iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105471

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AC109891

Gene Name

Pan2; PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000032441.4	ENSRNOT00000050792.4	ENSRNOP00000039314.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.30e-21	74.9	524	901

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 524  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 603
           56*********************...55654......57*************9*****************9999855655555444444 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ + a  +  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 604  gkGSLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLC-RCGSETVRASSTLLF 680
           444444444555566666666666...........3334445666688999*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + +
   Q: 681  TLSYPEDKTGKNYDFAQVLKRSICLEQNT---QAWCDSCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RLQAEVAFK--IAV 762
           **********999**99999888766665...69****************************99976666555..599999997..778 PP
   S: 262  spfcts.............................................peekqke......................kkkYeLiav 283
           ++f  +                                             +                             + Y+L+a 
   Q: 763  KKFGGEvkskefaladrkelrspegflccssmeelknvwlpfsirmkmtknK-----GldvcnwadehewgparaeeehgVYVYDLMAT 846
           8777775555666666666666666666666666666666666555555550.....055555555555555555555559******** PP
   S: 284  vvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleet 326
           vvH   s  +G  va++k            ++++W+lf+D  ++++++ e +++ 
   Q: 847  VVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKYEAVQFD 901
           *****9*************999988877777888************998877765 PP

Organism

Rattus norvegicus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEFSPAMHST LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLQEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGGATGTC CATTCTAGGT TCACTGGTGC TGTCCTGCTG AAGGCTGGGT CAGGCGTCTG 60
TAGGAACCGT GGCAAGGGAG GGTGTGACCC AGGTCTGACC AGCGGCCATT ATCGTCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	95.51	0.00e+00	2271.00
IUUC-Apl-003500	Anas platyrhynchos	84.14	0.00e+00	1846.00
IUUC-Aca-004930	Anolis carolinensis	83.24	0.00e+00	2005.00
IUUC-Acl-008214	Aspergillus clavatus	31.74	3.00e-160	559.00
IUUC-Afu-009112	Aspergillus fumigatus	31.68	6.00e-150	525.00
IUUC-Ang-009531	Aspergillus niger	30.90	1.00e-153	537.00
IUUC-Ame-011259	Astyanax mexicanus	75.35	0.00e+00	1838.00
IUUC-Bta-012371	Bos taurus	95.41	0.00e+00	2269.00
IUUC-Bci-013684	Botrytis cinerea	31.42	8.00e-139	488.00
IUUC-Cja-019297	Callithrix jacchus	93.36	0.00e+00	2213.00
IUUC-Cfa-020489	Canis familiaris	95.74	0.00e+00	2266.00
IUUC-Cpo-022392	Cavia porcellus	95.17	0.00e+00	2291.00
IUUC-Csa-023220	Chlorocebus sabaeus	95.34	0.00e+00	2272.00
IUUC-Csv-025841	Ciona savignyi	45.51	0.00e+00	889.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.67	9.00e-166	577.00
IUUC-Cne-026932	Cryptococcus neoformans	32.11	9.00e-142	498.00
IUUC-Dre-028482	Danio rerio	73.60	0.00e+00	1791.00
IUUC-Dno-029398	Dasypus novemcinctus	95.23	0.00e+00	2260.00
IUUC-Dor-030307	Dipodomys ordii	88.98	0.00e+00	1285.00
IUUC-Dme-032111	Drosophila melanogaster	41.69	0.00e+00	887.00
IUUC-Eca-033985	Equus caballus	95.99	0.00e+00	2279.00
IUUC-Eeu-034928	Erinaceus europaeus	82.19	0.00e+00	756.00
IUUC-Fca-035587	Felis catus	95.84	0.00e+00	2293.00
IUUC-Fal-037587	Ficedula albicollis	84.67	0.00e+00	1986.00
IUUC-Fso-038133	Fusarium solani	32.29	9.00e-100	358.00
IUUC-Gmo-039076	Gadus morhua	73.18	0.00e+00	1754.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.36	4.00e-142	499.00
IUUC-Gga-040948	Gallus gallus	84.74	0.00e+00	2027.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.11	0.00e+00	1813.00
IUUC-Ggo-045412	Gorilla gorilla	95.59	0.00e+00	2275.00
IUUC-Hsa-046076	Homo sapiens	95.59	0.00e+00	2278.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	89.62	0.00e+00	2083.00
IUUC-Kpa-049178	Komagataella pastoris	40.18	4.00e-66	246.00
IUUC-Lch-050279	Latimeria chalumnae	72.15	0.00e+00	1717.00
IUUC-Loc-052872	Lepisosteus oculatus	76.50	0.00e+00	1840.00
IUUC-Lma-052986	Leptosphaeria maculans	32.43	9.00e-163	567.00
IUUC-Laf-054181	Loxodonta africana	93.60	0.00e+00	2248.00
IUUC-Mcc-054812	Macaca mulatta	95.82	0.00e+00	2280.00
IUUC-Meu-056325	Macropus eugenii	91.01	0.00e+00	2160.00
IUUC-Mor-057246	Magnaporthe oryzae	29.28	7.00e-124	438.00
IUUC-Mpo-057464	Magnaporthe poae	32.08	6.00e-145	508.00
IUUC-Mla-058911	Melampsora laricipopulina	32.51	8.00e-101	362.00
IUUC-Mga-059335	Meleagris gallopavo	84.72	0.00e+00	1974.00
IUUC-Mvi-060461	Microbotryum violaceum	34.11	1.00e-145	510.00
IUUC-Mmr-060636	Microcebus murinus	95.83	0.00e+00	2273.00
IUUC-Mmu-063503	Mus musculus	97.92	0.00e+00	2349.00
IUUC-Mpu-066670	Mustela putorius furo	96.08	0.00e+00	2281.00
IUUC-Mlu-068119	Myotis lucifugus	94.49	0.00e+00	2301.00
IUUC-Nfi-068398	Neosartorya fischeri	32.36	1.00e-159	557.00
IUUC-Ncr-068927	Neurospora crassa	30.40	9.00e-135	474.00
IUUC-Nle-069651	Nomascus leucogenys	91.78	0.00e+00	2180.00
IUUC-Opr-070614	Ochotona princeps	94.85	0.00e+00	2231.00
IUUC-Ont-072433	Oreochromis niloticus	74.71	0.00e+00	1862.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.52	0.00e+00	1407.00
IUUC-Ocu-074401	Oryctolagus cuniculus	95.44	0.00e+00	2281.00
IUUC-Ola-087522	Oryzias latipes	74.38	0.00e+00	1798.00
IUUC-Oga-088226	Otolemur garnettii	94.78	0.00e+00	2289.00
IUUC-Oar-089241	Ovis aries	95.01	0.00e+00	2288.00
IUUC-Pan-092297	Papio anubis	95.85	0.00e+00	2035.00
IUUC-Psi-094043	Pelodiscus sinensis	81.35	0.00e+00	1893.00
IUUC-Pma-094394	Petromyzon marinus	68.96	0.00e+00	1564.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.24	2.00e-149	523.00
IUUC-Ppa-095188	Physcomitrella patens	32.13	7.00e-160	558.00
IUUC-Pfo-097517	Poecilia formosa	75.43	0.00e+00	1863.00
IUUC-Pca-100471	Procavia capensis	94.93	0.00e+00	2125.00
IUUC-Pva-102805	Pteropus vampyrus	91.07	0.00e+00	1774.00
IUUC-Pte-104021	Pyrenophora teres	32.02	8.00e-165	574.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.84	4.00e-164	572.00
IUUC-Sce-106235	Saccharomyces cerevisiae	38.84	5.00e-60	226.00
IUUC-Sha-106883	Sarcophilus harrisii	90.14	0.00e+00	1999.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.55	5.00e-146	512.00
IUUC-Sar-113323	Sorex araneus	93.82	0.00e+00	1657.00
IUUC-Sre-115075	Sporisorium reilianum	37.90	6.00e-61	229.00
IUUC-Ssc-116363	Sus scrofa	94.77	0.00e+00	2291.00
IUUC-Tru-118427	Takifugu rubripes	74.57	0.00e+00	1873.00
IUUC-Tni-120218	Tetraodon nigroviridis	74.96	0.00e+00	1879.00
IUUC-Tre-122177	Trichoderma reesei	31.33	6.00e-154	538.00
IUUC-Tme-127176	Tuber melanosporum	32.19	7.00e-142	498.00
IUUC-Tbe-127641	Tupaia belangeri	86.41	0.00e+00	786.00
IUUC-Ttr-128888	Tursiops truncatus	94.13	0.00e+00	1415.00
IUUC-Uma-129361	Ustilago maydis	39.00	5.00e-63	236.00
IUUC-Xtr-132811	Xenopus tropicalis	77.97	0.00e+00	1863.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence