iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045445

UUCD1 version

UUC-GoG-00442

Ensembl Protein ID

ENSGGOP00000010679.2

UniProt Accession

G3R5U6; G3R5U6_GORGO

Protein Name

Uncharacterized protein

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000010944.2	ENSGGOT00000010997.2	ENSGGOP00000010679.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-90	302.9	671	992

Active Site

Position(s)	Description	Evidence
962	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+k+l+v+f+gE g dlgGv++ef+++l++e+ +p++g+f+y e+++++++p + ++    e+ ++F f+G+l+g++l++ ++ +l
   Q: 671  NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGGSCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANL 754
           689********************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+++++
   Q: 755  PFPLALFKKLLDQMPSLEDLKELSPVLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYIN 838
           ***********************************87544444.....455555667779999************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G++++d+++++k++ y+ gy++++p+i +Fw+++++++ ee+k+fL F+
   Q: 839  YIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNACYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFL 927
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++rl ++ ++++k   f+++++ ++++ +++ TCf++L LP+Ys++e+++e L+ Ai++++gF+
   Q: 928  TGTDRLQMKDLNNMK-ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 992
           ***************.77999999****************************************96 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MERRSRRKSR RNGRSTAGKA AASQPAKSPG AQLWLFPSAA GLHRALLRRA EVTRQLCCSP 60
GRLAVLERGG AGVQVHQLLA GSGGARTPKC IKLGKNMKIH SVDQGAEHML ILSSDGKPFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGTCGCGGAG GAAGTCGCGG CGCAACGGGC GCTCGACCGC GGGCAAGGCC 60
GCCGCGTCCC AGCCCGCGAA GTCTCCGGGC GCACAGCTCT GGCTCTTTCC CAGCGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	74.42	0.00e+00	1529.00
IUUC-Bta-012422	Bos taurus	66.47	0.00e+00	1214.00
IUUC-Cja-018751	Callithrix jacchus	87.91	0.00e+00	1815.00
IUUC-Cfa-020247	Canis familiaris	74.07	0.00e+00	1442.00
IUUC-Csa-023204	Chlorocebus sabaeus	91.59	0.00e+00	1639.00
IUUC-Cho-025101	Choloepus hoffmanni	63.58	0.00e+00	629.00
IUUC-Dno-029795	Dasypus novemcinctus	67.93	0.00e+00	1082.00
IUUC-Dor-030862	Dipodomys ordii	66.16	0.00e+00	1282.00
IUUC-Eca-034358	Equus caballus	73.63	0.00e+00	1415.00
IUUC-Eeu-035282	Erinaceus europaeus	62.50	0.00e+00	677.00
IUUC-Fca-036505	Felis catus	74.95	0.00e+00	1499.00
IUUC-Hsa-046342	Homo sapiens	95.44	0.00e+00	1893.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	68.47	0.00e+00	1370.00
IUUC-Laf-053921	Loxodonta africana	70.78	0.00e+00	1424.00
IUUC-Mcc-054850	Macaca mulatta	91.70	0.00e+00	1642.00
IUUC-Mmr-060783	Microcebus murinus	64.03	0.00e+00	1136.00
IUUC-Mpu-066123	Mustela putorius furo	74.40	0.00e+00	1519.00
IUUC-Mlu-067914	Myotis lucifugus	73.61	0.00e+00	1359.00
IUUC-Nle-069986	Nomascus leucogenys	93.85	0.00e+00	1871.00
IUUC-Opr-070513	Ochotona princeps	66.75	0.00e+00	989.00
IUUC-Ocu-074305	Oryctolagus cuniculus	70.07	0.00e+00	1323.00
IUUC-Oar-089456	Ovis aries	74.30	0.00e+00	1452.00
IUUC-Ptr-091216	Pan troglodytes	85.08	0.00e+00	1652.00
IUUC-Pan-091706	Papio anubis	90.80	0.00e+00	1774.00
IUUC-Pab-097883	Pongo abelii	96.88	0.00e+00	798.00
IUUC-Pca-100320	Procavia capensis	64.40	0.00e+00	1299.00
IUUC-Pva-102646	Pteropus vampyrus	75.48	0.00e+00	1517.00
IUUC-Sar-113605	Sorex araneus	76.07	3.00e-138	485.00
IUUC-Tsy-119240	Tarsius syrichta	63.70	0.00e+00	1171.00
IUUC-Tbe-127787	Tupaia belangeri	69.38	0.00e+00	1303.00
IUUC-Ttr-128191	Tursiops truncatus	72.59	0.00e+00	1425.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence