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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046253
Ensembl Protein ID ENSP00000360108.4
UniProt Accession O75061; B7Z3V8; D3DQ65; D3DQ66; Q32M66; Q4G0K1; Q5T614; Q5T615; AUXI_HUMAN
Genbank Protein ID BAA32318.2; BAH12344.1; CAI18997.1; CAI18997.1; CAI18997.1; CAI18999.1; CAI18999.1; CAI18999.1; CAI23547.1; CAI23547.1; CAI23547.1; CAI23548.1; CAI23548.1; CAI23548.1; EAX06533.1; EAX06534.1; EAX06536.1; EAX06537.1; AAH51722.1; AAI09280.2; AAI09281.2
Protein Name Putative tyrosine-protein phosphatase auxilin; DnaJ homolog subfamily C member 6
Genbank Nucleotide ID AB007942; AK296408; AL139294; AL355487; AC119800; AL139294; AL355487; AC119800; AL355487; AC119800; AL139294; AL355487; AC119800; AL139294; AL356212; CH471059; CH471059; CH471059; BC051722; BC109279; BC109280
Gene Name DNAJC6; KIAA0473
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116675.15 ENST00000494710.6 ENSP00000473821.1
ENSG00000116675.15 ENST00000395325.7 ENSP00000378735.3
ENSG00000116675.15 ENST00000371069.4 ENSP00000360108.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProt
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 40.22 9.00e-11 64.30 IUUC-Sce-106221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).
 Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).
Protein Sequence
(Fasta)
MSLLGSYRKK TSNDGYESLQ LVDSNGDLSA GSGGVGGKQR VNAGAAARSP ARQPPDRAST 60
MDSSGASSPD MEPSYGGGLF DMVKGGAGRL FSNLKDNLKD TLKDTSSRVI QSVTSYTKGD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046253|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAAGTCGA AGCAGTGAGC AAGGAGGCCT CTCCAAGGAG CTGTTTCAAT CCACTGGATG 60
TGCCAGGACT CACCAGGAAT AAAAGGTTAG TCTCTAAGCC AGGCCCAATG GGGCTATTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046253|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0523--Neurodegeneration
KW-0907--Parkinson disease
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
Interpro

IPR000008--C2_dom
IPR001623--DnaJ_domain
IPR029021--Prot-tyrosine_phosphatase-like
IPR014020--Tensin_C2-dom
IPR029023--Tensin_phosphatase
PROSITE

PS51182--C2_TENSIN
PS50076--DNAJ_2
PS51181--PPASE_TENSIN
Pfam

PF00226--DnaJ
PF10409--PTEN_C2
SMART

SM00271--DnaJ
SM01326--PTEN_C2
Gene Ontology

GO:0005829--C:cytosol
GO:0014069--C:postsynaptic density
GO:0031982--C:vesicle
GO:0004725--F:protein tyrosine phosphatase activity
GO:0061024--P:membrane organization
GO:0006898--P:receptor-mediated endocytosis
GO:2000369--P:regulation of clathrin-dependent endocytosis
GO:0016191--P:synaptic vesicle uncoating
KEGG hsa:9829
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000572 Aegilops tauschii 43.02 3.00e-13 70.90
IUUC-Aml-001602 Ailuropoda melanoleuca 96.68 3.00e-100 357.00
IUUC-Atr-002789 Amborella trichopoda 48.05 4.00e-15 77.40
IUUC-Apl-003319 Anas platyrhynchos 75.05 0.00e+00 1220.00
IUUC-Aca-004679 Anolis carolinensis 73.28 0.00e+00 1207.00
IUUC-Aly-006371 Arabidopsis lyrata 42.06 2.00e-17 84.70
IUUC-Ath-007246 Arabidopsis thaliana 35.90 1.00e-19 91.30
IUUC-Ago-007899 Ashbya gossypii 41.82 2.00e-03 38.10
IUUC-Acl-008209 Aspergillus clavatus 39.25 1.00e-13 72.40
IUUC-Afl-008687 Aspergillus flavus 40.00 1.00e-14 75.50
IUUC-Afu-009038 Aspergillus fumigatus 40.19 5.00e-14 73.60
IUUC-Ani-009386 Aspergillus nidulans 36.07 2.00e-14 75.10
IUUC-Ang-009793 Aspergillus niger 36.15 7.00e-15 76.30
IUUC-Aor-009993 Aspergillus oryzae 40.00 1.00e-14 75.50
IUUC-Ate-010348 Aspergillus terreus 40.19 1.00e-14 75.50
IUUC-Ame-011836 Astyanax mexicanus 57.39 0.00e+00 858.00
IUUC-Bgr-012104 Blumeria graminis 32.06 8.00e-13 69.70
IUUC-Bta-012737 Bos taurus 95.71 0.00e+00 1553.00
IUUC-Bci-013716 Botrytis cinerea 38.32 4.00e-15 77.40
IUUC-Bdi-014164 Brachypodium distachyon 41.38 8.00e-18 86.30
IUUC-Bol-016505 Brassica oleracea 35.26 7.00e-19 89.00
IUUC-Bra-017031 Brassica rapa 35.26 5.00e-19 89.40
IUUC-Cel-018193 Caenorhabditis elegans 51.20 6.00e-35 142.00
IUUC-Cja-019196 Callithrix jacchus 98.45 0.00e+00 1667.00
IUUC-Cfa-020198 Canis familiaris 93.41 0.00e+00 1532.00
IUUC-Cpo-022425 Cavia porcellus 87.82 0.00e+00 1434.00
IUUC-Cre-022715 Chlamydomonas reinhardtii 42.22 1.00e-12 66.60
IUUC-Csa-023487 Chlorocebus sabaeus 99.23 0.00e+00 1572.00
IUUC-Cho-024924 Choloepus hoffmanni 89.22 0.00e+00 942.00
IUUC-Cin-025341 Ciona intestinalis 37.13 1.00e-160 560.00
IUUC-Csv-026368 Ciona savignyi 34.87 6.00e-57 215.00
IUUC-Cgl-026441 Colletotrichum gloeosporioides 37.78 6.00e-13 69.70
IUUC-Cne-027019 Cryptococcus neoformans 42.22 9.00e-12 65.90
IUUC-Cme-027261 Cyanidioschyzon merolae 35.90 9.00e-09 55.80
IUUC-Dre-027719 Danio rerio 57.89 0.00e+00 879.00
IUUC-Dno-029249 Dasypus novemcinctus 88.82 0.00e+00 1502.00
IUUC-Dor-030705 Dipodomys ordii 94.04 0.00e+00 1504.00
IUUC-Dse-031381 Dothistroma septosporum 44.94 1.00e-14 75.50
IUUC-Ete-032360 Echinops telfairi 92.82 0.00e+00 922.00
IUUC-Eca-033503 Equus caballus 95.26 0.00e+00 1519.00
IUUC-Fox-038054 Fusarium oxysporum 38.64 1.00e-12 68.90
IUUC-Fso-038394 Fusarium solani 39.77 3.00e-13 71.20
IUUC-Gmo-038798 Gadus morhua 55.74 0.00e+00 913.00
IUUC-Ggr-040006 Gaeumannomyces graminis 37.50 3.00e-14 74.70
IUUC-Gga-040208 Gallus gallus 76.34 0.00e+00 1205.00
IUUC-Gac-041725 Gasterosteus aculeatus 62.53 9.00e-179 620.00
IUUC-Gma-043549 Glycine max 40.00 1.00e-17 85.50
IUUC-Ggo-044959 Gorilla gorilla 99.67 0.00e+00 1576.00
IUUC-Hvu-047859 Hordeum vulgare 39.66 5.00e-17 83.60
IUUC-Itr-048009 Ictidomys tridecemlineatus 87.56 0.00e+00 1416.00
IUUC-Kpa-049310 Komagataella pastoris 45.16 9.00e-17 82.40
IUUC-Lch-049852 Latimeria chalumnae 65.51 0.00e+00 1130.00
IUUC-Lpe-050789 Leersia perrieri 38.79 4.00e-16 80.50
IUUC-Loc-052500 Lepisosteus oculatus 62.39 0.00e+00 1020.00
IUUC-Lma-053081 Leptosphaeria maculans 44.94 1.00e-14 75.50
IUUC-Laf-053442 Loxodonta africana 90.41 0.00e+00 1440.00
IUUC-Mcc-055357 Macaca mulatta 99.56 0.00e+00 1570.00
IUUC-Meu-055902 Macropus eugenii 80.26 2.00e-176 612.00
IUUC-Mor-057010 Magnaporthe oryzae 38.95 7.00e-14 73.20
IUUC-Mpo-057447 Magnaporthe poae 39.36 1.00e-14 75.10
IUUC-Mtr-058569 Medicago truncatula 39.17 2.00e-17 84.30
IUUC-Mla-059090 Melampsora laricipopulina 38.26 4.00e-15 77.00
IUUC-Mga-059288 Meleagris gallopavo 76.20 0.00e+00 1197.00
IUUC-Mvi-060375 Microbotryum violaceum 36.80 2.00e-14 75.10
IUUC-Mmr-060617 Microcebus murinus 96.05 0.00e+00 1507.00
IUUC-Mdo-062466 Monodelphis domestica 74.05 0.00e+00 962.00
IUUC-Mmu-063266 Mus musculus 92.27 0.00e+00 1665.00
IUUC-Mac-065191 Musa acuminata 40.52 2.00e-18 88.60
IUUC-Mpu-066264 Mustela putorius furo 94.97 0.00e+00 1526.00
IUUC-Mlu-067016 Myotis lucifugus 94.93 0.00e+00 1567.00
IUUC-Nfi-068286 Neosartorya fischeri 40.19 6.00e-14 73.20
IUUC-Ncr-068716 Neurospora crassa 41.11 1.00e-14 76.30
IUUC-Nle-069934 Nomascus leucogenys 99.48 0.00e+00 1673.00
IUUC-Ont-072687 Oreochromis niloticus 56.66 0.00e+00 861.00
IUUC-Ocu-074760 Oryctolagus cuniculus 88.45 0.00e+00 1384.00
IUUC-Oba-075068 Oryza barthii 41.18 6.00e-16 80.10
IUUC-Obr-076494 Oryza brachyantha 41.53 9.00e-18 85.90
IUUC-Ogl-077765 Oryza glaberrima 41.53 1.00e-17 85.90
IUUC-Ogu-078409 Oryza glumaepatula 38.79 3.00e-16 80.90
IUUC-Oin-079736 Oryza indica 41.53 7.00e-18 86.70
IUUC-Olo-080973 Oryza longistaminata 47.67 1.00e-15 78.20
IUUC-Ome-081515 Oryza meridionalis 33.95 2.00e-17 85.10
IUUC-Oni-083001 Oryza nivara 38.79 4.00e-16 80.50
IUUC-Opu-083179 Oryza punctata 41.53 8.00e-18 86.30
IUUC-Oru-085233 Oryza rufipogon 33.95 2.00e-17 84.70
IUUC-Osa-085672 Oryza sativa 41.53 6.00e-18 86.70
IUUC-Ola-086849 Oryzias latipes 57.00 0.00e+00 952.00
IUUC-Olu-087759 Ostreococcus lucimarinus 36.56 7.00e-10 58.90
IUUC-Oga-088457 Otolemur garnettii 93.83 0.00e+00 1553.00
IUUC-Oar-089865 Ovis aries 93.71 0.00e+00 1489.00
IUUC-Ptr-091246 Pan troglodytes 99.59 0.00e+00 1672.00
IUUC-Pan-092688 Papio anubis 96.73 0.00e+00 1408.00
IUUC-Psi-093294 Pelodiscus sinensis 74.00 0.00e+00 1134.00
IUUC-Pma-094391 Petromyzon marinus 32.47 1.00e-76 281.00
IUUC-Pno-095073 Phaeosphaeria nodorum 46.07 2.00e-14 75.10
IUUC-Ppa-095294 Physcomitrella patens 45.56 9.00e-16 79.70
IUUC-Pfo-096387 Poecilia formosa 54.20 0.00e+00 657.00
IUUC-Pab-097705 Pongo abelii 99.48 0.00e+00 1284.00
IUUC-Pop-098982 Populus trichocarpa 40.34 9.00e-19 88.60
IUUC-Pca-100190 Procavia capensis 91.47 0.00e+00 1242.00
IUUC-Ppe-101744 Prunus persica 40.34 5.00e-18 87.00
IUUC-Pva-102358 Pteropus vampyrus 94.77 0.00e+00 1598.00
IUUC-Pgr-103508 Puccinia graminis 34.68 2.00e-11 65.50
IUUC-Ptt-104005 Puccinia triticina 41.77 6.00e-11 63.20
IUUC-Pte-104104 Pyrenophora teres 43.82 6.00e-14 73.60
IUUC-Pyt-104479 Pyrenophora triticirepentis 43.82 6.00e-14 73.20
IUUC-Rno-105923 Rattus norvegicus 91.04 0.00e+00 1542.00
IUUC-Sce-106221 Saccharomyces cerevisiae 37.39 1.00e-11 65.10
IUUC-Sha-106749 Sarcophilus harrisii 78.80 0.00e+00 1311.00
IUUC-Sja-107998 Schizosaccharomyces japonicus 42.20 2.00e-16 81.30
IUUC-Spo-108127 Schizosaccharomyces pombe 40.74 2.00e-16 81.30
IUUC-Smo-108804 Selaginella moellendorffii 41.44 7.00e-16 80.10
IUUC-Sit-109875 Setaria italica 40.34 6.00e-18 86.70
IUUC-Sly-111651 Solanum lycopersicum 37.10 9.00e-18 85.90
IUUC-Stu-111986 Solanum tuberosum 37.90 4.00e-19 90.50
IUUC-Sar-113634 Sorex araneus 88.65 0.00e+00 945.00
IUUC-Sbi-114622 Sorghum bicolor 41.53 5.00e-18 87.00
IUUC-Sre-115214 Sporisorium reilianum 40.23 1.00e-10 62.80
IUUC-Ssc-115636 Sus scrofa 94.97 0.00e+00 1551.00
IUUC-Tgu-116847 Taeniopygia guttata 71.90 0.00e+00 893.00
IUUC-Tru-117730 Takifugu rubripes 56.12 0.00e+00 941.00
IUUC-Tsy-119269 Tarsius syrichta 87.15 0.00e+00 1056.00
IUUC-Tni-120061 Tetraodon nigroviridis 51.08 0.00e+00 677.00
IUUC-Tca-121218 Theobroma cacao 40.68 3.00e-17 84.30
IUUC-Tre-121980 Trichoderma reesei 33.06 9.00e-13 69.30
IUUC-Tvi-122538 Trichoderma virens 39.77 1.00e-13 72.00
IUUC-Tae-124301 Triticum aestivum 38.79 4.00e-16 80.50
IUUC-Tur-126241 Triticum urartu 38.79 7.00e-16 79.30
IUUC-Tme-127081 Tuber melanosporum 37.04 2.00e-13 71.60
IUUC-Tbe-128130 Tupaia belangeri 87.60 0.00e+00 646.00
IUUC-Uma-129632 Ustilago maydis 38.89 3.00e-12 68.20
IUUC-Vda-129786 Verticillium dahliae 32.52 2.00e-13 71.60
IUUC-Vpa-130526 Vicugna pacos 91.06 0.00e+00 1559.00
IUUC-Vvi-131028 Vitis vinifera 40.78 3.00e-16 80.10
IUUC-Xtr-132049 Xenopus tropicalis 65.67 0.00e+00 959.00
IUUC-Yli-134359 Yarrowia lipolytica 46.15 2.00e-14 75.10
IUUC-Zma-135446 Zea mays 43.48 7.00e-16 79.70
Created Date 25-Jun-2017

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