iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034352

UUCD1 version

UUC-EqC-00317

Ensembl Protein ID

ENSECAP00000006120.1

UniProt Accession

F6V3R9; F6V3R9_HORSE

Protein Name

Uncharacterized protein

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008140.1	ENSECAT00000008208.1	ENSECAP00000006120.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.2	37	76
E3 activity/RING/U-box	1.90e-10	40.8	33	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CSVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYQ 98
           579******************************99999*********9999999999999999885 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MGSVLSSDSG KSAPASATPR ALERRRDPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYQNC TECDTAVCLS EMRAHIRTCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCTCTTGG CAGCTGGCTG GGCGAGAGGC GCCGCGATGG GCTCCGTGCT GAGCAGCGAT 60
AGCGGCAAAT CCGCGCCCGC CTCGGCCACC CCGCGGGCCC TGGAGCGCAG AAGGGACCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ecb:100052335

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	94.40	8.00e-131	458.00
IUUC-Aca-004839	Anolis carolinensis	64.25	8.00e-69	252.00
IUUC-Bta-012827	Bos taurus	91.38	2.00e-126	444.00
IUUC-Bdi-014205	Brachypodium distachyon	43.08	1.00e-09	54.70
IUUC-Cja-018794	Callithrix jacchus	92.67	1.00e-127	448.00
IUUC-Cfa-021234	Canis familiaris	93.53	2.00e-120	424.00
IUUC-Cpo-022412	Cavia porcellus	80.17	2.00e-106	377.00
IUUC-Csa-023406	Chlorocebus sabaeus	93.53	5.00e-129	452.00
IUUC-Cho-024427	Choloepus hoffmanni	76.27	1.00e-75	274.00
IUUC-Dno-030085	Dasypus novemcinctus	93.53	6.00e-130	456.00
IUUC-Dor-030911	Dipodomys ordii	69.83	8.00e-77	279.00
IUUC-Ete-032469	Echinops telfairi	85.34	2.00e-118	417.00
IUUC-Eeu-034889	Erinaceus europaeus	78.88	3.00e-102	364.00
IUUC-Fca-036116	Felis catus	93.97	2.00e-122	431.00
IUUC-Hsa-046518	Homo sapiens	93.53	1.00e-128	451.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	96.05	1.00e-100	358.00
IUUC-Laf-053363	Loxodonta africana	92.31	3.00e-127	447.00
IUUC-Meu-056101	Macropus eugenii	79.15	7.00e-97	346.00
IUUC-Mdo-062046	Monodelphis domestica	76.82	1.00e-101	362.00
IUUC-Mmu-063184	Mus musculus	82.14	5.00e-58	216.00
IUUC-Mpu-065708	Mustela putorius furo	92.67	2.00e-128	451.00
IUUC-Mlu-067561	Myotis lucifugus	88.70	1.00e-93	334.00
IUUC-Nle-069665	Nomascus leucogenys	92.52	2.00e-117	414.00
IUUC-Opr-070301	Ochotona princeps	79.74	5.00e-106	376.00
IUUC-Ocu-074562	Oryctolagus cuniculus	92.86	3.00e-67	246.00
IUUC-Oga-088958	Otolemur garnettii	95.69	8.00e-132	462.00
IUUC-Oar-089541	Ovis aries	90.96	3.00e-96	343.00
IUUC-Ptr-090989	Pan troglodytes	93.97	9.00e-130	455.00
IUUC-Pan-092372	Papio anubis	92.67	3.00e-128	450.00
IUUC-Pab-098718	Pongo abelii	80.60	1.00e-103	367.00
IUUC-Pca-100453	Procavia capensis	90.52	3.00e-124	437.00
IUUC-Pva-102931	Pteropus vampyrus	94.83	8.00e-122	429.00
IUUC-Rno-105771	Rattus norvegicus	87.26	6.00e-101	359.00
IUUC-Sha-107557	Sarcophilus harrisii	76.82	1.00e-108	385.00
IUUC-Sar-113435	Sorex araneus	93.65	3.00e-68	249.00
IUUC-Ssc-116388	Sus scrofa	94.40	9.00e-131	458.00
IUUC-Tsy-119439	Tarsius syrichta	93.22	2.00e-98	350.00
IUUC-Tbe-127417	Tupaia belangeri	68.14	2.00e-72	264.00
IUUC-Ttr-129212	Tursiops truncatus	93.53	6.00e-130	456.00
IUUC-Vpa-130153	Vicugna pacos	91.81	1.00e-127	448.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence