iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092297

Ensembl Protein ID

ENSPANP00000012252.1

UniProt Accession

A0A096NH06; A0A096NH06_PAPAN

Genbank Protein ID

ENSPANP00000012252

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AHZZ01102089

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000018906.1	ENSPANT00000007646.1	ENSPANP00000012252.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.30e-21	75.5	386	768

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 386  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 465
           56*********************...55654......57*************9****************99999866777777776666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++        +e  +  +      ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 466  gkGNLARLIQRWNRFILTQLHQDMQE--------LEVPQ--AYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 543
           66666666777888888888888833........22222..3344467899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+       l+++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + +
   Q: 544  TLSYPDDKTGKNYDFAQVLKRSIC---LDQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RMQAEVAFK--MAV 625
           **********99999999987766...5555579****************************99977666555..588888887..566 PP
   S: 262  spfcts........peekqke..............................................................kkkYeL 280
           +++  +                                                                              + Y+L
   Q: 626  KKHGGEisknkefaL-----AdwkelgspegvlvcpsieelknvwlpfsirmkmtknkgldvcnwtdgdemqwgparaeeehgVYVYDL 709
           666655333444440.....0555555555555555555555555555555555555566666666666666666666666669***** PP
   S: 281  iavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
           +a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 710  MATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 768
           ********9*************999988877777888************9999888654 PP

Organism

Papio anubis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MARGGLIIFD YLLDENEDMH SLLLTDSSTL LIGGLQNHIL EIDLNTVQET QKYAVETPGV 60
TIMRQTNRFF FCGHTSGKVS LRDLRTFKVE HEFDAFSGSL SDFDVHGNLL AACGFSSRLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCGTG GGGGCCTCAT TATATTTGAT TACCTGTAAG TGGCTTCTCA GCTCTGGACT 60
GGGAACGAGG ATGCCTCATA GGGTGGGAAG GCTAAGGGAT TGGCAGCTTG TAAGGCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	97.84	0.00e+00	2093.00
IUUC-Apl-003500	Anas platyrhynchos	85.89	0.00e+00	1639.00
IUUC-Aca-004930	Anolis carolinensis	84.24	0.00e+00	1777.00
IUUC-Acl-008214	Aspergillus clavatus	31.28	4.00e-143	502.00
IUUC-Afu-009112	Aspergillus fumigatus	31.46	2.00e-134	474.00
IUUC-Ang-009531	Aspergillus niger	31.45	1.00e-140	494.00
IUUC-Ame-011259	Astyanax mexicanus	77.66	0.00e+00	1636.00
IUUC-Bta-012371	Bos taurus	98.21	0.00e+00	2098.00
IUUC-Bci-013684	Botrytis cinerea	31.10	1.00e-123	438.00
IUUC-Cja-019297	Callithrix jacchus	95.42	0.00e+00	2043.00
IUUC-Cfa-020489	Canis familiaris	97.73	0.00e+00	2085.00
IUUC-Cpo-022392	Cavia porcellus	96.52	0.00e+00	2056.00
IUUC-Csa-023220	Chlorocebus sabaeus	99.44	0.00e+00	2119.00
IUUC-Csv-025841	Ciona savignyi	47.20	0.00e+00	871.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.41	3.00e-147	516.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	6.00e-73	269.00
IUUC-Dre-028482	Danio rerio	75.58	0.00e+00	1588.00
IUUC-Dno-029398	Dasypus novemcinctus	97.36	0.00e+00	2071.00
IUUC-Dor-030307	Dipodomys ordii	90.41	0.00e+00	1315.00
IUUC-Dme-032111	Drosophila melanogaster	41.24	0.00e+00	814.00
IUUC-Eca-033985	Equus caballus	98.39	0.00e+00	2102.00
IUUC-Eeu-034928	Erinaceus europaeus	87.47	0.00e+00	694.00
IUUC-Fca-035587	Felis catus	97.84	0.00e+00	2093.00
IUUC-Fal-037587	Ficedula albicollis	85.34	0.00e+00	1752.00
IUUC-Fso-038133	Fusarium solani	29.55	3.00e-117	416.00
IUUC-Gmo-039076	Gadus morhua	75.51	0.00e+00	1565.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.77	9.00e-133	468.00
IUUC-Gga-040948	Gallus gallus	85.97	0.00e+00	1821.00
IUUC-Gac-042396	Gasterosteus aculeatus	76.28	0.00e+00	1612.00
IUUC-Ggo-045412	Gorilla gorilla	99.06	0.00e+00	2113.00
IUUC-Hsa-046076	Homo sapiens	99.06	0.00e+00	2116.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	89.70	0.00e+00	1867.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	9.00e-67	248.00
IUUC-Lch-050279	Latimeria chalumnae	71.93	0.00e+00	1500.00
IUUC-Loc-052872	Lepisosteus oculatus	78.36	0.00e+00	1664.00
IUUC-Lma-052986	Leptosphaeria maculans	32.57	5.00e-144	505.00
IUUC-Laf-054181	Loxodonta africana	95.59	0.00e+00	2058.00
IUUC-Mcc-054812	Macaca mulatta	99.81	0.00e+00	2119.00
IUUC-Meu-056325	Macropus eugenii	92.19	0.00e+00	1972.00
IUUC-Mor-057246	Magnaporthe oryzae	29.68	2.00e-119	424.00
IUUC-Mpo-057464	Magnaporthe poae	31.58	1.00e-134	474.00
IUUC-Mla-058911	Melampsora laricipopulina	32.60	5.00e-99	356.00
IUUC-Mga-059335	Meleagris gallopavo	86.39	0.00e+00	1773.00
IUUC-Mvi-060461	Microbotryum violaceum	34.06	6.00e-143	501.00
IUUC-Mmr-060636	Microcebus murinus	99.06	0.00e+00	2111.00
IUUC-Mmu-063503	Mus musculus	95.87	0.00e+00	2032.00
IUUC-Mpu-066670	Mustela putorius furo	98.39	0.00e+00	2100.00
IUUC-Mlu-068119	Myotis lucifugus	97.26	0.00e+00	2090.00
IUUC-Nfi-068398	Neosartorya fischeri	32.21	1.00e-143	504.00
IUUC-Ncr-068927	Neurospora crassa	29.98	1.00e-116	414.00
IUUC-Nle-069651	Nomascus leucogenys	94.55	0.00e+00	2016.00
IUUC-Opr-070614	Ochotona princeps	96.90	0.00e+00	2050.00
IUUC-Ont-072433	Oreochromis niloticus	76.46	0.00e+00	1655.00
IUUC-Oan-073283	Ornithorhynchus anatinus	74.22	0.00e+00	1428.00
IUUC-Ocu-074401	Oryctolagus cuniculus	96.72	0.00e+00	2074.00
IUUC-Ola-087522	Oryzias latipes	76.07	0.00e+00	1607.00
IUUC-Oga-088226	Otolemur garnettii	97.38	0.00e+00	2090.00
IUUC-Oar-089241	Ovis aries	97.74	0.00e+00	2116.00
IUUC-Psi-094043	Pelodiscus sinensis	81.95	0.00e+00	1674.00
IUUC-Pma-094394	Petromyzon marinus	70.07	0.00e+00	1500.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.17	2.00e-150	526.00
IUUC-Ppa-095188	Physcomitrella patens	33.36	2.00e-150	526.00
IUUC-Pfo-097517	Poecilia formosa	76.92	0.00e+00	1656.00
IUUC-Pca-100471	Procavia capensis	97.36	0.00e+00	2101.00
IUUC-Pva-102805	Pteropus vampyrus	93.50	0.00e+00	1843.00
IUUC-Pte-104021	Pyrenophora teres	32.13	4.00e-147	515.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.13	5.00e-147	515.00
IUUC-Rno-105471	Rattus norvegicus	95.85	0.00e+00	2033.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.55	3.00e-60	227.00
IUUC-Sha-106883	Sarcophilus harrisii	91.14	0.00e+00	1946.00
IUUC-Spo-108169	Schizosaccharomyces pombe	33.24	4.00e-137	482.00
IUUC-Sar-113323	Sorex araneus	96.30	0.00e+00	1724.00
IUUC-Sre-115075	Sporisorium reilianum	29.33	3.00e-67	250.00
IUUC-Ssc-116363	Sus scrofa	97.09	0.00e+00	2108.00
IUUC-Tru-118427	Takifugu rubripes	76.37	0.00e+00	1672.00
IUUC-Tni-120218	Tetraodon nigroviridis	76.40	0.00e+00	1664.00
IUUC-Tre-122177	Trichoderma reesei	31.82	6.00e-141	495.00
IUUC-Tme-127176	Tuber melanosporum	32.98	2.00e-141	497.00
IUUC-Tbe-127641	Tupaia belangeri	95.35	2.00e-173	603.00
IUUC-Ttr-128888	Tursiops truncatus	96.93	0.00e+00	1482.00
IUUC-Uma-129361	Ustilago maydis	38.42	3.00e-63	237.00
IUUC-Xtr-132811	Xenopus tropicalis	79.02	0.00e+00	1680.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence