iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117805

UUCD1 version

UUC-TaR-00420

Ensembl Protein ID

ENSTRUP00000020620.1

UniProt Accession

H2T7I0; H2T7I0_TAKRU

Protein Name

Uncharacterized protein

Gene Name

amfr

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000008237.1	ENSTRUT00000020701.1	ENSTRUP00000020616.1
ENSTRUG00000008237.1	ENSTRUT00000020702.1	ENSTRUP00000020617.1
ENSTRUG00000008237.1	ENSTRUT00000020703.1	ENSTRUP00000020618.1
ENSTRUG00000008237.1	ENSTRUT00000020704.1	ENSTRUP00000020619.1
ENSTRUG00000008237.1	ENSTRUT00000020705.1	ENSTRUP00000020620.1
ENSTRUG00000008237.1	ENSTRUT00000020706.1	ENSTRUP00000020621.1
ENSTRUG00000008237.1	ENSTRUT00000020707.1	ENSTRUP00000020622.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.70e-08	34.4	341	379
UBD/Alpha-Helix/CUE	1.00e-11	45.8	458	499

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC++++ +  + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 341  CAICWDSMLT-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 379
           ********99.999***************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++  +++++L ++t s+e +++n+Leg 
   Q: 458  QLTAMAHQIQEMFPQVPLYLVMQDL-QLTRSVEVTTDNILEGR 499
           6899*********************.***************95 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MPLLFLERFP WPSLQTYTAL SVALLAGSIF SAYTTVTDPG FGALETEEAA VPSELELQHL 60
TDDLSHRQVA TTVLWYLITD SLFVWVLVNT LCCSLMLIAK VIQFVVFGPL RVSEKQHLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTCTGC TATTTTTGGA GCGGTTCCCT TGGCCGAGCC TGCAGACATA CACGGCCCTA 60
AGCGTCGCCC TTCTGGCCGG GAGCATCTTC AGCGCCTACA CCACCGTGAC TGACCCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	70.56	0.00e+00	753.00
IUUC-Apl-003404	Anas platyrhynchos	73.48	0.00e+00	759.00
IUUC-Aca-004559	Anolis carolinensis	76.03	0.00e+00	733.00
IUUC-Ame-011640	Astyanax mexicanus	69.94	0.00e+00	819.00
IUUC-Bta-012980	Bos taurus	68.58	0.00e+00	778.00
IUUC-Cel-018598	Caenorhabditis elegans	25.23	9.00e-33	134.00
IUUC-Cja-019577	Callithrix jacchus	70.49	0.00e+00	824.00
IUUC-Cfa-020793	Canis familiaris	74.52	0.00e+00	753.00
IUUC-Cpo-022387	Cavia porcellus	70.89	0.00e+00	825.00
IUUC-Csa-023168	Chlorocebus sabaeus	70.72	0.00e+00	828.00
IUUC-Cho-024433	Choloepus hoffmanni	71.66	1.00e-175	608.00
IUUC-Cin-025215	Ciona intestinalis	44.23	8.00e-142	497.00
IUUC-Csv-026133	Ciona savignyi	45.45	9.00e-131	460.00
IUUC-Cgl-026549	Colletotrichum gloeosporioides	36.92	2.00e-06	45.40
IUUC-Dre-027594	Danio rerio	69.19	0.00e+00	780.00
IUUC-Dno-029407	Dasypus novemcinctus	74.57	0.00e+00	754.00
IUUC-Dor-030961	Dipodomys ordii	74.38	0.00e+00	748.00
IUUC-Ete-032962	Echinops telfairi	68.07	0.00e+00	637.00
IUUC-Eca-033683	Equus caballus	67.93	0.00e+00	772.00
IUUC-Eeu-034515	Erinaceus europaeus	78.10	5.00e-61	228.00
IUUC-Fca-035398	Felis catus	74.42	0.00e+00	739.00
IUUC-Fal-036758	Ficedula albicollis	67.72	0.00e+00	704.00
IUUC-Gmo-039014	Gadus morhua	76.29	0.00e+00	894.00
IUUC-Gga-040575	Gallus gallus	68.91	0.00e+00	809.00
IUUC-Gac-041414	Gasterosteus aculeatus	81.13	0.00e+00	902.00
IUUC-Hsa-046272	Homo sapiens	70.72	0.00e+00	830.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	74.00	0.00e+00	749.00
IUUC-Lch-050491	Latimeria chalumnae	70.10	0.00e+00	785.00
IUUC-Loc-052758	Lepisosteus oculatus	73.96	0.00e+00	837.00
IUUC-Laf-053452	Loxodonta africana	71.35	0.00e+00	761.00
IUUC-Mcc-055820	Macaca mulatta	74.27	0.00e+00	739.00
IUUC-Meu-056726	Macropus eugenii	69.94	0.00e+00	652.00
IUUC-Mga-059937	Meleagris gallopavo	73.20	0.00e+00	756.00
IUUC-Mmr-060730	Microcebus murinus	70.56	0.00e+00	805.00
IUUC-Mdo-062771	Monodelphis domestica	69.69	0.00e+00	818.00
IUUC-Mmu-064219	Mus musculus	71.55	0.00e+00	834.00
IUUC-Mac-065495	Musa acuminata	29.47	1.00e-30	127.00
IUUC-Mpu-066796	Mustela putorius furo	74.80	0.00e+00	742.00
IUUC-Mlu-068189	Myotis lucifugus	74.11	0.00e+00	758.00
IUUC-Nle-069239	Nomascus leucogenys	70.03	0.00e+00	783.00
IUUC-Opr-070702	Ochotona princeps	60.00	1.00e-87	317.00
IUUC-Ont-072033	Oreochromis niloticus	83.95	0.00e+00	1033.00
IUUC-Oan-073717	Ornithorhynchus anatinus	79.37	0.00e+00	691.00
IUUC-Ocu-074145	Oryctolagus cuniculus	68.91	0.00e+00	827.00
IUUC-Ogl-077929	Oryza glaberrima	40.85	2.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	79.63	0.00e+00	979.00
IUUC-Oga-088486	Otolemur garnettii	74.24	0.00e+00	752.00
IUUC-Oar-089310	Ovis aries	74.29	0.00e+00	757.00
IUUC-Ptr-090649	Pan troglodytes	74.76	0.00e+00	763.00
IUUC-Pan-091692	Papio anubis	66.45	0.00e+00	763.00
IUUC-Psi-093064	Pelodiscus sinensis	82.25	0.00e+00	656.00
IUUC-Pma-094763	Petromyzon marinus	75.82	8.00e-96	342.00
IUUC-Ppa-095969	Physcomitrella patens	30.77	2.00e-40	160.00
IUUC-Pfo-096810	Poecilia formosa	81.48	0.00e+00	987.00
IUUC-Pab-097859	Pongo abelii	73.00	0.00e+00	745.00
IUUC-Pop-099576	Populus trichocarpa	29.28	4.00e-27	116.00
IUUC-Pca-100344	Procavia capensis	69.36	0.00e+00	786.00
IUUC-Pva-103114	Pteropus vampyrus	47.56	1.00e-126	447.00
IUUC-Rno-105880	Rattus norvegicus	69.24	0.00e+00	780.00
IUUC-Sha-107015	Sarcophilus harrisii	74.67	0.00e+00	770.00
IUUC-Smo-109664	Selaginella moellendorffii	28.70	2.00e-33	136.00
IUUC-Sar-113397	Sorex araneus	80.70	9.00e-178	616.00
IUUC-Ssc-115988	Sus scrofa	64.82	1.00e-86	313.00
IUUC-Tgu-116717	Taeniopygia guttata	74.26	0.00e+00	761.00
IUUC-Tsy-119442	Tarsius syrichta	68.45	0.00e+00	657.00
IUUC-Tni-119777	Tetraodon nigroviridis	87.55	0.00e+00	778.00
IUUC-Tbe-127322	Tupaia belangeri	51.50	2.00e-75	276.00
IUUC-Ttr-128181	Tursiops truncatus	73.30	0.00e+00	756.00
IUUC-Vpa-130483	Vicugna pacos	69.43	2.00e-147	515.00
IUUC-Xtr-132614	Xenopus tropicalis	67.26	0.00e+00	688.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence