iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115933

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

CU207285

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000006386.2	ENSSSCT00000006999.2	ENSSSCP00000006809.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-36	122.0	50	80
UBD/Beta-Prp	4.10e-76	256.3	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgaves 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888888777********************************888888*************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 324
           *******************************.5554444444.589999999988765 PP

Organism

Sus scrofa

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTTCGTGT CTGAGGAGCT TCCGGGAGTC GCGGCAGAGG GACGCTGACG TGGAGGCAGC 60
CGTAAGGCGG CAGGGAGTGT CAGGGCTCGG ATTAACAGCT CGGAGCCAGA GACCGGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.85	0.00e+00	1324.00
IUUC-Aml-001758	Ailuropoda melanoleuca	98.86	0.00e+00	2503.00
IUUC-Atr-002493	Amborella trichopoda	54.14	0.00e+00	1317.00
IUUC-Apl-003385	Anas platyrhynchos	96.05	0.00e+00	2063.00
IUUC-Aca-005154	Anolis carolinensis	97.10	1.00e-121	428.00
IUUC-Aly-006020	Arabidopsis lyrata	61.71	0.00e+00	1097.00
IUUC-Ath-007058	Arabidopsis thaliana	61.99	0.00e+00	1092.00
IUUC-Ago-007992	Ashbya gossypii	44.97	0.00e+00	1036.00
IUUC-Acl-008027	Aspergillus clavatus	57.09	0.00e+00	1004.00
IUUC-Afl-008644	Aspergillus flavus	57.23	0.00e+00	1003.00
IUUC-Afu-008964	Aspergillus fumigatus	49.27	0.00e+00	1197.00
IUUC-Ani-009379	Aspergillus nidulans	56.48	0.00e+00	1012.00
IUUC-Ang-009756	Aspergillus niger	49.84	0.00e+00	1213.00
IUUC-Aor-010174	Aspergillus oryzae	49.19	0.00e+00	1188.00
IUUC-Ate-010302	Aspergillus terreus	49.64	0.00e+00	1229.00
IUUC-Ame-011229	Astyanax mexicanus	86.60	0.00e+00	2197.00
IUUC-Bgr-012300	Blumeria graminis	48.68	0.00e+00	1146.00
IUUC-Bta-012524	Bos taurus	99.35	0.00e+00	2484.00
IUUC-Bci-013781	Botrytis cinerea	48.78	0.00e+00	1199.00
IUUC-Bdi-014549	Brachypodium distachyon	54.53	0.00e+00	1350.00
IUUC-Bol-015925	Brassica oleracea	61.63	0.00e+00	1083.00
IUUC-Bra-016978	Brassica rapa	60.93	0.00e+00	1079.00
IUUC-Cel-018115	Caenorhabditis elegans	64.27	0.00e+00	1127.00
IUUC-Cja-019107	Callithrix jacchus	96.03	0.00e+00	2428.00
IUUC-Cfa-020675	Canis familiaris	98.76	0.00e+00	2464.00
IUUC-Cpo-021813	Cavia porcellus	98.86	0.00e+00	2494.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	64.57	0.00e+00	1113.00
IUUC-Csa-023523	Chlorocebus sabaeus	99.18	0.00e+00	2514.00
IUUC-Cho-024704	Choloepus hoffmanni	84.27	0.00e+00	1894.00
IUUC-Cin-025572	Ciona intestinalis	73.01	0.00e+00	1884.00
IUUC-Csv-025864	Ciona savignyi	75.30	0.00e+00	1298.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.35	0.00e+00	1023.00
IUUC-Cne-027053	Cryptococcus neoformans	52.22	0.00e+00	1253.00
IUUC-Cme-027222	Cyanidioschyzon merolae	32.26	5.00e-164	572.00
IUUC-Dre-027421	Danio rerio	86.86	0.00e+00	2239.00
IUUC-Dno-029303	Dasypus novemcinctus	98.86	0.00e+00	2492.00
IUUC-Dor-030290	Dipodomys ordii	97.88	0.00e+00	1120.00
IUUC-Dse-031543	Dothistroma septosporum	46.46	0.00e+00	1124.00
IUUC-Dme-031945	Drosophila melanogaster	69.09	0.00e+00	1703.00
IUUC-Ete-032873	Echinops telfairi	92.60	0.00e+00	2151.00
IUUC-Eca-033773	Equus caballus	97.06	0.00e+00	2429.00
IUUC-Eeu-034874	Erinaceus europaeus	85.93	0.00e+00	1509.00
IUUC-Fca-035739	Felis catus	98.05	0.00e+00	2412.00
IUUC-Fal-037263	Ficedula albicollis	87.86	0.00e+00	2134.00
IUUC-Fox-037738	Fusarium oxysporum	48.56	0.00e+00	1219.00
IUUC-Fso-038153	Fusarium solani	49.07	0.00e+00	1209.00
IUUC-Gmo-039602	Gadus morhua	82.40	0.00e+00	2055.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.44	0.00e+00	1015.00
IUUC-Gga-040590	Gallus gallus	96.90	0.00e+00	2424.00
IUUC-Gac-041318	Gasterosteus aculeatus	86.36	0.00e+00	2214.00
IUUC-Gma-043567	Glycine max	54.90	0.00e+00	1337.00
IUUC-Ggo-045029	Gorilla gorilla	98.30	0.00e+00	2502.00
IUUC-Hsa-046078	Homo sapiens	98.30	0.00e+00	2503.00
IUUC-Hvu-047556	Hordeum vulgare	55.26	0.00e+00	1363.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	97.84	0.00e+00	1740.00
IUUC-Kpa-049256	Komagataella pastoris	45.34	0.00e+00	1088.00
IUUC-Lch-049706	Latimeria chalumnae	93.06	0.00e+00	2320.00
IUUC-Lpe-051316	Leersia perrieri	62.87	0.00e+00	1110.00
IUUC-Loc-051867	Lepisosteus oculatus	71.93	0.00e+00	1216.00
IUUC-Lma-053138	Leptosphaeria maculans	56.43	0.00e+00	1024.00
IUUC-Laf-053510	Loxodonta africana	98.20	0.00e+00	2487.00
IUUC-Mcc-055836	Macaca mulatta	97.97	0.00e+00	2484.00
IUUC-Meu-056238	Macropus eugenii	87.13	0.00e+00	1177.00
IUUC-Mor-057172	Magnaporthe oryzae	48.87	0.00e+00	1200.00
IUUC-Mpo-057300	Magnaporthe poae	48.25	0.00e+00	1184.00
IUUC-Mtr-058248	Medicago truncatula	55.27	0.00e+00	1366.00
IUUC-Mla-059019	Melampsora laricipopulina	52.46	0.00e+00	1294.00
IUUC-Mga-059499	Meleagris gallopavo	96.74	0.00e+00	2419.00
IUUC-Mvi-060336	Microbotryum violaceum	52.96	0.00e+00	1275.00
IUUC-Mmr-061102	Microcebus murinus	98.30	0.00e+00	2456.00
IUUC-Mdo-062594	Monodelphis domestica	98.04	0.00e+00	2518.00
IUUC-Mmu-063736	Mus musculus	97.57	0.00e+00	2475.00
IUUC-Mac-065398	Musa acuminata	52.27	0.00e+00	1244.00
IUUC-Mpu-066701	Mustela putorius furo	98.94	0.00e+00	2454.00
IUUC-Mlu-067392	Myotis lucifugus	97.80	0.00e+00	2464.00
IUUC-Nfi-068270	Neosartorya fischeri	57.45	0.00e+00	1008.00
IUUC-Ncr-068892	Neurospora crassa	49.28	0.00e+00	1189.00
IUUC-Nle-069634	Nomascus leucogenys	99.24	0.00e+00	1376.00
IUUC-Opr-070952	Ochotona princeps	86.04	0.00e+00	1801.00
IUUC-Ont-072488	Oreochromis niloticus	88.32	0.00e+00	2226.00
IUUC-Ocu-074211	Oryctolagus cuniculus	99.10	0.00e+00	2502.00
IUUC-Oba-075761	Oryza barthii	62.75	0.00e+00	1110.00
IUUC-Obr-076429	Oryza brachyantha	62.75	0.00e+00	1109.00
IUUC-Ogl-077364	Oryza glaberrima	62.75	0.00e+00	1110.00
IUUC-Ogu-078257	Oryza glumaepatula	63.01	0.00e+00	1110.00
IUUC-Oin-079274	Oryza indica	62.63	0.00e+00	1108.00
IUUC-Olo-080466	Oryza longistaminata	62.67	0.00e+00	1095.00
IUUC-Ome-081668	Oryza meridionalis	62.41	0.00e+00	933.00
IUUC-Oni-082874	Oryza nivara	63.01	0.00e+00	1110.00
IUUC-Opu-083697	Oryza punctata	54.04	0.00e+00	1336.00
IUUC-Oru-084274	Oryza rufipogon	62.75	0.00e+00	1110.00
IUUC-Osa-085565	Oryza sativa	62.75	0.00e+00	1110.00
IUUC-Ola-086921	Oryzias latipes	87.04	0.00e+00	2205.00
IUUC-Olu-087639	Ostreococcus lucimarinus	56.38	0.00e+00	1372.00
IUUC-Oga-087991	Otolemur garnettii	93.73	0.00e+00	2355.00
IUUC-Oar-089590	Ovis aries	99.43	0.00e+00	2510.00
IUUC-Ptr-090808	Pan troglodytes	98.38	0.00e+00	2504.00
IUUC-Pan-092475	Papio anubis	98.69	0.00e+00	2500.00
IUUC-Psi-093044	Pelodiscus sinensis	79.87	0.00e+00	1694.00
IUUC-Pno-094839	Phaeosphaeria nodorum	48.09	0.00e+00	1118.00
IUUC-Ppa-095254	Physcomitrella patens	56.83	0.00e+00	1406.00
IUUC-Pfo-097493	Poecilia formosa	87.91	0.00e+00	2200.00
IUUC-Pab-098497	Pongo abelii	99.18	0.00e+00	2515.00
IUUC-Pop-099992	Populus trichocarpa	56.51	0.00e+00	1348.00
IUUC-Pca-100413	Procavia capensis	89.47	0.00e+00	1011.00
IUUC-Ppe-101899	Prunus persica	54.63	0.00e+00	1332.00
IUUC-Pva-102126	Pteropus vampyrus	94.81	0.00e+00	2381.00
IUUC-Pgr-103376	Puccinia graminis	52.68	0.00e+00	1311.00
IUUC-Ptt-103978	Puccinia triticina	47.47	0.00e+00	1095.00
IUUC-Pte-104126	Pyrenophora teres	56.83	0.00e+00	981.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	46.94	2.00e-179	622.00
IUUC-Rno-105428	Rattus norvegicus	98.37	0.00e+00	2486.00
IUUC-Sce-106464	Saccharomyces cerevisiae	44.03	0.00e+00	1018.00
IUUC-Sha-107301	Sarcophilus harrisii	98.10	0.00e+00	2464.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.86	0.00e+00	1099.00
IUUC-Spo-108217	Schizosaccharomyces pombe	47.13	0.00e+00	1142.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	48.87	0.00e+00	1206.00
IUUC-Smo-109582	Selaginella moellendorffii	65.87	0.00e+00	1160.00
IUUC-Sit-109697	Setaria italica	62.28	0.00e+00	1102.00
IUUC-Sly-111447	Solanum lycopersicum	55.07	0.00e+00	1366.00
IUUC-Stu-112564	Solanum tuberosum	54.94	0.00e+00	1365.00
IUUC-Sar-113313	Sorex araneus	88.73	0.00e+00	1491.00
IUUC-Sbi-114388	Sorghum bicolor	62.87	0.00e+00	1109.00
IUUC-Sre-115209	Sporisorium reilianum	57.71	0.00e+00	1048.00
IUUC-Tgu-117109	Taeniopygia guttata	81.32	0.00e+00	746.00
IUUC-Tru-117772	Takifugu rubripes	86.76	0.00e+00	2184.00
IUUC-Tsy-119105	Tarsius syrichta	84.18	0.00e+00	2097.00
IUUC-Tni-120556	Tetraodon nigroviridis	70.74	0.00e+00	1524.00
IUUC-Tca-121046	Theobroma cacao	54.60	0.00e+00	1374.00
IUUC-Tre-121951	Trichoderma reesei	57.18	0.00e+00	1019.00
IUUC-Tvi-122359	Trichoderma virens	57.45	0.00e+00	1025.00
IUUC-Tae-125527	Triticum aestivum	53.97	0.00e+00	1330.00
IUUC-Tur-126754	Triticum urartu	62.04	0.00e+00	1103.00
IUUC-Tme-127170	Tuber melanosporum	50.61	0.00e+00	1238.00
IUUC-Tbe-127882	Tupaia belangeri	97.25	0.00e+00	845.00
IUUC-Ttr-128217	Tursiops truncatus	96.76	0.00e+00	2434.00
IUUC-Uma-129337	Ustilago maydis	57.01	0.00e+00	1045.00
IUUC-Vda-129828	Verticillium dahliae	48.51	0.00e+00	1189.00
IUUC-Vpa-130537	Vicugna pacos	98.22	0.00e+00	2461.00
IUUC-Vvi-130958	Vitis vinifera	63.23	0.00e+00	1117.00
IUUC-Xtr-132857	Xenopus tropicalis	90.07	0.00e+00	2273.00
IUUC-Xma-133138	Xiphophorus maculatus	87.66	0.00e+00	2198.00
IUUC-Yli-134399	Yarrowia lipolytica	50.82	0.00e+00	868.00
IUUC-Zma-135612	Zea mays	54.45	0.00e+00	1343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence