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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106284
Ensembl Protein ID YGL190C
UniProt Accession Q00362; D6VTW4; 2ABA_YEAST
Genbank Protein ID AAA34482.1; CAA62954.1; CAA62785.1; CAA96902.1; DAA07925.1
Protein Name Protein phosphatase PP2A regulatory subunit B; Cell division control protein 55; PR55
Genbank Nucleotide ID M72716; X91837; X91489; Z72712; BK006941
Gene Name CDC55; YGL190C; G1345
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL190C YGL190C YGL190C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.80e-16 57.1 292 322
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf.sd.tllvsGsdD.gtikvWDlrt 32
           t+s+++++f ++ ++++s  +D  t+k+WD+  
   Q: 292  TSSISDIKFsPNgRYIAS--RDyLTVKIWDVNM 322
           689*******777*****..**666*****865 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa (PR65) (Subunit A) and a 55 kDa (PR55) (Subunit B) regulatory subunit. Interacts with YND1; this interaction mediates adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity and is disrupted by adenovirus E4orf4, which remains associated with both CDC55 and YND1.
 PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa (PR65) (Subunit A) and a 55 kDa (PR55) (Subunit B) regulatory subunit. Interacts with YND1; this interaction mediates adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity and is disrupted by adenovirus E4orf4, which remains associated with both CDC55 and YND1.
Protein Sequence
(Fasta)
MAQNNFDFKF SQCFGDKADI VVTEADLITA VEFDYTGNYL ATGDKGGRVV LFERSNSRHC 60
EYKFLTEFQS HDAEFDYLKS LEIEEKINEI KWLRPTQRSH FLLSTNDKTI KLWKVYEKNI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106284|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCACAAA ACAATTTTGA TTTTAAATTC AGCCAATGTT TTGGTGATAA AGCAGATATT 60
GTGGTGACAG AGGCGGATCT AATTACAGCT GTAGAATTTG ACTATACTGG AAATTATCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106284|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PS00678--WD_REPEATS_1
Pfam

PF00400--WD40
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005935--C:cellular bud neck
GO:0005934--C:cellular bud tip
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000329--C:fungal-type vacuole membrane
GO:0043332--C:mating projection tip
GO:0005634--C:nucleus
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0032502--P:developmental process
GO:0045143--P:homologous chromosome segregation
GO:0044818--P:mitotic G2/M transition checkpoint
GO:0001100--P:negative regulation of exit from mitosis
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0061586--P:positive regulation of transcription by transcription factor localization
GO:0006470--P:protein dephosphorylation
GO:0090266--P:regulation of mitotic cell cycle spindle assembly checkpoint
KEGG sce:YGL190C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001169 Aegilops tauschii 44.26 2.00e-112 397.00
IUUC-Aml-001777 Ailuropoda melanoleuca 56.94 4.00e-116 409.00
IUUC-Atr-002520 Amborella trichopoda 44.84 7.00e-122 428.00
IUUC-Apl-004226 Anas platyrhynchos 56.02 1.00e-112 397.00
IUUC-Aca-004276 Anolis carolinensis 56.73 4.00e-119 419.00
IUUC-Aly-006304 Arabidopsis lyrata 45.59 1.00e-129 454.00
IUUC-Ath-007621 Arabidopsis thaliana 45.88 4.00e-128 449.00
IUUC-Ago-007825 Ashbya gossypii 82.72 0.00e+00 674.00
IUUC-Acl-008202 Aspergillus clavatus 67.74 3.00e-144 502.00
IUUC-Afl-008646 Aspergillus flavus 56.45 2.00e-153 533.00
IUUC-Afu-009027 Aspergillus fumigatus 67.73 3.00e-144 503.00
IUUC-Ani-009191 Aspergillus nidulans 56.60 2.00e-155 540.00
IUUC-Ang-009769 Aspergillus niger 56.81 3.00e-157 546.00
IUUC-Aor-010030 Aspergillus oryzae 55.81 7.00e-150 521.00
IUUC-Ate-010549 Aspergillus terreus 56.12 1.00e-152 531.00
IUUC-Ame-011776 Astyanax mexicanus 56.34 5.00e-112 395.00
IUUC-Bgr-012221 Blumeria graminis 53.77 2.00e-156 543.00
IUUC-Bta-012662 Bos taurus 57.30 1.00e-117 414.00
IUUC-Bci-013801 Botrytis cinerea 41.67 2.00e-13 68.20
IUUC-Bdi-014767 Brachypodium distachyon 53.38 6.00e-110 389.00
IUUC-Bol-015881 Brassica oleracea 53.81 5.00e-124 435.00
IUUC-Bra-018100 Brassica rapa 53.81 3.00e-124 436.00
IUUC-Cel-018618 Caenorhabditis elegans 45.08 1.00e-125 441.00
IUUC-Cja-018822 Callithrix jacchus 57.30 2.00e-117 414.00
IUUC-Cfa-020968 Canis familiaris 57.02 5.00e-117 412.00
IUUC-Cpo-022206 Cavia porcellus 56.73 3.00e-119 419.00
IUUC-Cre-022876 Chlamydomonas reinhardtii 55.78 6.00e-127 445.00
IUUC-Csa-023864 Chlorocebus sabaeus 56.02 7.00e-113 398.00
IUUC-Cho-024810 Choloepus hoffmanni 57.10 6.00e-116 409.00
IUUC-Cin-025380 Ciona intestinalis 56.03 7.00e-114 402.00
IUUC-Csv-026097 Ciona savignyi 55.76 5.00e-114 402.00
IUUC-Cgl-026750 Colletotrichum gloeosporioides 66.49 1.00e-146 511.00
IUUC-Cne-026887 Cryptococcus neoformans 64.94 2.00e-140 489.00
IUUC-Cme-027332 Cyanidioschyzon merolae 53.55 4.00e-109 387.00
IUUC-Dre-027721 Danio rerio 56.75 3.00e-116 409.00
IUUC-Dno-029502 Dasypus novemcinctus 57.30 1.00e-117 414.00
IUUC-Dor-030390 Dipodomys ordii 57.18 3.00e-109 386.00
IUUC-Dse-031305 Dothistroma septosporum 55.28 5.00e-150 522.00
IUUC-Dme-032131 Drosophila melanogaster 56.57 6.00e-117 412.00
IUUC-Ete-032410 Echinops telfairi 47.66 1.00e-78 284.00
IUUC-Eca-033882 Equus caballus 57.30 1.00e-117 414.00
IUUC-Fca-035978 Felis catus 57.18 2.00e-117 413.00
IUUC-Fal-037650 Ficedula albicollis 57.34 6.00e-116 408.00
IUUC-Fox-037988 Fusarium oxysporum 67.28 3.00e-148 516.00
IUUC-Fso-038460 Fusarium solani 67.11 7.00e-146 508.00
IUUC-Gmo-039380 Gadus morhua 56.46 1.00e-117 414.00
IUUC-Ggr-039883 Gaeumannomyces graminis 53.90 1.00e-145 507.00
IUUC-Gga-040518 Gallus gallus 56.46 1.00e-118 417.00
IUUC-Gac-042418 Gasterosteus aculeatus 56.46 2.00e-117 413.00
IUUC-Gma-044053 Glycine max 52.28 3.00e-115 406.00
IUUC-Ggo-044599 Gorilla gorilla 56.02 1.00e-112 397.00
IUUC-Hsa-045992 Homo sapiens 56.95 7.00e-118 415.00
IUUC-Hvu-047813 Hordeum vulgare 54.25 5.00e-116 409.00
IUUC-Itr-048651 Ictidomys tridecemlineatus 56.02 7.00e-113 398.00
IUUC-Kpa-049100 Komagataella pastoris 72.30 1.00e-158 550.00
IUUC-Lch-050206 Latimeria chalumnae 56.73 1.00e-119 421.00
IUUC-Lpe-050866 Leersia perrieri 44.61 5.00e-122 429.00
IUUC-Loc-052535 Lepisosteus oculatus 56.99 6.00e-119 418.00
IUUC-Lma-053162 Leptosphaeria maculans 66.76 2.00e-143 500.00
IUUC-Laf-053989 Loxodonta africana 57.30 3.00e-117 413.00
IUUC-Mcc-054713 Macaca mulatta 56.95 6.00e-118 415.00
IUUC-Meu-056450 Macropus eugenii 56.23 5.00e-107 379.00
IUUC-Mor-057270 Magnaporthe oryzae 66.84 3.00e-145 506.00
IUUC-Mpo-057327 Magnaporthe poae 54.53 2.00e-149 520.00
IUUC-Mtr-058561 Medicago truncatula 52.80 1.00e-112 397.00
IUUC-Mla-059127 Melampsora laricipopulina 59.55 6.00e-140 488.00
IUUC-Mga-059946 Meleagris gallopavo 56.02 1.00e-112 397.00
IUUC-Mvi-060503 Microbotryum violaceum 58.12 4.00e-137 479.00
IUUC-Mmr-061468 Microcebus murinus 55.94 8.00e-118 414.00
IUUC-Mdo-062231 Monodelphis domestica 57.30 4.00e-117 412.00
IUUC-Mmu-063311 Mus musculus 56.32 8.00e-119 418.00
IUUC-Mac-065244 Musa acuminata 52.54 5.00e-114 402.00
IUUC-Mpu-066201 Mustela putorius furo 57.02 7.00e-117 412.00
IUUC-Mlu-066933 Myotis lucifugus 56.20 5.00e-118 415.00
IUUC-Nfi-068532 Neosartorya fischeri 67.73 1.00e-144 503.00
IUUC-Ncr-068905 Neurospora crassa 56.79 1.00e-159 553.00
IUUC-Nle-069840 Nomascus leucogenys 57.30 2.00e-117 414.00
IUUC-Opr-070857 Ochotona princeps 57.30 2.00e-117 414.00
IUUC-Ont-072224 Oreochromis niloticus 56.73 3.00e-118 416.00
IUUC-Oan-073540 Ornithorhynchus anatinus 56.68 1.00e-96 343.00
IUUC-Ocu-074693 Oryctolagus cuniculus 57.22 2.00e-116 410.00
IUUC-Oba-075019 Oryza barthii 44.30 4.00e-120 422.00
IUUC-Obr-076686 Oryza brachyantha 54.16 2.00e-121 427.00
IUUC-Ogl-077077 Oryza glaberrima 52.09 2.00e-111 394.00
IUUC-Ogu-078671 Oryza glumaepatula 44.49 1.00e-120 424.00
IUUC-Oin-079193 Oryza indica 44.30 2.00e-120 423.00
IUUC-Olo-080800 Oryza longistaminata 44.68 1.00e-117 414.00
IUUC-Ome-081334 Oryza meridionalis 44.49 9.00e-121 424.00
IUUC-Oni-082911 Oryza nivara 52.22 6.00e-113 399.00
IUUC-Opu-083579 Oryza punctata 52.83 1.00e-113 402.00
IUUC-Oru-084892 Oryza rufipogon 51.83 1.00e-117 414.00
IUUC-Osa-085954 Oryza sativa 44.30 2.00e-120 423.00
IUUC-Ola-086428 Oryzias latipes 56.20 5.00e-122 428.00
IUUC-Olu-087882 Ostreococcus lucimarinus 51.08 6.00e-115 405.00
IUUC-Oga-088363 Otolemur garnettii 57.30 1.00e-117 414.00
IUUC-Oar-090213 Ovis aries 57.18 2.00e-116 410.00
IUUC-Ptr-090700 Pan troglodytes 57.18 5.00e-117 412.00
IUUC-Pan-092846 Papio anubis 56.95 5.00e-118 415.00
IUUC-Psi-093292 Pelodiscus sinensis 56.76 2.00e-118 417.00
IUUC-Pma-094603 Petromyzon marinus 50.00 4.00e-55 205.00
IUUC-Pno-094992 Phaeosphaeria nodorum 67.29 7.00e-145 504.00
IUUC-Ppa-095935 Physcomitrella patens 45.55 4.00e-129 452.00
IUUC-Pfo-097231 Poecilia formosa 56.46 7.00e-118 415.00
IUUC-Pab-097563 Pongo abelii 57.30 1.00e-117 414.00
IUUC-Pop-099404 Populus trichocarpa 51.82 1.00e-114 404.00
IUUC-Pca-100203 Procavia capensis 56.56 1.00e-69 254.00
IUUC-Ppe-102006 Prunus persica 52.76 2.00e-116 410.00
IUUC-Pva-102279 Pteropus vampyrus 57.30 2.00e-117 414.00
IUUC-Pgr-103671 Puccinia graminis 58.45 1.00e-113 400.00
IUUC-Ptt-103844 Puccinia triticina 62.70 5.00e-142 495.00
IUUC-Pte-104403 Pyrenophora teres 65.64 1.00e-145 507.00
IUUC-Pyt-104776 Pyrenophora triticirepentis 53.82 2.00e-145 506.00
IUUC-Rno-105189 Rattus norvegicus 56.32 9.00e-119 418.00
IUUC-Sha-106616 Sarcophilus harrisii 57.30 2.00e-117 413.00
IUUC-Sja-107757 Schizosaccharomyces japonicus 54.20 5.00e-148 515.00
IUUC-Spo-108186 Schizosaccharomyces pombe 65.86 1.00e-140 490.00
IUUC-Smo-109273 Selaginella moellendorffii 52.66 9.00e-120 421.00
IUUC-Sit-110793 Setaria italica 43.83 3.00e-123 433.00
IUUC-Sly-111554 Solanum lycopersicum 52.93 4.00e-113 399.00
IUUC-Stu-111999 Solanum tuberosum 52.61 8.00e-114 402.00
IUUC-Sbi-114402 Sorghum bicolor 44.34 4.00e-123 432.00
IUUC-Sre-115166 Sporisorium reilianum 65.86 6.00e-137 478.00
IUUC-Ssc-115355 Sus scrofa 56.02 7.00e-113 398.00
IUUC-Tgu-116646 Taeniopygia guttata 56.94 5.00e-115 405.00
IUUC-Tru-118028 Takifugu rubripes 56.73 3.00e-118 416.00
IUUC-Tsy-119206 Tarsius syrichta 55.56 5.00e-113 399.00
IUUC-Tni-119681 Tetraodon nigroviridis 56.73 2.00e-118 416.00
IUUC-Tca-121708 Theobroma cacao 53.77 2.00e-115 407.00
IUUC-Tre-122188 Trichoderma reesei 67.02 3.00e-146 509.00
IUUC-Tvi-122271 Trichoderma virens 67.02 3.00e-146 509.00
IUUC-Tae-125564 Triticum aestivum 44.44 6.00e-119 419.00
IUUC-Tur-126274 Triticum urartu 44.85 7.00e-115 405.00
IUUC-Tme-127130 Tuber melanosporum 66.49 1.00e-141 494.00
IUUC-Tbe-127340 Tupaia belangeri 57.28 6.00e-104 369.00
IUUC-Ttr-128725 Tursiops truncatus 55.76 9.00e-111 391.00
IUUC-Uma-129346 Ustilago maydis 65.86 5.00e-137 478.00
IUUC-Vda-130007 Verticillium dahliae 67.98 4.00e-146 508.00
IUUC-Vpa-130425 Vicugna pacos 56.94 3.00e-113 399.00
IUUC-Vvi-130930 Vitis vinifera 52.28 1.00e-113 401.00
IUUC-Xtr-131852 Xenopus tropicalis 54.55 4.00e-115 405.00
IUUC-Xma-133068 Xiphophorus maculatus 56.73 3.00e-118 416.00
IUUC-Zma-135704 Zea mays 43.38 5.00e-116 409.00
Created Date 25-Jun-2017

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