iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027674

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 S; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S

Genbank Nucleotide ID

BC097122

Gene Name

ube2s; zgc:114060

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000031775.7	ENSDART00000047452.6	ENSDARP00000047451.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.60e-38	131.0	17	148

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           +ke+++l++dppegi++ p++e d+te++  i+Gpe+tpY+ggvF++++ + +d+P+ PP+  fltkifhPnv ++G++C+++lk  ++
   Q: 17   YKEVSALAADPPEGIKIYPSEE-DITELHTSIEGPEGTPYAGGVFRMRLVLGKDFPAVPPRGYFLTKIFHPNVGHKGEICVNVLK--RD 102
           79********************.9************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           W++ l +++vll+i+ ll +pnpes+lneea +ll ++ +ey +++
   Q: 103  WKAELGLRHVLLTIKCLLIHPNPESALNEEAGKLLLEDYKEYASRA 148
           ******************************************9886 PP

Organism

Danio rerio

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MNSNVENLPP QVLRLVYKEV SALAADPPEG IKIYPSEEDI TELHTSIEGP EGTPYAGGVF 60
RMRLVLGKDF PAVPPRGYFL TKIFHPNVGH KGEICVNVLK RDWKAELGLR HVLLTIKCLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATTCTGAT TGGTTAAACG TATTTCGAAC TGCTGCTTAG ACGAATTGTA TTTTTGTTCC 60
GTGTCAAAGA CTGCTAGCTG ATAACAGGCT ACAGTAGCCG TCAGCAGTAG CAGACTAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:565498

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000818	Aegilops tauschii	60.53	2.00e-46	178.00
IUUC-Aml-001979	Ailuropoda melanoleuca	81.17	3.00e-75	274.00
IUUC-Atr-002706	Amborella trichopoda	63.16	1.00e-46	179.00
IUUC-Aca-004432	Anolis carolinensis	74.07	7.00e-80	289.00
IUUC-Aly-005779	Arabidopsis lyrata	60.90	2.00e-54	205.00
IUUC-Ath-007162	Arabidopsis thaliana	60.26	5.00e-54	204.00
IUUC-Acl-008107	Aspergillus clavatus	46.45	2.00e-34	140.00
IUUC-Afl-008578	Aspergillus flavus	55.05	4.00e-33	135.00
IUUC-Afu-009034	Aspergillus fumigatus	52.34	1.00e-34	140.00
IUUC-Ani-009151	Aspergillus nidulans	51.91	9.00e-36	144.00
IUUC-Ang-009649	Aspergillus niger	49.23	6.00e-35	142.00
IUUC-Ame-010836	Astyanax mexicanus	84.42	2.00e-103	368.00
IUUC-Bta-012740	Bos taurus	81.29	1.00e-75	275.00
IUUC-Bdi-014601	Brachypodium distachyon	60.53	2.00e-46	179.00
IUUC-Bol-015087	Brassica oleracea	60.90	3.00e-54	204.00
IUUC-Bra-016867	Brassica rapa	60.90	1.00e-54	206.00
IUUC-Cja-019763	Callithrix jacchus	79.75	7.00e-77	280.00
IUUC-Cfa-020216	Canis familiaris	81.29	5.00e-76	277.00
IUUC-Cpo-021720	Cavia porcellus	77.06	1.00e-75	275.00
IUUC-Cre-022676	Chlamydomonas reinhardtii	56.67	2.00e-52	197.00
IUUC-Csa-023751	Chlorocebus sabaeus	79.14	2.00e-76	278.00
IUUC-Cho-024620	Choloepus hoffmanni	78.76	2.00e-53	200.00
IUUC-Cin-025632	Ciona intestinalis	55.15	9.00e-62	229.00
IUUC-Csv-025984	Ciona savignyi	60.00	1.00e-60	226.00
IUUC-Cne-026844	Cryptococcus neoformans	58.00	8.00e-51	193.00
IUUC-Cme-027294	Cyanidioschyzon merolae	57.69	1.00e-51	196.00
IUUC-Dno-029886	Dasypus novemcinctus	81.29	9.00e-76	276.00
IUUC-Dor-030440	Dipodomys ordii	68.47	3.00e-77	281.00
IUUC-Dse-031211	Dothistroma septosporum	47.06	1.00e-30	124.00
IUUC-Dme-031888	Drosophila melanogaster	58.33	2.00e-60	224.00
IUUC-Ete-032365	Echinops telfairi	57.44	4.00e-55	207.00
IUUC-Eca-033733	Equus caballus	79.50	3.00e-75	274.00
IUUC-Eeu-035342	Erinaceus europaeus	81.17	2.00e-74	271.00
IUUC-Fca-035964	Felis catus	78.18	1.00e-51	196.00
IUUC-Gmo-039357	Gadus morhua	89.89	2.00e-97	348.00
IUUC-Gga-040261	Gallus gallus	75.93	1.00e-44	172.00
IUUC-Gac-042593	Gasterosteus aculeatus	91.26	1.00e-97	349.00
IUUC-Gma-043578	Glycine max	60.26	6.00e-55	207.00
IUUC-Ggo-044626	Gorilla gorilla	84.21	5.00e-54	203.00
IUUC-Hsa-046058	Homo sapiens	79.75	8.00e-77	279.00
IUUC-Hvu-047459	Hordeum vulgare	59.49	5.00e-47	181.00
IUUC-Itr-048739	Ictidomys tridecemlineatus	68.14	3.00e-76	277.00
IUUC-Lch-049415	Latimeria chalumnae	77.08	9.00e-61	226.00
IUUC-Lpe-050956	Leersia perrieri	51.32	2.00e-31	129.00
IUUC-Lma-052996	Leptosphaeria maculans	56.88	2.00e-33	137.00
IUUC-Laf-053337	Loxodonta africana	81.17	4.00e-75	273.00
IUUC-Mcc-055485	Macaca mulatta	69.15	7.00e-73	266.00
IUUC-Meu-056123	Macropus eugenii	80.52	6.00e-75	273.00
IUUC-Mtr-058300	Medicago truncatula	61.59	7.00e-54	203.00
IUUC-Mla-059060	Melampsora laricipopulina	53.64	2.00e-47	181.00
IUUC-Mmr-061005	Microcebus murinus	81.29	6.00e-76	276.00
IUUC-Mdo-062979	Monodelphis domestica	82.40	6.00e-61	226.00
IUUC-Mmu-063778	Mus musculus	76.02	7.00e-76	276.00
IUUC-Mac-064575	Musa acuminata	57.23	4.00e-55	208.00
IUUC-Mpu-065829	Mustela putorius furo	77.84	2.00e-76	278.00
IUUC-Mlu-067498	Myotis lucifugus	77.27	2.00e-68	251.00
IUUC-Nfi-068520	Neosartorya fischeri	52.34	2.00e-34	140.00
IUUC-Nle-069727	Nomascus leucogenys	79.75	6.00e-77	280.00
IUUC-Opr-071066	Ochotona princeps	78.95	1.00e-53	201.00
IUUC-Ont-072363	Oreochromis niloticus	91.85	3.00e-97	347.00
IUUC-Oan-073383	Ornithorhynchus anatinus	75.37	1.00e-54	205.00
IUUC-Ocu-074599	Oryctolagus cuniculus	82.71	3.00e-65	241.00
IUUC-Oba-075186	Oryza barthii	62.50	5.00e-48	184.00
IUUC-Obr-076104	Oryza brachyantha	61.84	3.00e-46	178.00
IUUC-Ogl-077835	Oryza glaberrima	62.50	4.00e-48	184.00
IUUC-Ogu-078690	Oryza glumaepatula	62.50	4.00e-48	184.00
IUUC-Oin-080215	Oryza indica	62.50	5.00e-48	184.00
IUUC-Olo-080816	Oryza longistaminata	62.50	5.00e-48	184.00
IUUC-Ome-081657	Oryza meridionalis	62.50	1.00e-47	183.00
IUUC-Oni-082601	Oryza nivara	62.50	4.00e-48	184.00
IUUC-Opu-083367	Oryza punctata	62.50	1.00e-47	182.00
IUUC-Oru-084477	Oryza rufipogon	62.50	5.00e-48	184.00
IUUC-Osa-086119	Oryza sativa	62.50	4.00e-48	184.00
IUUC-Ola-086702	Oryzias latipes	93.44	4.00e-100	357.00
IUUC-Olu-087576	Ostreococcus lucimarinus	53.95	2.00e-47	181.00
IUUC-Oga-088946	Otolemur garnettii	79.38	7.00e-76	276.00
IUUC-Oar-089564	Ovis aries	78.31	5.00e-76	276.00
IUUC-Ptr-090620	Pan troglodytes	79.63	4.00e-76	277.00
IUUC-Pan-092382	Papio anubis	69.15	8.00e-73	266.00
IUUC-Psi-093891	Pelodiscus sinensis	80.70	4.00e-55	206.00
IUUC-Pma-094344	Petromyzon marinus	77.12	4.00e-70	257.00
IUUC-Pno-094981	Phaeosphaeria nodorum	51.61	8.00e-29	121.00
IUUC-Ppa-095452	Physcomitrella patens	60.90	7.00e-47	180.00
IUUC-Pfo-097288	Poecilia formosa	92.47	3.00e-98	351.00
IUUC-Pab-098506	Pongo abelii	79.63	3.00e-76	277.00
IUUC-Pop-100067	Populus trichocarpa	52.13	5.00e-54	204.00
IUUC-Pca-100749	Procavia capensis	67.49	1.00e-77	282.00
IUUC-Ppe-102084	Prunus persica	60.26	5.00e-54	204.00
IUUC-Pva-102755	Pteropus vampyrus	65.87	3.00e-76	278.00
IUUC-Pgr-103394	Puccinia graminis	53.16	3.00e-47	182.00
IUUC-Ptt-103750	Puccinia triticina	53.95	1.00e-46	179.00
IUUC-Pte-104240	Pyrenophora teres	51.45	1.00e-31	130.00
IUUC-Pyt-104483	Pyrenophora triticirepentis	50.72	5.00e-31	129.00
IUUC-Rno-105739	Rattus norvegicus	67.49	1.00e-77	282.00
IUUC-Smo-108939	Selaginella moellendorffii	60.53	9.00e-47	180.00
IUUC-Sit-109881	Setaria italica	61.84	6.00e-47	180.00
IUUC-Sly-111764	Solanum lycopersicum	60.26	2.00e-54	205.00
IUUC-Stu-111968	Solanum tuberosum	60.26	3.00e-54	205.00
IUUC-Sar-113093	Sorex araneus	55.61	1.00e-48	186.00
IUUC-Sbi-114015	Sorghum bicolor	61.18	1.00e-46	179.00
IUUC-Sre-115036	Sporisorium reilianum	42.67	6.00e-33	134.00
IUUC-Tru-117716	Takifugu rubripes	91.94	3.00e-98	350.00
IUUC-Tni-120210	Tetraodon nigroviridis	91.40	4.00e-98	350.00
IUUC-Tca-121315	Theobroma cacao	60.93	1.00e-54	206.00
IUUC-Tae-124474	Triticum aestivum	60.53	2.00e-46	179.00
IUUC-Tur-126669	Triticum urartu	60.53	4.00e-46	179.00
IUUC-Tme-127125	Tuber melanosporum	47.44	4.00e-37	148.00
IUUC-Tbe-128157	Tupaia belangeri	81.82	2.00e-75	275.00
IUUC-Ttr-128593	Tursiops truncatus	67.49	7.00e-75	273.00
IUUC-Uma-129592	Ustilago maydis	47.97	1.00e-39	155.00
IUUC-Vvi-131716	Vitis vinifera	59.21	3.00e-54	205.00
IUUC-Xtr-132592	Xenopus tropicalis	72.63	2.00e-79	288.00
IUUC-Xma-133064	Xiphophorus maculatus	89.42	1.00e-89	322.00
IUUC-Yli-134575	Yarrowia lipolytica	41.34	9.00e-37	146.00
IUUC-Zma-135328	Zea mays	60.53	2.00e-46	179.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence