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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063511
Ensembl Protein ID ENSMUSP00000134201.1
UniProt Accession Q69Z98; Q699J3; Q699J4; Q6DMN7; Q6PHM0; BRSK2_MOUSE
Genbank Protein ID AAT08447.1; AAT08448.1; AAT08449.1; AAT74618.1; BAD32546.1; AAH56498.1
Protein Name Serine/threonine-protein kinase BRSK2; Brain-specific serine/threonine-protein kinase 2; Serine/threonine-protein kinase SAD-A
Genbank Nucleotide ID AY533672; AY533673; AY533674; AY660739; AL603836; BC056498
Gene Name Brsk2; Kiaa4256; Sada
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000053046.15 ENSMUST00000018971.14 ENSMUSP00000018971.8
ENSMUSG00000053046.15 ENSMUST00000172652.7 ENSMUSP00000133438.1
ENSMUSG00000053046.15 ENSMUST00000105989.8 ENSMUSP00000101610.2
ENSMUSG00000053046.15 ENSMUST00000075528.11 ENSMUSP00000074969.5
ENSMUSG00000053046.15 ENSMUST00000174499.7 ENSMUSP00000134201.1
ENSMUSG00000053046.15 ENSMUST00000172967.7 ENSMUSP00000133750.1
ENSMUSG00000053046.15 ENSMUST00000173924.7 ENSMUSP00000134153.1
ENSMUSG00000053046.15 ENSMUST00000173705.7 ENSMUSP00000134170.1
ENSMUSG00000053046.15 ENSMUST00000174237.7 ENSMUSP00000134566.1
ENSMUSG00000053046.15 ENSMUST00000173313.1 ENSMUSP00000133868.1
ENSMUSG00000053046.15 ENSMUST00000173941.2 ENSMUSP00000133296.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 97.83 0.00e+00 1389.00 IUUC-Hsa-046912
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
 Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
Protein Sequence
(Fasta)
MTSTGKDGGG AQHAQYVGPY RLEKTLGKGQ TGLVKLGIHC VTCQKVAIKI VNREKLSESV 60
LMKVEREIAI LKLIEHPHVL KLHDVYENKK YLYLVLEHVS GGELFDYLVK KGRLTPKEAR 120
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Protein Fasta Sequence


>IUUC-Mmu-063511|UBD,UBA|Mus musculus
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Nucleotide Sequence
(Fasta)
GGCTCGGTTC GGTTGCTCGG CGGGGCTCGG CTGCACGGCC GCGGACGGGC GTGCGCTGGG 60
GGGGGGCGCG GGGCGCGGGC CTCGGAGGTG GCGGCGGAAG CCTGGTGCCC CCGCCCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063511|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0268--Exocytosis
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0051117--F:ATPase binding
GO:0000287--F:magnesium ion binding
GO:0019901--F:protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0007409--P:axonogenesis
GO:0051301--P:cell division
GO:0036503--P:ERAD pathway
GO:0030010--P:establishment of cell polarity
GO:0006887--P:exocytosis
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035556--P:intracellular signal transduction
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0007067--P:mitotic nuclear division
GO:0030182--P:neuron differentiation
GO:0048812--P:neuron projection morphogenesis
GO:0018105--P:peptidyl-serine phosphorylation
GO:0006468--P:protein phosphorylation
GO:0061178--P:regulation of insulin secretion involved in cellular response to glucose stimulus
KEGG mmu:75770
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003374 Anas platyrhynchos 92.83 0.00e+00 1217.00
IUUC-Bta-012608 Bos taurus 96.18 0.00e+00 1277.00
IUUC-Cel-018416 Caenorhabditis elegans 67.06 4.00e-156 545.00
IUUC-Cja-019882 Callithrix jacchus 96.42 0.00e+00 1275.00
IUUC-Cpo-021604 Cavia porcellus 96.86 0.00e+00 1305.00
IUUC-Csv-025996 Ciona savignyi 54.61 0.00e+00 658.00
IUUC-Dre-028706 Danio rerio 84.81 0.00e+00 1091.00
IUUC-Dme-031685 Drosophila melanogaster 75.88 2.00e-164 572.00
IUUC-Eca-033483 Equus caballus 96.45 0.00e+00 1225.00
IUUC-Fal-037499 Ficedula albicollis 93.38 0.00e+00 1212.00
IUUC-Gmo-039305 Gadus morhua 84.58 0.00e+00 701.00
IUUC-Gac-042120 Gasterosteus aculeatus 86.07 0.00e+00 959.00
IUUC-Hsa-046912 Homo sapiens 96.74 0.00e+00 1353.00
IUUC-Itr-048825 Ictidomys tridecemlineatus 98.44 0.00e+00 1304.00
IUUC-Mcc-055306 Macaca mulatta 96.61 0.00e+00 1293.00
IUUC-Mor-057261 Magnaporthe oryzae 41.19 2.00e-81 298.00
IUUC-Mga-059357 Meleagris gallopavo 93.49 0.00e+00 1212.00
IUUC-Mmr-061711 Microcebus murinus 81.92 0.00e+00 1044.00
IUUC-Mdo-062356 Monodelphis domestica 83.49 0.00e+00 978.00
IUUC-Mlu-068102 Myotis lucifugus 95.62 0.00e+00 917.00
IUUC-Ont-072425 Oreochromis niloticus 92.58 0.00e+00 1137.00
IUUC-Ola-086969 Oryzias latipes 88.13 0.00e+00 1130.00
IUUC-Pan-092910 Papio anubis 96.74 0.00e+00 1353.00
IUUC-Psi-093857 Pelodiscus sinensis 88.83 0.00e+00 984.00
IUUC-Pfo-097195 Poecilia formosa 92.43 0.00e+00 1135.00
IUUC-Rno-105039 Rattus norvegicus 85.33 0.00e+00 1130.00
IUUC-Sha-107449 Sarcophilus harrisii 90.00 0.00e+00 688.00
IUUC-Tgu-117372 Taeniopygia guttata 91.27 0.00e+00 1219.00
IUUC-Tru-118645 Takifugu rubripes 90.68 0.00e+00 1157.00
IUUC-Tni-120483 Tetraodon nigroviridis 76.76 0.00e+00 1016.00
IUUC-Tme-126887 Tuber melanosporum 48.77 3.00e-83 301.00
IUUC-Xtr-132457 Xenopus tropicalis 89.36 0.00e+00 1173.00
IUUC-Xma-134021 Xiphophorus maculatus 86.27 0.00e+00 1126.00
Created Date 25-Jun-2017

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