iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000062369.2	ENSMUST00000106814.2	ENSMUSP00000102427.2
ENSMUSG00000062369.2	ENSMUST00000076501.1	ENSMUSP00000075822.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-82	277.1	51	347

Active Site

Position(s)	Description	Evidence
60	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU01035, ECO:0000305\|PubMed:14583620}
307	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU01035}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsg 86
           +Gl+N gN+CY+N++LQcL+++p+l++++l+ ++++++      +p+g+ +++++  +++ +  +++  +++p++      ++ + f++
   Q: 51   CGLQNTGNSCYLNAALQCLTHTPPLADYMLSqEHSQTC-----CSPEGCKMCAMEAHVTQSLlhTHSGDVMKPSQ------NLTSAFHK 128
           7******************************3333333.....46788888888888877664555556777765......55567899 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
            +q+Da+Efl+f l++++e++                  l+ +++++++++ +s+i+d+F+g ++sqikc +c+ +s +++pfld++l+
   Q: 129  RKQEDAHEFLMFTLETMHESC------------------LQVHRQSEPTSEDSSPIHDIFGGWWRSQIKCHHCQGTSYSYDPFLDIPLD 199
           9********************..................778889999***************************************** PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +++ +     s++++L++  k+eel+gen yyc +c++k+ a+k+lkl + P+vL+l LkRf    ++++ +k+++kv++p+ Ldl+p+
   Q: 200  ISSVQ-----SVKQALQDTEKAEELCGENSYYCGRCRQKKPASKTLKLYSAPKVLMLVLKRF----SGSMGKKLDRKVSYPEFLDLKPY 279
           *****.....9***************************************************....567999***************** PP
   S: 265  ctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++p+ +   +  Y L+av+vH+G +++sGHY+++vk  +gkW+++dD+kVt+++ ++vl+   ++aYvlfY +
   Q: 280  LSQPTGG---PLPYALYAVLVHEGaTCHSGHYFCCVKAGHGKWYKMDDTKVTSCDVTSVLN---ENAYVLFYVQ 347
           ***9988...89*************************************************...********87 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

Protein Sequence
(Fasta)

MVVALSFPEA DPAMSPPSAP ELHQDEAQVV EELAANGKHS LSWESPQGPG CGLQNTGNSC 60
YLNAALQCLT HTPPLADYML SQEHSQTCCS PEGCKMCAME AHVTQSLLHT HSGDVMKPSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCATTTGT CCTCACTTGC AGACATTCTC TGGAGAGAAA GACTTCCTGC TGATCCCTTA 60
GAAGACTACA GCAAGTTATT TGAAGAGGTC TTTGAAGTCA TGGTGGTTGC TCTCTCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:381944

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence