iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-092942

Ensembl Protein ID

ENSPSIP00000019005.1

UniProt Accession

K7GFE4; K7GFE4_PELSI

Genbank Protein ID

ENSPSIP00000019005

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01050061

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000016885.1	ENSPSIT00000019091.1	ENSPSIP00000019005.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.60e-101	338.3	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp +   ++ +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVIFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPVRP--PHLRLKVYEFAGRLVGKCLYESslgga 571
           7999**************************************788999*********998..459******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtneNk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKLGQLEKVVELVTGGAQVPVTNENKI 657
           99***********************************99****99...9****999999999999999999****************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++ +  g ++ ++++++wFw v+++f++e
   Q: 658  FYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvMVGGSWHFREKVMRWFWTVVSSFTQE 746
           **************************************************************6668889******************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQHEDRER RGERTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV QICHVELAMD IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGCTGTG GGCTTCGAGC TGATGGCGCC TTTCAGATGC GACCTAGTTC TACCTGATTT 60
GCTGAGGTGA TCATGAAGCA TGATGAATAC AAGCATCAGC ACAGGCTGAG TTACAGCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

pss:102450546

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	92.58	0.00e+00	1560.00
IUUC-Apl-004071	Anas platyrhynchos	94.41	0.00e+00	1519.00
IUUC-Aca-005218	Anolis carolinensis	94.78	0.00e+00	1554.00
IUUC-Ame-011871	Astyanax mexicanus	80.07	0.00e+00	1395.00
IUUC-Bta-012978	Bos taurus	92.10	0.00e+00	1552.00
IUUC-Cja-019081	Callithrix jacchus	92.47	0.00e+00	1558.00
IUUC-Cfa-020736	Canis familiaris	90.72	0.00e+00	1470.00
IUUC-Cpo-021581	Cavia porcellus	92.10	0.00e+00	1553.00
IUUC-Csa-024189	Chlorocebus sabaeus	89.77	0.00e+00	859.00
IUUC-Cho-024751	Choloepus hoffmanni	92.10	0.00e+00	1492.00
IUUC-Cin-025773	Ciona intestinalis	42.86	5.00e-149	521.00
IUUC-Csv-026090	Ciona savignyi	41.06	8.00e-174	603.00
IUUC-Dre-027788	Danio rerio	80.19	0.00e+00	1398.00
IUUC-Dno-030022	Dasypus novemcinctus	92.10	0.00e+00	1553.00
IUUC-Dme-031577	Drosophila melanogaster	46.80	0.00e+00	718.00
IUUC-Ete-032402	Echinops telfairi	90.11	0.00e+00	1482.00
IUUC-Eca-033908	Equus caballus	92.83	0.00e+00	1564.00
IUUC-Eeu-034869	Erinaceus europaeus	94.60	0.00e+00	894.00
IUUC-Fca-036023	Felis catus	93.20	0.00e+00	1566.00
IUUC-Fal-037477	Ficedula albicollis	94.90	0.00e+00	1568.00
IUUC-Gmo-039197	Gadus morhua	80.80	0.00e+00	1380.00
IUUC-Gga-040704	Gallus gallus	94.78	0.00e+00	1565.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.10	0.00e+00	1379.00
IUUC-Ggo-044527	Gorilla gorilla	89.32	0.00e+00	1487.00
IUUC-Hsa-046082	Homo sapiens	92.59	0.00e+00	1560.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	92.83	0.00e+00	1564.00
IUUC-Lch-049772	Latimeria chalumnae	77.89	0.00e+00	1266.00
IUUC-Loc-052541	Lepisosteus oculatus	82.18	0.00e+00	1415.00
IUUC-Laf-053852	Loxodonta africana	92.10	0.00e+00	1548.00
IUUC-Mcc-054759	Macaca mulatta	89.84	0.00e+00	776.00
IUUC-Meu-056247	Macropus eugenii	77.18	0.00e+00	836.00
IUUC-Mga-060161	Meleagris gallopavo	93.69	0.00e+00	1545.00
IUUC-Mmr-061447	Microcebus murinus	92.71	0.00e+00	1560.00
IUUC-Mdo-062110	Monodelphis domestica	93.07	0.00e+00	1520.00
IUUC-Mmu-064349	Mus musculus	91.62	0.00e+00	1550.00
IUUC-Mpu-065824	Mustela putorius furo	92.95	0.00e+00	1553.00
IUUC-Mlu-067729	Myotis lucifugus	92.71	0.00e+00	1540.00
IUUC-Nle-069721	Nomascus leucogenys	92.35	0.00e+00	1547.00
IUUC-Opr-070189	Ochotona princeps	92.53	0.00e+00	1549.00
IUUC-Ont-072122	Oreochromis niloticus	80.44	0.00e+00	1373.00
IUUC-Oan-072700	Ornithorhynchus anatinus	83.76	0.00e+00	1221.00
IUUC-Ocu-074057	Oryctolagus cuniculus	92.47	0.00e+00	1560.00
IUUC-Ola-087492	Oryzias latipes	79.59	0.00e+00	1388.00
IUUC-Oga-088084	Otolemur garnettii	92.59	0.00e+00	1553.00
IUUC-Oar-090354	Ovis aries	91.77	0.00e+00	1527.00
IUUC-Ptr-091456	Pan troglodytes	92.47	0.00e+00	1555.00
IUUC-Pan-092596	Papio anubis	91.38	0.00e+00	1531.00
IUUC-Pma-094662	Petromyzon marinus	63.38	0.00e+00	770.00
IUUC-Pfo-096838	Poecilia formosa	80.56	0.00e+00	1352.00
IUUC-Pab-097849	Pongo abelii	92.10	0.00e+00	1553.00
IUUC-Pca-100498	Procavia capensis	90.38	0.00e+00	886.00
IUUC-Pva-102599	Pteropus vampyrus	92.83	0.00e+00	1544.00
IUUC-Rno-105776	Rattus norvegicus	92.35	0.00e+00	1551.00
IUUC-Sha-106699	Sarcophilus harrisii	92.95	0.00e+00	1517.00
IUUC-Sar-113621	Sorex araneus	90.77	0.00e+00	1504.00
IUUC-Ssc-115742	Sus scrofa	92.59	0.00e+00	1560.00
IUUC-Tgu-116490	Taeniopygia guttata	94.41	0.00e+00	1567.00
IUUC-Tru-117679	Takifugu rubripes	79.95	0.00e+00	1364.00
IUUC-Tsy-119607	Tarsius syrichta	88.94	0.00e+00	1078.00
IUUC-Tni-120376	Tetraodon nigroviridis	76.33	0.00e+00	1283.00
IUUC-Tbe-127348	Tupaia belangeri	62.94	3.00e-171	594.00
IUUC-Ttr-128786	Tursiops truncatus	89.06	0.00e+00	1488.00
IUUC-Vpa-130180	Vicugna pacos	91.43	0.00e+00	1227.00
IUUC-Xtr-132631	Xenopus tropicalis	68.48	0.00e+00	1153.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence