iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010431

Ensembl Protein ID

CADATEAP00006518

UniProt Accession

Q0CT11; CREB_ASPTN

Genbank Protein ID

EAU36447.1

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase creB; Carbon catabolite repression protein B; Deubiquitinating enzyme creB; Ubiquitin thioesterase creB; Ubiquitin-hydrolyzing enzyme creB; Ubiquitin-specific-processing protease creB

Genbank Nucleotide ID

CH476597

Gene Name

ATEG_03173; creB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00006518	CADATEAT00006518	CADATEAP00006518

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-88	295.3	53	456

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
419	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 10   CYmNSvLQcLsnipelrelllekkkeklneenp............................................................ 42
            Y+NS+LQcL+   ++re++ + ++ +++ e+                                                             
   Q: 53   NYCNSILQCLYYSVPFREAVIN-YPTRTPIESLtaalaetlrypnpnahleaeaqaekqkaanaqrpgappnqpqkpedkdspeykkkmalqt 144
           5*********************.55555544445566666666666777777888888899999999*********99999999999999999 PP
   S: 43   ............kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk...eknkpkeee 118
                        +++++l +sl++lfe+++  +s+ + v p+++l++l++e+e+f++ ++qDa+Efl+ ll+++  +++    +   + + e
   Q: 145  fplletknnapsYGMSESLFTSLKDLFESVVgsQSRIGIVRPQHFLDVLRREHEMFRTAMHQDAHEFLNLLLNEVVANVEAealK---QPSLE 234
           99999999999889999*************99999999*****************************************774431...33222 PP
   S: 119  eeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenky 206
           ++    e+s++     ++ +k+  ++ ++++lF+g+l+s+++cl+c++vs+r+e fldls+++++++     s+++cL++f++ee+l+++nk+
   Q: 235  RSLPPAESSESvehsgSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEVFLDLSVDLEQHS-----SVTSCLRKFSAEEMLCERNKF 322
           222222222223345566677778889****************************************.....9******************** PP
   S: 207  ycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvay 298
           +c++c ++qeaek++k+k+lP++L lhLkRf+++e+ ++ +k++ +v +p +L l  f+t+++ ++  ++ YeL+avvvH G ++ +GHYva+
   Q: 323  HCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRL--FNTTDDAED-PDRLYELYAVVVHIGgGPYHGHYVAI 412
           **************************************************88887..566645544.49************************ PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg.....staYvlfYkr 337
           +k ++++WllfdD+ V++v+++ v ++ g     + aYvlfY++
   Q: 413  IKTQDRGWLLFDDEMVEPVDKNYVRNFFGdkpglACAYVLFYQE 456
           **************************999*************97 PP

Organism

Aspergillus terreus

Functional Description
(View)

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).

Protein Sequence
(Fasta)

MGSLFRSFRR DAGATAPSVG ATPAKKEPPP PPMTPLEKML QDMGAIREDG SDNYCNSILQ 60
CLYYSVPFRE AVINYPTRTP IESLTAALAE TLRYPNPNAH LEAEAQAEKQ KAANAQRPGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTCAT TGTTCAGGAG CTTCCGACGA GATGCGGTAG GTCACGGCTG ACTCGGCTCT 60
CCCCTTCTTG GGTCTCATCC ACCACCGATA TCGCGACTGG TCCTGCGGCC ATATGTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0045013--P:carbon catabolite repression of transcription
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	46.47	3.00e-82	296.00
IUUC-Aml-001964	Ailuropoda melanoleuca	50.33	5.00e-86	309.00
IUUC-Atr-002650	Amborella trichopoda	46.98	8.00e-81	291.00
IUUC-Apl-003411	Anas platyrhynchos	50.17	3.00e-85	306.00
IUUC-Aca-005212	Anolis carolinensis	50.66	8.00e-86	308.00
IUUC-Aly-005830	Arabidopsis lyrata	46.43	9.00e-77	278.00
IUUC-Ath-006663	Arabidopsis thaliana	47.00	1.00e-79	288.00
IUUC-Ago-007871	Ashbya gossypii	42.12	3.00e-65	241.00
IUUC-Acl-008239	Aspergillus clavatus	84.20	0.00e+00	833.00
IUUC-Afl-008602	Aspergillus flavus	78.00	0.00e+00	967.00
IUUC-Afu-008816	Aspergillus fumigatus	85.87	0.00e+00	862.00
IUUC-Ani-009137	Aspergillus nidulans	65.95	0.00e+00	816.00
IUUC-Ang-009703	Aspergillus niger	72.98	0.00e+00	870.00
IUUC-Aor-009901	Aspergillus oryzae	76.83	0.00e+00	904.00
IUUC-Ame-011015	Astyanax mexicanus	51.17	3.00e-86	310.00
IUUC-Bgr-012071	Blumeria graminis	47.91	5.00e-151	526.00
IUUC-Bta-012981	Bos taurus	51.17	1.00e-86	311.00
IUUC-Bci-013837	Botrytis cinerea	55.79	3.00e-163	566.00
IUUC-Bdi-014008	Brachypodium distachyon	47.10	7.00e-81	291.00
IUUC-Bol-015138	Brassica oleracea	47.00	1.00e-76	278.00
IUUC-Bra-016956	Brassica rapa	48.03	8.00e-80	288.00
IUUC-Cel-018379	Caenorhabditis elegans	41.37	3.00e-75	273.00
IUUC-Cja-018831	Callithrix jacchus	50.84	3.00e-86	310.00
IUUC-Cfa-020534	Canis familiaris	50.00	2.00e-85	307.00
IUUC-Cpo-021703	Cavia porcellus	50.50	4.00e-86	309.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	46.69	4.00e-65	239.00
IUUC-Csa-023841	Chlorocebus sabaeus	49.16	4.00e-81	293.00
IUUC-Cho-024902	Choloepus hoffmanni	39.74	1.00e-57	215.00
IUUC-Cin-025659	Ciona intestinalis	40.17	2.00e-70	258.00
IUUC-Csv-025828	Ciona savignyi	38.96	6.00e-71	259.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	57.41	3.00e-161	560.00
IUUC-Cne-026900	Cryptococcus neoformans	38.79	2.00e-66	245.00
IUUC-Cme-027339	Cyanidioschyzon merolae	32.65	1.00e-37	149.00
IUUC-Dre-027845	Danio rerio	50.50	3.00e-86	310.00
IUUC-Dno-029460	Dasypus novemcinctus	50.00	3.00e-85	306.00
IUUC-Dor-030972	Dipodomys ordii	51.89	5.00e-76	276.00
IUUC-Dse-031470	Dothistroma septosporum	51.55	4.00e-161	559.00
IUUC-Dme-032038	Drosophila melanogaster	56.57	3.00e-68	250.00
IUUC-Ete-032659	Echinops telfairi	54.24	8.00e-55	205.00
IUUC-Eca-033439	Equus caballus	50.33	4.00e-86	309.00
IUUC-Eeu-034916	Erinaceus europaeus	51.87	4.00e-67	246.00
IUUC-Fca-035524	Felis catus	50.17	9.00e-86	308.00
IUUC-Fal-036833	Ficedula albicollis	51.17	1.00e-85	308.00
IUUC-Fox-037682	Fusarium oxysporum	60.18	3.00e-155	540.00
IUUC-Fso-038299	Fusarium solani	58.37	3.00e-148	517.00
IUUC-Gmo-038763	Gadus morhua	50.50	2.00e-85	307.00
IUUC-Ggr-039806	Gaeumannomyces graminis	56.43	9.00e-162	561.00
IUUC-Gga-041151	Gallus gallus	50.17	3.00e-85	306.00
IUUC-Gac-041967	Gasterosteus aculeatus	50.50	7.00e-86	308.00
IUUC-Gma-042927	Glycine max	48.39	5.00e-83	299.00
IUUC-Ggo-044659	Gorilla gorilla	49.16	7.00e-81	292.00
IUUC-Hsa-045700	Homo sapiens	50.84	3.00e-86	310.00
IUUC-Hvu-047692	Hordeum vulgare	46.60	9.00e-81	291.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	50.33	4.00e-86	309.00
IUUC-Kpa-049250	Komagataella pastoris	51.09	3.00e-94	337.00
IUUC-Lch-050435	Latimeria chalumnae	50.84	5.00e-85	305.00
IUUC-Lpe-051368	Leersia perrieri	45.31	9.00e-79	285.00
IUUC-Loc-051968	Lepisosteus oculatus	49.83	3.00e-84	303.00
IUUC-Lma-053300	Leptosphaeria maculans	56.48	2.00e-170	591.00
IUUC-Laf-053887	Loxodonta africana	50.33	5.00e-86	309.00
IUUC-Mcc-055701	Macaca mulatta	50.84	3.00e-86	310.00
IUUC-Mor-057072	Magnaporthe oryzae	60.08	1.00e-163	568.00
IUUC-Mpo-057424	Magnaporthe poae	58.53	2.00e-160	557.00
IUUC-Mtr-057715	Medicago truncatula	47.30	2.00e-81	294.00
IUUC-Mla-059142	Melampsora laricipopulina	52.84	5.00e-102	364.00
IUUC-Mga-059195	Meleagris gallopavo	50.17	5.00e-85	306.00
IUUC-Mvi-060357	Microbotryum violaceum	56.69	1.00e-86	313.00
IUUC-Mmr-060751	Microcebus murinus	50.33	5.00e-86	309.00
IUUC-Mdo-062735	Monodelphis domestica	50.33	6.00e-86	308.00
IUUC-Mmu-063263	Mus musculus	50.17	7.00e-85	305.00
IUUC-Mac-065323	Musa acuminata	47.45	1.00e-78	285.00
IUUC-Mpu-066038	Mustela putorius furo	49.16	2.00e-81	294.00
IUUC-Mlu-068128	Myotis lucifugus	50.33	5.00e-86	309.00
IUUC-Nfi-068611	Neosartorya fischeri	72.35	0.00e+00	877.00
IUUC-Ncr-068699	Neurospora crassa	59.52	4.00e-163	566.00
IUUC-Nle-069767	Nomascus leucogenys	50.84	3.00e-86	310.00
IUUC-Opr-070980	Ochotona princeps	49.50	2.00e-81	294.00
IUUC-Ont-072658	Oreochromis niloticus	50.50	7.00e-86	308.00
IUUC-Oan-073372	Ornithorhynchus anatinus	50.17	6.00e-85	305.00
IUUC-Ocu-074322	Oryctolagus cuniculus	50.66	6.00e-86	308.00
IUUC-Oba-075220	Oryza barthii	45.74	5.00e-79	285.00
IUUC-Obr-076208	Oryza brachyantha	46.18	1.00e-74	271.00
IUUC-Ogl-077216	Oryza glaberrima	45.74	5.00e-79	285.00
IUUC-Ogu-078836	Oryza glumaepatula	45.74	5.00e-79	285.00
IUUC-Oin-079522	Oryza indica	45.74	5.00e-79	285.00
IUUC-Olo-080882	Oryza longistaminata	45.74	5.00e-79	285.00
IUUC-Ome-081549	Oryza meridionalis	45.74	5.00e-79	285.00
IUUC-Oni-082982	Oryza nivara	45.74	5.00e-79	285.00
IUUC-Opu-083532	Oryza punctata	45.31	2.00e-79	287.00
IUUC-Oru-084568	Oryza rufipogon	45.74	5.00e-79	285.00
IUUC-Osa-085299	Oryza sativa	45.74	5.00e-79	285.00
IUUC-Ola-087418	Oryzias latipes	50.50	5.00e-86	309.00
IUUC-Olu-087809	Ostreococcus lucimarinus	44.48	1.00e-65	241.00
IUUC-Oga-088298	Otolemur garnettii	50.33	1.00e-85	308.00
IUUC-Oar-090269	Ovis aries	51.17	7.00e-86	309.00
IUUC-Ptr-090467	Pan troglodytes	50.84	3.00e-86	310.00
IUUC-Pan-092437	Papio anubis	50.67	4.00e-85	306.00
IUUC-Psi-092993	Pelodiscus sinensis	49.83	9.00e-86	308.00
IUUC-Pma-094388	Petromyzon marinus	49.17	6.00e-83	299.00
IUUC-Pno-095044	Phaeosphaeria nodorum	58.11	1.00e-168	584.00
IUUC-Ppa-095415	Physcomitrella patens	49.17	7.00e-83	298.00
IUUC-Pfo-097052	Poecilia formosa	50.50	9.00e-86	308.00
IUUC-Pab-097797	Pongo abelii	50.84	3.00e-86	310.00
IUUC-Pop-099016	Populus trichocarpa	49.68	3.00e-84	303.00
IUUC-Pca-100835	Procavia capensis	53.53	2.00e-70	256.00
IUUC-Ppe-101474	Prunus persica	48.25	3.00e-83	300.00
IUUC-Pva-102878	Pteropus vampyrus	51.19	9.00e-87	311.00
IUUC-Pgr-103306	Puccinia graminis	55.05	2.00e-104	372.00
IUUC-Pte-104356	Pyrenophora teres	52.72	1.00e-167	582.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	51.22	5.00e-153	532.00
IUUC-Rno-106060	Rattus norvegicus	50.33	2.00e-85	307.00
IUUC-Sce-106367	Saccharomyces cerevisiae	41.64	5.00e-73	267.00
IUUC-Sha-107087	Sarcophilus harrisii	50.33	5.00e-86	309.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	53.69	2.00e-91	328.00
IUUC-Spo-108095	Schizosaccharomyces pombe	43.68	7.00e-101	359.00
IUUC-Smo-109064	Selaginella moellendorffii	50.00	3.00e-79	286.00
IUUC-Sit-110819	Setaria italica	46.18	1.00e-80	291.00
IUUC-Sly-111210	Solanum lycopersicum	48.72	9.00e-82	295.00
IUUC-Stu-112398	Solanum tuberosum	48.49	4.00e-81	293.00
IUUC-Sar-113216	Sorex araneus	50.17	4.00e-84	303.00
IUUC-Sbi-114724	Sorghum bicolor	47.10	5.00e-82	296.00
IUUC-Sre-115197	Sporisorium reilianum	51.88	8.00e-93	333.00
IUUC-Ssc-116321	Sus scrofa	51.51	4.00e-87	313.00
IUUC-Tgu-117482	Taeniopygia guttata	50.50	3.00e-84	303.00
IUUC-Tru-118613	Takifugu rubripes	50.50	5.00e-86	309.00
IUUC-Tsy-119520	Tarsius syrichta	53.88	3.00e-60	223.00
IUUC-Tni-120293	Tetraodon nigroviridis	50.50	5.00e-86	309.00
IUUC-Tca-121329	Theobroma cacao	48.33	2.00e-82	297.00
IUUC-Tre-122226	Trichoderma reesei	57.20	3.00e-159	553.00
IUUC-Tvi-122330	Trichoderma virens	57.03	9.00e-157	545.00
IUUC-Tae-124807	Triticum aestivum	47.91	1.00e-82	298.00
IUUC-Tur-126563	Triticum urartu	47.91	8.00e-83	298.00
IUUC-Tme-126890	Tuber melanosporum	67.37	2.00e-136	478.00
IUUC-Tbe-127783	Tupaia belangeri	50.33	6.00e-86	308.00
IUUC-Ttr-129083	Tursiops truncatus	50.66	2.00e-86	310.00
IUUC-Uma-129409	Ustilago maydis	53.00	2.00e-93	335.00
IUUC-Vda-129736	Verticillium dahliae	47.14	9.00e-147	512.00
IUUC-Vpa-130391	Vicugna pacos	47.49	1.00e-76	278.00
IUUC-Vvi-131371	Vitis vinifera	48.22	5.00e-83	299.00
IUUC-Xtr-132464	Xenopus tropicalis	50.33	4.00e-84	303.00
IUUC-Xma-133475	Xiphophorus maculatus	50.50	9.00e-86	308.00
IUUC-Yli-134632	Yarrowia lipolytica	60.57	3.00e-126	444.00
IUUC-Zma-134951	Zea mays	46.43	2.00e-80	290.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence