iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005318

UUCD1 version

UUC-AnC-00494

Ensembl Protein ID

ENSACAP00000002658.3

UniProt Accession

G1KB40; G1KB40_ANOCA

Protein Name

Uncharacterized protein

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000002680.3	ENSACAT00000002725.3	ENSACAP00000002658.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-61	200.6	508	541
UBD/Beta-Prp	1.60e-102	342.6	259	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 508  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 541
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 259  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 343
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 344  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 426
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 427  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 511
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 512  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 541
           *************************98776 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSTLESVTYL PEKGLYCQRL PSSRTHGGTE SLKGKNTDNM GFYGTLKMIF YKMKRKLDHG 60
SEVRSFSLGK KPCKVSEYTS TTGLVPCSAT PTTFGDLRAA NGQGQQRRRI TSIQPPTGLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTCTCAG ACAAGCTCGA CGCATGTATA TGTGTGCTGG GAGAAGCTGT TTGATCCTGA 60
GCTTCGTTCT CATCCTTCGC AGTGGAGTTG TGGTTGCTGG ATCTGCTGCT GCTGCTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	97.64	0.00e+00	1095.00
IUUC-Apl-003489	Anas platyrhynchos	97.82	0.00e+00	1097.00
IUUC-Ago-007794	Ashbya gossypii	31.28	4.00e-62	232.00
IUUC-Acl-008123	Aspergillus clavatus	32.60	5.00e-75	275.00
IUUC-Afl-008730	Aspergillus flavus	31.54	5.00e-74	272.00
IUUC-Afu-009014	Aspergillus fumigatus	32.93	7.00e-76	278.00
IUUC-Ani-009332	Aspergillus nidulans	33.47	5.00e-80	291.00
IUUC-Ang-009790	Aspergillus niger	31.71	6.00e-76	278.00
IUUC-Aor-010215	Aspergillus oryzae	30.91	1.00e-74	273.00
IUUC-Ate-010535	Aspergillus terreus	32.28	2.00e-76	280.00
IUUC-Ame-010898	Astyanax mexicanus	95.01	0.00e+00	1042.00
IUUC-Bgr-012075	Blumeria graminis	33.67	2.00e-79	290.00
IUUC-Bta-012391	Bos taurus	98.99	0.00e+00	1196.00
IUUC-Bci-013725	Botrytis cinerea	33.40	2.00e-78	286.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	7.00e-131	460.00
IUUC-Cja-018902	Callithrix jacchus	98.00	0.00e+00	1098.00
IUUC-Cfa-020237	Canis familiaris	98.00	0.00e+00	1097.00
IUUC-Cpo-022234	Cavia porcellus	99.16	0.00e+00	1200.00
IUUC-Csa-023532	Chlorocebus sabaeus	98.00	0.00e+00	1098.00
IUUC-Cho-025026	Choloepus hoffmanni	81.60	0.00e+00	729.00
IUUC-Cin-025516	Ciona intestinalis	70.34	2.00e-140	491.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	750.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	35.22	2.00e-85	310.00
IUUC-Cne-027018	Cryptococcus neoformans	33.27	4.00e-73	269.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	1.00e-30	127.00
IUUC-Dre-028303	Danio rerio	93.72	0.00e+00	1042.00
IUUC-Dno-029576	Dasypus novemcinctus	96.53	0.00e+00	1079.00
IUUC-Dor-030196	Dipodomys ordii	96.55	0.00e+00	1073.00
IUUC-Dme-031702	Drosophila melanogaster	76.36	0.00e+00	800.00
IUUC-Ete-032791	Echinops telfairi	90.37	0.00e+00	996.00
IUUC-Eca-033424	Equus caballus	99.16	0.00e+00	1197.00
IUUC-Eeu-034996	Erinaceus europaeus	94.74	0.00e+00	1060.00
IUUC-Fca-036422	Felis catus	98.00	0.00e+00	1098.00
IUUC-Fal-037267	Ficedula albicollis	97.62	0.00e+00	1088.00
IUUC-Fox-037800	Fusarium oxysporum	34.27	3.00e-84	305.00
IUUC-Fso-038258	Fusarium solani	34.41	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	80.81	0.00e+00	929.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.86	2.00e-85	309.00
IUUC-Gga-040667	Gallus gallus	98.53	0.00e+00	1098.00
IUUC-Gac-042423	Gasterosteus aculeatus	75.64	0.00e+00	827.00
IUUC-Ggo-044422	Gorilla gorilla	98.00	0.00e+00	1098.00
IUUC-Hsa-045898	Homo sapiens	98.00	0.00e+00	1098.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.57	0.00e+00	965.00
IUUC-Kpa-049097	Komagataella pastoris	32.06	7.00e-76	278.00
IUUC-Lch-050414	Latimeria chalumnae	97.60	0.00e+00	1078.00
IUUC-Loc-052348	Lepisosteus oculatus	97.29	0.00e+00	1095.00
IUUC-Lma-053185	Leptosphaeria maculans	33.00	1.00e-73	271.00
IUUC-Laf-054054	Loxodonta africana	97.82	0.00e+00	1097.00
IUUC-Mcc-055056	Macaca mulatta	98.00	0.00e+00	1098.00
IUUC-Meu-056778	Macropus eugenii	95.90	1.00e-179	622.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	5.00e-73	269.00
IUUC-Mpo-057542	Magnaporthe poae	39.13	2.00e-73	271.00
IUUC-Mla-059081	Melampsora laricipopulina	32.76	6.00e-77	281.00
IUUC-Mga-059255	Meleagris gallopavo	98.35	0.00e+00	1098.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	7.00e-67	249.00
IUUC-Mmr-061292	Microcebus murinus	98.00	0.00e+00	1098.00
IUUC-Mdo-062304	Monodelphis domestica	98.17	0.00e+00	1102.00
IUUC-Mmu-063610	Mus musculus	97.46	0.00e+00	1096.00
IUUC-Mpu-065931	Mustela putorius furo	98.00	0.00e+00	1097.00
IUUC-Mlu-066976	Myotis lucifugus	97.82	0.00e+00	1099.00
IUUC-Nfi-068428	Neosartorya fischeri	32.13	4.00e-75	275.00
IUUC-Ncr-068688	Neurospora crassa	36.17	2.00e-87	316.00
IUUC-Nle-070174	Nomascus leucogenys	98.00	0.00e+00	1098.00
IUUC-Opr-070851	Ochotona princeps	85.79	0.00e+00	648.00
IUUC-Ont-071997	Oreochromis niloticus	94.58	0.00e+00	1093.00
IUUC-Oan-072936	Ornithorhynchus anatinus	97.82	0.00e+00	1098.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.26	0.00e+00	1100.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	8.00e-30	125.00
IUUC-Ola-087098	Oryzias latipes	93.39	0.00e+00	1058.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	3.00e-38	151.00
IUUC-Oga-088884	Otolemur garnettii	99.74	0.00e+00	777.00
IUUC-Oar-090220	Ovis aries	98.53	0.00e+00	1093.00
IUUC-Ptr-090492	Pan troglodytes	98.00	0.00e+00	1098.00
IUUC-Pan-091770	Papio anubis	98.00	0.00e+00	1098.00
IUUC-Psi-093207	Pelodiscus sinensis	99.16	0.00e+00	1199.00
IUUC-Pma-094749	Petromyzon marinus	83.39	0.00e+00	966.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	2.00e-70	260.00
IUUC-Pfo-096493	Poecilia formosa	95.56	0.00e+00	1053.00
IUUC-Pab-098141	Pongo abelii	99.16	0.00e+00	1198.00
IUUC-Pca-100571	Procavia capensis	97.19	0.00e+00	777.00
IUUC-Pva-102988	Pteropus vampyrus	98.18	0.00e+00	1098.00
IUUC-Pgr-103612	Puccinia graminis	35.41	1.00e-61	231.00
IUUC-Pte-104275	Pyrenophora teres	32.37	6.00e-74	272.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	32.31	6.00e-73	268.00
IUUC-Rno-105706	Rattus norvegicus	97.28	0.00e+00	1095.00
IUUC-Sce-106343	Saccharomyces cerevisiae	30.54	4.00e-60	225.00
IUUC-Sha-107653	Sarcophilus harrisii	97.64	0.00e+00	1098.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	34.02	3.00e-79	289.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.35	1.00e-62	234.00
IUUC-Sar-113600	Sorex araneus	91.47	0.00e+00	1004.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	5.00e-67	249.00
IUUC-Ssc-115787	Sus scrofa	96.19	0.00e+00	1070.00
IUUC-Tgu-117510	Taeniopygia guttata	98.35	0.00e+00	1097.00
IUUC-Tru-117819	Takifugu rubripes	95.01	0.00e+00	1076.00
IUUC-Tsy-118828	Tarsius syrichta	98.00	0.00e+00	1098.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.44	0.00e+00	1092.00
IUUC-Tre-122193	Trichoderma reesei	36.46	2.00e-85	309.00
IUUC-Tvi-122615	Trichoderma virens	35.23	8.00e-84	304.00
IUUC-Tme-127021	Tuber melanosporum	34.86	4.00e-84	305.00
IUUC-Tbe-127925	Tupaia belangeri	99.26	0.00e+00	1095.00
IUUC-Ttr-128899	Tursiops truncatus	97.64	0.00e+00	1095.00
IUUC-Uma-129449	Ustilago maydis	46.89	3.00e-66	247.00
IUUC-Vda-129802	Verticillium dahliae	36.40	2.00e-87	316.00
IUUC-Vpa-130082	Vicugna pacos	97.84	0.00e+00	920.00
IUUC-Xtr-132213	Xenopus tropicalis	97.97	0.00e+00	1088.00
IUUC-Xma-133646	Xiphophorus maculatus	95.49	0.00e+00	1075.00
IUUC-Yli-134429	Yarrowia lipolytica	34.48	6.00e-87	314.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence