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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063839
UUCD1 version UUC-MuM-00691
Ensembl Protein ID ENSMUSP00000034437.7
UniProt Accession Q8C0M0; Q3TC49; Q3UWJ3; Q69Z65; Q6NZK7; Q8BLZ2; Q8BWK9; WDR59_MOUSE
Genbank Protein ID ABK41112.1; BAD32579.1; BAC27062.1; BAC30708.1; BAC34902.1; BAE22922.1; BAE42108.1; AAH66082.1
Protein Name WD repeat-containing protein 59; CUL4- and DDB1-associated WDR protein 12
Genbank Nucleotide ID EF011622; AK173301; AK030644; AK040807; AK052262; AK136303; AK170910; BC066082
Gene Name Wdr59; Cdw12; Kiaa1923
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031959.15 ENSMUST00000038193.14 ENSMUSP00000043671.8
ENSMUSG00000031959.15 ENSMUST00000034437.7 ENSMUSP00000034437.7
ENSMUSG00000031959.15 ENSMUST00000211981.1 ENSMUSP00000148397.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-20 73.9 190 224
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           H +++++l++ +d  ++++++s D+++k WD+r+ 
   Q: 190  HLSKIHGLDWhPDseHIFATSSQDNSVKFWDYRQP 224
           99*********6665778*************9876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG HRKISRQSKW 60
DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT LQGHTRVISD LDWAVFEPDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063839|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGATTTATT AGCAGGCTGT GTGGGGCTTA CTCACGCGGG GAGTCTCGGA CTTGGGGGTG 60
GGGTTGGGGG TGGAGGGTCG CCTGCTGGCA CCCCACGATC GGGCTAGTGA GATGGCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063839|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50908--RWD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00591--RWD
SM00320--WD40
Gene Ontology

GO:0061700--C:GATOR2 complex
GO:0034198--P:cellular response to amino acid starvation
GO:0032008--P:positive regulation of TOR signaling
KEGG mmu:319481
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002149 Ailuropoda melanoleuca 93.05 0.00e+00 1875.00
IUUC-Apl-004021 Anas platyrhynchos 85.79 0.00e+00 1659.00
IUUC-Aca-004977 Anolis carolinensis 85.31 0.00e+00 1732.00
IUUC-Ago-007961 Ashbya gossypii 25.12 2.00e-60 228.00
IUUC-Acl-008161 Aspergillus clavatus 27.31 3.00e-54 207.00
IUUC-Afl-008686 Aspergillus flavus 28.36 6.00e-58 219.00
IUUC-Afu-008932 Aspergillus fumigatus 28.33 5.00e-56 213.00
IUUC-Ani-009493 Aspergillus nidulans 27.45 2.00e-57 218.00
IUUC-Ang-009876 Aspergillus niger 28.63 5.00e-58 220.00
IUUC-Aor-009926 Aspergillus oryzae 28.36 6.00e-58 220.00
IUUC-Ate-010274 Aspergillus terreus 34.06 9.00e-51 196.00
IUUC-Ame-011297 Astyanax mexicanus 71.93 0.00e+00 1430.00
IUUC-Bgr-012173 Blumeria graminis 31.78 2.00e-43 172.00
IUUC-Bta-013261 Bos taurus 93.66 0.00e+00 1895.00
IUUC-Bci-013971 Botrytis cinerea 33.33 6.00e-47 183.00
IUUC-Cja-019167 Callithrix jacchus 92.95 0.00e+00 1878.00
IUUC-Cfa-020287 Canis familiaris 93.35 0.00e+00 1879.00
IUUC-Cpo-022510 Cavia porcellus 91.43 0.00e+00 1793.00
IUUC-Csa-023474 Chlorocebus sabaeus 96.17 0.00e+00 1964.00
IUUC-Cho-024634 Choloepus hoffmanni 90.44 0.00e+00 765.00
IUUC-Cin-025642 Ciona intestinalis 32.51 3.00e-133 469.00
IUUC-Csv-025848 Ciona savignyi 44.17 1.00e-53 202.00
IUUC-Cgl-026531 Colletotrichum gloeosporioides 32.69 8.00e-45 176.00
IUUC-Cne-027088 Cryptococcus neoformans 32.32 1.00e-43 172.00
IUUC-Dre-028753 Danio rerio 70.10 0.00e+00 1379.00
IUUC-Dno-029733 Dasypus novemcinctus 91.13 0.00e+00 1832.00
IUUC-Dor-030781 Dipodomys ordii 94.15 0.00e+00 983.00
IUUC-Dme-031803 Drosophila melanogaster 34.03 3.00e-150 526.00
IUUC-Ete-032622 Echinops telfairi 84.29 0.00e+00 1664.00
IUUC-Eca-033344 Equus caballus 93.96 0.00e+00 1882.00
IUUC-Eeu-034523 Erinaceus europaeus 84.00 0.00e+00 1635.00
IUUC-Fca-035650 Felis catus 94.06 0.00e+00 1900.00
IUUC-Fal-037404 Ficedula albicollis 85.55 0.00e+00 1697.00
IUUC-Fox-037955 Fusarium oxysporum 34.06 4.00e-42 167.00
IUUC-Fso-038289 Fusarium solani 34.06 2.00e-46 182.00
IUUC-Gmo-038547 Gadus morhua 69.38 0.00e+00 1417.00
IUUC-Ggr-039858 Gaeumannomyces graminis 36.13 7.00e-43 170.00
IUUC-Gga-041030 Gallus gallus 86.10 0.00e+00 1709.00
IUUC-Gac-042581 Gasterosteus aculeatus 71.90 0.00e+00 1459.00
IUUC-Ggo-044641 Gorilla gorilla 93.76 0.00e+00 1897.00
IUUC-Hsa-046134 Homo sapiens 94.06 0.00e+00 1899.00
IUUC-Itr-048551 Ictidomys tridecemlineatus 95.39 0.00e+00 738.00
IUUC-Kpa-049091 Komagataella pastoris 33.64 1.00e-45 178.00
IUUC-Lch-050288 Latimeria chalumnae 73.17 0.00e+00 1447.00
IUUC-Loc-052802 Lepisosteus oculatus 75.03 0.00e+00 1523.00
IUUC-Lma-053296 Leptosphaeria maculans 33.86 8.00e-49 189.00
IUUC-Laf-053997 Loxodonta africana 96.07 0.00e+00 1974.00
IUUC-Mcc-055855 Macaca mulatta 93.86 0.00e+00 1883.00
IUUC-Meu-056898 Macropus eugenii 89.88 0.00e+00 728.00
IUUC-Mor-056913 Magnaporthe oryzae 35.38 5.00e-42 167.00
IUUC-Mpo-057612 Magnaporthe poae 36.50 2.00e-43 171.00
IUUC-Mla-059097 Melampsora laricipopulina 31.90 4.00e-48 187.00
IUUC-Mga-059218 Meleagris gallopavo 85.96 0.00e+00 1675.00
IUUC-Mvi-060251 Microbotryum violaceum 31.29 7.00e-46 179.00
IUUC-Mmr-061093 Microcebus murinus 90.63 0.00e+00 1812.00
IUUC-Mdo-062757 Monodelphis domestica 89.92 0.00e+00 1797.00
IUUC-Mpu-065977 Mustela putorius furo 93.76 0.00e+00 1891.00
IUUC-Mlu-067460 Myotis lucifugus 92.20 0.00e+00 1888.00
IUUC-Nfi-068250 Neosartorya fischeri 28.04 1.00e-54 208.00
IUUC-Ncr-068710 Neurospora crassa 32.71 9.00e-45 176.00
IUUC-Nle-070011 Nomascus leucogenys 93.86 0.00e+00 1891.00
IUUC-Opr-070731 Ochotona princeps 90.88 0.00e+00 1078.00
IUUC-Ont-072165 Oreochromis niloticus 68.83 0.00e+00 1409.00
IUUC-Oan-072887 Ornithorhynchus anatinus 92.60 0.00e+00 1878.00
IUUC-Ocu-073926 Oryctolagus cuniculus 95.86 0.00e+00 1790.00
IUUC-Ola-087111 Oryzias latipes 68.27 0.00e+00 1383.00
IUUC-Oga-088850 Otolemur garnettii 93.86 0.00e+00 1890.00
IUUC-Oar-090291 Ovis aries 93.35 0.00e+00 1888.00
IUUC-Ptr-091044 Pan troglodytes 93.76 0.00e+00 1888.00
IUUC-Pan-092374 Papio anubis 95.97 0.00e+00 1959.00
IUUC-Psi-093170 Pelodiscus sinensis 55.24 0.00e+00 959.00
IUUC-Pma-094544 Petromyzon marinus 66.29 4.00e-170 590.00
IUUC-Pno-095068 Phaeosphaeria nodorum 30.86 4.00e-44 174.00
IUUC-Pfo-096480 Poecilia formosa 69.05 0.00e+00 1356.00
IUUC-Pab-098134 Pongo abelii 92.52 0.00e+00 1850.00
IUUC-Pca-100763 Procavia capensis 70.75 0.00e+00 954.00
IUUC-Pva-102544 Pteropus vampyrus 92.75 0.00e+00 1886.00
IUUC-Pgr-103257 Puccinia graminis 32.02 1.00e-49 192.00
IUUC-Ptt-103942 Puccinia triticina 31.23 4.00e-45 177.00
IUUC-Pte-104065 Pyrenophora teres 32.20 5.00e-46 180.00
IUUC-Rno-105468 Rattus norvegicus 97.21 0.00e+00 1842.00
IUUC-Sce-106356 Saccharomyces cerevisiae 27.78 3.00e-56 214.00
IUUC-Sha-106662 Sarcophilus harrisii 92.02 0.00e+00 1823.00
IUUC-Sja-107973 Schizosaccharomyces japonicus 27.43 7.00e-70 259.00
IUUC-Spo-108265 Schizosaccharomyces pombe 33.13 6.00e-49 189.00
IUUC-Ssl-108662 Sclerotinia sclerotiorum 33.14 6.00e-46 180.00
IUUC-Sar-113525 Sorex araneus 88.32 0.00e+00 1047.00
IUUC-Sre-115163 Sporisorium reilianum 36.05 3.00e-40 160.00
IUUC-Ssc-115381 Sus scrofa 93.04 0.00e+00 1034.00
IUUC-Tgu-116525 Taeniopygia guttata 82.29 0.00e+00 1633.00
IUUC-Tru-118432 Takifugu rubripes 69.65 0.00e+00 1437.00
IUUC-Tsy-119306 Tarsius syrichta 81.05 0.00e+00 927.00
IUUC-Tni-120757 Tetraodon nigroviridis 69.87 0.00e+00 1410.00
IUUC-Tre-122187 Trichoderma reesei 35.05 3.00e-47 184.00
IUUC-Tvi-122367 Trichoderma virens 35.37 3.00e-47 184.00
IUUC-Tme-126986 Tuber melanosporum 29.20 4.00e-55 210.00
IUUC-Tbe-127800 Tupaia belangeri 78.86 0.00e+00 1343.00
IUUC-Ttr-129154 Tursiops truncatus 89.13 0.00e+00 1005.00
IUUC-Uma-129366 Ustilago maydis 35.57 2.00e-39 158.00
IUUC-Vda-129827 Verticillium dahliae 33.97 3.00e-47 184.00
IUUC-Vpa-130493 Vicugna pacos 93.54 0.00e+00 1839.00
IUUC-Xtr-131941 Xenopus tropicalis 79.58 0.00e+00 1585.00
IUUC-Xma-133903 Xiphophorus maculatus 68.18 0.00e+00 1387.00
Created Date 25-Jun-2017

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