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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046602
Ensembl Protein ID ENSP00000357928.1
UniProt Accession O60508; B2RBC5; O75471; Q5SRN0; Q9UPG1; PRP17_HUMAN
Genbank Protein ID AAC39730.1; BAG37172.1; AAI17146.1; AAI26115.1; AAC25166.1; AAD01552.1
Protein Name Pre-mRNA-processing factor 17; Cell division cycle 40 homolog; EH-binding protein 3; PRP17 homolog
Genbank Nucleotide ID AF038392; AL671518; BC117145; BC126114; AF061241; AF015044
Gene Name CDC40; EHB3; PRP17; PRPF17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168438.14 ENST00000368932.5 ENSP00000357928.1
ENSG00000168438.14 ENST00000368930.5 ENSP00000357926.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.60e-30 104.8 330 367
UBD/Beta-Prp 7.60e-46 158.3 279 486
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDlrtgvll 36
           gH+  v++++f++  t ++s+++D  +k+WD+ tg ++
   Q: 330  GHSKAVRDICFNTagTQFLSAAYDRYLKLWDTETGQCI 367
           8**********444699******************996 PP
   

   UBD/Beta-Prp
   S: 85   kcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           k++h+++gh++ v +++++p sg+ l+s s d  i++w++  ++ cl+ t+ gh+++v+ ++++  g  + s+++Dr ++lWd +tg+++ +
   Q: 279  KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLR-TFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISR 369
           667777777777777777777777777777777777777633556666.7777777777777777777777777777777777777777777 PP
   S: 175  ltgghtdsvyslsfdsng...kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
           +t  + +  y+++f+++    + +v+g  d+++  wd+++ge+v+++  h   v+ + f +++ r+vs+s+D+s+r+W  +     k ++ +
   Q: 370  FT--NRKVPYCVKFNPDEdkqNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEP 459
           76..4666677777776666677777777777777777777777777777777777777777777777777777777755555556666666 PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvn 290
             ++++  +ls++++ l+  s d+++ 
   Q: 460  SMHSMPAVTLSPNGKWLACQSMDNQIL 486
           666666666666666666666665554 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
 Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.
Protein Sequence
(Fasta)
MSAAIAALAA SYGSGSGSES DSDSESSRCP LPAADSLMHL TKSPSSKPSL AVAVDSAPEV 60
AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR TQQMAAPRNM LSGYAEPAHI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046602|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGCTGCAC GCTGGGAGTG CAGGACCGCG AGGCCTCAAG GTATTTTGGA ACTCATATTC 60
TTTAGTCAAC TAGGTCCTAA ATGTTATAAA CTATTATAAT TCTCCCTTTT TCCCTAGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046602|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR032847--PRPF17
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0003723--F:RNA binding
GO:0031124--P:mRNA 3'-end processing
GO:0006406--P:mRNA export from nucleus
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006405--P:RNA export from nucleus
GO:0008380--P:RNA splicing
GO:0006369--P:termination of RNA polymerase II transcription
KEGG hsa:51362
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000473 Aegilops tauschii 50.00 5.00e-144 504.00
IUUC-Aml-002243 Ailuropoda melanoleuca 98.33 0.00e+00 811.00
IUUC-Atr-002502 Amborella trichopoda 51.13 1.00e-153 536.00
IUUC-Apl-003885 Anas platyrhynchos 94.07 0.00e+00 1019.00
IUUC-Aca-004854 Anolis carolinensis 69.84 0.00e+00 750.00
IUUC-Aly-006158 Arabidopsis lyrata 49.38 9.00e-156 543.00
IUUC-Ath-007474 Arabidopsis thaliana 52.25 2.00e-155 542.00
IUUC-Ago-007726 Ashbya gossypii 37.34 1.00e-70 260.00
IUUC-Acl-008220 Aspergillus clavatus 43.57 1.00e-132 467.00
IUUC-Afl-008473 Aspergillus flavus 42.51 8.00e-130 457.00
IUUC-Afu-008773 Aspergillus fumigatus 43.32 1.00e-130 460.00
IUUC-Ani-009323 Aspergillus nidulans 43.21 2.00e-117 416.00
IUUC-Ang-009851 Aspergillus niger 43.36 6.00e-131 461.00
IUUC-Aor-009950 Aspergillus oryzae 42.51 8.00e-130 457.00
IUUC-Ate-010372 Aspergillus terreus 44.61 2.00e-132 466.00
IUUC-Ame-011660 Astyanax mexicanus 85.56 0.00e+00 981.00
IUUC-Bgr-012230 Blumeria graminis 44.25 3.00e-125 442.00
IUUC-Bta-012568 Bos taurus 98.73 0.00e+00 1092.00
IUUC-Bci-013646 Botrytis cinerea 45.14 3.00e-122 432.00
IUUC-Bdi-014199 Brachypodium distachyon 50.48 2.00e-145 508.00
IUUC-Bol-015695 Brassica oleracea 50.18 4.00e-162 565.00
IUUC-Bra-017923 Brassica rapa 50.71 1.00e-162 566.00
IUUC-Cel-018535 Caenorhabditis elegans 51.45 3.00e-178 618.00
IUUC-Cja-019071 Callithrix jacchus 99.28 0.00e+00 1097.00
IUUC-Cfa-020559 Canis familiaris 98.73 0.00e+00 1091.00
IUUC-Cpo-022356 Cavia porcellus 99.09 0.00e+00 1095.00
IUUC-Cre-022594 Chlamydomonas reinhardtii 44.02 2.00e-77 281.00
IUUC-Csa-023125 Chlorocebus sabaeus 99.46 0.00e+00 1098.00
IUUC-Cho-024676 Choloepus hoffmanni 90.12 0.00e+00 949.00
IUUC-Cin-025229 Ciona intestinalis 71.23 0.00e+00 772.00
IUUC-Csv-025868 Ciona savignyi 71.58 4.00e-41 158.00
IUUC-Cgl-026739 Colletotrichum gloeosporioides 41.27 6.00e-108 384.00
IUUC-Cne-026885 Cryptococcus neoformans 51.85 7.00e-153 534.00
IUUC-Dre-027631 Danio rerio 85.35 0.00e+00 987.00
IUUC-Dno-029815 Dasypus novemcinctus 87.97 0.00e+00 1003.00
IUUC-Dor-031143 Dipodomys ordii 83.70 0.00e+00 916.00
IUUC-Dse-031520 Dothistroma septosporum 45.81 4.00e-96 345.00
IUUC-Dme-032050 Drosophila melanogaster 62.59 0.00e+00 748.00
IUUC-Ete-032866 Echinops telfairi 95.65 0.00e+00 1056.00
IUUC-Eca-033384 Equus caballus 98.91 0.00e+00 1090.00
IUUC-Eeu-034471 Erinaceus europaeus 84.42 0.00e+00 855.00
IUUC-Fca-035727 Felis catus 98.55 0.00e+00 1091.00
IUUC-Fal-036774 Ficedula albicollis 94.64 0.00e+00 1031.00
IUUC-Fox-037951 Fusarium oxysporum 42.33 4.00e-127 448.00
IUUC-Fso-038287 Fusarium solani 43.33 8.00e-125 440.00
IUUC-Gmo-039670 Gadus morhua 82.27 0.00e+00 951.00
IUUC-Ggr-039764 Gaeumannomyces graminis 40.22 1.00e-116 413.00
IUUC-Gga-040293 Gallus gallus 95.36 0.00e+00 1034.00
IUUC-Gac-042159 Gasterosteus aculeatus 85.61 0.00e+00 989.00
IUUC-Gma-044299 Glycine max 50.38 2.00e-145 509.00
IUUC-Ggo-044864 Gorilla gorilla 100.00 0.00e+00 1103.00
IUUC-Itr-047985 Ictidomys tridecemlineatus 99.28 0.00e+00 818.00
IUUC-Kpa-049318 Komagataella pastoris 45.85 5.00e-96 345.00
IUUC-Lch-049796 Latimeria chalumnae 76.56 0.00e+00 853.00
IUUC-Lpe-051153 Leersia perrieri 50.09 1.00e-146 513.00
IUUC-Loc-052467 Lepisosteus oculatus 87.55 0.00e+00 996.00
IUUC-Lma-053107 Leptosphaeria maculans 48.16 3.00e-113 402.00
IUUC-Laf-053787 Loxodonta africana 98.01 0.00e+00 1117.00
IUUC-Mcc-055706 Macaca mulatta 99.64 0.00e+00 1100.00
IUUC-Meu-056757 Macropus eugenii 80.68 0.00e+00 636.00
IUUC-Mor-057079 Magnaporthe oryzae 38.86 2.00e-115 409.00
IUUC-Mpo-057533 Magnaporthe poae 50.71 3.00e-112 399.00
IUUC-Mtr-057950 Medicago truncatula 62.39 1.00e-135 476.00
IUUC-Mla-058910 Melampsora laricipopulina 47.05 5.00e-148 518.00
IUUC-Mga-059366 Meleagris gallopavo 94.27 0.00e+00 1031.00
IUUC-Mvi-060349 Microbotryum violaceum 58.94 4.00e-137 482.00
IUUC-Mmr-061209 Microcebus murinus 99.09 0.00e+00 1132.00
IUUC-Mdo-062118 Monodelphis domestica 95.47 0.00e+00 1100.00
IUUC-Mmu-063173 Mus musculus 98.91 0.00e+00 1092.00
IUUC-Mac-065080 Musa acuminata 50.00 1.00e-153 536.00
IUUC-Mpu-066659 Mustela putorius furo 98.55 0.00e+00 1090.00
IUUC-Mlu-067029 Myotis lucifugus 98.19 0.00e+00 1063.00
IUUC-Nfi-068334 Neosartorya fischeri 44.86 5.00e-132 464.00
IUUC-Ncr-068675 Neurospora crassa 38.61 6.00e-103 368.00
IUUC-Nle-070113 Nomascus leucogenys 98.73 0.00e+00 1095.00
IUUC-Opr-070685 Ochotona princeps 90.40 0.00e+00 1038.00
IUUC-Ont-071680 Oreochromis niloticus 85.19 0.00e+00 983.00
IUUC-Oan-073573 Ornithorhynchus anatinus 96.46 0.00e+00 960.00
IUUC-Ocu-074074 Oryctolagus cuniculus 98.55 0.00e+00 1126.00
IUUC-Oba-075625 Oryza barthii 50.18 3.00e-147 515.00
IUUC-Obr-076510 Oryza brachyantha 51.33 2.00e-147 515.00
IUUC-Ogl-077275 Oryza glaberrima 50.18 3.00e-147 515.00
IUUC-Ogu-078563 Oryza glumaepatula 50.00 3.00e-147 515.00
IUUC-Oin-079898 Oryza indica 63.45 2.00e-134 472.00
IUUC-Olo-081080 Oryza longistaminata 52.02 3.00e-141 495.00
IUUC-Oni-083121 Oryza nivara 50.18 3.00e-147 515.00
IUUC-Opu-083329 Oryza punctata 50.09 8.00e-147 513.00
IUUC-Oru-084807 Oryza rufipogon 49.61 7.00e-129 454.00
IUUC-Osa-086039 Oryza sativa 50.27 6.00e-148 517.00
IUUC-Ola-087149 Oryzias latipes 84.10 0.00e+00 972.00
IUUC-Olu-087627 Ostreococcus lucimarinus 43.55 2.00e-121 429.00
IUUC-Oga-088359 Otolemur garnettii 98.91 0.00e+00 1094.00
IUUC-Oar-089390 Ovis aries 98.73 0.00e+00 1088.00
IUUC-Ptr-090894 Pan troglodytes 100.00 0.00e+00 1103.00
IUUC-Pan-092476 Papio anubis 99.64 0.00e+00 1100.00
IUUC-Psi-093527 Pelodiscus sinensis 93.12 0.00e+00 986.00
IUUC-Pno-094771 Phaeosphaeria nodorum 48.19 9.00e-113 400.00
IUUC-Ppa-095386 Physcomitrella patens 50.47 2.00e-155 542.00
IUUC-Pfo-096139 Poecilia formosa 86.47 0.00e+00 993.00
IUUC-Pab-097838 Pongo abelii 99.39 0.00e+00 975.00
IUUC-Pop-098945 Populus trichocarpa 51.50 7.00e-153 534.00
IUUC-Pca-100876 Procavia capensis 82.79 0.00e+00 932.00
IUUC-Ppe-101777 Prunus persica 50.85 4.00e-151 528.00
IUUC-Pva-102418 Pteropus vampyrus 97.83 0.00e+00 1084.00
IUUC-Pgr-103456 Puccinia graminis 50.37 6.00e-159 554.00
IUUC-Ptt-103731 Puccinia triticina 46.10 3.00e-145 509.00
IUUC-Pte-104386 Pyrenophora teres 49.51 2.00e-114 406.00
IUUC-Pyt-104560 Pyrenophora triticirepentis 50.49 2.00e-114 406.00
IUUC-Rno-105694 Rattus norvegicus 94.38 0.00e+00 1024.00
IUUC-Sce-106339 Saccharomyces cerevisiae 37.63 3.00e-75 275.00
IUUC-Sha-106709 Sarcophilus harrisii 95.65 0.00e+00 1098.00
IUUC-Sja-107817 Schizosaccharomyces japonicus 40.35 4.00e-124 438.00
IUUC-Spo-108331 Schizosaccharomyces pombe 42.15 2.00e-122 432.00
IUUC-Ssl-108530 Sclerotinia sclerotiorum 47.31 6.00e-117 414.00
IUUC-Smo-108778 Selaginella moellendorffii 45.30 5.00e-127 447.00
IUUC-Sit-110446 Setaria italica 48.62 4.00e-145 508.00
IUUC-Sly-111330 Solanum lycopersicum 50.56 6.00e-151 527.00
IUUC-Stu-112610 Solanum tuberosum 50.18 4.00e-151 528.00
IUUC-Sar-113065 Sorex araneus 78.33 1.00e-126 446.00
IUUC-Sbi-114005 Sorghum bicolor 49.71 6.00e-143 501.00
IUUC-Sre-114988 Sporisorium reilianum 50.37 2.00e-158 553.00
IUUC-Ssc-115760 Sus scrofa 98.91 0.00e+00 1095.00
IUUC-Tgu-116493 Taeniopygia guttata 95.16 0.00e+00 1037.00
IUUC-Tru-118489 Takifugu rubripes 81.87 0.00e+00 951.00
IUUC-Tsy-119332 Tarsius syrichta 98.73 0.00e+00 1129.00
IUUC-Tni-120202 Tetraodon nigroviridis 78.79 0.00e+00 882.00
IUUC-Tca-121429 Theobroma cacao 49.72 1.00e-150 526.00
IUUC-Tre-122162 Trichoderma reesei 43.01 3.00e-124 438.00
IUUC-Tvi-122500 Trichoderma virens 42.57 3.00e-121 429.00
IUUC-Tae-125557 Triticum aestivum 48.71 8.00e-144 504.00
IUUC-Tur-126554 Triticum urartu 48.61 6.00e-142 497.00
IUUC-Tme-126919 Tuber melanosporum 45.14 1.00e-138 486.00
IUUC-Tbe-127968 Tupaia belangeri 93.12 0.00e+00 1050.00
IUUC-Ttr-129215 Tursiops truncatus 98.19 0.00e+00 1081.00
IUUC-Uma-129622 Ustilago maydis 49.29 7.00e-160 557.00
IUUC-Vda-129750 Verticillium dahliae 44.04 4.00e-124 438.00
IUUC-Vpa-130617 Vicugna pacos 96.32 0.00e+00 980.00
IUUC-Vvi-131238 Vitis vinifera 61.81 3.00e-134 472.00
IUUC-Xtr-131865 Xenopus tropicalis 90.07 0.00e+00 1013.00
IUUC-Xma-133627 Xiphophorus maculatus 86.65 0.00e+00 995.00
IUUC-Yli-134390 Yarrowia lipolytica 45.76 5.00e-116 411.00
IUUC-Zma-135925 Zea mays 51.24 8.00e-141 494.00
Created Date 25-Jun-2017

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