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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046142
Ensembl Protein ID ENSP00000348602.2
UniProt Accession P49418; A4D1X8; A4D1X9; O43538; Q75MJ8; Q75MK5; Q75MM3; Q8N4G0; AMPH_HUMAN
Genbank Protein ID AAA21865.1; CAA57197.1; AAC02977.1; AAS07391.1; AAS07563.1; AAS07541.1; EAL23989.1; EAL23990.1; EAW94110.1; EAW94111.1; AAH34376.1
Protein Name Amphiphysin
Genbank Nucleotide ID U07616; X81438; AF034996; AC011309; AC012490; AC007245; CH236951; CH236951; CH471073; CH471073; BC034376
Gene Name AMPH; AMPH1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078053.16 ENST00000325590.9 ENSP00000317441.5
ENSG00000078053.16 ENST00000356264.6 ENSP00000348602.2
ENSG00000078053.16 ENST00000441628.5 ENSP00000415085.1
ENSG00000078053.16 ENST00000450124.1 ENSP00000400404.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 17244534
Classification
Family E-value Score Start End
UBD/SH3 2.80e-23 83.3 623 695
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvk........elegkrGlfPenFvekle 63
           +++kv++l+d+ea+n+deLtl++Gdvvlv+   ++++qd+gWl+gvk        +l++++GlfPenF+++l+
   Q: 623  FLYKVETLHDFEAANSDELTLQRGDVVLVVpsdSEADQDAGWLVGVKesdwlqyrDLATYKGLFPENFTRRLD 695
           789*******************************************************************985 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Heterodimer with BIN1. Binds SH3GLB1 and AP2A2 (By similarity). Interacts with AP2B1. Interacts with REPS1 and SGIP1; may be involved in clathrin-mediated endocytosis.
 Heterodimer with BIN1. Binds SH3GLB1 and AP2A2 (By similarity). Interacts with AP2B1. Interacts with REPS1 and SGIP1; may be involved in clathrin-mediated endocytosis.
Protein Sequence
(Fasta)
MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE AEGTRLQREL 60
RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE KCDVLWEDFH QKLVDGSLLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046142|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGTCCCGAC GCATCCCGCC CCCGCTCTGT CGCTTTAAGC TGGTCCCGCC GCCGCGCCCC 60
GCCCTCACCC CTCCGCGCTC CGCGGCTCCC CGCCGCTTCT CCCGCTCCTC CCTTGCTCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046142|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003017--Amphiphysin_1
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PRINTS

PR01251--AMPHIPHYSIN
PR01252--AMPHIPHYSIN1
PR00452--SH3DOMAIN
SMART

SM00721--BAR
SM00326--SH3
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0031256--C:leading edge membrane
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0005543--F:phospholipid binding
GO:0007268--P:chemical synaptic transmission
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
KEGG hsa:273
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001261 Ailuropoda melanoleuca 89.35 0.00e+00 990.00
IUUC-Apl-003820 Anas platyrhynchos 87.56 0.00e+00 646.00
IUUC-Aca-004603 Anolis carolinensis 69.13 0.00e+00 803.00
IUUC-Aly-005669 Arabidopsis lyrata 31.88 3.60e-02 32.30
IUUC-Acl-008143 Aspergillus clavatus 29.09 3.00e-17 82.40
IUUC-Afu-008953 Aspergillus fumigatus 30.00 2.00e-18 85.90
IUUC-Ani-009357 Aspergillus nidulans 29.05 1.00e-15 76.30
IUUC-Ang-009877 Aspergillus niger 30.04 2.00e-17 82.80
IUUC-Ate-010244 Aspergillus terreus 30.18 5.00e-18 84.70
IUUC-Ame-010666 Astyanax mexicanus 65.67 3.00e-137 482.00
IUUC-Bgr-012176 Blumeria graminis 28.91 3.00e-17 82.00
IUUC-Bta-013010 Bos taurus 87.63 0.00e+00 990.00
IUUC-Bci-013618 Botrytis cinerea 30.45 6.00e-18 84.70
IUUC-Cel-018166 Caenorhabditis elegans 33.88 1.00e-39 157.00
IUUC-Cja-019833 Callithrix jacchus 93.29 0.00e+00 1148.00
IUUC-Cfa-021194 Canis familiaris 87.52 0.00e+00 988.00
IUUC-Cpo-021536 Cavia porcellus 85.56 0.00e+00 896.00
IUUC-Cre-022932 Chlamydomonas reinhardtii 33.33 2.50e-02 32.30
IUUC-Csa-023774 Chlorocebus sabaeus 97.12 0.00e+00 1048.00
IUUC-Cho-024492 Choloepus hoffmanni 83.24 8.00e-145 508.00
IUUC-Cin-025739 Ciona intestinalis 34.03 6.00e-41 162.00
IUUC-Csv-026073 Ciona savignyi 36.36 5.00e-46 179.00
IUUC-Dre-028065 Danio rerio 69.61 4.00e-138 485.00
IUUC-Dno-029023 Dasypus novemcinctus 94.96 2.00e-162 566.00
IUUC-Dor-030535 Dipodomys ordii 85.75 2.00e-166 579.00
IUUC-Dse-031269 Dothistroma septosporum 28.18 2.00e-17 82.80
IUUC-Dme-032153 Drosophila melanogaster 38.34 1.00e-53 204.00
IUUC-Ete-032623 Echinops telfairi 71.41 0.00e+00 723.00
IUUC-Eca-033701 Equus caballus 88.69 0.00e+00 1009.00
IUUC-Eeu-034674 Erinaceus europaeus 98.22 4.00e-156 545.00
IUUC-Fca-035827 Felis catus 84.58 0.00e+00 900.00
IUUC-Fal-036846 Ficedula albicollis 66.78 0.00e+00 644.00
IUUC-Fox-037819 Fusarium oxysporum 29.79 2.00e-19 89.40
IUUC-Gmo-038933 Gadus morhua 67.49 1.00e-125 444.00
IUUC-Gga-041211 Gallus gallus 71.06 0.00e+00 868.00
IUUC-Gac-041862 Gasterosteus aculeatus 60.99 6.00e-128 451.00
IUUC-Ggo-045200 Gorilla gorilla 99.14 0.00e+00 1263.00
IUUC-Itr-048747 Ictidomys tridecemlineatus 88.14 0.00e+00 937.00
IUUC-Loc-052158 Lepisosteus oculatus 78.81 9.00e-160 557.00
IUUC-Lma-053251 Leptosphaeria maculans 26.99 5.00e-19 88.20
IUUC-Laf-054138 Loxodonta africana 87.91 0.00e+00 1091.00
IUUC-Mcc-055712 Macaca mulatta 96.55 0.00e+00 1152.00
IUUC-Meu-056810 Macropus eugenii 70.21 2.00e-99 356.00
IUUC-Mla-058828 Melampsora laricipopulina 27.60 8.00e-21 94.00
IUUC-Mvi-060216 Microbotryum violaceum 24.65 4.00e-15 75.10
IUUC-Mmr-060725 Microcebus murinus 88.22 0.00e+00 1033.00
IUUC-Mdo-062060 Monodelphis domestica 91.49 0.00e+00 682.00
IUUC-Mmu-063567 Mus musculus 83.50 0.00e+00 925.00
IUUC-Mpu-066178 Mustela putorius furo 86.28 0.00e+00 976.00
IUUC-Mlu-068015 Myotis lucifugus 97.77 0.00e+00 679.00
IUUC-Ncr-068637 Neurospora crassa 30.91 2.00e-17 82.80
IUUC-Nle-069053 Nomascus leucogenys 99.42 0.00e+00 1269.00
IUUC-Opr-070978 Ochotona princeps 80.24 4.00e-114 405.00
IUUC-Ont-072062 Oreochromis niloticus 65.09 1.00e-129 457.00
IUUC-Oan-073435 Ornithorhynchus anatinus 92.84 0.00e+00 696.00
IUUC-Ocu-073813 Oryctolagus cuniculus 90.64 0.00e+00 963.00
IUUC-Ola-086692 Oryzias latipes 60.32 2.00e-108 386.00
IUUC-Oga-088339 Otolemur garnettii 87.80 0.00e+00 932.00
IUUC-Oar-090177 Ovis aries 87.11 0.00e+00 959.00
IUUC-Ptr-091411 Pan troglodytes 99.57 0.00e+00 1268.00
IUUC-Pan-091792 Papio anubis 96.13 0.00e+00 1144.00
IUUC-Psi-093054 Pelodiscus sinensis 87.92 5.00e-163 567.00
IUUC-Pma-094171 Petromyzon marinus 59.14 2.00e-120 426.00
IUUC-Pno-094918 Phaeosphaeria nodorum 27.96 2.00e-19 89.40
IUUC-Pfo-097291 Poecilia formosa 69.50 4.00e-107 380.00
IUUC-Pab-098558 Pongo abelii 99.57 0.00e+00 1268.00
IUUC-Pva-103023 Pteropus vampyrus 87.15 7.00e-165 574.00
IUUC-Ptt-103759 Puccinia triticina 26.47 2.00e-14 72.40
IUUC-Pte-104041 Pyrenophora teres 27.96 6.00e-19 87.80
IUUC-Rno-105656 Rattus norvegicus 83.55 0.00e+00 926.00
IUUC-Sha-106518 Sarcophilus harrisii 77.66 0.00e+00 872.00
IUUC-Spo-108153 Schizosaccharomyces pombe 27.07 1.00e-15 76.60
IUUC-Ssl-108407 Sclerotinia sclerotiorum 30.45 6.00e-18 84.70
IUUC-Smo-108832 Selaginella moellendorffii 30.49 3.10e-02 34.30
IUUC-Sar-113003 Sorex araneus 71.47 0.00e+00 743.00
IUUC-Ssc-115617 Sus scrofa 88.10 0.00e+00 1006.00
IUUC-Tgu-117450 Taeniopygia guttata 89.21 0.00e+00 681.00
IUUC-Tru-118595 Takifugu rubripes 64.59 6.00e-119 420.00
IUUC-Tsy-119402 Tarsius syrichta 88.86 2.00e-171 596.00
IUUC-Tni-120824 Tetraodon nigroviridis 64.49 3.00e-122 432.00
IUUC-Tre-121889 Trichoderma reesei 30.00 2.00e-20 92.80
IUUC-Tbe-127836 Tupaia belangeri 74.57 0.00e+00 796.00
IUUC-Ttr-129272 Tursiops truncatus 98.45 0.00e+00 657.00
IUUC-Vda-129687 Verticillium dahliae 27.88 3.00e-11 63.20
IUUC-Vpa-130758 Vicugna pacos 98.91 0.00e+00 649.00
IUUC-Xtr-132779 Xenopus tropicalis 68.31 8.00e-142 497.00
IUUC-Yli-134343 Yarrowia lipolytica 26.64 7.00e-16 77.40
Created Date 25-Jun-2017

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