iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004459

UUCD1 version

UUC-AnC-00990

Ensembl Protein ID

ENSACAP00000008111.2

UniProt Accession

G1KHK7; G1KHK7_ANOCA

Protein Name

Uncharacterized protein

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008007.3	ENSACAT00000008283.3	ENSACAP00000008111.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-97	326.9	317	934
ULD/UDP/UBQ/UBQ_Other	2.10e-12	46.7	160	236

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+LQcLsn+p+l+e++le +++ ++n+enp ++ ge+++++++l++++w+++ ++v+pr ++++++ + +ef+ ++
   Q: 317  CGLSNLGNTCFMNSALQCLSNTPPLTEYFLEdEYEAEINQENPLGMRGEIAEAYAELIKQMWSGRYTHVAPRIFKTQVGXALPEFRYFN 405
           7******************************9******************************************************666 PP
   S: 89   qqDaq.Eflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
            q +q    ++ l +l++++        +e++  +    ++       a+e++  +n+s+i+d+F+g +ks+++c++c +vs++++pf+
   Q: 406  SQKSQlASSCWELWELKSKIPG----GPKELMLYRAYGCEQYvvvakeAWENHRLRNDSIIVDIFHGLFKSTLVCPKCSKVSVTFDPFC 490
           5555514555568888888833....3333333332222222444455***************************************** PP
   S: 171  dlslpvpgkeetkke.......................................................................... 185
           +l+lp+p+k+++ +e                                                                          
   Q: 491  YLTLPLPMKKDRTMEvlfvfadpqrkpsqcrvvvpmmggvtdlcdalsqlsgipaenmvvtdvynhrfhkifqmdeglsnimpkdnifv 579
           **********99999************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 580  yeiskpaedgaecvtlsiyfrekkarqssatpatvlygqplliavpkhkltldylysvilerigryvkipskedcpdvcsdnetcngsn 668
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 669  svsegeveemehqngeeenkekiletdasqsedgtqvesgkeglhhrkrlftfslvnsygtseinslptegkilklsshatvaidwdsd 757
           ***************************************************************************************** PP
   S: 186  ..............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqk 244
                                          l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++  
   Q: 758  trkllfdeheaqafekhcsmfqpqkrktavALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPRILVVHLKRFSYNRY-- 844
           **********************************************************************************99885.. PP
   S: 245  srekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaY 331
            r k+++ vefp++ L++s+f+++p  +   ++ Y+Liav +H+G+++ GHY+ay+kn  +gkW++fdDs+V++ +ee++++   + aY
   Q: 845  WRDKLDTVVEFPIRdLNMSEFVCDPAAS---PYVYDLIAVSNHYGGMGVGHYTAYAKNkINGKWYYFDDSSVSPASEEQIVT---KAAY 927
           567*********************9876...9**************************45777*******************...**** PP
   S: 332  vlfYkrr 338
           vlfY+rr
   Q: 928  VLFYQRR 934
           *****96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 7    sldgseltlk.vnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           + d+++l  + ++++dtVa++ ++++k+++ip   ++rL+ +       + L + d t++d gl++g+++++++k+++
   Q: 160  NNDSTNLVSSyFSKADTVATIEKEMRKQFNIPdGKEIRLWSRymsntyEQ-LsKLDSTIQDAGLYQGQVVLIEVKNED 236
           455555555558999*****************999*****7777766333.46********************99886 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAAAEAGFEG GGGGGSSGGA TASPRPDAGT QRTELTPLLG APLCPGESWY LIDSRWFKQW 60
KKYVGFDSWD LYNVGEPNLY PGPIDNSGLF ADSETQTLKE HLIDELDYVL VPTEAWNKLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCTG CTGAAGCGGG GTTCGAGGGC GGCGGAGGTG GCGGAAGCAG CGGCGGAGCC 60
ACGGCCAGCC CGAGGCCGGA CGCGGGGACG CAGCGGACTG AGCTGACGCC GCTTTTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	69.75	0.00e+00	1247.00
IUUC-Apl-004068	Anas platyrhynchos	73.32	0.00e+00	1301.00
IUUC-Aly-006315	Arabidopsis lyrata	34.39	1.00e-120	427.00
IUUC-Ath-007343	Arabidopsis thaliana	34.61	4.00e-131	462.00
IUUC-Ame-011064	Astyanax mexicanus	61.36	0.00e+00	850.00
IUUC-Bta-012929	Bos taurus	69.83	0.00e+00	1258.00
IUUC-Bra-016885	Brassica rapa	33.62	1.00e-126	447.00
IUUC-Cja-018798	Callithrix jacchus	69.04	0.00e+00	1214.00
IUUC-Cfa-020599	Canis familiaris	69.76	0.00e+00	1254.00
IUUC-Cpo-022144	Cavia porcellus	69.56	0.00e+00	1222.00
IUUC-Csa-023770	Chlorocebus sabaeus	70.03	0.00e+00	1165.00
IUUC-Cho-024595	Choloepus hoffmanni	62.04	0.00e+00	751.00
IUUC-Dno-029316	Dasypus novemcinctus	68.94	0.00e+00	1239.00
IUUC-Ete-032970	Echinops telfairi	63.21	0.00e+00	748.00
IUUC-Eca-034012	Equus caballus	70.01	0.00e+00	1220.00
IUUC-Fca-035373	Felis catus	67.21	0.00e+00	1223.00
IUUC-Fal-037634	Ficedula albicollis	74.87	0.00e+00	1328.00
IUUC-Gmo-038866	Gadus morhua	61.28	0.00e+00	1056.00
IUUC-Gga-040729	Gallus gallus	69.81	0.00e+00	1270.00
IUUC-Gac-042631	Gasterosteus aculeatus	63.89	0.00e+00	1150.00
IUUC-Ggo-045337	Gorilla gorilla	68.21	0.00e+00	1080.00
IUUC-Hsa-045669	Homo sapiens	69.90	0.00e+00	1233.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	69.36	0.00e+00	1243.00
IUUC-Lpe-051424	Leersia perrieri	34.28	7.00e-127	447.00
IUUC-Laf-053803	Loxodonta africana	69.76	0.00e+00	1266.00
IUUC-Mcc-055556	Macaca mulatta	67.64	0.00e+00	1158.00
IUUC-Meu-056742	Macropus eugenii	66.05	0.00e+00	815.00
IUUC-Mga-059300	Meleagris gallopavo	69.39	0.00e+00	1220.00
IUUC-Mdo-061848	Monodelphis domestica	71.15	0.00e+00	1273.00
IUUC-Mmu-063960	Mus musculus	69.97	0.00e+00	1241.00
IUUC-Mpu-066920	Mustela putorius furo	70.04	0.00e+00	1256.00
IUUC-Mlu-068088	Myotis lucifugus	69.65	0.00e+00	1239.00
IUUC-Nle-070010	Nomascus leucogenys	69.36	0.00e+00	1228.00
IUUC-Oan-073363	Ornithorhynchus anatinus	67.69	0.00e+00	1189.00
IUUC-Ocu-074242	Oryctolagus cuniculus	65.60	0.00e+00	1156.00
IUUC-Olo-080315	Oryza longistaminata	33.12	1.00e-118	421.00
IUUC-Ome-081271	Oryza meridionalis	33.30	1.00e-120	427.00
IUUC-Opu-083691	Oryza punctata	32.25	2.00e-117	416.00
IUUC-Ola-086553	Oryzias latipes	63.29	0.00e+00	1202.00
IUUC-Oga-088562	Otolemur garnettii	64.12	0.00e+00	1090.00
IUUC-Oar-090439	Ovis aries	69.83	0.00e+00	1257.00
IUUC-Ptr-090801	Pan troglodytes	69.76	0.00e+00	1232.00
IUUC-Pan-092717	Papio anubis	66.16	0.00e+00	1113.00
IUUC-Psi-093942	Pelodiscus sinensis	75.68	0.00e+00	1289.00
IUUC-Pop-099801	Populus trichocarpa	35.70	9.00e-133	467.00
IUUC-Pca-100161	Procavia capensis	62.42	0.00e+00	1072.00
IUUC-Ppe-101587	Prunus persica	36.36	8.00e-134	471.00
IUUC-Rno-106081	Rattus norvegicus	68.59	0.00e+00	1268.00
IUUC-Sha-106937	Sarcophilus harrisii	70.31	0.00e+00	1263.00
IUUC-Sja-107748	Schizosaccharomyces japonicus	27.97	2.00e-78	286.00
IUUC-Smo-109356	Selaginella moellendorffii	37.28	1.00e-95	343.00
IUUC-Sly-111746	Solanum lycopersicum	35.88	5.00e-131	461.00
IUUC-Stu-112671	Solanum tuberosum	36.18	1.00e-131	463.00
IUUC-Sar-113542	Sorex araneus	66.96	0.00e+00	1197.00
IUUC-Ssc-115637	Sus scrofa	69.44	0.00e+00	1247.00
IUUC-Tgu-117267	Taeniopygia guttata	72.10	0.00e+00	1284.00
IUUC-Tru-118634	Takifugu rubripes	63.75	0.00e+00	1114.00
IUUC-Tca-121001	Theobroma cacao	34.34	9.00e-130	457.00
IUUC-Tur-126392	Triticum urartu	34.43	7.00e-87	315.00
IUUC-Tme-127062	Tuber melanosporum	30.63	4.00e-103	369.00
IUUC-Tbe-127669	Tupaia belangeri	57.99	0.00e+00	677.00
IUUC-Ttr-128778	Tursiops truncatus	69.15	0.00e+00	1225.00
IUUC-Xtr-132305	Xenopus tropicalis	64.41	0.00e+00	1193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence