iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045700

UUCD1 version

UUC-HoS-01085

Ensembl Protein ID

ENSP00000282344.6

UniProt Accession

O75317; A8K0X0; Q5VZV3; Q8TC49; UBP12_HUMAN

Genbank Protein ID

AAC23551.1; BAF82374.1; CAH70555.1; CAH70555.1; CAI16331.1; CAI16331.1; EAX08392.1; AAH26072.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12

Genbank Nucleotide ID

AF022789; AK289685; AL158062; AL355473; AL355473; AL158062; CH471075; BC026072

Gene Name

USP12; UBH1; USP12L1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000152484.13	ENST00000282344.10	ENSP00000282344.6
ENSG00000152484.13	ENST00000612674.1	ENSP00000480395.1
ENSG00000152484.13	ENST00000620323.1	ENSP00000478929.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21183687

Classification

Family	E-value	Score	Start	End
DUB/USP	8.40e-98	329.3	39	368

Active Site

Position(s)	Description	Evidence
48	Nucleophile	{ECO:0000269\|PubMed:27373336}
317	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqq 90
           +Gl N+gNtCY+NSvLQ+L++++++re +l  +k++      + +k++ll++l++lf+++   k+k +++ p+++++ l+ke+e f++y+qq
   Q: 39   FGLVNFGNTCYCNSVLQALYFCRPFREKVLA-YKSQ------PRKKESLLTCLADLFHSIAtqKKKVGVIPPKKFITRLRKENELFDNYMQQ 123
           6******************************.4444......456789************976777779*********************** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
           Da+Efl++ll+++ + l++   ++k+e+++ +  + + ++e+++ +  +++++++Fqg+l+++++cl+c+++ss++e+fldls++v++++  
   Q: 124  DAHEFLNYLLNTIADILQE---ERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNT-- 210
           *****************44...444444444444555567888888899*****************************************.. PP
   S: 183  kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke 274
              s+++cL+ f+++e+l++e kyyce+c++kqea k++k+kklP +L lhLkRf++  + ++ +k++ +v fpleL l  f+ts +   + 
   Q: 211  ---SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRL--FNTSGDA-TNP 296
           ...9**********************************************************************66665..7777444.446 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ++ Y+L+avvvH G +++ GHY+a+vk+ ++ WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 297  DRMYDLVAVVVHCGsGPNRGHYIAIVKS-HDFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 368
           9***************************.555*******************999*****************97 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).

Protein Sequence
(Fasta)

MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 60
RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGCAGC GGCTGCGCCC TGCGCCGGGG CGGAGCCGGG GGCGGGCCGG CGGCCGGCAG 60
GCGGGGGCTG GGGCCCGAGG CCGGGAGTGC CTGAGCGCCG GCGGCGACGA CGGCAGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:219333

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001964	Ailuropoda melanoleuca	97.03	0.00e+00	733.00
IUUC-Apl-003411	Anas platyrhynchos	98.06	0.00e+00	717.00
IUUC-Aca-005212	Anolis carolinensis	98.38	0.00e+00	763.00
IUUC-Acl-008239	Aspergillus clavatus	49.33	1.00e-77	284.00
IUUC-Afl-008602	Aspergillus flavus	50.84	2.00e-79	290.00
IUUC-Afu-008816	Aspergillus fumigatus	50.17	7.00e-78	285.00
IUUC-Ani-009137	Aspergillus nidulans	48.82	8.00e-76	278.00
IUUC-Ang-009703	Aspergillus niger	49.66	8.00e-79	288.00
IUUC-Aor-009901	Aspergillus oryzae	50.84	9.00e-80	291.00
IUUC-Ate-010431	Aspergillus terreus	50.84	3.00e-78	286.00
IUUC-Ame-011015	Astyanax mexicanus	92.45	0.00e+00	712.00
IUUC-Bgr-012071	Blumeria graminis	44.04	2.00e-74	273.00
IUUC-Bta-012981	Bos taurus	99.19	0.00e+00	746.00
IUUC-Bci-013837	Botrytis cinerea	41.05	2.00e-73	270.00
IUUC-Cja-018831	Callithrix jacchus	100.00	0.00e+00	777.00
IUUC-Cfa-020534	Canis familiaris	99.19	0.00e+00	771.00
IUUC-Cpo-021703	Cavia porcellus	99.44	0.00e+00	740.00
IUUC-Csa-023604	Chlorocebus sabaeus	100.00	0.00e+00	710.00
IUUC-Cho-024902	Choloepus hoffmanni	82.77	2.00e-165	574.00
IUUC-Cin-025659	Ciona intestinalis	57.08	4.00e-131	461.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	42.67	8.00e-75	275.00
IUUC-Dre-027845	Danio rerio	93.26	0.00e+00	714.00
IUUC-Dno-029460	Dasypus novemcinctus	99.15	0.00e+00	739.00
IUUC-Dor-030972	Dipodomys ordii	99.61	5.00e-147	513.00
IUUC-Dse-031470	Dothistroma septosporum	48.22	1.00e-76	281.00
IUUC-Ete-033125	Echinops telfairi	78.57	2.00e-128	451.00
IUUC-Eca-033439	Equus caballus	99.44	0.00e+00	740.00
IUUC-Fca-035524	Felis catus	98.87	0.00e+00	739.00
IUUC-Fal-036833	Ficedula albicollis	95.11	0.00e+00	716.00
IUUC-Gmo-038763	Gadus morhua	92.74	0.00e+00	712.00
IUUC-Gga-041151	Gallus gallus	98.65	0.00e+00	739.00
IUUC-Gac-041967	Gasterosteus aculeatus	93.28	0.00e+00	716.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	99.44	0.00e+00	743.00
IUUC-Lch-050435	Latimeria chalumnae	97.46	0.00e+00	713.00
IUUC-Loc-051968	Lepisosteus oculatus	96.22	0.00e+00	736.00
IUUC-Lma-053300	Leptosphaeria maculans	47.90	6.00e-79	288.00
IUUC-Laf-053887	Loxodonta africana	99.46	0.00e+00	773.00
IUUC-Mcc-055701	Macaca mulatta	99.73	0.00e+00	775.00
IUUC-Mga-059195	Meleagris gallopavo	96.21	0.00e+00	721.00
IUUC-Mmr-060751	Microcebus murinus	99.46	0.00e+00	773.00
IUUC-Mdo-062735	Monodelphis domestica	97.31	0.00e+00	733.00
IUUC-Mmu-063263	Mus musculus	98.38	0.00e+00	765.00
IUUC-Mlu-068128	Myotis lucifugus	99.44	0.00e+00	740.00
IUUC-Nfi-068611	Neosartorya fischeri	50.17	7.00e-78	285.00
IUUC-Ncr-068699	Neurospora crassa	44.63	3.00e-75	276.00
IUUC-Nle-069767	Nomascus leucogenys	100.00	0.00e+00	746.00
IUUC-Opr-070582	Ochotona princeps	92.09	0.00e+00	649.00
IUUC-Ont-072658	Oreochromis niloticus	93.55	0.00e+00	717.00
IUUC-Oan-073372	Ornithorhynchus anatinus	98.02	0.00e+00	732.00
IUUC-Ocu-074322	Oryctolagus cuniculus	96.76	0.00e+00	726.00
IUUC-Ola-087418	Oryzias latipes	93.55	0.00e+00	718.00
IUUC-Oga-088298	Otolemur garnettii	96.50	0.00e+00	723.00
IUUC-Oar-090269	Ovis aries	97.52	0.00e+00	720.00
IUUC-Ptr-090467	Pan troglodytes	100.00	0.00e+00	777.00
IUUC-Pan-092437	Papio anubis	97.01	0.00e+00	721.00
IUUC-Psi-092993	Pelodiscus sinensis	99.15	0.00e+00	739.00
IUUC-Pno-095044	Phaeosphaeria nodorum	48.18	7.00e-78	285.00
IUUC-Pfo-097052	Poecilia formosa	93.55	0.00e+00	718.00
IUUC-Pab-097797	Pongo abelii	100.00	0.00e+00	777.00
IUUC-Pca-100835	Procavia capensis	90.21	5.00e-168	583.00
IUUC-Pva-102878	Pteropus vampyrus	88.41	0.00e+00	654.00
IUUC-Pte-104356	Pyrenophora teres	48.20	8.00e-78	285.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	48.52	4.00e-78	286.00
IUUC-Rno-104918	Rattus norvegicus	95.93	0.00e+00	716.00
IUUC-Sha-107087	Sarcophilus harrisii	99.46	0.00e+00	773.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	43.12	5.00e-67	248.00
IUUC-Spo-108095	Schizosaccharomyces pombe	46.05	5.00e-75	275.00
IUUC-Sar-113216	Sorex araneus	98.87	0.00e+00	709.00
IUUC-Ssc-116321	Sus scrofa	97.78	0.00e+00	719.00
IUUC-Tgu-117482	Taeniopygia guttata	93.75	0.00e+00	704.00
IUUC-Tru-118613	Takifugu rubripes	93.28	0.00e+00	716.00
IUUC-Tsy-119520	Tarsius syrichta	89.02	1.00e-125	442.00
IUUC-Tni-120293	Tetraodon nigroviridis	93.28	0.00e+00	716.00
IUUC-Tre-122226	Trichoderma reesei	45.25	2.00e-75	277.00
IUUC-Tvi-122330	Trichoderma virens	45.42	3.00e-75	276.00
IUUC-Tme-126890	Tuber melanosporum	46.75	2.00e-90	327.00
IUUC-Tbe-127783	Tupaia belangeri	98.31	0.00e+00	698.00
IUUC-Ttr-129083	Tursiops truncatus	99.73	0.00e+00	775.00
IUUC-Vda-129736	Verticillium dahliae	38.06	4.00e-57	216.00
IUUC-Vpa-130391	Vicugna pacos	94.92	0.00e+00	674.00
IUUC-Xtr-132464	Xenopus tropicalis	99.15	0.00e+00	712.00
IUUC-Xma-133475	Xiphophorus maculatus	93.55	0.00e+00	718.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence