iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073167

UUCD1 version

UUC-OrA-00824

Ensembl Protein ID

ENSOANP00000005145.2

UniProt Accession

F6SMM8; F6SMM8_ORNAN

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000003247.2	ENSOANT00000005146.2	ENSOANP00000005145.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.70e-167	556.7	3	677

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgv+++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk+++++++++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVRGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q++ ++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l+vlk++         
   Q: 174  VPIKGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYESKLHVLKMNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqtqksqeaqapedpkpgsskapavldanrthlasegshadgaedtarpcqqaptnsppnksklavkppvsghngasan 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  pspivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrqhqqysddeddyedeeeedarntnsalrqrvplmvkarexylshsqpsp 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  tpsnestdtaseigsafnsplrspirsanptrpsspvtshiskvlfgeddsllrvdcmrynravrdlgpvistgllhlaedgvlcpliv 527
           ***************************************************************************************** PP
   S: 260  ...................................................keLlkLlkdieseeekieaqlddekekrkkfkiddirR 297
                                                              keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rR
   Q: 528  tegekssptssrqselaqvvakveekplpeasdskgtsrnaeqpggekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRR 616
           ***************************************************************************************** PP
   S: 298  tenydeficifikdlaregilrklveetisevrefgvnegrlakqrkqgrekkirplkrkr 358
           t+nydefic+fi++la+eg+l++lve++is++r++gv++grl+kqrk++r+k++rp+k+kr
   Q: 617  THNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKR 677
           ***********************************************************98 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVRGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATAAAG GGTGGCTGGA GCTGGAGAGC GACCCAGGTG GGAACGAGGA CCATGCAGTT 60
GGGAACGGCG GGGGCGGGAA GAGGGAAGGG TGCGGAGCGA CGGGGGCGGG GGAGATGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	78.80	0.00e+00	1050.00
IUUC-Apl-003405	Anas platyrhynchos	66.93	8.00e-167	579.00
IUUC-Aca-004836	Anolis carolinensis	76.17	0.00e+00	1073.00
IUUC-Ago-007999	Ashbya gossypii	37.56	7.00e-29	120.00
IUUC-Ang-009859	Aspergillus niger	40.96	2.00e-42	165.00
IUUC-Ame-011946	Astyanax mexicanus	75.77	7.00e-170	590.00
IUUC-Bta-013131	Bos taurus	75.66	0.00e+00	894.00
IUUC-Cja-019599	Callithrix jacchus	80.38	0.00e+00	1088.00
IUUC-Cfa-021003	Canis familiaris	80.38	0.00e+00	1056.00
IUUC-Cpo-022143	Cavia porcellus	80.25	0.00e+00	1080.00
IUUC-Csa-023477	Chlorocebus sabaeus	79.97	0.00e+00	1079.00
IUUC-Cho-024734	Choloepus hoffmanni	82.93	2.00e-92	333.00
IUUC-Csv-025842	Ciona savignyi	58.90	4.00e-96	343.00
IUUC-Dre-027793	Danio rerio	61.62	0.00e+00	830.00
IUUC-Dno-029253	Dasypus novemcinctus	79.09	0.00e+00	1047.00
IUUC-Dor-030891	Dipodomys ordii	74.62	0.00e+00	982.00
IUUC-Dme-031796	Drosophila melanogaster	61.57	4.00e-93	334.00
IUUC-Ete-032646	Echinops telfairi	93.17	1.00e-131	462.00
IUUC-Eca-033805	Equus caballus	79.56	0.00e+00	1065.00
IUUC-Eeu-035216	Erinaceus europaeus	84.34	8.00e-116	410.00
IUUC-Fca-035611	Felis catus	79.39	0.00e+00	1003.00
IUUC-Fal-037186	Ficedula albicollis	75.42	0.00e+00	927.00
IUUC-Gmo-038824	Gadus morhua	76.86	2.00e-178	618.00
IUUC-Gga-040875	Gallus gallus	77.79	0.00e+00	1038.00
IUUC-Gac-042226	Gasterosteus aculeatus	67.67	0.00e+00	906.00
IUUC-Ggo-045122	Gorilla gorilla	80.66	0.00e+00	1090.00
IUUC-Hsa-045882	Homo sapiens	80.52	0.00e+00	1088.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	80.80	0.00e+00	1064.00
IUUC-Lch-049960	Latimeria chalumnae	70.70	0.00e+00	959.00
IUUC-Loc-052408	Lepisosteus oculatus	80.51	0.00e+00	625.00
IUUC-Laf-054187	Loxodonta africana	80.25	0.00e+00	1081.00
IUUC-Mcc-055273	Macaca mulatta	79.01	0.00e+00	1051.00
IUUC-Meu-056267	Macropus eugenii	75.76	0.00e+00	1050.00
IUUC-Mga-059958	Meleagris gallopavo	89.22	7.00e-157	545.00
IUUC-Mmr-061280	Microcebus murinus	80.14	0.00e+00	1057.00
IUUC-Mdo-062625	Monodelphis domestica	82.42	0.00e+00	1174.00
IUUC-Mmu-063853	Mus musculus	79.15	0.00e+00	1069.00
IUUC-Mlu-067771	Myotis lucifugus	79.97	0.00e+00	1058.00
IUUC-Opr-070741	Ochotona princeps	79.29	0.00e+00	1090.00
IUUC-Ont-072172	Oreochromis niloticus	66.71	0.00e+00	928.00
IUUC-Ocu-074176	Oryctolagus cuniculus	79.50	0.00e+00	1036.00
IUUC-Ola-087203	Oryzias latipes	86.74	4.00e-137	480.00
IUUC-Oga-089153	Otolemur garnettii	78.95	0.00e+00	1041.00
IUUC-Oar-090008	Ovis aries	80.08	0.00e+00	1062.00
IUUC-Ptr-091234	Pan troglodytes	80.66	0.00e+00	1090.00
IUUC-Pan-092005	Papio anubis	80.11	0.00e+00	1079.00
IUUC-Psi-093995	Pelodiscus sinensis	86.13	0.00e+00	670.00
IUUC-Pma-094110	Petromyzon marinus	58.66	2.00e-68	252.00
IUUC-Pfo-097418	Poecilia formosa	77.66	9.00e-176	609.00
IUUC-Pab-098267	Pongo abelii	80.52	0.00e+00	1062.00
IUUC-Pca-101084	Procavia capensis	77.66	0.00e+00	994.00
IUUC-Pva-102292	Pteropus vampyrus	78.06	0.00e+00	718.00
IUUC-Rno-105251	Rattus norvegicus	77.76	0.00e+00	1042.00
IUUC-Sha-107100	Sarcophilus harrisii	81.50	0.00e+00	1150.00
IUUC-Sar-113559	Sorex araneus	73.55	0.00e+00	888.00
IUUC-Ssc-115688	Sus scrofa	79.56	0.00e+00	1080.00
IUUC-Tgu-117424	Taeniopygia guttata	76.91	0.00e+00	1041.00
IUUC-Tru-118585	Takifugu rubripes	63.03	0.00e+00	843.00
IUUC-Tsy-119299	Tarsius syrichta	68.23	0.00e+00	775.00
IUUC-Tni-120808	Tetraodon nigroviridis	65.99	0.00e+00	892.00
IUUC-Tbe-127705	Tupaia belangeri	87.63	9.00e-171	592.00
IUUC-Ttr-128225	Tursiops truncatus	78.74	0.00e+00	1044.00
IUUC-Vpa-130193	Vicugna pacos	77.37	9.00e-100	357.00
IUUC-Xtr-132449	Xenopus tropicalis	71.18	0.00e+00	925.00
IUUC-Xma-133232	Xiphophorus maculatus	74.55	2.00e-173	602.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence