iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071249

Ensembl Protein ID

ENSONIP00000018957.1

UniProt Accession

I3KCW2; I3KCW2_ORENI

Genbank Protein ID

ENSONIP00000018957

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01051117

Gene Name

herc1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000015060.1	ENSONIT00000018974.1	ENSONIP00000018957.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-15	56.5	3505	3537
E3 activity/HECT	6.80e-90	302.2	4582	4916

Active Site

Position(s)	Description	Evidence
4885	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v  + + s  +ll+++++Dgt++vW++++
   Q: 3505 HQSRVITCGWcSKkGLLATSGNDGTVRVWNVTK 3537
           899988889*9778****************975 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     eh+  F+flG+l+g+a+++++
   Q: 4582 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLLNPsacldEHMLQFKFLGILMGVAIRTKK 4668
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l ledleevd  ++++lk+i++ ++s i+e +++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4669 PLDLHLAPLVWKQLCCIPLLLEDLEEVDLLYVQTLKSILHIEDSGITEDNFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4755
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e i++qv+a+reG+++++p  llsl+t+++le+++cG++ei  + lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4756 EYVERAIEYRLHE-IDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICCDVLKKVVRYRE-VDEQHSLVQWFWQTLEEFSN 4840
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4841 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQAVMAERLRYAINNCRSIDM 4916
           *****************6.899999.679999956666***********************************99987 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MALMIPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYSK LLANKEVVLL PQQVLCLKGP 60
QLPDFERESL SSDEQEHYLD ALLSSQLALA KMVCSDSPFA AALRKRVLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGACAGGCA GATAGAGAGA TAGACAGGTC TCAGCGTCAT AGCCCGGGGC TGGGGCTCTG 60
TACGGGGTTG ACAGTGAACA CACTGCCGCT TGCAGGATTC ACTCGCTGCA GGACGAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	81.44	0.00e+00	7365.00
IUUC-Apl-003461	Anas platyrhynchos	81.36	0.00e+00	7378.00
IUUC-Aca-004452	Anolis carolinensis	78.33	0.00e+00	6784.00
IUUC-Ame-011268	Astyanax mexicanus	59.58	0.00e+00	2150.00
IUUC-Bta-013213	Bos taurus	81.57	0.00e+00	7363.00
IUUC-Cja-019298	Callithrix jacchus	81.22	0.00e+00	7345.00
IUUC-Cfa-021213	Canis familiaris	81.57	0.00e+00	7436.00
IUUC-Cpo-021674	Cavia porcellus	79.74	0.00e+00	4950.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.03	6.00e-49	187.00
IUUC-Csa-023341	Chlorocebus sabaeus	80.89	0.00e+00	7310.00
IUUC-Cho-024567	Choloepus hoffmanni	74.06	0.00e+00	1415.00
IUUC-Dre-028289	Danio rerio	81.29	0.00e+00	7318.00
IUUC-Dno-029988	Dasypus novemcinctus	81.09	0.00e+00	7321.00
IUUC-Dor-030636	Dipodomys ordii	75.69	0.00e+00	1889.00
IUUC-Ete-032598	Echinops telfairi	81.07	0.00e+00	1286.00
IUUC-Eca-033754	Equus caballus	81.24	0.00e+00	7358.00
IUUC-Eeu-034702	Erinaceus europaeus	70.64	0.00e+00	1231.00
IUUC-Fca-035900	Felis catus	81.48	0.00e+00	7388.00
IUUC-Fal-037034	Ficedula albicollis	83.37	0.00e+00	3706.00
IUUC-Gmo-039260	Gadus morhua	84.07	0.00e+00	1414.00
IUUC-Gga-040321	Gallus gallus	81.21	0.00e+00	7423.00
IUUC-Gac-042444	Gasterosteus aculeatus	56.50	0.00e+00	2138.00
IUUC-Gma-043808	Glycine max	32.11	1.00e-40	162.00
IUUC-Ggo-045134	Gorilla gorilla	75.76	0.00e+00	3877.00
IUUC-Hsa-046516	Homo sapiens	81.21	0.00e+00	7336.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	84.23	0.00e+00	2211.00
IUUC-Lch-049903	Latimeria chalumnae	82.22	0.00e+00	7437.00
IUUC-Loc-052149	Lepisosteus oculatus	84.12	0.00e+00	7467.00
IUUC-Laf-053426	Loxodonta africana	81.52	0.00e+00	7427.00
IUUC-Mcc-055826	Macaca mulatta	81.17	0.00e+00	7362.00
IUUC-Meu-056521	Macropus eugenii	68.37	0.00e+00	1856.00
IUUC-Mga-059567	Meleagris gallopavo	89.12	0.00e+00	1981.00
IUUC-Mmr-061512	Microcebus murinus	80.76	0.00e+00	7269.00
IUUC-Mdo-062177	Monodelphis domestica	78.13	0.00e+00	5091.00
IUUC-Mmu-064373	Mus musculus	81.28	0.00e+00	7363.00
IUUC-Mpu-066148	Mustela putorius furo	81.52	0.00e+00	7369.00
IUUC-Mlu-067680	Myotis lucifugus	80.99	0.00e+00	7299.00
IUUC-Nle-069633	Nomascus leucogenys	80.88	0.00e+00	7282.00
IUUC-Opr-070609	Ochotona princeps	83.43	0.00e+00	1199.00
IUUC-Oan-073157	Ornithorhynchus anatinus	80.84	0.00e+00	7296.00
IUUC-Ocu-074841	Oryctolagus cuniculus	81.43	0.00e+00	7389.00
IUUC-Ola-086889	Oryzias latipes	88.97	0.00e+00	8119.00
IUUC-Oga-088459	Otolemur garnettii	80.45	0.00e+00	7286.00
IUUC-Oar-089888	Ovis aries	81.55	0.00e+00	7343.00
IUUC-Ptr-091114	Pan troglodytes	81.11	0.00e+00	7344.00
IUUC-Pan-092442	Papio anubis	81.05	0.00e+00	7339.00
IUUC-Psi-093833	Pelodiscus sinensis	80.24	0.00e+00	4840.00
IUUC-Pma-094275	Petromyzon marinus	78.09	0.00e+00	1747.00
IUUC-Pfo-097262	Poecilia formosa	89.35	0.00e+00	7980.00
IUUC-Pab-097760	Pongo abelii	79.37	0.00e+00	4089.00
IUUC-Pca-100465	Procavia capensis	79.42	0.00e+00	3825.00
IUUC-Ppe-101345	Prunus persica	32.47	7.00e-47	182.00
IUUC-Pva-102950	Pteropus vampyrus	82.22	0.00e+00	3548.00
IUUC-Rno-104892	Rattus norvegicus	81.17	0.00e+00	7312.00
IUUC-Sha-106633	Sarcophilus harrisii	80.75	0.00e+00	7232.00
IUUC-Sar-113251	Sorex araneus	71.65	0.00e+00	2055.00
IUUC-Ssc-116391	Sus scrofa	81.47	0.00e+00	7387.00
IUUC-Tgu-116554	Taeniopygia guttata	81.36	0.00e+00	7368.00
IUUC-Tru-118695	Takifugu rubripes	89.99	0.00e+00	8364.00
IUUC-Tsy-119647	Tarsius syrichta	70.56	0.00e+00	4634.00
IUUC-Tni-120707	Tetraodon nigroviridis	89.62	0.00e+00	8291.00
IUUC-Tbe-127346	Tupaia belangeri	75.62	0.00e+00	2181.00
IUUC-Ttr-128542	Tursiops truncatus	74.39	0.00e+00	4671.00
IUUC-Vpa-130611	Vicugna pacos	83.25	0.00e+00	3462.00
IUUC-Xtr-131933	Xenopus tropicalis	78.50	0.00e+00	7062.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence