iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074745

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02035617

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000007994.3	ENSOCUT00000008000.3	ENSOCUP00000006915.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-122	408.7	1253	1585

Active Site

Position(s)	Description	Evidence
1553	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1253 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1338
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1339 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1421
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1422 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1508
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1509 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1585
           ************************999***********************************************985 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDIRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATTGATGC GTGTACACGT GGTGGGTCAT TATGCTGCTG CACCTGTGTA GTGTGAAGGT 60
CAGTGTGCTT TTCTGATTCT AAGAACCCAT CCATGTCATT CCATTGGAAA TCCACTCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	84.92	0.00e+00	2144.00
IUUC-Apl-003299	Anas platyrhynchos	79.84	0.00e+00	2389.00
IUUC-Aca-005024	Anolis carolinensis	78.41	0.00e+00	2368.00
IUUC-Bta-012604	Bos taurus	86.24	0.00e+00	2558.00
IUUC-Cja-019880	Callithrix jacchus	83.96	0.00e+00	2199.00
IUUC-Cfa-021216	Canis familiaris	90.38	0.00e+00	1787.00
IUUC-Cpo-021466	Cavia porcellus	96.77	0.00e+00	1714.00
IUUC-Csa-023080	Chlorocebus sabaeus	89.70	0.00e+00	2632.00
IUUC-Cho-024740	Choloepus hoffmanni	92.76	0.00e+00	1137.00
IUUC-Dre-028750	Danio rerio	80.59	0.00e+00	1494.00
IUUC-Dno-030019	Dasypus novemcinctus	87.78	0.00e+00	2566.00
IUUC-Dor-031030	Dipodomys ordii	73.57	0.00e+00	1132.00
IUUC-Ete-032352	Echinops telfairi	94.44	0.00e+00	1263.00
IUUC-Eca-033948	Equus caballus	87.01	0.00e+00	2489.00
IUUC-Eeu-034474	Erinaceus europaeus	70.36	0.00e+00	1557.00
IUUC-Fca-036148	Felis catus	88.91	0.00e+00	2549.00
IUUC-Fal-036957	Ficedula albicollis	79.98	0.00e+00	2403.00
IUUC-Gmo-038714	Gadus morhua	69.30	0.00e+00	1018.00
IUUC-Gga-041194	Gallus gallus	79.27	0.00e+00	2375.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.95	0.00e+00	1374.00
IUUC-Ggo-045442	Gorilla gorilla	75.14	0.00e+00	1937.00
IUUC-Hsa-045730	Homo sapiens	89.71	0.00e+00	2634.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	89.11	0.00e+00	2626.00
IUUC-Lch-050185	Latimeria chalumnae	70.69	0.00e+00	1944.00
IUUC-Loc-052744	Lepisosteus oculatus	74.45	0.00e+00	2223.00
IUUC-Laf-054368	Loxodonta africana	98.45	0.00e+00	1508.00
IUUC-Mcc-055487	Macaca mulatta	89.65	0.00e+00	2628.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	729.00
IUUC-Mga-059545	Meleagris gallopavo	79.36	0.00e+00	2382.00
IUUC-Mmr-061078	Microcebus murinus	87.71	0.00e+00	2489.00
IUUC-Mdo-062176	Monodelphis domestica	84.01	0.00e+00	1689.00
IUUC-Mmu-063513	Mus musculus	84.66	0.00e+00	2463.00
IUUC-Mpu-065786	Mustela putorius furo	89.21	0.00e+00	2579.00
IUUC-Mlu-067780	Myotis lucifugus	81.11	0.00e+00	2290.00
IUUC-Nle-069213	Nomascus leucogenys	89.34	0.00e+00	2559.00
IUUC-Opr-070208	Ochotona princeps	97.81	0.00e+00	1499.00
IUUC-Ont-072132	Oreochromis niloticus	81.29	0.00e+00	1364.00
IUUC-Oan-072807	Ornithorhynchus anatinus	86.19	0.00e+00	1744.00
IUUC-Ola-086981	Oryzias latipes	73.72	0.00e+00	1476.00
IUUC-Oga-087965	Otolemur garnettii	87.88	0.00e+00	2454.00
IUUC-Oar-089749	Ovis aries	86.68	0.00e+00	1798.00
IUUC-Ptr-091243	Pan troglodytes	89.71	0.00e+00	2632.00
IUUC-Pan-092201	Papio anubis	88.95	0.00e+00	2595.00
IUUC-Psi-093511	Pelodiscus sinensis	78.15	0.00e+00	2322.00
IUUC-Pfo-097001	Poecilia formosa	65.52	0.00e+00	1573.00
IUUC-Pab-098728	Pongo abelii	87.31	0.00e+00	2514.00
IUUC-Pca-100129	Procavia capensis	82.89	0.00e+00	1261.00
IUUC-Pva-102250	Pteropus vampyrus	77.73	0.00e+00	2055.00
IUUC-Rno-105031	Rattus norvegicus	84.36	0.00e+00	2475.00
IUUC-Tgu-117515	Taeniopygia guttata	80.74	0.00e+00	2385.00
IUUC-Tru-117914	Takifugu rubripes	77.22	0.00e+00	1378.00
IUUC-Tsy-119379	Tarsius syrichta	79.36	0.00e+00	791.00
IUUC-Tni-120178	Tetraodon nigroviridis	75.94	0.00e+00	1390.00
IUUC-Tbe-127762	Tupaia belangeri	81.28	0.00e+00	1865.00
IUUC-Ttr-128806	Tursiops truncatus	92.19	0.00e+00	1719.00
IUUC-Xtr-132903	Xenopus tropicalis	74.56	0.00e+00	1837.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence