iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-58	200.1	286	815

Active Site

Position(s)	Description	Evidence
295	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
771	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+gNtCY+N vLQ+L +ip + ++l++   + +++ + ++++ ++l     +++ +++ + ++     ++kal  + e f   +q
   Q: 286  QGLPNVGNTCYINVVLQSLCSIPLFINDLFN---QGFPWIKAPKDDFNMLLMQLLVLKDIYNARFRQKLLIGITKALPIFGEIFAVDRQ 371
           6******************************...88998766555555554444556788899999999999***************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekkkkknk.slisdlFqgqlksqikclecdnvssreepfldlslp 175
           +Da+Efl+ +l ql+e++++  +  +++e+++ +  l ++  a++ + +k + ++++++F+++l s+i c++c+ +  + ep  +ls++
   Q: 372  NDAHEFLSLCLVQLKETFQR-VTMMWQSENDSGDFYLLKDifADYATINKMPvCPVTNNFEFELLSSIFCKACGLTLFKGEPSRYLSIN 459
           ******************55.55556666555555554445677777777667************************************ PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +p+  +    s+q+ L+ f+++eele      cekc  + +++  +++ +lP+v+i+hLkR++f+e+ ++ +k ++ + + + L ls +
   Q: 460  IPQGGKD--MSIQSTLDLFFSAEELE----HRCEKCL-YNKSVSFHRFGRLPRVIIVHLKRYHFNES-WVMKKDERPILVSKYLRLSCH 540
           **98854..7****************....59****8.56689*********************987.********************* PP
   S: 265  cts...................................................................................... 267
           c++                                                                                      
   Q: 541  CSKstkpppplrpgehvknldllkplevlgseilklpfnsvrtsrskgfetinitsnreseaqsgkrvsevlsgkvqqensgkgdtahi 629
           ***999******99999999999999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 630  vgseltketeklkkheeehrpsdldsgsireaqkyqqaekcnegrsdkqislealtqsrpkpisqeqtenlgkttlshtqdssqssqss 718
           99999988888888888888888888888888888888877777777777777777777777777777777777777766666666665 PP
   S: 268  .........................peekqke.....kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevle 324
                                    +     +     ++ Y+L+ +++H G s+++GHY+ ++ + k++ W++++D +Vt ++e+ v +
   Q: 719  sdsskssrcsddldkkakptrkvdpT-----KlnkkeDNVYRLVNIINHIGnSPNGGHYINDAFDFKRQsWFTYSDLHVTRTQEDFVYR 802
           55555555555555555555555544.....055555****************************99999******************* PP
   S: 325  etgstaYvlfYkr 337
            ++st+Yv+fY++
   Q: 803  GRSSTGYVFFYMH 815
           999********98 PP

Organism

Mus musculus

Functional Description
(View)

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

Protein Sequence
(Fasta)

MEPILINAQV QMWSAKAGMS KSRNALIETC VGKREVKLIL YFSTGKIKTL QLHDNIKSVV 60
LQTYGEDQNY LHLTFKNNDF LFVEKLTTTD ARRLKRFLDK TSQGSIRPAR SDERCGEPST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACCAATGA GGAGTAAGTA TCTAGGGTAG GGAGGGTCTC TAATTAAAGA GAAGATGAGA 60
GTAAATATTA TCCCTGTCAA TCTTCTTAGC CACAACCAAT CTAGATCCGT GGGGGTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:83563

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cpo-022049	Cavia porcellus	41.08	9.00e-113	401.00
IUUC-Dor-030370	Dipodomys ordii	41.44	1.00e-126	447.00
IUUC-Itr-047983	Ictidomys tridecemlineatus	41.16	3.00e-171	595.00
IUUC-Opr-070989	Ochotona princeps	28.91	3.00e-86	313.00
IUUC-Ocu-073860	Oryctolagus cuniculus	38.96	5.00e-159	555.00
IUUC-Oar-089263	Ovis aries	38.00	3.00e-113	402.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence