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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Rno-105641
UUCD1 version UUC-RaN-00001
Ensembl Protein ID ENSRNOP00000069425.1
UniProt Accession A0A0G2JVC1; A0A0G2JVC1_RAT
Genbank Protein ID ENSRNOP00000069425
Protein Name MDM2 proto-oncogene
Genbank Nucleotide ID AABR07057209
Gene Name Mdm2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006304.7 ENSRNOT00000066767.2 ENSRNOP00000063449.1
ENSRNOG00000006304.7 ENSRNOT00000086116.1 ENSRNOP00000069425.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17329546
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0043 17.9 430 471
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledfkdgplv.lpCgHvf.hadClqkwpglknssskefrCPlCr 46
    C iC+ ++k+g +v + gH++ +++C +k+ ++++ CP+Cr
   Q: 430 CVICQGRPKNGCIVhGKTGHLMsCFTCAKKL------KKRNKPCPVCR 471
    ********998554266***777*****999......**********8 PP
   

Organism Rattus norvegicus
Protein Sequence
(Fasta)
MCNTNMSVST EGAAGTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDIYTM KEIIFYIGQY 60
IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVVV SQQDSGTSPS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Rno-105641|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTTTGTTA ACGGGGCCTC CGAAGCCGGG GTAGCCTAGG AGCGGCCGCG TTCTACGTCA 60
GGAGCCGCTG TCGCTTCGCT CGACCTCCCG AGCGAAATGG TCTCTCAAGT CCCGGCCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-105641|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0045202--C:synapse
GO:0016874--F:ligase activity
GO:0002039--F:p53 binding
GO:0042975--F:peroxisome proliferator activated receptor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071312--P:cellular response to alkaloid
GO:0071236--P:cellular response to antibiotic
GO:0071391--P:cellular response to estrogen stimulus
GO:0071363--P:cellular response to growth factor stimulus
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071456--P:cellular response to hypoxia
GO:0071407--P:cellular response to organic cyclic compound
GO:0071310--P:cellular response to organic substance
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0071494--P:cellular response to UV-C
GO:0071301--P:cellular response to vitamin B1
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629--P:negative regulation of gene expression
GO:0010977--P:negative regulation of neuron projection development
GO:0010955--P:negative regulation of protein processing
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018205--P:peptidyl-lysine modification
GO:0010628--P:positive regulation of gene expression
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046827--P:positive regulation of protein export from nucleus
GO:1904754--P:positive regulation of vascular associated smooth muscle cell migration
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0045472--P:response to ether
GO:1904404--P:response to formaldehyde
GO:0010039--P:response to iron ion
GO:0032026--P:response to magnesium ion
GO:0043278--P:response to morphine
GO:0048545--P:response to steroid hormone
GO:0009636--P:response to toxic substance
GO:1990785--P:response to water-immersion restraint stress
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002039 Ailuropoda melanoleuca 82.45 0.00e+00 694.00
IUUC-Apl-003193 Anas platyrhynchos 61.18 2.00e-139 488.00
IUUC-Aca-004305 Anolis carolinensis 55.58 3.00e-107 382.00
IUUC-Ame-010675 Astyanax mexicanus 43.39 5.00e-83 301.00
IUUC-Bta-013270 Bos taurus 82.69 0.00e+00 676.00
IUUC-Cja-019744 Callithrix jacchus 81.71 0.00e+00 687.00
IUUC-Cfa-020807 Canis familiaris 80.88 0.00e+00 639.00
IUUC-Cpo-022182 Cavia porcellus 79.59 0.00e+00 658.00
IUUC-Cre-022828 Chlamydomonas reinhardtii 35.42 1.00e-05 40.80
IUUC-Csa-023541 Chlorocebus sabaeus 83.06 0.00e+00 685.00
IUUC-Cho-024831 Choloepus hoffmanni 66.54 2.00e-73 268.00
IUUC-Cin-025448 Ciona intestinalis 27.85 3.00e-19 88.60
IUUC-Csv-026151 Ciona savignyi 28.24 1.00e-11 63.20
IUUC-Dre-028419 Danio rerio 41.48 2.00e-49 189.00
IUUC-Dno-028950 Dasypus novemcinctus 80.00 0.00e+00 677.00
IUUC-Dor-031048 Dipodomys ordii 72.22 8.00e-92 330.00
IUUC-Ete-032264 Echinops telfairi 68.54 4.00e-95 342.00
IUUC-Eca-033301 Equus caballus 74.29 0.00e+00 629.00
IUUC-Eeu-035005 Erinaceus europaeus 69.73 2.00e-155 541.00
IUUC-Fca-035454 Felis catus 81.84 0.00e+00 682.00
IUUC-Fal-036720 Ficedula albicollis 56.48 7.00e-64 237.00
IUUC-Gmo-039296 Gadus morhua 43.35 2.00e-44 172.00
IUUC-Gga-040251 Gallus gallus 61.05 2.00e-134 472.00
IUUC-Gac-041528 Gasterosteus aculeatus 40.20 2.00e-35 143.00
IUUC-Ggo-044948 Gorilla gorilla 76.33 0.00e+00 630.00
IUUC-Hsa-046376 Homo sapiens 83.06 0.00e+00 687.00
IUUC-Itr-048328 Ictidomys tridecemlineatus 82.96 0.00e+00 667.00
IUUC-Lch-050037 Latimeria chalumnae 51.84 6.00e-103 367.00
IUUC-Loc-051837 Lepisosteus oculatus 49.49 2.00e-106 379.00
IUUC-Laf-053483 Loxodonta africana 77.19 0.00e+00 644.00
IUUC-Mcc-055294 Macaca mulatta 83.27 0.00e+00 689.00
IUUC-Mga-060007 Meleagris gallopavo 59.16 8.00e-128 450.00
IUUC-Mmr-060673 Microcebus murinus 82.86 0.00e+00 697.00
IUUC-Mdo-063057 Monodelphis domestica 65.85 5.00e-168 583.00
IUUC-Mmu-063207 Mus musculus 89.37 0.00e+00 731.00
IUUC-Mpu-065836 Mustela putorius furo 80.61 0.00e+00 688.00
IUUC-Mlu-068193 Myotis lucifugus 77.53 0.00e+00 652.00
IUUC-Nle-069927 Nomascus leucogenys 83.47 0.00e+00 691.00
IUUC-Opr-070590 Ochotona princeps 75.97 0.00e+00 630.00
IUUC-Ont-071984 Oreochromis niloticus 40.32 1.00e-73 270.00
IUUC-Oan-072744 Ornithorhynchus anatinus 66.14 2.00e-147 515.00
IUUC-Ocu-074071 Oryctolagus cuniculus 81.95 0.00e+00 667.00
IUUC-Ola-087329 Oryzias latipes 37.54 1.00e-47 184.00
IUUC-Oga-088135 Otolemur garnettii 75.30 0.00e+00 638.00
IUUC-Oar-090078 Ovis aries 82.65 0.00e+00 701.00
IUUC-Ptr-091399 Pan troglodytes 83.47 0.00e+00 691.00
IUUC-Pan-092720 Papio anubis 83.27 0.00e+00 689.00
IUUC-Psi-093591 Pelodiscus sinensis 62.01 8.00e-119 420.00
IUUC-Pma-094500 Petromyzon marinus 34.26 7.00e-27 113.00
IUUC-Pfo-096316 Poecilia formosa 39.48 1.00e-48 187.00
IUUC-Pab-097696 Pongo abelii 83.06 0.00e+00 681.00
IUUC-Pop-099579 Populus trichocarpa 36.00 2.00e-07 49.30
IUUC-Pca-100974 Procavia capensis 74.75 0.00e+00 656.00
IUUC-Pva-102488 Pteropus vampyrus 76.83 2.00e-174 605.00
IUUC-Sha-107314 Sarcophilus harrisii 65.79 6.00e-174 603.00
IUUC-Sar-112938 Sorex araneus 75.92 0.00e+00 650.00
IUUC-Ssc-115495 Sus scrofa 81.43 0.00e+00 671.00
IUUC-Tgu-116623 Taeniopygia guttata 61.95 2.00e-133 469.00
IUUC-Tru-117820 Takifugu rubripes 38.89 1.00e-45 177.00
IUUC-Tsy-119162 Tarsius syrichta 58.20 4.00e-66 244.00
IUUC-Tni-119793 Tetraodon nigroviridis 43.92 1.00e-46 180.00
IUUC-Tbe-127816 Tupaia belangeri 67.65 2.00e-107 382.00
IUUC-Ttr-129194 Tursiops truncatus 72.94 4.00e-162 564.00
IUUC-Vpa-130326 Vicugna pacos 77.55 2.00e-178 619.00
IUUC-Xtr-132216 Xenopus tropicalis 51.57 7.00e-106 377.00
Created Date 25-Jun-2017

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