iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037160

Ensembl Protein ID

ENSFALP00000005401.1

UniProt Accession

U3JRJ7; U3JRJ7_FICAL

Genbank Protein ID

ENSFALP00000005401

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGTO01021767

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000005186.1	ENSFALT00000005427.1	ENSFALP00000005401.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	88.05	3.00e-131	465.00	IUUC-Hsa-046179
E3 activity/RING/RING	88.00	7.00e-131	463.00	IUUC-Mmu-063206
E3 activity/RING/RING	88.00	5.00e-131	463.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ficedula albicollis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

GGGGGEQQQQ QQELTSLFEC PICFDYVLPP ILQCQAGHLV CKQCRQQLSL CPTCRGSLTP 60
NIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPKHEAI CEYRPYSCPC PGTSCDWEGS 120

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Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG 60
GGGGGGGGGG GGGGGGGGAG CAGCAGCAGC AGCAGCAGGA GCTGACCTCG CTCTTCGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	88.05	1.00e-132	465.00
IUUC-Bta-012750	Bos taurus	88.05	1.00e-132	465.00
IUUC-Cja-019800	Callithrix jacchus	88.05	8.00e-133	466.00
IUUC-Cfa-020505	Canis familiaris	88.05	2.00e-132	464.00
IUUC-Cpo-021394	Cavia porcellus	88.05	4.00e-133	466.00
IUUC-Csa-023374	Chlorocebus sabaeus	88.05	8.00e-133	466.00
IUUC-Cho-024933	Choloepus hoffmanni	88.05	1.00e-132	465.00
IUUC-Dno-029260	Dasypus novemcinctus	87.76	8.00e-130	456.00
IUUC-Ete-032946	Echinops telfairi	87.65	2.00e-132	464.00
IUUC-Eca-033546	Equus caballus	88.05	3.00e-133	467.00
IUUC-Eeu-034861	Erinaceus europaeus	84.46	3.00e-126	444.00
IUUC-Gga-040252	Gallus gallus	88.84	8.00e-134	469.00
IUUC-Ggo-044618	Gorilla gorilla	88.05	8.00e-133	466.00
IUUC-Hsa-046179	Homo sapiens	88.05	8.00e-133	466.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	88.05	2.00e-132	464.00
IUUC-Laf-054257	Loxodonta africana	88.05	6.00e-131	459.00
IUUC-Mcc-055023	Macaca mulatta	88.05	8.00e-133	466.00
IUUC-Meu-055922	Macropus eugenii	86.45	3.00e-129	453.00
IUUC-Mga-060070	Meleagris gallopavo	87.30	2.00e-130	458.00
IUUC-Mmr-061494	Microcebus murinus	88.05	8.00e-133	466.00
IUUC-Mdo-061971	Monodelphis domestica	88.05	3.00e-132	463.00
IUUC-Mmu-063206	Mus musculus	88.00	4.00e-132	463.00
IUUC-Mpu-066597	Mustela putorius furo	88.05	8.00e-133	466.00
IUUC-Mlu-067199	Myotis lucifugus	87.65	5.00e-132	463.00
IUUC-Nle-069342	Nomascus leucogenys	88.05	8.00e-133	466.00
IUUC-Ocu-073950	Oryctolagus cuniculus	88.00	5.00e-132	463.00
IUUC-Oga-089154	Otolemur garnettii	88.05	8.00e-133	466.00
IUUC-Oar-089446	Ovis aries	88.05	1.00e-132	464.00
IUUC-Ptr-091088	Pan troglodytes	88.05	8.00e-133	466.00
IUUC-Psi-093079	Pelodiscus sinensis	88.45	1.00e-132	465.00
IUUC-Pab-098092	Pongo abelii	88.05	8.00e-133	466.00
IUUC-Pca-100328	Procavia capensis	85.66	3.00e-128	451.00
IUUC-Rno-105477	Rattus norvegicus	88.00	4.00e-132	463.00
IUUC-Sha-107630	Sarcophilus harrisii	88.45	1.00e-132	464.00
IUUC-Ssc-116441	Sus scrofa	88.05	1.00e-132	465.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence