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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046675
UUCD1 version UUC-HoS-00657
Ensembl Protein ID ENSP00000398824.2
UniProt Accession Q96BD5; D3DQP5; Q6AWA2; Q9C0G7; Q9H8V9; Q9HAK6; Q9NZE9; PF21A_HUMAN
Genbank Protein ID AAM09095.1; BAB21787.1; BAB13839.1; BAB14492.1; EAW68012.1; EAW68013.1; EAW68015.1; EAW68017.1; AAH15714.1; CAH10542.1; AAF64262.1
Protein Name PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80
Genbank Nucleotide ID AY090777; AB051483; AK021530; AK023258; CH471064; CH471064; CH471064; CH471064; BC015714; BX648236; AF208848
Gene Name PHF21A; BHC80; KIAA1696; BM-006
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135365.15 ENST00000323180.10 ENSP00000323152.6
ENSG00000135365.15 ENST00000530587.5 ENSP00000435984.1
ENSG00000135365.15 ENST00000418153.6 ENSP00000398824.2
ENSG00000135365.15 ENST00000525676.5 ENSP00000431964.1
ENSG00000135365.15 ENST00000532028.1 ENSP00000431621.1
ENSG00000135365.15 ENST00000532883.5 ENSP00000432094.1
ENSG00000135365.15 ENST00000524497.5 ENSP00000431273.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.40e-10 40.3 489 534
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC+++g+    l++C+ C++++H +Cl ++  ++ p+   wiCp+C++
   Q: 489  DFCSVCRKSGQ----LLMCDTCSRVYHLDCLDPP-LKTIPKGM-WICPRCQD 534
           79*********....*******************.*******7.******85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
 Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Protein Sequence
(Fasta)
MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK 60
NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046675|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTGAGAGAGA GAGGAGAGGA GAGGAGGAGG AGGAGGAGGG AGAAGGGAAC AACCTACCAT 60
CTTAACACAC TAATATCTAA AAAGTGCGAG AGGCCCAGAG CAGCAGCAGA AGCAGCAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046675|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
SMART

SM00249--PHD
Gene Ontology

GO:1990391--C:DNA repair complex
GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0004407--F:histone deacetylase activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0007596--P:blood coagulation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:51317
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001656 Ailuropoda melanoleuca 96.66 0.00e+00 1054.00
IUUC-Atr-002930 Amborella trichopoda 46.43 8.00e-10 59.70
IUUC-Apl-003874 Anas platyrhynchos 88.40 0.00e+00 1033.00
IUUC-Aca-004684 Anolis carolinensis 87.08 0.00e+00 743.00
IUUC-Ame-010638 Astyanax mexicanus 66.07 8.00e-129 454.00
IUUC-Bgr-012025 Blumeria graminis 38.89 6.00e-09 57.00
IUUC-Bta-013460 Bos taurus 97.32 0.00e+00 1016.00
IUUC-Cja-019170 Callithrix jacchus 99.56 0.00e+00 1177.00
IUUC-Cfa-020760 Canis familiaris 96.92 0.00e+00 1149.00
IUUC-Cpo-021549 Cavia porcellus 96.48 0.00e+00 1102.00
IUUC-Csa-023461 Chlorocebus sabaeus 99.50 0.00e+00 1048.00
IUUC-Dre-027928 Danio rerio 56.22 3.00e-158 552.00
IUUC-Dno-029450 Dasypus novemcinctus 96.10 0.00e+00 970.00
IUUC-Dor-030699 Dipodomys ordii 96.62 0.00e+00 1144.00
IUUC-Dse-031258 Dothistroma septosporum 42.31 1.00e-09 59.70
IUUC-Ete-033073 Echinops telfairi 82.65 0.00e+00 874.00
IUUC-Eca-033822 Equus caballus 94.60 0.00e+00 1027.00
IUUC-Fca-035562 Felis catus 96.33 0.00e+00 1141.00
IUUC-Fal-037269 Ficedula albicollis 88.45 0.00e+00 1083.00
IUUC-Gmo-038592 Gadus morhua 56.36 2.00e-124 439.00
IUUC-Gga-040795 Gallus gallus 88.74 0.00e+00 1087.00
IUUC-Gac-042224 Gasterosteus aculeatus 61.36 8.00e-175 607.00
IUUC-Ggo-045327 Gorilla gorilla 99.85 0.00e+00 1178.00
IUUC-Itr-048946 Ictidomys tridecemlineatus 96.85 0.00e+00 671.00
IUUC-Lch-050609 Latimeria chalumnae 73.28 0.00e+00 805.00
IUUC-Loc-052407 Lepisosteus oculatus 70.32 0.00e+00 771.00
IUUC-Laf-053876 Loxodonta africana 98.25 0.00e+00 1040.00
IUUC-Mcc-054954 Macaca mulatta 97.08 0.00e+00 1131.00
IUUC-Meu-056821 Macropus eugenii 82.34 0.00e+00 1009.00
IUUC-Mtr-058324 Medicago truncatula 40.58 2.00e-10 61.60
IUUC-Mga-059320 Meleagris gallopavo 88.48 0.00e+00 1049.00
IUUC-Mmr-061278 Microcebus murinus 94.59 0.00e+00 1088.00
IUUC-Mdo-062891 Monodelphis domestica 89.28 0.00e+00 1102.00
IUUC-Mmu-063907 Mus musculus 93.18 0.00e+00 1082.00
IUUC-Mac-065599 Musa acuminata 39.44 4.00e-11 63.90
IUUC-Mpu-065839 Mustela putorius furo 97.50 0.00e+00 1134.00
IUUC-Mlu-068142 Myotis lucifugus 98.24 0.00e+00 1138.00
IUUC-Ncr-068727 Neurospora crassa 42.86 9.00e-11 63.50
IUUC-Nle-069423 Nomascus leucogenys 99.56 0.00e+00 1175.00
IUUC-Opr-070236 Ochotona princeps 87.88 0.00e+00 835.00
IUUC-Ont-071327 Oreochromis niloticus 58.57 2.00e-128 452.00
IUUC-Oan-073405 Ornithorhynchus anatinus 96.56 0.00e+00 961.00
IUUC-Ocu-074391 Oryctolagus cuniculus 95.46 0.00e+00 1110.00
IUUC-Ola-086548 Oryzias latipes 61.21 6.00e-178 617.00
IUUC-Oga-088488 Otolemur garnettii 98.68 0.00e+00 1144.00
IUUC-Oar-090334 Ovis aries 97.84 0.00e+00 1112.00
IUUC-Ptr-091018 Pan troglodytes 100.00 0.00e+00 1183.00
IUUC-Psi-093596 Pelodiscus sinensis 90.00 0.00e+00 905.00
IUUC-Pma-094616 Petromyzon marinus 63.67 3.00e-100 357.00
IUUC-Pfo-097233 Poecilia formosa 57.08 9.00e-162 563.00
IUUC-Pab-097801 Pongo abelii 99.71 0.00e+00 1178.00
IUUC-Pop-099691 Populus trichocarpa 44.29 1.00e-11 65.50
IUUC-Ppe-101956 Prunus persica 47.83 3.00e-13 70.50
IUUC-Pva-102419 Pteropus vampyrus 98.53 0.00e+00 1143.00
IUUC-Pyt-104775 Pyrenophora triticirepentis 37.88 3.00e-12 68.20
IUUC-Rno-104900 Rattus norvegicus 92.81 0.00e+00 1113.00
IUUC-Sha-107328 Sarcophilus harrisii 92.70 0.00e+00 1066.00
IUUC-Sar-113573 Sorex araneus 99.05 0.00e+00 761.00
IUUC-Ssc-115924 Sus scrofa 98.86 0.00e+00 962.00
IUUC-Tgu-117422 Taeniopygia guttata 88.87 0.00e+00 1092.00
IUUC-Tru-118697 Takifugu rubripes 75.46 2.00e-103 370.00
IUUC-Tsy-119092 Tarsius syrichta 98.57 1.00e-177 617.00
IUUC-Tni-120185 Tetraodon nigroviridis 61.95 5.00e-130 458.00
IUUC-Tca-121730 Theobroma cacao 46.55 9.00e-11 62.80
IUUC-Ttr-128860 Tursiops truncatus 95.18 0.00e+00 1133.00
IUUC-Vpa-130333 Vicugna pacos 90.60 0.00e+00 1076.00
IUUC-Xtr-131763 Xenopus tropicalis 74.73 0.00e+00 731.00
IUUC-Xma-134282 Xiphophorus maculatus 75.28 5.00e-101 362.00
Created Date 25-Jun-2017

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