iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pno-095053

Ensembl Protein ID

SNOT_06299

UniProt Accession

Q0UPL5; PAN2_PHANO

Genbank Protein ID

EAT86130.2

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

CH445333

Gene Name

PAN2; SNOG_06299

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SNOG_06299	SNOT_06299	SNOT_06299

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-13	49.8	379	704

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs..........gyeqq 90
           Gl+ +    Y NS+LQ   ++p +r+l l+++ + +  e       +ll++l  l+  l k    + + +++lk+++ +++ +s               
   Q: 379  GLETHITNSYANSLLQLFRFTPLIRNLALQHTASPCLFE------SCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSlnlleefapnVALTS 471
           677777778*********************777777765......699999999999999999999999999999999998877555555554433344 PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.... 185
             q + +flld+++ee+                      ++  +   ++sl++++++ q + +++c +c+n++ r  +++  +l  p k+ +k++    
   Q: 472  MIQNLNRFLLDKISEEF----------------------RQMLPSHGGTSLMDQVLETQARASMRCAQCANETIRGGKNFVNELVYPAKHVMKNTripr 548
           45677777777777777......................345678899*******************************99999999999887778888 PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fctspeekqke........ 274
            +++++L++ ++++  +   + +c+kc+++q+++++ +++++P vL+l+    + + +   ++ +    e+ + +d  + +c +  ++  +        
   Q: 549  pTFSQILKASVERQDQT---RGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQTHEAKLLWSIPNWLPHEIGIIVDQGQfYCFE-GQDL-Klhlqrgvf 642
           89999998777776655...37**************************999886666655555555556666667777845555.3333.236888888 PP
   S: 275  .kkkYeLiavv..vHsGslssGHYvayvkn........ekgkWllfdDskVtevkeeevlee 325
               YeL++vv  + sG++++ H va ++          ++kW lf+D  V++++ ee l++
   Q: 643  dIMVYELVGVVadINSGEHQKPHLVATINTgpssrepdAEDKWHLFNDFLVRPIPREEALRF 704
           89*********555789*************888888777888************99998876 PP

Organism

Phaeosphaeria nodorum

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MNFTSKGTRE ILIAGCQEQM FKVDVEKGIV VDTLPVDAQY TIMKRAGQYL CAATKTGGIH 60
ILDSNSLSVI KVFEGHTGSI SDMDAKGDFL ATCGWSPRQQ YAYMLDPFTN VFSLKTLKQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTCA CCTCCAAAGG AACGCGCGAG ATCTTGATTG CAGGATGTCA GGAGCAGATG 60
TTCAAAGTCG ATGTCGAAAA GGGCATTGTT GTGGACACAG TGAGTCTACA TAGCAACCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

pno:SNOG_06299

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.73	2.00e-146	511.00
IUUC-Apl-003500	Anas platyrhynchos	31.34	9.00e-127	446.00
IUUC-Aca-004930	Anolis carolinensis	32.05	5.00e-145	506.00
IUUC-Acl-008214	Aspergillus clavatus	51.18	0.00e+00	1080.00
IUUC-Afu-009112	Aspergillus fumigatus	51.18	0.00e+00	1053.00
IUUC-Ang-009531	Aspergillus niger	51.04	0.00e+00	1056.00
IUUC-Ame-011259	Astyanax mexicanus	29.37	4.00e-73	268.00
IUUC-Bta-012371	Bos taurus	32.11	6.00e-148	516.00
IUUC-Bci-013684	Botrytis cinerea	48.78	0.00e+00	966.00
IUUC-Cja-019297	Callithrix jacchus	32.01	5.00e-145	507.00
IUUC-Cfa-020489	Canis familiaris	32.04	1.00e-146	512.00
IUUC-Cpo-022392	Cavia porcellus	31.62	5.00e-146	510.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.71	5.00e-146	510.00
IUUC-Csv-025841	Ciona savignyi	30.03	7.00e-116	410.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	53.88	0.00e+00	1085.00
IUUC-Cne-026932	Cryptococcus neoformans	35.84	7.00e-158	549.00
IUUC-Dre-028482	Danio rerio	41.94	1.00e-69	256.00
IUUC-Dno-029398	Dasypus novemcinctus	31.15	3.00e-135	474.00
IUUC-Dor-030307	Dipodomys ordii	31.11	3.00e-94	338.00
IUUC-Dme-032111	Drosophila melanogaster	28.09	3.00e-66	245.00
IUUC-Eca-033985	Equus caballus	31.83	3.00e-147	514.00
IUUC-Eeu-034928	Erinaceus europaeus	31.58	6.00e-35	141.00
IUUC-Fca-035587	Felis catus	32.05	3.00e-148	518.00
IUUC-Fal-037587	Ficedula albicollis	31.45	4.00e-75	275.00
IUUC-Fso-038133	Fusarium solani	45.19	0.00e+00	826.00
IUUC-Gmo-039076	Gadus morhua	29.98	6.00e-69	254.00
IUUC-Ggr-039957	Gaeumannomyces graminis	47.67	0.00e+00	953.00
IUUC-Gga-040948	Gallus gallus	32.26	4.00e-143	501.00
IUUC-Gac-042396	Gasterosteus aculeatus	29.97	4.00e-73	268.00
IUUC-Ggo-045412	Gorilla gorilla	31.43	4.00e-145	507.00
IUUC-Hsa-046076	Homo sapiens	31.43	4.00e-145	507.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.84	2.00e-118	418.00
IUUC-Kpa-049178	Komagataella pastoris	35.05	6.00e-168	583.00
IUUC-Lch-050279	Latimeria chalumnae	39.71	2.00e-66	246.00
IUUC-Loc-052872	Lepisosteus oculatus	29.89	5.00e-73	268.00
IUUC-Lma-052986	Leptosphaeria maculans	89.59	0.00e+00	1918.00
IUUC-Laf-054181	Loxodonta africana	31.66	3.00e-142	498.00
IUUC-Mcc-054812	Macaca mulatta	31.80	4.00e-146	510.00
IUUC-Meu-056325	Macropus eugenii	32.41	6.00e-144	503.00
IUUC-Mor-057246	Magnaporthe oryzae	43.73	0.00e+00	822.00
IUUC-Mpo-057464	Magnaporthe poae	48.45	0.00e+00	974.00
IUUC-Mla-058911	Melampsora laricipopulina	39.88	2.00e-121	428.00
IUUC-Mga-059335	Meleagris gallopavo	32.94	5.00e-143	500.00
IUUC-Mvi-060461	Microbotryum violaceum	36.88	2.00e-169	588.00
IUUC-Mmr-060636	Microcebus murinus	31.62	1.00e-144	506.00
IUUC-Mmu-063503	Mus musculus	30.17	2.00e-80	292.00
IUUC-Mpu-066670	Mustela putorius furo	31.92	2.00e-147	514.00
IUUC-Mlu-068119	Myotis lucifugus	32.11	2.00e-148	518.00
IUUC-Nfi-068398	Neosartorya fischeri	51.94	0.00e+00	1080.00
IUUC-Ncr-068927	Neurospora crassa	46.77	0.00e+00	876.00
IUUC-Nle-069651	Nomascus leucogenys	30.60	7.00e-137	480.00
IUUC-Opr-070614	Ochotona princeps	31.37	2.00e-145	508.00
IUUC-Ont-072433	Oreochromis niloticus	29.57	8.00e-74	270.00
IUUC-Oan-073283	Ornithorhynchus anatinus	38.71	9.00e-60	223.00
IUUC-Ocu-074401	Oryctolagus cuniculus	31.39	2.00e-80	292.00
IUUC-Ola-087522	Oryzias latipes	32.26	8.00e-139	486.00
IUUC-Oga-088226	Otolemur garnettii	31.03	1.00e-79	290.00
IUUC-Oar-089241	Ovis aries	32.08	3.00e-148	518.00
IUUC-Pan-092297	Papio anubis	31.80	2.00e-147	514.00
IUUC-Psi-094043	Pelodiscus sinensis	30.74	3.00e-74	271.00
IUUC-Pma-094394	Petromyzon marinus	31.80	7.00e-135	473.00
IUUC-Ppa-095188	Physcomitrella patens	28.69	9.00e-111	393.00
IUUC-Pfo-097517	Poecilia formosa	29.05	4.00e-73	268.00
IUUC-Pca-100471	Procavia capensis	32.44	2.00e-147	515.00
IUUC-Pva-102805	Pteropus vampyrus	32.12	2.00e-90	325.00
IUUC-Pte-104021	Pyrenophora teres	88.94	0.00e+00	1905.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	88.85	0.00e+00	1896.00
IUUC-Rno-105471	Rattus norvegicus	30.88	2.00e-146	512.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.91	6.00e-124	436.00
IUUC-Sha-106883	Sarcophilus harrisii	32.51	2.00e-142	498.00
IUUC-Spo-108169	Schizosaccharomyces pombe	38.10	0.00e+00	645.00
IUUC-Sar-113323	Sorex araneus	33.40	2.00e-127	448.00
IUUC-Sre-115075	Sporisorium reilianum	50.00	9.00e-56	211.00
IUUC-Ssc-116363	Sus scrofa	31.13	3.00e-81	295.00
IUUC-Tru-118427	Takifugu rubripes	30.32	1.00e-77	283.00
IUUC-Tni-120218	Tetraodon nigroviridis	30.32	5.00e-77	281.00
IUUC-Tre-122177	Trichoderma reesei	52.92	0.00e+00	1064.00
IUUC-Tme-127176	Tuber melanosporum	46.51	0.00e+00	881.00
IUUC-Tbe-127641	Tupaia belangeri	35.12	8.00e-31	127.00
IUUC-Ttr-128888	Tursiops truncatus	32.61	2.00e-104	372.00
IUUC-Uma-129361	Ustilago maydis	42.65	4.00e-62	232.00
IUUC-Xtr-132811	Xenopus tropicalis	29.95	9.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence