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Tag Content
UUCD2 ID IUUC-Bta-013299
UUCD1 version UUC-BoT-01142
Ensembl Protein ID ENSBTAP00000012432.4
UniProt Accession A5PJS6; UBP10_BOVIN
Genbank Protein ID AAI42224.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
Genbank Nucleotide ID BC142223
Gene Name USP10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000009446.4 ENSBTAT00000012432.4 ENSBTAP00000012432.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.70e-68 231.4 418 796
Active Site
Position(s) Description Evidence
426 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
751 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+
   Q: 418  GLINKGNWCYINATLQALVACPPMYHLMKL-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPT 504
           9***************************99.333333.334799***************7666654333337777888888888***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde............a 130
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+ +                  k+++++e e+e+      e            +
   Q: 505  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkkllspnndkltisngPKSHSVNEDEQEEPG----EgsedeweqvgprN 589
           *9999999999966599********************4456688877777775555333333333333333....25555555555551 PP
   S: 131  eekkkkknk...........slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyyc 208
                   k           ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y+
   Q: 590  --------KtsvtrqadfvqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YT 662
           ........444444555666***********9.688999999*******************99...****************8....99 PP
   S: 209  ekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssG 293
           +k ++++e +++++l+klP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +G
   Q: 663  TKTRQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKNKNfkcHRTYRLFAVVYHHGsSATGG 750
           9999***************************9998886.****************999988777777879******************* PP
   S: 294  HYvayvknekgk.WllfdDskVtevkeeevleetg.staYvlfYkr 337
           HY+++v +   + Wl++dD++V++v++++v++  + +taY+l+Y+r
   Q: 751  HYTTDVFQIGLNgWLRIDDQTVKVVSQQQVVRPAAeRTAYLLYYRR 796
           ********87777*****************997778********98 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.
 Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.
Protein Sequence
(Fasta)
MALRSPQYIF GDFSPDEFNQ FFVTPRASVE LPPYGGTVLC GAQAADDLPD GHDYQRIEFG 60
VNEVIEPSDT LPRTPNYSIS STLNPQAPEF ILSCTTSKKL PDDIDKEVNY SSANCQYPGP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013299|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGAGAAGATG GCGGCGGCGG GGGAAGCAGC GTGAGGAGCC GGACGAGCGC CGAGGCTCAT 60
TGAAACGGGC CGCCATGGCC CTCCGCAGCC CGCAGGTAGC CGCCAGCCGG CGCCCTCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013299|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0967--Endosome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF07145--PAM2
PF00443--UCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0044325--F:ion channel binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006914--P:autophagy
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006281--P:DNA repair
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:510164
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000082 Aegilops tauschii 29.80 3.00e-42 166.00
IUUC-Aml-001584 Ailuropoda melanoleuca 88.92 0.00e+00 1295.00
IUUC-Atr-002927 Amborella trichopoda 35.22 9.00e-58 218.00
IUUC-Apl-003988 Anas platyrhynchos 78.02 0.00e+00 1113.00
IUUC-Aca-004461 Anolis carolinensis 87.43 5.00e-157 546.00
IUUC-Aly-006038 Arabidopsis lyrata 35.13 6.00e-54 205.00
IUUC-Ath-007328 Arabidopsis thaliana 35.13 3.00e-53 202.00
IUUC-Ago-007717 Ashbya gossypii 30.34 2.00e-43 170.00
IUUC-Acl-008188 Aspergillus clavatus 36.32 6.00e-62 232.00
IUUC-Afl-008456 Aspergillus flavus 40.07 1.00e-47 183.00
IUUC-Afu-009067 Aspergillus fumigatus 37.59 1.00e-65 244.00
IUUC-Ani-009483 Aspergillus nidulans 34.08 1.00e-59 224.00
IUUC-Ang-009639 Aspergillus niger 36.86 1.00e-58 221.00
IUUC-Aor-010040 Aspergillus oryzae 36.80 2.00e-59 224.00
IUUC-Ate-010310 Aspergillus terreus 35.73 2.00e-61 231.00
IUUC-Ame-011012 Astyanax mexicanus 70.73 1.00e-165 577.00
IUUC-Bgr-012311 Blumeria graminis 34.89 6.00e-44 172.00
IUUC-Bci-013783 Botrytis cinerea 38.32 8.00e-58 218.00
IUUC-Bdi-015039 Brachypodium distachyon 31.54 5.00e-47 182.00
IUUC-Bol-015806 Brassica oleracea 36.41 1.00e-61 230.00
IUUC-Bra-017076 Brassica rapa 36.41 1.00e-61 230.00
IUUC-Cja-018715 Callithrix jacchus 86.65 0.00e+00 1267.00
IUUC-Cfa-020194 Canis familiaris 89.29 0.00e+00 1305.00
IUUC-Cpo-022272 Cavia porcellus 73.97 0.00e+00 987.00
IUUC-Cre-022713 Chlamydomonas reinhardtii 34.23 3.00e-34 140.00
IUUC-Csa-023310 Chlorocebus sabaeus 87.41 0.00e+00 1280.00
IUUC-Cho-024966 Choloepus hoffmanni 74.96 0.00e+00 887.00
IUUC-Cin-025616 Ciona intestinalis 48.33 3.00e-103 369.00
IUUC-Csv-026043 Ciona savignyi 47.07 2.00e-97 349.00
IUUC-Cgl-026421 Colletotrichum gloeosporioides 34.89 7.00e-46 179.00
IUUC-Cne-026962 Cryptococcus neoformans 35.97 9.00e-51 195.00
IUUC-Cme-027113 Cyanidioschyzon merolae 32.35 9.00e-37 148.00
IUUC-Dre-028072 Danio rerio 75.37 0.00e+00 685.00
IUUC-Dno-029489 Dasypus novemcinctus 86.65 0.00e+00 1287.00
IUUC-Dor-031068 Dipodomys ordii 72.92 2.00e-137 482.00
IUUC-Dse-031553 Dothistroma septosporum 37.64 3.00e-55 210.00
IUUC-Dme-031759 Drosophila melanogaster 43.27 1.00e-81 298.00
IUUC-Ete-032549 Echinops telfairi 76.56 0.00e+00 836.00
IUUC-Eca-033380 Equus caballus 89.92 0.00e+00 1318.00
IUUC-Eeu-034818 Erinaceus europaeus 83.25 0.00e+00 1237.00
IUUC-Fca-035535 Felis catus 87.47 0.00e+00 1229.00
IUUC-Fal-036627 Ficedula albicollis 76.60 0.00e+00 1076.00
IUUC-Fox-037904 Fusarium oxysporum 36.59 2.00e-54 207.00
IUUC-Fso-038170 Fusarium solani 32.87 2.00e-51 197.00
IUUC-Gmo-039499 Gadus morhua 66.85 0.00e+00 629.00
IUUC-Ggr-040042 Gaeumannomyces graminis 36.39 5.00e-61 229.00
IUUC-Gga-040571 Gallus gallus 76.15 0.00e+00 1118.00
IUUC-Gac-041345 Gasterosteus aculeatus 77.63 0.00e+00 631.00
IUUC-Gma-044407 Glycine max 33.85 2.00e-56 213.00
IUUC-Ggo-044652 Gorilla gorilla 87.00 0.00e+00 1292.00
IUUC-Hsa-045864 Homo sapiens 87.25 0.00e+00 1298.00
IUUC-Hvu-047071 Hordeum vulgare 32.50 4.00e-51 195.00
IUUC-Itr-048216 Ictidomys tridecemlineatus 88.70 0.00e+00 969.00
IUUC-Kpa-049132 Komagataella pastoris 31.18 7.00e-45 175.00
IUUC-Lch-050040 Latimeria chalumnae 68.94 0.00e+00 890.00
IUUC-Loc-052449 Lepisosteus oculatus 76.60 0.00e+00 672.00
IUUC-Lma-053248 Leptosphaeria maculans 37.40 2.00e-59 224.00
IUUC-Laf-054121 Loxodonta africana 86.15 0.00e+00 1278.00
IUUC-Mcc-055514 Macaca mulatta 87.41 0.00e+00 1280.00
IUUC-Meu-056873 Macropus eugenii 70.38 0.00e+00 800.00
IUUC-Mor-057243 Magnaporthe oryzae 34.67 3.00e-57 217.00
IUUC-Mpo-057439 Magnaporthe poae 35.92 3.00e-60 226.00
IUUC-Mtr-058457 Medicago truncatula 33.85 9.00e-56 211.00
IUUC-Mla-058929 Melampsora laricipopulina 31.31 7.00e-55 208.00
IUUC-Mga-060157 Meleagris gallopavo 76.33 0.00e+00 1113.00
IUUC-Mvi-060442 Microbotryum violaceum 37.34 8.00e-52 199.00
IUUC-Mmr-061062 Microcebus murinus 85.31 0.00e+00 1271.00
IUUC-Mdo-062798 Monodelphis domestica 78.87 0.00e+00 1144.00
IUUC-Mmu-064050 Mus musculus 79.12 0.00e+00 1183.00
IUUC-Mac-065619 Musa acuminata 33.08 1.00e-51 196.00
IUUC-Mpu-066554 Mustela putorius furo 88.18 0.00e+00 1281.00
IUUC-Mlu-068003 Myotis lucifugus 87.91 0.00e+00 1295.00
IUUC-Nfi-068612 Neosartorya fischeri 37.06 5.00e-63 236.00
IUUC-Ncr-068878 Neurospora crassa 35.14 5.00e-52 199.00
IUUC-Nle-069661 Nomascus leucogenys 87.50 0.00e+00 1288.00
IUUC-Opr-070944 Ochotona princeps 80.43 1.00e-163 570.00
IUUC-Ont-071266 Oreochromis niloticus 57.57 0.00e+00 754.00
IUUC-Oan-073442 Ornithorhynchus anatinus 77.23 0.00e+00 1078.00
IUUC-Ocu-073788 Oryctolagus cuniculus 78.92 0.00e+00 1061.00
IUUC-Oba-075085 Oryza barthii 33.09 1.00e-35 143.00
IUUC-Obr-076663 Oryza brachyantha 33.16 5.00e-44 172.00
IUUC-Ogl-076937 Oryza glaberrima 29.80 2.00e-46 180.00
IUUC-Ogu-078909 Oryza glumaepatula 29.97 1.00e-44 174.00
IUUC-Oin-079617 Oryza indica 31.94 1.00e-47 184.00
IUUC-Olo-081043 Oryza longistaminata 26.26 2.00e-24 107.00
IUUC-Ome-081646 Oryza meridionalis 24.48 1.00e-21 98.60
IUUC-Oni-082914 Oryza nivara 29.97 8.00e-45 175.00
IUUC-Oru-084878 Oryza rufipogon 29.97 8.00e-45 175.00
IUUC-Osa-085822 Oryza sativa 30.67 2.00e-48 187.00
IUUC-Ola-086931 Oryzias latipes 70.06 2.00e-178 619.00
IUUC-Oga-088443 Otolemur garnettii 85.77 0.00e+00 1278.00
IUUC-Oar-089325 Ovis aries 93.96 0.00e+00 1290.00
IUUC-Ptr-091584 Pan troglodytes 84.00 0.00e+00 1199.00
IUUC-Pan-092551 Papio anubis 85.25 0.00e+00 1252.00
IUUC-Psi-093366 Pelodiscus sinensis 72.97 0.00e+00 674.00
IUUC-Pno-095136 Phaeosphaeria nodorum 35.54 2.00e-52 201.00
IUUC-Ppa-095574 Physcomitrella patens 36.61 6.00e-56 211.00
IUUC-Pfo-097462 Poecilia formosa 74.46 0.00e+00 652.00
IUUC-Pab-098547 Pongo abelii 87.38 0.00e+00 1284.00
IUUC-Pop-099529 Populus trichocarpa 36.92 1.00e-60 227.00
IUUC-Pca-101066 Procavia capensis 76.38 0.00e+00 1092.00
IUUC-Ppe-102110 Prunus persica 37.53 6.00e-58 218.00
IUUC-Pva-103015 Pteropus vampyrus 83.65 0.00e+00 1221.00
IUUC-Ptt-103998 Puccinia triticina 33.33 4.00e-53 202.00
IUUC-Pte-104417 Pyrenophora teres 34.34 1.00e-54 208.00
IUUC-Pyt-104820 Pyrenophora triticirepentis 35.62 1.00e-54 208.00
IUUC-Rno-105533 Rattus norvegicus 80.52 0.00e+00 1195.00
IUUC-Sce-106160 Saccharomyces cerevisiae 27.63 1.00e-37 152.00
IUUC-Sha-106590 Sarcophilus harrisii 78.74 0.00e+00 1141.00
IUUC-Sja-107669 Schizosaccharomyces japonicus 36.34 7.00e-57 214.00
IUUC-Spo-108353 Schizosaccharomyces pombe 36.67 9.00e-64 237.00
IUUC-Ssl-108599 Sclerotinia sclerotiorum 37.13 3.00e-57 217.00
IUUC-Smo-108842 Selaginella moellendorffii 36.92 2.00e-37 148.00
IUUC-Sit-110781 Setaria italica 31.52 1.00e-52 201.00
IUUC-Sly-111797 Solanum lycopersicum 33.76 6.00e-53 201.00
IUUC-Stu-112188 Solanum tuberosum 35.03 1.00e-53 203.00
IUUC-Sbi-114862 Sorghum bicolor 32.51 5.00e-45 175.00
IUUC-Sre-115162 Sporisorium reilianum 35.60 7.00e-66 245.00
IUUC-Ssc-115505 Sus scrofa 95.79 3.00e-159 553.00
IUUC-Tgu-116535 Taeniopygia guttata 76.57 0.00e+00 1085.00
IUUC-Tru-117542 Takifugu rubripes 75.75 0.00e+00 683.00
IUUC-Tni-120200 Tetraodon nigroviridis 57.11 0.00e+00 767.00
IUUC-Tca-121548 Theobroma cacao 34.60 1.00e-44 174.00
IUUC-Tre-122124 Trichoderma reesei 36.73 3.00e-59 223.00
IUUC-Tvi-122457 Trichoderma virens 35.15 1.00e-52 201.00
IUUC-Tae-125646 Triticum aestivum 32.66 2.00e-52 201.00
IUUC-Tme-127180 Tuber melanosporum 40.56 4.00e-69 256.00
IUUC-Tbe-127530 Tupaia belangeri 72.57 0.00e+00 972.00
IUUC-Ttr-128549 Tursiops truncatus 84.59 0.00e+00 1247.00
IUUC-Uma-129381 Ustilago maydis 34.65 2.00e-66 248.00
IUUC-Vda-129889 Verticillium dahliae 32.89 6.00e-51 196.00
IUUC-Vpa-130100 Vicugna pacos 84.01 0.00e+00 1204.00
IUUC-Vvi-131366 Vitis vinifera 36.64 2.00e-61 229.00
IUUC-Xtr-132048 Xenopus tropicalis 61.79 0.00e+00 880.00
IUUC-Xma-133593 Xiphophorus maculatus 75.32 0.00e+00 645.00
IUUC-Yli-134338 Yarrowia lipolytica 31.42 3.00e-32 133.00
IUUC-Zma-135586 Zea mays 31.53 2.00e-47 183.00
Created Date 25-Jun-2017

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