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Tag Content
iUUCD ID IUUC-Ont-071613
Ensembl Protein ID ENSONIP00000005635.1
UniProt Accession I3J9U5; I3J9U5_ORENI
Genbank Protein ID ENSONIP00000005635
Protein Name Histone deacetylase
Genbank Nucleotide ID AERX01009574
Gene Name hdac4 (1 of many); hdac4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSONIG00000004475.1 ENSONIT00000005639.1 ENSONIP00000005635.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 71.78 0.00e+00 1274.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
825 N/A {ECO:0000256|PIRSR:PIRSR037911-1}
Organism Oreochromis niloticus
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Protein Sequence
(Fasta)
MSTHSRQGGL TSTEKPLELI KPAAHNHFVD VSTAALPSTA TAILPMDLRV VDHAHHHQQQ 60
PSFGLVPPPH PTPPTSTSTE TGRGPVISQQ EQHLQQELVA LKHKQQLQRQ LLIAEFQRQH 120
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Protein Fasta Sequence



>IUUC-Ont-071613|E3,E3 activity/Other|Oreochromis niloticus
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Nucleotide Sequence
(Fasta)
CGGAAACACA GGGGGTTGTC TGACACGTGA TTAATTCAGT ATGGCGGATC TGTTGGCTGA 60
GTGATTTTTT TTTTTTTTTA ACGGCACCGA CGGGTCCTAA AACCCTGCTC CGTGGATGCT 120
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Nucleotide Fasta Sequence



>IUUC-Ont-071613|E3,E3 activity/Other|Oreochromis niloticus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002279 Ailuropoda melanoleuca 74.40 0.00e+00 1296.00
IUUC-Apl-003250 Anas platyrhynchos 71.15 0.00e+00 1234.00
IUUC-Aca-004668 Anolis carolinensis 81.09 0.00e+00 855.00
IUUC-Bta-013215 Bos taurus 75.00 0.00e+00 1284.00
IUUC-Cja-019816 Callithrix jacchus 72.27 0.00e+00 1281.00
IUUC-Cfa-020861 Canis familiaris 74.34 0.00e+00 1276.00
IUUC-Cpo-021562 Cavia porcellus 72.47 0.00e+00 1283.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 52.70 7.00e-54 203.00
IUUC-Csa-023612 Chlorocebus sabaeus 71.41 0.00e+00 1251.00
IUUC-Csv-026359 Ciona savignyi 53.72 2.00e-90 325.00
IUUC-Dre-028284 Danio rerio 88.17 0.00e+00 881.00
IUUC-Dno-029951 Dasypus novemcinctus 69.02 0.00e+00 1174.00
IUUC-Dor-030362 Dipodomys ordii 63.32 0.00e+00 1038.00
IUUC-Dme-031766 Drosophila melanogaster 57.85 4.00e-155 542.00
IUUC-Fca-036187 Felis catus 74.68 0.00e+00 1319.00
IUUC-Gmo-038473 Gadus morhua 83.26 0.00e+00 796.00
IUUC-Gga-040501 Gallus gallus 73.59 0.00e+00 1264.00
IUUC-Gac-042335 Gasterosteus aculeatus 83.22 0.00e+00 1498.00
IUUC-Ggo-045380 Gorilla gorilla 72.07 0.00e+00 1254.00
IUUC-Hsa-046925 Homo sapiens 72.37 0.00e+00 1278.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 71.77 0.00e+00 1251.00
IUUC-Lch-050325 Latimeria chalumnae 72.62 0.00e+00 1232.00
IUUC-Loc-052231 Lepisosteus oculatus 87.00 0.00e+00 865.00
IUUC-Laf-054490 Loxodonta africana 70.68 0.00e+00 1249.00
IUUC-Mcc-055265 Macaca mulatta 71.36 0.00e+00 1258.00
IUUC-Meu-056676 Macropus eugenii 80.82 7.00e-180 624.00
IUUC-Mmr-061633 Microcebus murinus 66.00 0.00e+00 1107.00
IUUC-Mmu-063089 Mus musculus 72.91 0.00e+00 1268.00
IUUC-Mpu-065887 Mustela putorius furo 75.10 0.00e+00 1308.00
IUUC-Mlu-067470 Myotis lucifugus 72.44 0.00e+00 1300.00
IUUC-Nle-069099 Nomascus leucogenys 64.62 0.00e+00 716.00
IUUC-Oan-073275 Ornithorhynchus anatinus 73.57 0.00e+00 1273.00
IUUC-Ola-087031 Oryzias latipes 81.16 0.00e+00 1490.00
IUUC-Oga-088201 Otolemur garnettii 66.21 0.00e+00 1147.00
IUUC-Oar-089997 Ovis aries 69.21 0.00e+00 1112.00
IUUC-Ptr-091116 Pan troglodytes 72.47 0.00e+00 1288.00
IUUC-Pan-092132 Papio anubis 71.30 0.00e+00 879.00
IUUC-Psi-093734 Pelodiscus sinensis 83.95 0.00e+00 834.00
IUUC-Pma-094347 Petromyzon marinus 68.41 0.00e+00 682.00
IUUC-Pfo-096293 Poecilia formosa 85.86 0.00e+00 1552.00
IUUC-Pab-098491 Pongo abelii 68.89 0.00e+00 1182.00
IUUC-Pca-101004 Procavia capensis 61.31 0.00e+00 635.00
IUUC-Pva-102961 Pteropus vampyrus 54.88 0.00e+00 635.00
IUUC-Rno-105005 Rattus norvegicus 72.81 0.00e+00 1263.00
IUUC-Sha-107646 Sarcophilus harrisii 63.08 1.00e-168 587.00
IUUC-Ssc-115428 Sus scrofa 72.51 0.00e+00 1278.00
IUUC-Tgu-116776 Taeniopygia guttata 70.86 0.00e+00 1212.00
IUUC-Tru-118180 Takifugu rubripes 81.55 0.00e+00 1529.00
IUUC-Tsy-119468 Tarsius syrichta 61.82 2.00e-151 530.00
IUUC-Tni-120196 Tetraodon nigroviridis 81.56 0.00e+00 1457.00
IUUC-Ttr-128360 Tursiops truncatus 67.39 0.00e+00 786.00
IUUC-Xtr-132956 Xenopus tropicalis 80.75 0.00e+00 821.00
Created Date 25-Jun-2017

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