iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044527

UUCD1 version

UUC-GoG-00896

Ensembl Protein ID

ENSGGOP00000024803.1

UniProt Accession

G3S9N6; G3S9N6_GORGO

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000008612.2	ENSGGOT00000034234.1	ENSGGOP00000024803.1
ENSGGOG00000008612.2	ENSGGOT00000008653.2	ENSGGOP00000008421.2
ENSGGOG00000008612.2	ENSGGOT00000025465.1	ENSGGOP00000018275.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-92	311.5	486	823

Active Site

Position(s)	Description	Evidence
791	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++ ++   +lk++ef+Grl+gk+l+++     
   Q: 486  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRPTH--LRLKMYEFAGRLVGKCLYESslgga 572
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtn+Nk 
   Q: 573  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKI 658
           99***********************************99****99...9****9****9999999************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelel.licGeeeidvedlkket.kykggytedspaiqwFwevleefss 258
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+ele   +   +  ++  + + +  y + +++++++++wFw v++++++
   Q: 659  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELEEpRLLRLSLGSSCLWLECIiLY-SYWEKKKKVMRWFWTVVSSLTQ 746
           *******************************************97344455677777888877455.5599****************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ee +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  EELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 823
           *************************99555555.**************************************9***97 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTTGGGG AAACGGCAAT CCCCCGAGCC GGTTCCCAGG CCGGGTGGAG ACCAACTCTG 60
GGGTCTCTTG GTAGGAGAGT GGAGAGCACG TCTTCTGCTG AGTGCTGCCG CCCCTTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	94.41	0.00e+00	1576.00
IUUC-Apl-004071	Anas platyrhynchos	87.91	0.00e+00	1404.00
IUUC-Aca-005218	Anolis carolinensis	88.16	0.00e+00	1432.00
IUUC-Ame-011871	Astyanax mexicanus	77.06	0.00e+00	1323.00
IUUC-Bta-012978	Bos taurus	94.05	0.00e+00	1571.00
IUUC-Cja-019081	Callithrix jacchus	96.12	0.00e+00	1600.00
IUUC-Cfa-020736	Canis familiaris	91.84	0.00e+00	1476.00
IUUC-Cpo-021581	Cavia porcellus	93.93	0.00e+00	1567.00
IUUC-Csa-024189	Chlorocebus sabaeus	98.96	0.00e+00	945.00
IUUC-Cho-024751	Choloepus hoffmanni	93.08	0.00e+00	1487.00
IUUC-Cin-025773	Ciona intestinalis	40.99	1.00e-140	493.00
IUUC-Csv-026090	Ciona savignyi	39.53	1.00e-164	573.00
IUUC-Dre-027788	Danio rerio	77.43	0.00e+00	1324.00
IUUC-Dno-030022	Dasypus novemcinctus	94.30	0.00e+00	1571.00
IUUC-Dme-031577	Drosophila melanogaster	45.58	0.00e+00	679.00
IUUC-Ete-032402	Echinops telfairi	93.17	0.00e+00	1517.00
IUUC-Eca-033908	Equus caballus	95.39	0.00e+00	1590.00
IUUC-Eeu-034869	Erinaceus europaeus	92.87	0.00e+00	863.00
IUUC-Fca-036023	Felis catus	94.42	0.00e+00	1575.00
IUUC-Fal-037477	Ficedula albicollis	88.63	0.00e+00	1465.00
IUUC-Gmo-039197	Gadus morhua	77.31	0.00e+00	1298.00
IUUC-Gga-040704	Gallus gallus	88.39	0.00e+00	1456.00
IUUC-Gac-041511	Gasterosteus aculeatus	76.09	0.00e+00	1305.00
IUUC-Hsa-046082	Homo sapiens	96.48	0.00e+00	1605.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	94.54	0.00e+00	1578.00
IUUC-Lch-049772	Latimeria chalumnae	75.54	0.00e+00	1223.00
IUUC-Loc-052541	Lepisosteus oculatus	78.77	0.00e+00	1331.00
IUUC-Laf-053852	Loxodonta africana	94.17	0.00e+00	1566.00
IUUC-Mcc-054759	Macaca mulatta	99.77	0.00e+00	858.00
IUUC-Meu-056247	Macropus eugenii	78.06	0.00e+00	840.00
IUUC-Mga-060161	Meleagris gallopavo	87.56	0.00e+00	1437.00
IUUC-Mmr-061447	Microcebus murinus	94.78	0.00e+00	1578.00
IUUC-Mdo-062110	Monodelphis domestica	91.50	0.00e+00	1474.00
IUUC-Mmu-064349	Mus musculus	93.81	0.00e+00	1570.00
IUUC-Mpu-065824	Mustela putorius furo	94.42	0.00e+00	1567.00
IUUC-Mlu-067729	Myotis lucifugus	94.54	0.00e+00	1544.00
IUUC-Nle-069721	Nomascus leucogenys	95.87	0.00e+00	1585.00
IUUC-Opr-070189	Ochotona princeps	94.13	0.00e+00	1557.00
IUUC-Ont-072122	Oreochromis niloticus	77.91	0.00e+00	1302.00
IUUC-Oan-072700	Ornithorhynchus anatinus	80.83	0.00e+00	1164.00
IUUC-Ocu-074057	Oryctolagus cuniculus	94.42	0.00e+00	1572.00
IUUC-Ola-087492	Oryzias latipes	76.24	0.00e+00	1304.00
IUUC-Oga-088084	Otolemur garnettii	95.02	0.00e+00	1578.00
IUUC-Oar-090354	Ovis aries	94.36	0.00e+00	1553.00
IUUC-Ptr-091456	Pan troglodytes	96.48	0.00e+00	1603.00
IUUC-Pan-092596	Papio anubis	95.27	0.00e+00	1585.00
IUUC-Psi-092942	Pelodiscus sinensis	89.60	0.00e+00	1465.00
IUUC-Pma-094662	Petromyzon marinus	57.68	0.00e+00	704.00
IUUC-Pfo-096838	Poecilia formosa	77.67	0.00e+00	1285.00
IUUC-Pab-097849	Pongo abelii	96.12	0.00e+00	1602.00
IUUC-Pca-100498	Procavia capensis	95.60	0.00e+00	936.00
IUUC-Pva-102599	Pteropus vampyrus	94.54	0.00e+00	1557.00
IUUC-Rno-105776	Rattus norvegicus	94.17	0.00e+00	1560.00
IUUC-Sha-106699	Sarcophilus harrisii	91.38	0.00e+00	1476.00
IUUC-Sar-113621	Sorex araneus	92.51	0.00e+00	1518.00
IUUC-Ssc-115742	Sus scrofa	94.42	0.00e+00	1577.00
IUUC-Tgu-116490	Taeniopygia guttata	88.15	0.00e+00	1461.00
IUUC-Tru-117679	Takifugu rubripes	76.82	0.00e+00	1290.00
IUUC-Tsy-119607	Tarsius syrichta	89.44	0.00e+00	1077.00
IUUC-Tni-120376	Tetraodon nigroviridis	73.55	0.00e+00	1216.00
IUUC-Tbe-127348	Tupaia belangeri	64.77	3.00e-176	611.00
IUUC-Ttr-128786	Tursiops truncatus	90.78	0.00e+00	1505.00
IUUC-Vpa-130180	Vicugna pacos	97.00	0.00e+00	1302.00
IUUC-Xtr-132631	Xenopus tropicalis	65.66	0.00e+00	1097.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence