iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115787

Ensembl Protein ID

ENSSSCP00000022261.1

UniProt Accession

I3LDX6; I3LDX6_PIG

Protein Name

Uncharacterized protein

Gene Name

LOC100620112

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000020879.1	ENSSSCT00000027687.1	ENSSSCP00000022261.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-56	186.3	613	646
UBD/Beta-Prp	1.20e-89	300.7	383	646

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 613  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 646
           9*********449******************976 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           t          + +gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl gh+++v+++++
   Q: 383  T----------CXSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 459
           4..........678************************************..************************************* PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsn 191
           ++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht++vysl+fd  
   Q: 460  HE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSLQFDG- 541
           **..************************.****************..***************************9.***********9. PP
   S: 192  gkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvl 280
             ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++v++l+f++n +
   Q: 542  -IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFV 627
           .9**************************************..*********************************************** PP
   S: 281  vlgsedskvniwklkknep 299
           ++ s+d++v++w+lk+ e+
   Q: 628  ITSSDDGTVKLWDLKTGEF 646
           **************98776 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MNQELLSVGS KRRRTGGSLR GNPSSSQADE EQMNRVVEEE QQQRQPEEEH TARNGEVVGA 60
EPRPGAQNAS QQGQLEENNN RFISVDEDSS GNQEEQEEDE DHAGEQEEED EEEEEMDQES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATGTGAAA ACCTTTGCGT CTTCTGATAG TCTAGCCAAG GTCCAAGAAG TAGCAAGCTG 60
GCTTTTGGAA ATGAATCAGG AACTGCTCTC TGTGGGCAGC AAAAGACGAC GAACTGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001480--Bulb-type_lectin_dom
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	96.33	0.00e+00	1201.00
IUUC-Apl-003489	Anas platyrhynchos	88.83	0.00e+00	1170.00
IUUC-Aca-005318	Anolis carolinensis	96.19	0.00e+00	1072.00
IUUC-Ago-007794	Ashbya gossypii	31.29	4.00e-62	232.00
IUUC-Acl-008123	Aspergillus clavatus	31.80	9.00e-72	264.00
IUUC-Afl-008730	Aspergillus flavus	30.71	1.00e-70	261.00
IUUC-Afu-009014	Aspergillus fumigatus	32.13	2.00e-72	266.00
IUUC-Ani-009332	Aspergillus nidulans	33.07	2.00e-77	283.00
IUUC-Ang-009790	Aspergillus niger	30.93	5.00e-72	265.00
IUUC-Aor-010215	Aspergillus oryzae	30.12	2.00e-71	263.00
IUUC-Ate-010535	Aspergillus terreus	42.20	2.00e-64	239.00
IUUC-Ame-010898	Astyanax mexicanus	92.34	0.00e+00	1018.00
IUUC-Bgr-012075	Blumeria graminis	32.81	1.00e-75	277.00
IUUC-Bta-012391	Bos taurus	96.91	0.00e+00	1076.00
IUUC-Bci-013725	Botrytis cinerea	38.19	1.00e-67	250.00
IUUC-Cel-018495	Caenorhabditis elegans	48.24	1.00e-127	449.00
IUUC-Cja-018902	Callithrix jacchus	96.46	0.00e+00	1195.00
IUUC-Cfa-020237	Canis familiaris	95.93	0.00e+00	1202.00
IUUC-Cpo-022234	Cavia porcellus	96.91	0.00e+00	1078.00
IUUC-Csa-023532	Chlorocebus sabaeus	96.61	0.00e+00	1173.00
IUUC-Cho-025026	Choloepus hoffmanni	82.13	0.00e+00	746.00
IUUC-Cin-025516	Ciona intestinalis	67.89	1.00e-134	471.00
IUUC-Csv-026312	Ciona savignyi	73.79	0.00e+00	733.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.41	5.00e-82	298.00
IUUC-Cne-027018	Cryptococcus neoformans	32.13	2.00e-68	253.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	2.00e-31	130.00
IUUC-Dre-028303	Danio rerio	92.24	0.00e+00	1021.00
IUUC-Dno-029576	Dasypus novemcinctus	94.48	0.00e+00	1177.00
IUUC-Dor-030196	Dipodomys ordii	91.24	0.00e+00	1182.00
IUUC-Dse-031558	Dothistroma septosporum	38.31	2.00e-67	250.00
IUUC-Dme-031702	Drosophila melanogaster	74.80	0.00e+00	778.00
IUUC-Ete-032791	Echinops telfairi	89.07	0.00e+00	975.00
IUUC-Eca-033424	Equus caballus	96.91	0.00e+00	1076.00
IUUC-Eeu-034996	Erinaceus europaeus	92.54	0.00e+00	1160.00
IUUC-Fca-036422	Felis catus	95.50	0.00e+00	1213.00
IUUC-Fal-037267	Ficedula albicollis	96.53	0.00e+00	1070.00
IUUC-Fox-037800	Fusarium oxysporum	33.67	2.00e-81	296.00
IUUC-Fso-038258	Fusarium solani	33.81	2.00e-80	293.00
IUUC-Gmo-039119	Gadus morhua	81.90	0.00e+00	874.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.26	4.00e-82	298.00
IUUC-Gga-040667	Gallus gallus	91.77	0.00e+00	1168.00
IUUC-Gac-042423	Gasterosteus aculeatus	73.35	0.00e+00	782.00
IUUC-Ggo-044422	Gorilla gorilla	96.61	0.00e+00	1177.00
IUUC-Hsa-045898	Homo sapiens	96.46	0.00e+00	1176.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	97.65	0.00e+00	944.00
IUUC-Kpa-049097	Komagataella pastoris	31.74	2.00e-71	263.00
IUUC-Lch-050414	Latimeria chalumnae	92.46	0.00e+00	1061.00
IUUC-Loc-052348	Lepisosteus oculatus	94.19	0.00e+00	1045.00
IUUC-Lma-053185	Leptosphaeria maculans	31.80	5.00e-69	256.00
IUUC-Laf-054054	Loxodonta africana	95.35	0.00e+00	1211.00
IUUC-Mcc-055056	Macaca mulatta	96.61	0.00e+00	1173.00
IUUC-Meu-056778	Macropus eugenii	90.91	0.00e+00	708.00
IUUC-Mor-057133	Magnaporthe oryzae	38.11	4.00e-69	256.00
IUUC-Mpo-057542	Magnaporthe poae	38.11	2.00e-69	256.00
IUUC-Mla-059081	Melampsora laricipopulina	39.01	7.00e-69	254.00
IUUC-Mga-059255	Meleagris gallopavo	91.65	0.00e+00	1156.00
IUUC-Mvi-060490	Microbotryum violaceum	37.50	2.00e-62	234.00
IUUC-Mmr-061292	Microcebus murinus	96.61	0.00e+00	1198.00
IUUC-Mdo-062304	Monodelphis domestica	91.67	0.00e+00	1176.00
IUUC-Mmu-063610	Mus musculus	92.11	0.00e+00	1236.00
IUUC-Mpu-065931	Mustela putorius furo	96.19	0.00e+00	1201.00
IUUC-Mlu-066976	Myotis lucifugus	95.76	0.00e+00	1240.00
IUUC-Nfi-068428	Neosartorya fischeri	31.33	8.00e-72	264.00
IUUC-Ncr-068688	Neurospora crassa	35.83	2.00e-84	306.00
IUUC-Nle-070174	Nomascus leucogenys	96.32	0.00e+00	1175.00
IUUC-Opr-070851	Ochotona princeps	84.21	0.00e+00	627.00
IUUC-Ont-071997	Oreochromis niloticus	91.47	0.00e+00	1044.00
IUUC-Oan-072936	Ornithorhynchus anatinus	93.06	0.00e+00	1221.00
IUUC-Ocu-074742	Oryctolagus cuniculus	98.03	0.00e+00	1111.00
IUUC-Obr-076806	Oryza brachyantha	31.52	9.00e-30	125.00
IUUC-Oin-079809	Oryza indica	31.52	7.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	92.24	0.00e+00	1033.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.73	6.00e-38	150.00
IUUC-Oga-088884	Otolemur garnettii	97.63	0.00e+00	756.00
IUUC-Oar-090220	Ovis aries	95.63	0.00e+00	1196.00
IUUC-Ptr-090492	Pan troglodytes	96.46	0.00e+00	1176.00
IUUC-Pan-091770	Papio anubis	96.88	0.00e+00	1174.00
IUUC-Psi-093207	Pelodiscus sinensis	96.91	0.00e+00	1078.00
IUUC-Pma-094749	Petromyzon marinus	81.83	0.00e+00	917.00
IUUC-Pno-095026	Phaeosphaeria nodorum	37.77	3.00e-66	246.00
IUUC-Pfo-096493	Poecilia formosa	92.56	0.00e+00	1031.00
IUUC-Pab-098141	Pongo abelii	96.91	0.00e+00	1076.00
IUUC-Pca-100571	Procavia capensis	95.37	0.00e+00	818.00
IUUC-Pva-102988	Pteropus vampyrus	96.19	0.00e+00	1207.00
IUUC-Pgr-103597	Puccinia graminis	41.47	7.00e-60	225.00
IUUC-Ptt-103698	Puccinia triticina	35.55	7.00e-42	165.00
IUUC-Pte-104275	Pyrenophora teres	31.78	2.00e-70	260.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	38.24	2.00e-66	246.00
IUUC-Rno-105706	Rattus norvegicus	91.16	0.00e+00	1204.00
IUUC-Sce-106343	Saccharomyces cerevisiae	31.07	2.00e-58	219.00
IUUC-Sha-107653	Sarcophilus harrisii	94.21	0.00e+00	1218.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.08	8.00e-75	275.00
IUUC-Spo-108115	Schizosaccharomyces pombe	31.37	1.00e-59	223.00
IUUC-Sar-113600	Sorex araneus	91.80	0.00e+00	1091.00
IUUC-Sre-114901	Sporisorium reilianum	44.21	6.00e-68	252.00
IUUC-Tgu-117510	Taeniopygia guttata	91.51	0.00e+00	1158.00
IUUC-Tru-117819	Takifugu rubripes	92.14	0.00e+00	1054.00
IUUC-Tsy-118828	Tarsius syrichta	96.19	0.00e+00	1212.00
IUUC-Tni-120468	Tetraodon nigroviridis	91.83	0.00e+00	1044.00
IUUC-Tre-122193	Trichoderma reesei	35.82	3.00e-82	299.00
IUUC-Tvi-122615	Trichoderma virens	34.62	1.00e-80	293.00
IUUC-Tme-127021	Tuber melanosporum	33.94	1.00e-80	293.00
IUUC-Tbe-127925	Tupaia belangeri	98.15	0.00e+00	1076.00
IUUC-Ttr-128899	Tursiops truncatus	96.61	0.00e+00	1196.00
IUUC-Uma-129449	Ustilago maydis	43.16	4.00e-67	249.00
IUUC-Vda-129802	Verticillium dahliae	35.86	1.00e-84	307.00
IUUC-Vpa-130082	Vicugna pacos	96.28	0.00e+00	1017.00
IUUC-Xtr-132213	Xenopus tropicalis	86.76	0.00e+00	1139.00
IUUC-Xma-133646	Xiphophorus maculatus	92.88	0.00e+00	1025.00
IUUC-Yli-134429	Yarrowia lipolytica	33.54	4.00e-83	301.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence