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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Ath-006830
Ensembl Protein ID AT5G56280.1
UniProt Accession Q8W206; Q84WB5; Q941I1; Q9FG76; CSN6A_ARATH
Genbank Protein ID AAL07275.1; AAL58106.1; BAB08872.1; AED96744.1; AAO42068.1
Protein Name COP9 signalosome complex subunit 6a
Genbank Nucleotide ID AY048692; AF395063; AB026656; CP002688; BT004034
Gene Name CSN6A; At5g56280; K24C1.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G56280 AT5G56280.1 AT5G56280.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINAHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 39.48 4.00e-58 222.00 IUUC-Dre-028843
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description



     Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
Protein Sequence
(Fasta)
MAPSSSSGLT FKLHPLVIVN ISDHYTRVKT QLNPPASICA SGHGSNNGEA MFQQNPRVYG 60
CVIGVQRGRT VEIFNSFELL YDPSTQTLDR SFLEKKQELY KKVFPDFYIL GWYSTGSDAE 120
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Protein Fasta Sequence



>IUUC-Ath-006830|DUB,JAMM|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
AAATAAAAAA AATCTTCATA AAAAAACTAA AAACCCAAAA ACCAAAGAAT TCATCAAAGG 60
AGAGAGAGAT CGACAATGGC ACCTTCGTCA TCAAGCGGTT TAACCTTCAA GCTACATCCT 120
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Nucleotide Fasta Sequence



>IUUC-Ath-006830|DUB,JAMM|Arabidopsis thaliana
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0607--Phytochrome signaling pathway
KW-1185--Reference proteome
KW-0736--Signalosome

Interpro

IPR000555--JAMM/MPN+_dom
IPR033859--MPN_CSN6
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0010387--P:COP9 signalosome assembly
GO:0007275--P:multicellular organism development
GO:0030163--P:protein catabolic process
GO:0000338--P:protein deneddylation
GO:0009585--P:red, far-red light phototransduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG ath:AT5G56280
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000900 Aegilops tauschii 70.45 1.00e-128 451.00
IUUC-Aml-001678 Ailuropoda melanoleuca 38.19 6.00e-56 210.00
IUUC-Atr-002442 Amborella trichopoda 76.21 5.00e-112 396.00
IUUC-Aca-004366 Anolis carolinensis 33.04 1.00e-31 129.00
IUUC-Aly-005748 Arabidopsis lyrata 96.21 3.00e-177 613.00
IUUC-Acl-008087 Aspergillus clavatus 26.74 1.00e-19 90.10
IUUC-Afl-008629 Aspergillus flavus 24.86 7.00e-12 64.30
IUUC-Afu-008973 Aspergillus fumigatus 27.94 1.00e-21 96.70
IUUC-Ani-009239 Aspergillus nidulans 31.31 2.00e-16 79.70
IUUC-Ang-009845 Aspergillus niger 27.81 2.00e-20 92.80
IUUC-Aor-010137 Aspergillus oryzae 26.20 9.00e-14 70.50
IUUC-Ate-010588 Aspergillus terreus 30.67 1.00e-15 76.60
IUUC-Ame-011532 Astyanax mexicanus 33.72 8.00e-14 67.40
IUUC-Bgr-012126 Blumeria graminis 28.31 4.00e-12 65.10
IUUC-Bta-012891 Bos taurus 38.19 8.00e-56 209.00
IUUC-Bci-013650 Botrytis cinerea 27.08 5.00e-21 94.70
IUUC-Bdi-014189 Brachypodium distachyon 79.19 4.00e-132 463.00
IUUC-Bol-015194 Brassica oleracea 82.08 9.00e-153 531.00
IUUC-Bra-017180 Brassica rapa 90.54 4.00e-166 576.00
IUUC-Cel-018511 Caenorhabditis elegans 24.76 2.00e-22 99.40
IUUC-Cja-019862 Callithrix jacchus 38.31 4.00e-56 211.00
IUUC-Cfa-020552 Canis familiaris 38.19 8.00e-56 209.00
IUUC-Cpo-022433 Cavia porcellus 38.31 5.00e-56 210.00
IUUC-Cre-022699 Chlamydomonas reinhardtii 41.69 3.00e-60 224.00
IUUC-Csa-023484 Chlorocebus sabaeus 38.31 4.00e-56 211.00
IUUC-Cho-024874 Choloepus hoffmanni 36.33 2.00e-35 142.00
IUUC-Cin-025747 Ciona intestinalis 39.56 3.00e-54 204.00
IUUC-Csv-025914 Ciona savignyi 38.80 6.00e-53 200.00
IUUC-Cgl-026665 Colletotrichum gloeosporioides 27.32 2.00e-17 82.80
IUUC-Cne-026818 Cryptococcus neoformans 33.65 2.00e-43 169.00
IUUC-Dre-028843 Danio rerio 39.61 1.00e-64 239.00
IUUC-Dno-029674 Dasypus novemcinctus 38.31 5.00e-56 210.00
IUUC-Dme-032196 Drosophila melanogaster 38.39 4.00e-59 220.00
IUUC-Ete-032593 Echinops telfairi 30.19 6.00e-19 86.70
IUUC-Eca-033933 Equus caballus 38.31 4.00e-56 210.00
IUUC-Fca-035946 Felis catus 38.19 9.00e-56 209.00
IUUC-Fso-038175 Fusarium solani 27.75 8.00e-17 80.90
IUUC-Gmo-038747 Gadus morhua 39.61 4.00e-58 217.00
IUUC-Gac-042199 Gasterosteus aculeatus 39.61 1.00e-58 219.00
IUUC-Gma-043702 Glycine max 80.12 4.00e-144 503.00
IUUC-Ggo-044978 Gorilla gorilla 38.19 8.00e-56 209.00
IUUC-Hsa-045797 Homo sapiens 38.31 5.00e-56 210.00
IUUC-Hvu-047511 Hordeum vulgare 76.51 5.00e-136 476.00
IUUC-Itr-048615 Ictidomys tridecemlineatus 38.31 3.00e-56 211.00
IUUC-Lch-049546 Latimeria chalumnae 36.03 9.00e-50 189.00
IUUC-Lpe-051207 Leersia perrieri 76.21 6.00e-134 469.00
IUUC-Loc-052106 Lepisosteus oculatus 40.26 4.00e-59 220.00
IUUC-Lma-053122 Leptosphaeria maculans 25.26 2.00e-15 76.30
IUUC-Laf-054454 Loxodonta africana 38.31 8.00e-56 209.00
IUUC-Mcc-054679 Macaca mulatta 38.19 5.00e-56 210.00
IUUC-Meu-056427 Macropus eugenii 37.22 3.00e-53 201.00
IUUC-Mor-057093 Magnaporthe oryzae 21.55 1.00e-12 67.00
IUUC-Mtr-058343 Medicago truncatula 81.25 1.00e-146 511.00
IUUC-Mla-059002 Melampsora laricipopulina 34.98 3.00e-35 141.00
IUUC-Mvi-060487 Microbotryum violaceum 35.71 8.00e-52 196.00
IUUC-Mmr-060577 Microcebus murinus 38.31 6.00e-56 210.00
IUUC-Mdo-061918 Monodelphis domestica 38.19 7.00e-56 210.00
IUUC-Mmu-063355 Mus musculus 38.19 8.00e-56 209.00
IUUC-Mac-064465 Musa acuminata 77.99 1.00e-143 501.00
IUUC-Mpu-066813 Mustela putorius furo 38.19 8.00e-56 209.00
IUUC-Mlu-067500 Myotis lucifugus 38.31 4.00e-56 210.00
IUUC-Nfi-068452 Neosartorya fischeri 28.72 3.00e-22 99.00
IUUC-Nle-070166 Nomascus leucogenys 38.19 5.00e-56 210.00
IUUC-Opr-071028 Ochotona princeps 38.31 5.00e-56 210.00
IUUC-Ont-072575 Oreochromis niloticus 39.48 4.00e-58 217.00
IUUC-Ocu-074744 Oryctolagus cuniculus 38.31 5.00e-56 210.00
IUUC-Oba-075665 Oryza barthii 77.42 1.00e-133 468.00
IUUC-Obr-076094 Oryza brachyantha 81.82 7.00e-118 415.00
IUUC-Ogl-077223 Oryza glaberrima 77.42 1.00e-133 468.00
IUUC-Ogu-077975 Oryza glumaepatula 77.42 1.00e-133 468.00
IUUC-Oin-079690 Oryza indica 76.13 2.00e-129 454.00
IUUC-Ome-081114 Oryza meridionalis 77.74 7.00e-133 466.00
IUUC-Oni-082275 Oryza nivara 77.10 6.00e-132 462.00
IUUC-Opu-083281 Oryza punctata 77.74 9.00e-133 465.00
IUUC-Oru-084767 Oryza rufipogon 77.42 1.00e-132 464.00
IUUC-Osa-085506 Oryza sativa 77.42 1.00e-132 464.00
IUUC-Ola-086468 Oryzias latipes 39.16 5.00e-58 217.00
IUUC-Oga-088732 Otolemur garnettii 38.31 8.00e-56 209.00
IUUC-Oar-089714 Ovis aries 38.19 1.00e-55 209.00
IUUC-Ptr-091383 Pan troglodytes 38.31 6.00e-56 210.00
IUUC-Pan-091752 Papio anubis 38.31 4.00e-56 211.00
IUUC-Psi-094080 Pelodiscus sinensis 37.54 8.00e-60 223.00
IUUC-Ppa-095312 Physcomitrella patens 72.93 2.00e-135 474.00
IUUC-Pfo-096180 Poecilia formosa 38.64 5.00e-58 217.00
IUUC-Pab-098521 Pongo abelii 38.31 4.00e-56 211.00
IUUC-Pop-099014 Populus trichocarpa 83.28 2.00e-146 511.00
IUUC-Pca-100331 Procavia capensis 40.16 2.00e-54 204.00
IUUC-Ppe-101223 Prunus persica 77.09 1.00e-133 468.00
IUUC-Pva-103061 Pteropus vampyrus 38.31 5.00e-56 210.00
IUUC-Pgr-103302 Puccinia graminis 30.58 2.00e-34 139.00
IUUC-Ptt-103773 Puccinia triticina 32.69 4.00e-38 150.00
IUUC-Pte-104297 Pyrenophora teres 31.82 1.00e-16 80.50
IUUC-Rno-105606 Rattus norvegicus 38.19 1.00e-55 209.00
IUUC-Sha-106621 Sarcophilus harrisii 38.19 5.00e-56 210.00
IUUC-Ssl-108446 Sclerotinia sclerotiorum 27.63 2.00e-20 92.40
IUUC-Smo-108791 Selaginella moellendorffii 69.75 9.00e-122 428.00
IUUC-Sit-110800 Setaria italica 77.81 1.00e-132 465.00
IUUC-Sly-111003 Solanum lycopersicum 78.86 8.00e-140 488.00
IUUC-Stu-112083 Solanum tuberosum 78.55 8.00e-141 492.00
IUUC-Sar-113677 Sorex araneus 47.06 4.00e-04 37.70
IUUC-Sbi-113936 Sorghum bicolor 76.60 5.00e-132 462.00
IUUC-Sre-114955 Sporisorium reilianum 35.47 3.00e-49 187.00
IUUC-Tru-118518 Takifugu rubripes 39.48 3.00e-58 218.00
IUUC-Tsy-119285 Tarsius syrichta 47.06 8.00e-04 36.20
IUUC-Tni-120511 Tetraodon nigroviridis 39.29 3.00e-58 218.00
IUUC-Tca-121233 Theobroma cacao 83.80 2.00e-153 534.00
IUUC-Tae-123297 Triticum aestivum 76.83 2.00e-136 477.00
IUUC-Tur-126485 Triticum urartu 61.27 5.00e-97 346.00
IUUC-Tme-127071 Tuber melanosporum 28.98 7.00e-27 114.00
IUUC-Tbe-127457 Tupaia belangeri 37.86 1.00e-50 192.00
IUUC-Ttr-128708 Tursiops truncatus 37.58 5.00e-51 193.00
IUUC-Uma-129646 Ustilago maydis 35.06 8.00e-49 186.00
IUUC-Vpa-130606 Vicugna pacos 36.84 4.00e-24 104.00
IUUC-Vvi-131045 Vitis vinifera 83.28 2.00e-149 520.00
IUUC-Xtr-132674 Xenopus tropicalis 39.61 2.00e-64 238.00
IUUC-Xma-133413 Xiphophorus maculatus 38.96 2.00e-58 218.00
IUUC-Yli-134661 Yarrowia lipolytica 25.65 1.00e-20 92.80
IUUC-Zma-135166 Zea mays 76.21 6.00e-131 459.00
Created Date 25-Jun-2017

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