iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092201

Ensembl Protein ID

ENSPANP00000005246.1

UniProt Accession

A0A096MZ57; A0A096MZ57_PAPAN

Genbank Protein ID

ENSPANP00000005246

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01049408

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000022845.1	ENSPANT00000025610.1	ENSPANP00000005246.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-122	408.7	1263	1595

Active Site

Position(s)	Description	Evidence
1563	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1263 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1348
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1349 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1431
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1432 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1518
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1519 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1595
           ************************999***********************************************985 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

LLTVSLLPQN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIGNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCTCACTG TCTCTTTGCT CCCACAGAAT CTGTACCAGA ACAGGTTTTT AGGCCTGGCC 60
GCCATGGCGT CTCCTTCTAG AAACTCCCAG AGCCGACGCC GGTGCAAGGA GCCTCTCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	87.47	0.00e+00	2195.00
IUUC-Apl-003299	Anas platyrhynchos	79.98	0.00e+00	2435.00
IUUC-Aca-005024	Anolis carolinensis	79.17	0.00e+00	2387.00
IUUC-Bta-012604	Bos taurus	88.17	0.00e+00	2644.00
IUUC-Cja-019880	Callithrix jacchus	92.35	0.00e+00	2415.00
IUUC-Cfa-021216	Canis familiaris	91.69	0.00e+00	1817.00
IUUC-Cpo-021466	Cavia porcellus	97.10	0.00e+00	1725.00
IUUC-Csa-023080	Chlorocebus sabaeus	98.44	0.00e+00	2904.00
IUUC-Cho-024740	Choloepus hoffmanni	82.63	0.00e+00	1186.00
IUUC-Dre-028750	Danio rerio	73.32	0.00e+00	1554.00
IUUC-Dno-030019	Dasypus novemcinctus	90.53	0.00e+00	2699.00
IUUC-Dor-031030	Dipodomys ordii	73.57	0.00e+00	1140.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1264.00
IUUC-Eca-033948	Equus caballus	89.47	0.00e+00	2566.00
IUUC-Eeu-034474	Erinaceus europaeus	70.55	0.00e+00	837.00
IUUC-Fca-036148	Felis catus	89.78	0.00e+00	2625.00
IUUC-Fal-036957	Ficedula albicollis	80.43	0.00e+00	2412.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1019.00
IUUC-Gga-041194	Gallus gallus	80.21	0.00e+00	2415.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.78	0.00e+00	1376.00
IUUC-Ggo-045442	Gorilla gorilla	82.84	0.00e+00	2182.00
IUUC-Hsa-045730	Homo sapiens	98.06	0.00e+00	2892.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	91.97	0.00e+00	2737.00
IUUC-Lch-050185	Latimeria chalumnae	72.28	0.00e+00	1397.00
IUUC-Loc-052744	Lepisosteus oculatus	74.65	0.00e+00	2212.00
IUUC-Laf-054368	Loxodonta africana	98.71	0.00e+00	1509.00
IUUC-Mcc-055487	Macaca mulatta	98.50	0.00e+00	2921.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	731.00
IUUC-Mga-059545	Meleagris gallopavo	80.79	0.00e+00	2421.00
IUUC-Mmr-061078	Microcebus murinus	90.51	0.00e+00	2581.00
IUUC-Mdo-062176	Monodelphis domestica	84.96	0.00e+00	1717.00
IUUC-Mmu-063513	Mus musculus	87.18	0.00e+00	2548.00
IUUC-Mpu-065786	Mustela putorius furo	89.59	0.00e+00	2623.00
IUUC-Mlu-067780	Myotis lucifugus	83.51	0.00e+00	2375.00
IUUC-Nle-069213	Nomascus leucogenys	97.63	0.00e+00	2814.00
IUUC-Opr-070208	Ochotona princeps	97.44	0.00e+00	1498.00
IUUC-Ont-072132	Oreochromis niloticus	81.49	0.00e+00	1367.00
IUUC-Oan-072807	Ornithorhynchus anatinus	88.11	0.00e+00	1802.00
IUUC-Ocu-074745	Oryctolagus cuniculus	88.95	0.00e+00	2546.00
IUUC-Ola-086981	Oryzias latipes	74.12	0.00e+00	1493.00
IUUC-Oga-087965	Otolemur garnettii	95.71	0.00e+00	1876.00
IUUC-Oar-089749	Ovis aries	91.23	0.00e+00	1882.00
IUUC-Ptr-091243	Pan troglodytes	97.94	0.00e+00	2887.00
IUUC-Psi-093511	Pelodiscus sinensis	79.35	0.00e+00	2378.00
IUUC-Pfo-097001	Poecilia formosa	65.96	0.00e+00	1581.00
IUUC-Pab-098728	Pongo abelii	95.58	0.00e+00	2773.00
IUUC-Pca-100129	Procavia capensis	82.93	0.00e+00	1263.00
IUUC-Pva-102250	Pteropus vampyrus	79.29	0.00e+00	2174.00
IUUC-Rno-105031	Rattus norvegicus	87.09	0.00e+00	2584.00
IUUC-Tgu-117515	Taeniopygia guttata	81.81	0.00e+00	2412.00
IUUC-Tru-117914	Takifugu rubripes	75.86	0.00e+00	1382.00
IUUC-Tsy-119379	Tarsius syrichta	90.95	0.00e+00	800.00
IUUC-Tni-120178	Tetraodon nigroviridis	71.57	0.00e+00	1460.00
IUUC-Tbe-127762	Tupaia belangeri	84.50	0.00e+00	2007.00
IUUC-Ttr-128806	Tursiops truncatus	93.61	0.00e+00	1746.00
IUUC-Xtr-132903	Xenopus tropicalis	75.50	0.00e+00	1875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence