macropus eugenii 73.12 5.00e-157 548.00
IUUC-Mtr-057945 Medicago truncatula 30.54 4.00e-33 136.00
IUUC-Mga-059551 Meleagris gallopavo 62.86 0.00e+00 929.00
IUUC-Mvi-060391 Microbotryum violaceum 32.65 3.00e-19 90.50
IUUC-Mmr-061747 Microcebus murinus 93.08 0.00e+00 1441.00
IUUC-Mdo-062220 Monodelphis domestica 68.92 0.00e+00 1051.00
IUUC-Mmu-063582 Mus musculus 81.91 0.00e+00 1254.00
IUUC-Mac-064941 Musa acuminata 33.83 2.00e-38 154.00
IUUC-Mpu-066339 Mustela putorius furo 90.57 0.00e+00 1447.00
IUUC-Mlu-067511 Myotis lucifugus 84.99 0.00e+00 1333.00
IUUC-Nle-069252 Nomascus leucogenys 92.50 0.00e+00 1469.00
IUUC-Opr-070969 Ochotona princeps 85.84 0.00e+00 1310.00
IUUC-Ont-071786 Oreochromis niloticus 50.94 9.00e-116 410.00
IUUC-Ocu-074704 Oryctolagus cuniculus 90.73 0.00e+00 1410.00
IUUC-Oba-075094 Oryza barthii 31.19 1.00e-32 135.00
IUUC-Obr-076743 Oryza brachyantha 31.27 1.00e-31 132.00
IUUC-Ogl-077739 Oryza glaberrima 31.19 7.00e-33 135.00
IUUC-Ogu-078851 Oryza glumaepatula 31.19 1.00e-32 135.00
IUUC-Oin-079402 Oryza indica 31.19 1.00e-32 135.00
IUUC-Olo-080431 Oryza longistaminata 31.19 1.00e-32 135.00
IUUC-Ome-081580 Oryza meridionalis 31.19 1.00e-32 134.00
IUUC-Oni-082644 Oryza nivara 31.19 1.00e-32 135.00
IUUC-Opu-083452 Oryza punctata 30.03 3.00e-32 134.00
IUUC-Oru-084546 Oryza rufipogon 31.19 1.00e-32 135.00
IUUC-Osa-085858 Oryza sativa 31.19 1.00e-32 135.00
IUUC-Oga-088713 Otolemur garnettii 90.57 0.00e+00 1442.00
IUUC-Oar-089887 Ovis aries 91.17 0.00e+00 1420.00
IUUC-Ptr-091670 Pan troglodytes 92.02 0.00e+00 1462.00
IUUC-Pan-092293 Papio anubis 92.74 0.00e+00 1472.00
IUUC-Psi-093101 Pelodiscus sinensis 67.10 0.00e+00 949.00
IUUC-Ppa-095622 Physcomitrella patens 30.39 6.00e-35 142.00
IUUC-Pfo-097202 Poecilia formosa 46.46 0.00e+00 648.00
IUUC-Pab-098773 Pongo abelii 91.94 0.00e+00 1137.00
IUUC-Pop-099136 Populus trichocarpa 30.57 3.00e-40 160.00
IUUC-Pca-101069 Procavia capensis 71.54 0.00e+00 876.00
IUUC-Ppe-101794 Prunus persica 30.41 1.00e-34 141.00
IUUC-Pva-103092 Pteropus vampyrus 86.93 0.00e+00 690.00
IUUC-Rno-105237 Rattus norvegicus 82.63 0.00e+00 1265.00
IUUC-Sha-106889 Sarcophilus harrisii 73.04 0.00e+00 1126.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 28.32 2.00e-11 64.30
IUUC-Sit-110283 Setaria italica 30.90 9.00e-30 125.00
IUUC-Sly-111487 Solanum lycopersicum 29.95 5.00e-40 159.00
IUUC-Stu-112820 Solanum tuberosum 28.92 1.00e-38 154.00
IUUC-Sar-113530 Sorex araneus 82.61 0.00e+00 1304.00
IUUC-Sbi-113785 Sorghum bicolor 39.35 3.00e-25 110.00
IUUC-Ssc-116091 Sus scrofa 89.89 0.00e+00 1387.00
IUUC-Tgu-117478 Taeniopygia guttata 59.31 0.00e+00 870.00
IUUC-Tru-118640 Takifugu rubripes 53.04 1.00e-118 420.00
IUUC-Tsy-119042 Tarsius syrichta 77.83 0.00e+00 909.00
IUUC-Tni-120015 Tetraodon nigroviridis 45.98 2.00e-179 622.00
IUUC-Tca-121701 Theobroma cacao 29.01 2.00e-38 154.00
IUUC-Tae-125785 Triticum aestivum 29.45 1.00e-27 118.00
IUUC-Tur-126788 Triticum urartu 29.14 3.00e-27 116.00
IUUC-Tbe-127309 Tupaia belangeri 77.79 0.00e+00 1116.00
IUUC-Ttr-128271 Tursiops truncatus 90.33 0.00e+00 1436.00
IUUC-Vpa-130674 Vicugna pacos 90.86 0.00e+00 1328.00
IUUC-Xtr-131869 Xenopus tropicalis 53.02 0.00e+00 795.00
IUUC-Xma-134195 Xiphophorus maculatus 53.57 4.00e-118 418.00
IUUC-Zma-135157 Zea mays 31.27 2.00e-27 118.00
Created Date 25-Jun-2017

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