• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Ocu-074704
UUCD1 version UUC-OrC-01036
Ensembl Protein ID ENSOCUP00000027154.1
UniProt Accession U3KPJ4; U3KPJ4_RABIT
Genbank Protein ID ENSOCUP00000027154
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AAGW02017579
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000007779.3 ENSOCUT00000034105.1 ENSOCUP00000027154.1
ENSOCUG00000007779.3 ENSOCUT00000007781.2 ENSOCUP00000006722.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 6.00e-89 298.6 313 942
Active Site
Position(s) Description Evidence
322 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
878 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 313  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 392
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 393  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 481
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 482  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdndsyvkerndipsgtskhlqkkakkqakkqakn 570
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 571  qrrqqkiqgkvlhlndictidhsedneceaemslqgevdiksnhisqeevtpeecgvnqkdlngqekiiesvtdnqnsteevdvknvnm 659
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 660  dndlevlassptecsgnlngaylqeesneevdisngfknlnlnvtlepdeinieilndsytpetkvyevvnedpetafctlanreafnt 748
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 749  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQYngpkentkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 835
           ******************************777778888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 836  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqglemqsTKGQWFHISDTHVQA 924
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 925  VPTTKVLN---SQAYLLFYER 942
           ********...********98 PP
   
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MQSSLLWRRD TTYPEAPADN ARPSTDYCFR GTPALTGACV KPRGRLRAYS CAPFASAVGP 60
QRKPSSQSRP QHGCGKPAPV FPRSERPWTL RRESKGPYQP WKIKGKNVSC RRSRRKTELA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074704|DUB,USP|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCAAAGGA GTACAGGCTT ACAAAATCGG AAGTGCTGCT GAAAAGAAAA AAATTCTTTT 60
GGTAAACCCT TGGTTAAAAT CGGGGGGGGG GGGGGAACCG TGAATCTCCA CACCAAGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074704|DUB,USP|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 29.97 4.00e-29 123.00
IUUC-Aml-001931 Ailuropoda melanoleuca 90.73 0.00e+00 1352.00
IUUC-Atr-003015 Amborella trichopoda 31.99 9.00e-37 149.00
IUUC-Apl-004145 Anas platyrhynchos 63.55 0.00e+00 912.00
IUUC-Aca-004314 Anolis carolinensis 59.37 0.00e+00 874.00
IUUC-Aly-006422 Arabidopsis lyrata 28.09 4.00e-29 124.00
IUUC-Ath-006732 Arabidopsis thaliana 33.33 2.00e-32 134.00
IUUC-Ame-011659 Astyanax mexicanus 50.60 8.00e-108 384.00
IUUC-Bta-013362 Bos taurus 89.86 0.00e+00 1353.00
IUUC-Bdi-014465 Brachypodium distachyon 30.49 5.00e-30 126.00
IUUC-Bol-015941 Brassica oleracea 30.83 5.00e-33 136.00
IUUC-Bra-016751 Brassica rapa 30.05 1.00e-30 129.00
IUUC-Cja-019177 Callithrix jacchus 89.41 0.00e+00 1405.00
IUUC-Cfa-020051 Canis familiaris 91.35 0.00e+00 1372.00
IUUC-Cpo-021886 Cavia porcellus 82.14 0.00e+00 1256.00
IUUC-Csa-024103 Chlorocebus sabaeus 92.34 0.00e+00 1426.00
IUUC-Cho-024315 Choloepus hoffmanni 78.12 7.00e-130 457.00
IUUC-Cin-025775 Ciona intestinalis 49.65 3.00e-39 153.00
IUUC-Csv-026075 Ciona savignyi 50.24 8.00e-58 218.00
IUUC-Cme-027348 Cyanidioschyzon merolae 38.51 4.00e-20 93.20
IUUC-Dre-028388 Danio rerio 48.67 0.00e+00 634.00
IUUC-Dno-029409 Dasypus novemcinctus 88.38 0.00e+00 1363.00
IUUC-Dor-030443 Dipodomys ordii 79.42 0.00e+00 632.00
IUUC-Ete-032807 Echinops telfairi 83.49 0.00e+00 681.00
IUUC-Eca-033479 Equus caballus 90.98 0.00e+00 1402.00
IUUC-Eeu-034835 Erinaceus europaeus 83.64 0.00e+00 658.00
IUUC-Fca-036320 Felis catus 91.84 0.00e+00 1418.00
IUUC-Fal-037029 Ficedula albicollis 59.88 0.00e+00 819.00
IUUC-Gmo-039480 Gadus morhua 53.26 3.00e-110 392.00
IUUC-Gga-040527 Gallus gallus 63.17 0.00e+00 902.00
IUUC-Gac-042343 Gasterosteus aculeatus 47.14 0.00e+00 642.00
IUUC-Gma-044402 Glycine max 28.28 2.00e-32 134.00
IUUC-Ggo-045598 Gorilla gorilla 91.47 0.00e+00 1409.00
IUUC-Hsa-046598 Homo sapiens 91.22 0.00e+00 1399.00
IUUC-Hvu-047146 Hordeum vulgare 29.97 4.00e-29 123.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 90.73 0.00e+00 1402.00
IUUC-Lch-050536 Latimeria chalumnae 53.46 0.00e+00 734.00
IUUC-Lpe-050703 Leersia perrieri 29.94 3.00e-29 124.00
IUUC-Loc-051814 Lepisosteus oculatus 55.61 1.00e-123 437.00
IUUC-Laf-053732 Loxodonta africana 86.82 0.00e+00 1373.00
IUUC-Mcc-054661 Macaca mulatta 92.71 0.00e+00 1427.00
IUUC-Meu-055967 Macropus eugenii 71.79 2.00e-151 530.00
IUUC-Mga-059551 Meleagris gallopavo 63.50 0.00e+00 913.00
IUUC-Mvi-060391 Microbotryum violaceum 33.68 6.00e-19 89.70
IUUC-Mmr-061747 Microcebus murinus 92.94 0.00e+00 1425.00
IUUC-Mdo-062220 Monodelphis domestica 69.18 0.00e+00 1027.00
IUUC-Mmu-063582 Mus musculus 81.45 0.00e+00 1238.00
IUUC-Mac-064941 Musa acuminata 28.41 7.00e-54 205.00
IUUC-Mpu-066339 Mustela putorius furo 90.61 0.00e+00 1401.00
IUUC-Mlu-067511 Myotis lucifugus 85.66 0.00e+00 1295.00
IUUC-Nle-069252 Nomascus leucogenys 92.34 0.00e+00 1422.00
IUUC-Opr-070969 Ochotona princeps 90.06 0.00e+00 1376.00
IUUC-Ont-071786 Oreochromis niloticus 50.74 1.00e-111 397.00
IUUC-Oba-075094 Oryza barthii 28.96 1.00e-30 129.00
IUUC-Obr-076743 Oryza brachyantha 31.79 1.00e-31 132.00
IUUC-Ogl-077739 Oryza glaberrima 28.96 1.00e-30 128.00
IUUC-Ogu-078851 Oryza glumaepatula 28.96 1.00e-30 129.00
IUUC-Oin-079402 Oryza indica 28.96 1.00e-30 128.00
IUUC-Olo-080431 Oryza longistaminata 28.96 1.00e-30 129.00
IUUC-Ome-081580 Oryza meridionalis 29.82 1.00e-30 128.00
IUUC-Oni-082644 Oryza nivara 28.96 1.00e-30 128.00
IUUC-Opu-083452 Oryza punctata 28.05 3.00e-30 127.00
IUUC-Oru-084546 Oryza rufipogon 28.96 1.00e-30 128.00
IUUC-Osa-085858 Oryza sativa 28.96 1.00e-30 128.00
IUUC-Oga-088713 Otolemur garnettii 90.11 0.00e+00 1390.00
IUUC-Oar-089971 Ovis aries 89.40 0.00e+00 1397.00
IUUC-Ptr-091670 Pan troglodytes 91.47 0.00e+00 1409.00
IUUC-Pan-092293 Papio anubis 92.71 0.00e+00 1427.00
IUUC-Psi-093101 Pelodiscus sinensis 66.42 0.00e+00 911.00
IUUC-Ppa-095622 Physcomitrella patens 30.20 1.00e-34 142.00
IUUC-Pfo-097202 Poecilia formosa 50.23 3.00e-113 402.00
IUUC-Pab-098773 Pongo abelii 92.40 0.00e+00 1125.00
IUUC-Pop-099136 Populus trichocarpa 30.03 3.00e-38 154.00
IUUC-Pca-101069 Procavia capensis 68.36 0.00e+00 1108.00
IUUC-Ppe-101794 Prunus persica 30.61 2.00e-34 141.00
IUUC-Pva-103092 Pteropus vampyrus 86.67 0.00e+00 671.00
IUUC-Rno-105237 Rattus norvegicus 83.11 0.00e+00 1244.00
IUUC-Sha-106889 Sarcophilus harrisii 73.54 0.00e+00 1116.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.91 2.00e-11 64.30
IUUC-Sit-110283 Setaria italica 32.85 2.00e-28 121.00
IUUC-Sly-111491 Solanum lycopersicum 27.59 1.00e-34 142.00
IUUC-Stu-112820 Solanum tuberosum 29.34 1.00e-37 151.00
IUUC-Sar-113530 Sorex araneus 82.20 0.00e+00 1261.00
IUUC-Sbi-113785 Sorghum bicolor 39.35 3.00e-25 110.00
IUUC-Ssc-116091 Sus scrofa 90.65 0.00e+00 1362.00
IUUC-Tgu-117478 Taeniopygia guttata 59.56 0.00e+00 845.00
IUUC-Tru-118640 Takifugu rubripes 52.42 5.00e-114 405.00
IUUC-Tsy-119042 Tarsius syrichta 78.59 0.00e+00 911.00
IUUC-Tni-120015 Tetraodon nigroviridis 45.13 3.00e-174 605.00
IUUC-Tca-121701 Theobroma cacao 28.43 3.00e-36 147.00
IUUC-Tae-125785 Triticum aestivum 29.97 1.00e-27 118.00
IUUC-Tur-126788 Triticum urartu 29.66 2.00e-27 117.00
IUUC-Tbe-127309 Tupaia belangeri 78.29 0.00e+00 1117.00
IUUC-Ttr-128271 Tursiops truncatus 90.11 0.00e+00 1385.00
IUUC-Vpa-130674 Vicugna pacos 90.38 0.00e+00 1276.00
IUUC-Xtr-131869 Xenopus tropicalis 51.44 0.00e+00 778.00
IUUC-Xma-134195 Xiphophorus maculatus 54.39 2.00e-114 407.00
IUUC-Zma-135157 Zea mays 30.86 3.00e-27 117.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved