iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074199

UUCD1 version

UUC-OrC-00329

Ensembl Protein ID

ENSOCUP00000007808.2

UniProt Accession

G1SWE5; G1SWE5_RABIT

Protein Name

Uncharacterized protein

Gene Name

WDR61

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000009040.3	ENSOCUT00000009040.3	ENSOCUP00000007808.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-32	109.7	188	225
UBD/Beta-Prp	1.40e-57	195.2	12	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ ++++l f +d  llv++sdDg ik++D++t+ +l
   Q: 188  GHAMPIRSLTFsPDsQLLVTASDDGYIKIYDVSTCSSL 225
           79999*******999*****************998776 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvh 88
           +++h++ i +v++    +++++ ++tgs d+ +kvw++ ++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ 
   Q: 12   EQAHDDAIWSVAWgtnkKENTETVVTGSLDDLVKVWKWCDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100
           5677888888999988889999******************999989******************************************* PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++ +   ++++l+fsp++++l++G+h+  ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g
   Q: 101  SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
           ******************************************.*********************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            h  +++sl+f+++++ lv++s+dg++k++d++t + + ++ +   ++  v        l   ssD+s+++Wd+ ++++++t+  h+++
   Q: 189  -HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVSTCSSLCKVCA---WIDAVVSY--CRSLFDSSSDKSVKVWDVGTRTCVHTFFDHQDQ 271
           .*******************************98865555555...55544444..5559999************************** PP
   S: 267  visvav 272
           v+ v++
   Q: 272  VWGVKY 277
           **9987 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MTNQYSILFK QEQAHDDAIW SVAWGTNKKE NTETVVTGSL DDLVKVWKWC DERLDLQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGAATGGG GCGTGGCTTT CTCCCCTCTC CCCGCCCACC CACCTCCGCG TCTGCTGCAC 60
GTGCGGCATA GTGACGGTAG GGGGCGCTGC GACGTGAGCT AGCGCCCTGG GGGGCGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005829--C:cytosol
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000774	Aegilops tauschii	31.38	8.00e-41	160.00
IUUC-Aml-002245	Ailuropoda melanoleuca	85.25	2.00e-138	484.00
IUUC-Atr-003142	Amborella trichopoda	46.62	2.00e-31	129.00
IUUC-Apl-003179	Anas platyrhynchos	78.03	3.00e-128	450.00
IUUC-Aca-004880	Anolis carolinensis	76.07	4.00e-133	467.00
IUUC-Aly-005956	Arabidopsis lyrata	34.78	2.00e-47	182.00
IUUC-Ath-007230	Arabidopsis thaliana	34.45	3.00e-43	168.00
IUUC-Acl-008297	Aspergillus clavatus	29.02	5.00e-23	102.00
IUUC-Ame-011511	Astyanax mexicanus	72.88	2.00e-123	434.00
IUUC-Bgr-012189	Blumeria graminis	30.26	2.00e-26	112.00
IUUC-Bta-012936	Bos taurus	84.59	3.00e-137	480.00
IUUC-Bdi-015020	Brachypodium distachyon	34.15	3.00e-40	158.00
IUUC-Bol-016345	Brassica oleracea	36.12	1.00e-48	186.00
IUUC-Bra-017323	Brassica rapa	36.12	1.00e-48	186.00
IUUC-Cja-019961	Callithrix jacchus	84.92	2.00e-137	481.00
IUUC-Cfa-020862	Canis familiaris	85.25	2.00e-138	484.00
IUUC-Cpo-021356	Cavia porcellus	84.77	2.00e-135	474.00
IUUC-Cre-022602	Chlamydomonas reinhardtii	36.96	1.00e-48	186.00
IUUC-Csa-024067	Chlorocebus sabaeus	84.59	1.00e-136	479.00
IUUC-Cho-024421	Choloepus hoffmanni	62.12	2.00e-51	194.00
IUUC-Cin-025261	Ciona intestinalis	56.72	3.00e-99	354.00
IUUC-Cgl-026446	Colletotrichum gloeosporioides	27.41	1.00e-24	106.00
IUUC-Dre-027706	Danio rerio	62.50	6.00e-99	353.00
IUUC-Dno-029084	Dasypus novemcinctus	84.69	2.00e-136	478.00
IUUC-Dor-030353	Dipodomys ordii	83.33	1.00e-127	448.00
IUUC-Dme-031836	Drosophila melanogaster	48.68	2.00e-73	269.00
IUUC-Ete-032261	Echinops telfairi	81.97	2.00e-131	461.00
IUUC-Eca-034231	Equus caballus	84.87	5.00e-138	483.00
IUUC-Eeu-034828	Erinaceus europaeus	83.74	2.00e-127	448.00
IUUC-Fca-036569	Felis catus	85.57	5.00e-139	486.00
IUUC-Fal-037469	Ficedula albicollis	79.34	7.00e-131	459.00
IUUC-Fox-038047	Fusarium oxysporum	31.31	1.00e-25	110.00
IUUC-Gmo-039579	Gadus morhua	73.68	9.00e-122	429.00
IUUC-Gga-040808	Gallus gallus	79.45	4.00e-124	437.00
IUUC-Gac-042100	Gasterosteus aculeatus	73.68	1.00e-122	432.00
IUUC-Gma-044408	Glycine max	38.13	6.00e-50	191.00
IUUC-Ggo-045227	Gorilla gorilla	84.92	2.00e-137	481.00
IUUC-Hsa-045839	Homo sapiens	84.92	2.00e-137	481.00
IUUC-Hvu-047591	Hordeum vulgare	35.31	7.00e-43	167.00
IUUC-Itr-048741	Ictidomys tridecemlineatus	85.25	6.00e-138	483.00
IUUC-Lch-049549	Latimeria chalumnae	71.48	6.00e-121	426.00
IUUC-Lpe-050746	Leersia perrieri	35.67	3.00e-40	158.00
IUUC-Loc-052540	Lepisosteus oculatus	75.08	5.00e-121	427.00
IUUC-Lma-052992	Leptosphaeria maculans	26.78	2.00e-25	109.00
IUUC-Laf-053907	Loxodonta africana	85.25	6.00e-138	483.00
IUUC-Mcc-055828	Macaca mulatta	79.38	3.00e-133	467.00
IUUC-Meu-056075	Macropus eugenii	78.43	2.00e-105	374.00
IUUC-Mor-056971	Magnaporthe oryzae	30.77	1.00e-24	106.00
IUUC-Mtr-057728	Medicago truncatula	37.12	5.00e-47	181.00
IUUC-Mga-059872	Meleagris gallopavo	79.67	2.00e-131	461.00
IUUC-Mvi-060564	Microbotryum violaceum	31.21	4.00e-31	128.00
IUUC-Mmr-060985	Microcebus murinus	82.24	5.00e-129	453.00
IUUC-Mdo-062758	Monodelphis domestica	77.38	1.00e-129	455.00
IUUC-Mmu-063580	Mus musculus	83.61	8.00e-136	476.00
IUUC-Mac-064880	Musa acuminata	37.25	8.00e-51	193.00
IUUC-Mpu-066577	Mustela putorius furo	84.59	2.00e-136	478.00
IUUC-Nle-069573	Nomascus leucogenys	84.92	2.00e-137	481.00
IUUC-Opr-070216	Ochotona princeps	85.71	6.00e-136	476.00
IUUC-Ont-071981	Oreochromis niloticus	73.68	1.00e-123	436.00
IUUC-Oan-073223	Ornithorhynchus anatinus	84.38	3.00e-90	323.00
IUUC-Oba-075255	Oryza barthii	36.44	5.00e-33	134.00
IUUC-Obr-076168	Oryza brachyantha	41.89	8.00e-27	114.00
IUUC-Ogl-077777	Oryza glaberrima	35.12	2.00e-40	159.00
IUUC-Ogu-078780	Oryza glumaepatula	35.12	2.00e-40	159.00
IUUC-Oin-079228	Oryza indica	35.12	6.00e-43	167.00
IUUC-Ome-081421	Oryza meridionalis	35.12	3.00e-39	155.00
IUUC-Oni-082997	Oryza nivara	35.12	6.00e-43	167.00
IUUC-Opu-083931	Oryza punctata	35.45	7.00e-41	160.00
IUUC-Oru-084645	Oryza rufipogon	35.12	2.00e-40	159.00
IUUC-Osa-085842	Oryza sativa	35.12	6.00e-43	167.00
IUUC-Ola-086696	Oryzias latipes	72.70	4.00e-119	420.00
IUUC-Olu-087643	Ostreococcus lucimarinus	38.66	8.00e-35	139.00
IUUC-Oga-088272	Otolemur garnettii	83.61	1.00e-134	472.00
IUUC-Oar-089416	Ovis aries	84.59	3.00e-137	480.00
IUUC-Ptr-090944	Pan troglodytes	84.92	2.00e-137	481.00
IUUC-Pan-091861	Papio anubis	84.92	2.00e-137	481.00
IUUC-Psi-093750	Pelodiscus sinensis	80.00	7.00e-131	459.00
IUUC-Pma-094608	Petromyzon marinus	70.19	2.00e-109	388.00
IUUC-Pno-094832	Phaeosphaeria nodorum	31.25	1.00e-24	107.00
IUUC-Ppa-095737	Physcomitrella patens	37.00	5.00e-49	187.00
IUUC-Pfo-096479	Poecilia formosa	74.67	2.00e-117	415.00
IUUC-Pab-098179	Pongo abelii	84.92	2.00e-137	481.00
IUUC-Pop-099532	Populus trichocarpa	38.11	8.00e-52	197.00
IUUC-Pca-100664	Procavia capensis	66.79	5.00e-86	310.00
IUUC-Ppe-102056	Prunus persica	37.28	2.00e-49	189.00
IUUC-Pva-102859	Pteropus vampyrus	85.25	2.00e-137	481.00
IUUC-Pte-104236	Pyrenophora teres	33.89	1.00e-23	103.00
IUUC-Rno-105826	Rattus norvegicus	83.28	3.00e-135	474.00
IUUC-Sha-106660	Sarcophilus harrisii	78.48	2.00e-123	434.00
IUUC-Sja-107800	Schizosaccharomyces japonicus	30.88	2.00e-30	125.00
IUUC-Spo-108244	Schizosaccharomyces pombe	29.66	5.00e-29	121.00
IUUC-Smo-109234	Selaginella moellendorffii	40.20	2.00e-54	206.00
IUUC-Sit-110048	Setaria italica	34.59	3.00e-34	139.00
IUUC-Sly-111618	Solanum lycopersicum	36.93	2.00e-45	176.00
IUUC-Stu-112543	Solanum tuberosum	37.28	1.00e-48	186.00
IUUC-Sar-113743	Sorex araneus	96.35	2.00e-119	421.00
IUUC-Sbi-114309	Sorghum bicolor	37.22	1.00e-35	143.00
IUUC-Ssc-115560	Sus scrofa	79.02	6.00e-124	436.00
IUUC-Tgu-117300	Taeniopygia guttata	79.67	2.00e-131	461.00
IUUC-Tru-117933	Takifugu rubripes	73.68	3.00e-123	434.00
IUUC-Tsy-119574	Tarsius syrichta	74.43	6.00e-114	403.00
IUUC-Tni-120191	Tetraodon nigroviridis	72.03	3.00e-85	307.00
IUUC-Tca-120983	Theobroma cacao	36.48	2.00e-47	182.00
IUUC-Tae-124056	Triticum aestivum	33.89	6.00e-43	167.00
IUUC-Tur-126711	Triticum urartu	33.33	6.00e-41	160.00
IUUC-Tme-127066	Tuber melanosporum	33.60	5.00e-30	125.00
IUUC-Tbe-127802	Tupaia belangeri	85.57	5.00e-139	486.00
IUUC-Ttr-128861	Tursiops truncatus	97.17	5.00e-56	210.00
IUUC-Vpa-130618	Vicugna pacos	86.78	1.00e-117	415.00
IUUC-Vvi-130981	Vitis vinifera	39.08	7.00e-49	187.00
IUUC-Xtr-132460	Xenopus tropicalis	73.36	3.00e-118	417.00
IUUC-Xma-134154	Xiphophorus maculatus	74.67	1.00e-117	415.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence