iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049889

Ensembl Protein ID

ENSLACP00000019289.2

UniProt Accession

H3BBL8; H3BBL8_LATCH

Genbank Protein ID

ENSLACP00000019289

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AFYH01038045

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000016968.2	ENSLACT00000019423.2	ENSLACP00000019289.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	38.38	3.00e-15	74.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Latimeria chalumnae

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPVSLQLE FGGGAELLFN GIKKHCVTLP EQSKPWDIRQ LLVWIKTNML KERPELFIQG 60
TTVRPGILVL VNDADWELMG ELDYKLKDQD NVVFISTLHG G 101

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Nucleotide Sequence
(Fasta)

AAGCTGACTG TGTCTCTTGA GTTATTTTTG GTTAGCCTAA TGTAGGTATA AGACCTTTAT 60
GTATTTTGGT CGGAGAACTG AGTTTATTCT AAACTCCTAT TCACTCTATC ATTCACACTG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

KEGG

lcm:102351930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	81.19	5.00e-46	175.00
IUUC-Atr-003089	Amborella trichopoda	56.57	2.00e-29	119.00
IUUC-Apl-003382	Anas platyrhynchos	82.42	8.00e-42	160.00
IUUC-Aca-004981	Anolis carolinensis	82.18	1.00e-47	180.00
IUUC-Aly-005517	Arabidopsis lyrata	56.52	1.00e-26	110.00
IUUC-Ath-006718	Arabidopsis thaliana	57.50	2.00e-23	99.80
IUUC-Ago-007917	Ashbya gossypii	42.42	2.00e-19	86.70
IUUC-Acl-008054	Aspergillus clavatus	66.04	5.00e-16	75.10
IUUC-Afl-008704	Aspergillus flavus	53.33	5.00e-20	88.20
IUUC-Aor-009890	Aspergillus oryzae	52.94	2.00e-23	100.00
IUUC-Bta-012448	Bos taurus	80.20	6.00e-46	174.00
IUUC-Bci-013865	Botrytis cinerea	41.58	2.00e-19	87.00
IUUC-Bdi-014980	Brachypodium distachyon	65.62	1.00e-22	97.40
IUUC-Bol-016055	Brassica oleracea	57.50	2.00e-23	99.80
IUUC-Bra-016845	Brassica rapa	57.50	2.00e-23	99.80
IUUC-Cel-018485	Caenorhabditis elegans	30.10	1.00e-09	54.30
IUUC-Cja-019587	Callithrix jacchus	79.21	1.00e-45	174.00
IUUC-Cfa-020653	Canis familiaris	79.21	8.00e-46	174.00
IUUC-Cpo-021622	Cavia porcellus	79.21	1.00e-45	174.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	54.08	3.00e-26	109.00
IUUC-Csa-023756	Chlorocebus sabaeus	79.75	6.00e-34	135.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.54	4.00e-22	95.90
IUUC-Cne-026953	Cryptococcus neoformans	52.43	3.00e-27	113.00
IUUC-Cme-027314	Cyanidioschyzon merolae	42.42	7.00e-18	81.30
IUUC-Dre-027884	Danio rerio	80.20	2.00e-46	176.00
IUUC-Dno-029262	Dasypus novemcinctus	80.00	1.00e-34	138.00
IUUC-Dor-030601	Dipodomys ordii	52.48	8.00e-23	97.80
IUUC-Dme-031893	Drosophila melanogaster	60.78	4.00e-30	122.00
IUUC-Ete-032773	Echinops telfairi	76.24	4.00e-42	161.00
IUUC-Eca-034187	Equus caballus	78.22	1.00e-45	173.00
IUUC-Eeu-034808	Erinaceus europaeus	78.22	4.00e-45	172.00
IUUC-Fca-036107	Felis catus	81.19	2.00e-46	176.00
IUUC-Fal-036607	Ficedula albicollis	80.22	3.00e-40	155.00
IUUC-Fox-037698	Fusarium oxysporum	44.23	4.00e-22	96.30
IUUC-Gmo-039492	Gadus morhua	76.24	2.00e-44	169.00
IUUC-Ggr-039965	Gaeumannomyces graminis	43.27	6.00e-19	86.30
IUUC-Gga-041268	Gallus gallus	83.17	2.00e-47	179.00
IUUC-Gac-042111	Gasterosteus aculeatus	79.21	3.00e-47	179.00
IUUC-Gma-043240	Glycine max	65.62	2.00e-22	96.70
IUUC-Ggo-045176	Gorilla gorilla	78.48	3.00e-27	114.00
IUUC-Hsa-046077	Homo sapiens	79.21	2.00e-39	152.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	78.65	2.00e-33	132.00
IUUC-Kpa-049157	Komagataella pastoris	42.42	6.00e-19	84.70
IUUC-Lpe-050783	Leersia perrieri	61.90	8.00e-21	91.30
IUUC-Loc-052400	Lepisosteus oculatus	80.20	2.00e-46	176.00
IUUC-Lma-053259	Leptosphaeria maculans	45.54	7.00e-21	91.70
IUUC-Laf-053596	Loxodonta africana	78.64	1.00e-44	170.00
IUUC-Mcc-054845	Macaca mulatta	76.53	3.00e-40	155.00
IUUC-Meu-055968	Macropus eugenii	79.21	1.00e-46	176.00
IUUC-Mor-057126	Magnaporthe oryzae	42.31	3.00e-18	83.60
IUUC-Mpo-057311	Magnaporthe poae	44.55	5.00e-20	89.70
IUUC-Mtr-058266	Medicago truncatula	64.06	1.00e-21	94.40
IUUC-Mla-058847	Melampsora laricipopulina	42.72	7.00e-14	68.60
IUUC-Mga-059468	Meleagris gallopavo	81.32	4.00e-41	158.00
IUUC-Mvi-060235	Microbotryum violaceum	37.75	1.00e-19	88.60
IUUC-Mdo-061948	Monodelphis domestica	77.23	7.00e-46	174.00
IUUC-Mmu-063946	Mus musculus	76.24	3.00e-44	169.00
IUUC-Mac-064812	Musa acuminata	65.62	1.00e-23	100.00
IUUC-Mpu-066763	Mustela putorius furo	77.23	2.00e-44	169.00
IUUC-Mlu-066970	Myotis lucifugus	78.48	5.00e-34	135.00
IUUC-Ncr-068824	Neurospora crassa	43.56	3.00e-19	86.30
IUUC-Nle-069849	Nomascus leucogenys	79.75	7.00e-34	135.00
IUUC-Opr-070227	Ochotona princeps	79.21	1.00e-45	174.00
IUUC-Ont-072530	Oreochromis niloticus	80.20	4.00e-47	178.00
IUUC-Oan-073191	Ornithorhynchus anatinus	79.78	5.00e-41	158.00
IUUC-Ocu-074460	Oryctolagus cuniculus	79.59	2.00e-44	169.00
IUUC-Oba-075499	Oryza barthii	62.50	3.00e-21	94.00
IUUC-Obr-076896	Oryza brachyantha	60.94	4.00e-21	94.40
IUUC-Ogl-077834	Oryza glaberrima	62.50	1.00e-21	94.00
IUUC-Ogu-078622	Oryza glumaepatula	62.50	1.00e-21	94.00
IUUC-Oin-079358	Oryza indica	62.50	3.00e-21	94.40
IUUC-Olo-081035	Oryza longistaminata	51.55	3.00e-22	97.40
IUUC-Oni-082425	Oryza nivara	62.50	1.00e-21	94.00
IUUC-Opu-083461	Oryza punctata	61.90	9.00e-21	92.40
IUUC-Oru-084875	Oryza rufipogon	56.34	1.00e-19	87.00
IUUC-Oga-089128	Otolemur garnettii	78.22	2.00e-45	172.00
IUUC-Oar-089896	Ovis aries	80.20	6.00e-46	174.00
IUUC-Ptr-091618	Pan troglodytes	78.48	3.00e-27	114.00
IUUC-Pan-092238	Papio anubis	79.75	6.00e-34	135.00
IUUC-Psi-093879	Pelodiscus sinensis	84.16	4.00e-46	175.00
IUUC-Pma-094484	Petromyzon marinus	78.22	9.00e-36	140.00
IUUC-Ppa-095801	Physcomitrella patens	55.56	4.00e-22	95.50
IUUC-Pfo-097192	Poecilia formosa	80.20	9.00e-47	177.00
IUUC-Pab-098203	Pongo abelii	79.21	5.00e-39	151.00
IUUC-Pop-099614	Populus trichocarpa	51.19	2.00e-21	93.60
IUUC-Pca-100507	Procavia capensis	79.75	3.00e-34	135.00
IUUC-Ppe-101174	Prunus persica	57.58	1.00e-28	117.00
IUUC-Pva-102735	Pteropus vampyrus	77.23	7.00e-42	161.00
IUUC-Pgr-103510	Puccinia graminis	42.72	3.00e-13	66.60
IUUC-Ptt-103918	Puccinia triticina	37.86	8.00e-11	58.50
IUUC-Pte-104173	Pyrenophora teres	44.66	4.00e-21	92.40
IUUC-Pyt-104806	Pyrenophora triticirepentis	44.66	4.00e-21	92.40
IUUC-Rno-105820	Rattus norvegicus	78.22	2.00e-45	172.00
IUUC-Sce-106366	Saccharomyces cerevisiae	38.38	8.00e-16	74.70
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.71	2.00e-17	80.10
IUUC-Spo-108074	Schizosaccharomyces pombe	41.84	3.00e-10	56.20
IUUC-Smo-108944	Selaginella moellendorffii	59.55	3.00e-26	108.00
IUUC-Sit-110277	Setaria italica	53.57	5.00e-22	95.10
IUUC-Sly-111505	Solanum lycopersicum	53.57	2.00e-23	99.80
IUUC-Stu-112076	Solanum tuberosum	52.38	6.00e-23	98.20
IUUC-Sbi-114274	Sorghum bicolor	57.89	5.00e-22	95.50
IUUC-Sre-114953	Sporisorium reilianum	53.92	6.00e-25	105.00
IUUC-Ssc-115418	Sus scrofa	77.23	2.00e-45	172.00
IUUC-Tgu-117311	Taeniopygia guttata	80.22	3.00e-40	155.00
IUUC-Tru-118598	Takifugu rubripes	79.78	2.00e-40	155.00
IUUC-Tni-120109	Tetraodon nigroviridis	78.43	2.00e-44	169.00
IUUC-Tca-120942	Theobroma cacao	55.42	5.00e-23	98.60
IUUC-Tre-122099	Trichoderma reesei	48.39	1.00e-15	74.30
IUUC-Tvi-122285	Trichoderma virens	50.96	7.00e-20	88.60
IUUC-Tae-125193	Triticum aestivum	64.06	1.00e-21	93.60
IUUC-Tur-126677	Triticum urartu	53.95	6.00e-19	85.50
IUUC-Tme-127120	Tuber melanosporum	45.19	5.00e-22	95.90
IUUC-Tbe-128050	Tupaia belangeri	56.44	4.00e-28	115.00
IUUC-Ttr-129019	Tursiops truncatus	76.24	2.00e-42	163.00
IUUC-Uma-129483	Ustilago maydis	51.96	9.00e-24	101.00
IUUC-Vda-129690	Verticillium dahliae	39.29	1.00e-15	74.70
IUUC-Vvi-131174	Vitis vinifera	51.81	7.00e-22	94.70
IUUC-Xma-133862	Xiphophorus maculatus	80.20	9.00e-47	177.00
IUUC-Yli-134398	Yarrowia lipolytica	42.42	2.00e-18	83.20
IUUC-Zma-134964	Zea mays	60.94	2.00e-20	90.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence