iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020194

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03004017

Gene Name

USP10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000019946.3	ENSCAFT00000031734.3	ENSCAFP00000029546.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-68	230.0	417	795

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avspr 71
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+
   Q: 417  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPT 503
           9***************************99.333333.334799***************7666654333337777888888888***** PP
   S: 72   ellkalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde............. 129
            +++ l  +++++s + +q+Da+E+l f+l++l+ee+ +                  k+++++e           +             
   Q: 504  YIYRLLTVIKSSLSeKGRQEDAEEYLGFILNGLHEEMLSlkkllspnnekltisngPKSHSVTE-----------Ddqeepgegsedew 581
           *9999999999966599********************555567776655666444333333333...........13344444666666 PP
   S: 130  .........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyyce 209
                    +  ++ +  +++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y++
   Q: 582  eqvgprnktSVTRQAEFVQTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDRIR---TVQDALESLVARESVQG----YTT 662
           6666665544445555555***********9.688999999*******************99...****************8....999 PP
   S: 210  kckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssGH 294
           k k+++e +++++l+klP+vL+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +GH
   Q: 663  KTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKNKNfkcHRTYRLFAVVYHHGsSATGGH 750
           99****************************9998886.****************999988777777879******************** PP
   S: 295  Yvayvknekgk.WllfdDskVtevkeeevleetg.staYvlfYkr 337
           Y+++v +   + Wl++dD+ V+++++ +v++ t+ +taY+l+Y+r
   Q: 751  YTTDVFQIGLNgWLRIDDQAVKVINQYQVVKPTAeRTAYLLYYRR 795
           *******87777*******************9889********98 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

QGLFSLFQYI FGDFSPDEFN QFFVTPRSSV ELPPYNGAVL CGTQATDELP DGQEYQRIEF 60
GVNEVIEPND TLPRTPNYSI SSTLNPQAPE FILSCTTSKK PPDDLDKEAT YSSVDCQYPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGCCTGT TTTCTCTTTT CCAGTATATT TTTGGAGATT TTAGCCCTGA TGAATTCAAT 60
CAGTTCTTTG TGACTCCTCG CTCTTCAGTT GAGGTAAGAC CAAACATTTT CTTGACTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	31.06	2.00e-46	180.00
IUUC-Aml-001584	Ailuropoda melanoleuca	94.98	0.00e+00	1419.00
IUUC-Atr-002927	Amborella trichopoda	35.55	7.00e-59	221.00
IUUC-Apl-003988	Anas platyrhynchos	78.92	0.00e+00	1160.00
IUUC-Aca-004461	Anolis carolinensis	88.02	1.00e-163	568.00
IUUC-Aly-006038	Arabidopsis lyrata	36.15	1.00e-56	214.00
IUUC-Ath-007328	Arabidopsis thaliana	35.64	2.00e-54	206.00
IUUC-Ago-007717	Ashbya gossypii	31.01	5.00e-46	179.00
IUUC-Acl-008188	Aspergillus clavatus	34.82	1.00e-62	234.00
IUUC-Afl-008456	Aspergillus flavus	37.70	1.00e-48	187.00
IUUC-Afu-009067	Aspergillus fumigatus	36.02	3.00e-66	246.00
IUUC-Ani-009483	Aspergillus nidulans	32.86	5.00e-62	233.00
IUUC-Ang-009639	Aspergillus niger	35.20	1.00e-59	224.00
IUUC-Aor-010040	Aspergillus oryzae	35.25	9.00e-61	228.00
IUUC-Ate-010310	Aspergillus terreus	31.82	7.00e-63	235.00
IUUC-Ame-011012	Astyanax mexicanus	78.05	5.00e-165	575.00
IUUC-Bgr-012311	Blumeria graminis	34.59	6.00e-45	176.00
IUUC-Bta-013299	Bos taurus	89.04	0.00e+00	1296.00
IUUC-Bci-013783	Botrytis cinerea	37.18	1.00e-58	221.00
IUUC-Bdi-015039	Brachypodium distachyon	32.52	1.00e-50	194.00
IUUC-Bol-015806	Brassica oleracea	37.44	6.00e-64	238.00
IUUC-Bra-017076	Brassica rapa	37.44	8.00e-64	238.00
IUUC-Cja-018715	Callithrix jacchus	87.75	0.00e+00	1327.00
IUUC-Cpo-022272	Cavia porcellus	73.74	0.00e+00	1025.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	34.12	5.00e-35	142.00
IUUC-Csa-023310	Chlorocebus sabaeus	89.14	0.00e+00	1348.00
IUUC-Cho-024966	Choloepus hoffmanni	78.25	0.00e+00	936.00
IUUC-Cin-025616	Ciona intestinalis	47.37	2.00e-106	379.00
IUUC-Csv-026043	Ciona savignyi	46.71	5.00e-100	357.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	33.87	4.00e-46	180.00
IUUC-Cne-026962	Cryptococcus neoformans	35.79	5.00e-51	196.00
IUUC-Cme-027113	Cyanidioschyzon merolae	31.85	2.00e-40	160.00
IUUC-Dre-028072	Danio rerio	78.06	0.00e+00	716.00
IUUC-Dno-029489	Dasypus novemcinctus	88.02	0.00e+00	1347.00
IUUC-Dor-031068	Dipodomys ordii	73.12	7.00e-136	478.00
IUUC-Dse-031553	Dothistroma septosporum	37.11	2.00e-57	217.00
IUUC-Dme-031759	Drosophila melanogaster	41.83	4.00e-83	303.00
IUUC-Ete-032549	Echinops telfairi	79.19	0.00e+00	877.00
IUUC-Eca-033380	Equus caballus	89.79	0.00e+00	1372.00
IUUC-Eeu-034818	Erinaceus europaeus	85.37	0.00e+00	1261.00
IUUC-Fca-035535	Felis catus	92.84	0.00e+00	1311.00
IUUC-Fal-036627	Ficedula albicollis	76.20	0.00e+00	1101.00
IUUC-Fox-037904	Fusarium oxysporum	37.05	9.00e-55	208.00
IUUC-Fso-038170	Fusarium solani	33.87	5.00e-53	202.00
IUUC-Gmo-039499	Gadus morhua	62.92	0.00e+00	655.00
IUUC-Ggr-040042	Gaeumannomyces graminis	36.07	8.00e-62	232.00
IUUC-Gga-040571	Gallus gallus	79.22	0.00e+00	1151.00
IUUC-Gac-041345	Gasterosteus aculeatus	78.54	0.00e+00	655.00
IUUC-Gma-044407	Glycine max	35.38	2.00e-59	223.00
IUUC-Ggo-044652	Gorilla gorilla	89.14	0.00e+00	1367.00
IUUC-Hsa-045864	Homo sapiens	89.39	0.00e+00	1372.00
IUUC-Hvu-047071	Hordeum vulgare	33.75	6.00e-54	204.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	90.39	0.00e+00	1003.00
IUUC-Kpa-049132	Komagataella pastoris	31.19	5.00e-48	185.00
IUUC-Lch-050040	Latimeria chalumnae	70.34	0.00e+00	923.00
IUUC-Loc-052449	Lepisosteus oculatus	74.32	0.00e+00	699.00
IUUC-Lma-053248	Leptosphaeria maculans	37.30	1.00e-59	224.00
IUUC-Laf-054121	Loxodonta africana	87.42	0.00e+00	1322.00
IUUC-Mcc-055514	Macaca mulatta	89.27	0.00e+00	1351.00
IUUC-Meu-056873	Macropus eugenii	72.84	0.00e+00	840.00
IUUC-Mor-057243	Magnaporthe oryzae	34.18	4.00e-58	220.00
IUUC-Mpo-057439	Magnaporthe poae	35.62	1.00e-60	228.00
IUUC-Mtr-058457	Medicago truncatula	34.36	1.00e-57	217.00
IUUC-Mla-058929	Melampsora laricipopulina	31.03	6.00e-56	212.00
IUUC-Mga-060157	Meleagris gallopavo	77.37	0.00e+00	1154.00
IUUC-Mvi-060442	Microbotryum violaceum	34.50	2.00e-53	204.00
IUUC-Mmr-061062	Microcebus murinus	88.62	0.00e+00	1365.00
IUUC-Mdo-062798	Monodelphis domestica	81.26	0.00e+00	1207.00
IUUC-Mmu-064050	Mus musculus	81.08	0.00e+00	1234.00
IUUC-Mac-065619	Musa acuminata	34.09	2.00e-53	203.00
IUUC-Mpu-066554	Mustela putorius furo	93.86	0.00e+00	1402.00
IUUC-Mlu-068003	Myotis lucifugus	89.91	0.00e+00	1368.00
IUUC-Nfi-068612	Neosartorya fischeri	34.53	2.00e-64	240.00
IUUC-Ncr-068878	Neurospora crassa	35.66	1.00e-51	198.00
IUUC-Nle-069661	Nomascus leucogenys	89.39	0.00e+00	1352.00
IUUC-Opr-070944	Ochotona princeps	79.90	3.00e-164	572.00
IUUC-Ont-071266	Oreochromis niloticus	58.56	0.00e+00	781.00
IUUC-Oan-073442	Ornithorhynchus anatinus	79.73	0.00e+00	1135.00
IUUC-Ocu-073788	Oryctolagus cuniculus	80.11	0.00e+00	1107.00
IUUC-Oba-075085	Oryza barthii	33.81	6.00e-38	150.00
IUUC-Obr-076663	Oryza brachyantha	33.16	1.00e-46	181.00
IUUC-Ogl-076937	Oryza glaberrima	30.30	7.00e-49	188.00
IUUC-Ogu-078909	Oryza glumaepatula	30.49	4.00e-47	182.00
IUUC-Oin-079617	Oryza indica	31.96	1.00e-48	188.00
IUUC-Olo-081043	Oryza longistaminata	26.32	3.00e-25	110.00
IUUC-Ome-081646	Oryza meridionalis	25.00	5.00e-24	106.00
IUUC-Oni-082914	Oryza nivara	30.49	3.00e-47	183.00
IUUC-Oru-084878	Oryza rufipogon	30.49	3.00e-47	183.00
IUUC-Osa-085822	Oryza sativa	31.12	4.00e-51	195.00
IUUC-Ola-086931	Oryzias latipes	57.73	0.00e+00	768.00
IUUC-Oga-088443	Otolemur garnettii	88.79	0.00e+00	1375.00
IUUC-Oar-089325	Ovis aries	86.43	0.00e+00	1204.00
IUUC-Ptr-091584	Pan troglodytes	86.36	0.00e+00	1277.00
IUUC-Pan-092551	Papio anubis	87.63	0.00e+00	1316.00
IUUC-Psi-093366	Pelodiscus sinensis	74.05	0.00e+00	685.00
IUUC-Pno-095136	Phaeosphaeria nodorum	35.41	3.00e-52	200.00
IUUC-Ppa-095574	Physcomitrella patens	33.53	7.00e-61	228.00
IUUC-Pfo-097462	Poecilia formosa	77.25	0.00e+00	681.00
IUUC-Pab-098547	Pongo abelii	89.52	0.00e+00	1349.00
IUUC-Pop-099529	Populus trichocarpa	37.18	2.00e-62	233.00
IUUC-Pca-101066	Procavia capensis	78.03	0.00e+00	1153.00
IUUC-Ppe-102110	Prunus persica	36.39	8.00e-60	224.00
IUUC-Pva-103015	Pteropus vampyrus	85.88	0.00e+00	1269.00
IUUC-Ptt-103998	Puccinia triticina	33.17	6.00e-53	202.00
IUUC-Pte-104417	Pyrenophora teres	34.42	8.00e-55	209.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	35.62	7.00e-55	209.00
IUUC-Rno-105533	Rattus norvegicus	82.12	0.00e+00	1240.00
IUUC-Sce-106160	Saccharomyces cerevisiae	27.88	2.00e-39	157.00
IUUC-Sha-106590	Sarcophilus harrisii	81.59	0.00e+00	1204.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	36.12	1.00e-56	214.00
IUUC-Spo-108353	Schizosaccharomyces pombe	37.44	8.00e-66	244.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	35.97	3.00e-58	220.00
IUUC-Smo-108842	Selaginella moellendorffii	36.92	1.00e-38	152.00
IUUC-Sit-110781	Setaria italica	32.43	1.00e-56	214.00
IUUC-Sly-111797	Solanum lycopersicum	33.50	1.00e-54	207.00
IUUC-Stu-112188	Solanum tuberosum	35.79	1.00e-55	211.00
IUUC-Sbi-114862	Sorghum bicolor	32.78	1.00e-45	177.00
IUUC-Sre-115162	Sporisorium reilianum	35.45	5.00e-67	249.00
IUUC-Ssc-115505	Sus scrofa	96.44	1.00e-166	578.00
IUUC-Tgu-116535	Taeniopygia guttata	76.29	0.00e+00	1108.00
IUUC-Tru-117542	Takifugu rubripes	77.63	0.00e+00	709.00
IUUC-Tni-120200	Tetraodon nigroviridis	58.00	0.00e+00	809.00
IUUC-Tca-121548	Theobroma cacao	35.24	1.00e-44	174.00
IUUC-Tre-122124	Trichoderma reesei	36.41	7.00e-61	228.00
IUUC-Tvi-122457	Trichoderma virens	35.12	5.00e-54	206.00
IUUC-Tae-125646	Triticum aestivum	34.43	8.00e-57	215.00
IUUC-Tme-127180	Tuber melanosporum	40.16	3.00e-71	263.00
IUUC-Tbe-127530	Tupaia belangeri	74.58	0.00e+00	1031.00
IUUC-Ttr-128549	Tursiops truncatus	81.83	0.00e+00	1220.00
IUUC-Uma-129381	Ustilago maydis	33.84	7.00e-66	245.00
IUUC-Vda-129889	Verticillium dahliae	32.37	1.00e-51	198.00
IUUC-Vpa-130100	Vicugna pacos	84.38	0.00e+00	1254.00
IUUC-Vvi-131366	Vitis vinifera	36.39	2.00e-64	239.00
IUUC-Xtr-132048	Xenopus tropicalis	62.59	0.00e+00	914.00
IUUC-Xma-133593	Xiphophorus maculatus	77.94	0.00e+00	678.00
IUUC-Yli-134338	Yarrowia lipolytica	30.92	1.00e-33	138.00
IUUC-Zma-135586	Zea mays	31.66	4.00e-49	189.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence