• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105847
Ensembl Protein ID ENSRNOP00000071837.1
UniProt Accession Q9WUD9; G3V776; Q45QJ2; Q9JJ10; SRC_RAT
Genbank Protein ID AAD24180.1; AAF80335.1; EDL96675.1; EDL96676.1; EDL96677.1; EDL96678.1; EDL96679.1; AAZ23848.1; AAZ23849.1
Protein Name Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src
Genbank Nucleotide ID AF130457; AF157016; AABR06027223; CH474005; CH474005; CH474005; CH474005; DQ120509; DQ120510
Gene Name Src
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009495.6 ENSRNOT00000080516.1 ENSRNOP00000071837.1
ENSRNOG00000009495.6 ENSRNOT00000012739.4 ENSRNOP00000012739.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.30e-12 47.1 88 148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi....ekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++    + +  +++W+ + +  +g+ G +P+n+v+ 
   Q: 88   TFVALYDYESRTETDLSFKKGERLQIVnntrKVDVREGDWWLAHSLSTGQTGYIPSNYVAP 148
           5789***********************64444455689********************975 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances DDX58/RIG-I-elicited antiviral signaling (By similarity). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Required for podosome formation (By similarity).
 Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances DDX58/RIG-I-elicited antiviral signaling (By similarity). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Required for podosome formation (By similarity).
Protein Sequence
(Fasta)
MGSNKSKPKD ASQRRRSLEP AENVHGAGGA FPASQTPSKP ASADGHRGPN AAFVPPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105847|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGGACCAT GGGCAGCAAC AAGAGCAAGC CCAAGGACGC CAGCCAGAGG CGCCGCAGCC 60
TGGAGCCCGC GGAGAACGTG CATGGGGCAG GTGGCGCCTT CCCTGCCTCA CAGACACCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105847|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0130--Cell adhesion
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0391--Immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0002102--C:podosome
GO:0014069--C:postsynaptic density
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0050839--F:cell adhesion molecule binding
GO:0019899--F:enzyme binding
GO:0030331--F:estrogen receptor binding
GO:0070851--F:growth factor receptor binding
GO:0020037--F:heme binding
GO:0005158--F:insulin receptor binding
GO:0044325--F:ion channel binding
GO:0016301--F:kinase activity
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0005080--F:protein kinase C binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0032148--P:activation of protein kinase B activity
GO:0034332--P:adherens junction organization
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007049--P:cell cycle
GO:0016477--P:cell migration
GO:0008283--P:cell proliferation
GO:0071398--P:cellular response to fatty acid
GO:0071498--P:cellular response to fluid shear stress
GO:0071456--P:cellular response to hypoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071393--P:cellular response to progesterone stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0051895--P:negative regulation of focal adhesion assembly
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0018105--P:peptidyl-serine phosphorylation
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0045785--P:positive regulation of cell adhesion
GO:0045737--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050715--P:positive regulation of cytokine secretion
GO:2000573--P:positive regulation of DNA biosynthetic process
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0010628--P:positive regulation of gene expression
GO:0010907--P:positive regulation of glucose metabolic process
GO:0046628--P:positive regulation of insulin receptor signaling pathway
GO:1902533--P:positive regulation of intracellular signal transduction
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0043406--P:positive regulation of MAP kinase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010641--P:positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0071803--P:positive regulation of podosome assembly
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0051222--P:positive regulation of protein transport
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0050847--P:progesterone receptor signaling pathway
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0060491--P:regulation of cell projection assembly
GO:0042127--P:regulation of cell proliferation
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0071801--P:regulation of podosome assembly
GO:0043393--P:regulation of protein binding
GO:0010447--P:response to acidic pH
GO:0042493--P:response to drug
GO:0051602--P:response to electrical stimulus
GO:0070542--P:response to fatty acid
GO:0042542--P:response to hydrogen peroxide
GO:0070555--P:response to interleukin-1
GO:0009612--P:response to mechanical stimulus
GO:0051385--P:response to mineralocorticoid
GO:0031667--P:response to nutrient levels
GO:0009615--P:response to virus
GO:0016337--P:single organismal cell-cell adhesion
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0045056--P:transcytosis
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development
KEGG rno:83805
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001713 Ailuropoda melanoleuca 97.05 0.00e+00 1089.00
IUUC-Aca-004237 Anolis carolinensis 90.77 0.00e+00 1014.00
IUUC-Ame-011887 Astyanax mexicanus 78.14 0.00e+00 875.00
IUUC-Bta-012982 Bos taurus 95.26 0.00e+00 1073.00
IUUC-Bdi-014324 Brachypodium distachyon 34.38 9.00e-23 102.00
IUUC-Cja-019995 Callithrix jacchus 98.53 0.00e+00 1095.00
IUUC-Cfa-020060 Canis familiaris 97.05 0.00e+00 1088.00
IUUC-Cpo-021557 Cavia porcellus 93.74 0.00e+00 1040.00
IUUC-Csa-023711 Chlorocebus sabaeus 98.71 0.00e+00 1095.00
IUUC-Cin-025390 Ciona intestinalis 69.72 0.00e+00 662.00
IUUC-Dre-028491 Danio rerio 81.99 0.00e+00 885.00
IUUC-Dno-029651 Dasypus novemcinctus 94.02 0.00e+00 1052.00
IUUC-Ete-033170 Echinops telfairi 97.38 0.00e+00 929.00
IUUC-Eca-033970 Equus caballus 91.34 0.00e+00 996.00
IUUC-Fca-036113 Felis catus 97.05 0.00e+00 1088.00
IUUC-Fal-036785 Ficedula albicollis 93.91 0.00e+00 1056.00
IUUC-Gga-040899 Gallus gallus 92.07 0.00e+00 1031.00
IUUC-Gac-042332 Gasterosteus aculeatus 80.26 0.00e+00 888.00
IUUC-Ggo-044829 Gorilla gorilla 85.27 0.00e+00 907.00
IUUC-Hsa-046192 Homo sapiens 98.90 0.00e+00 1098.00
IUUC-Itr-049014 Ictidomys tridecemlineatus 98.15 0.00e+00 1085.00
IUUC-Lch-049892 Latimeria chalumnae 85.77 0.00e+00 958.00
IUUC-Lpe-051166 Leersia perrieri 33.79 9.00e-23 102.00
IUUC-Loc-052812 Lepisosteus oculatus 81.09 0.00e+00 892.00
IUUC-Laf-053977 Loxodonta africana 97.79 0.00e+00 1103.00
IUUC-Mcc-055159 Macaca mulatta 96.75 0.00e+00 1085.00
IUUC-Mga-060135 Meleagris gallopavo 93.73 0.00e+00 1054.00
IUUC-Mmr-061168 Microcebus murinus 95.31 0.00e+00 1089.00
IUUC-Mdo-063030 Monodelphis domestica 91.86 0.00e+00 1045.00
IUUC-Mmu-063893 Mus musculus 99.45 0.00e+00 1123.00
IUUC-Mpu-066411 Mustela putorius furo 97.05 0.00e+00 1088.00
IUUC-Mlu-068139 Myotis lucifugus 97.24 0.00e+00 1091.00
IUUC-Nle-070178 Nomascus leucogenys 95.58 0.00e+00 1028.00
IUUC-Ont-072130 Oreochromis niloticus 80.76 0.00e+00 912.00
IUUC-Ocu-074403 Oryctolagus cuniculus 95.41 0.00e+00 1057.00
IUUC-Ola-086527 Oryzias latipes 80.58 0.00e+00 912.00
IUUC-Oga-088493 Otolemur garnettii 97.61 0.00e+00 1087.00
IUUC-Oar-090279 Ovis aries 95.62 0.00e+00 1075.00
IUUC-Ptr-091050 Pan troglodytes 98.90 0.00e+00 1098.00
IUUC-Pan-091862 Papio anubis 97.61 0.00e+00 1076.00
IUUC-Psi-093071 Pelodiscus sinensis 92.80 0.00e+00 1039.00
IUUC-Pfo-096578 Poecilia formosa 81.16 0.00e+00 920.00
IUUC-Pab-097902 Pongo abelii 96.75 0.00e+00 1087.00
IUUC-Ppe-102072 Prunus persica 34.53 8.00e-26 112.00
IUUC-Pva-103176 Pteropus vampyrus 83.61 0.00e+00 909.00
IUUC-Sha-107539 Sarcophilus harrisii 92.99 0.00e+00 1039.00
IUUC-Sbi-114480 Sorghum bicolor 35.78 2.00e-23 104.00
IUUC-Ssc-115762 Sus scrofa 96.72 0.00e+00 1094.00
IUUC-Tru-117849 Takifugu rubripes 81.17 0.00e+00 890.00
IUUC-Tni-120843 Tetraodon nigroviridis 80.58 0.00e+00 902.00
IUUC-Ttr-128702 Tursiops truncatus 92.08 0.00e+00 1022.00
IUUC-Vvi-131181 Vitis vinifera 33.21 7.00e-22 99.40
IUUC-Xtr-132291 Xenopus tropicalis 86.95 0.00e+00 949.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved