iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	9371400

Classification

Family	E-value	Score	Start	End
E2/UBC	5.50e-50	168.8	90	224

Active Site

Position(s)	Description	Evidence
170	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R++kel+e++ dpp+++sa+p+ + +l+ew  +ilGp++++YeggvF l+i+f+++YPfkPPkv+f t+i+h+n++++G +Cl+ilk  ++Wspal++
   Q: 90   RIQKELAEITLDPPPNCSAGPKGD-NLYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILK--DNWSPALTI 184
           99**********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vllsi+sll+++np++pl  ++a+++ +nree+++++r
   Q: 185  SKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIAR 224
           ***********************************99876 PP

Organism

Drosophila melanogaster

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG RGSNANGGAS 60
GSNAGGGDEP RKEAKTTPRI SRALGTSAKR IQKELAEITL DPPPNCSAGP KGDNLYEWVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCGCTAA GGATGAGCGG ACAGCGCGAG CACCTAGAGA CGGACCCGGA CCGATAGCTG 60
GCTACAAACA TACAAATTAT CGAGTTTCTA ACAAAGATAA AGTCGGCTCT GCGTCGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0019915--P:lipid storage
GO:0000209--P:protein polyubiquitination

KEGG

dme:Dmel_CG6720

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001532	Ailuropoda melanoleuca	91.45	1.00e-83	300.00
IUUC-Apl-003415	Anas platyrhynchos	94.41	3.00e-80	289.00
IUUC-Aca-005044	Anolis carolinensis	87.65	1.00e-80	291.00
IUUC-Ame-011419	Astyanax mexicanus	93.71	6.00e-80	288.00
IUUC-Bta-012796	Bos taurus	92.31	5.00e-77	279.00
IUUC-Cja-019670	Callithrix jacchus	94.41	3.00e-80	289.00
IUUC-Cfa-021171	Canis familiaris	94.41	3.00e-80	289.00
IUUC-Cpo-022266	Cavia porcellus	91.45	1.00e-83	300.00
IUUC-Cre-022791	Chlamydomonas reinhardtii	81.08	2.00e-71	260.00
IUUC-Csa-023464	Chlorocebus sabaeus	94.41	3.00e-80	289.00
IUUC-Cho-024986	Choloepus hoffmanni	92.80	1.00e-69	254.00
IUUC-Cin-025161	Ciona intestinalis	86.75	1.00e-75	275.00
IUUC-Csv-025982	Ciona savignyi	90.07	1.00e-84	304.00
IUUC-Cme-027286	Cyanidioschyzon merolae	78.38	3.00e-69	253.00
IUUC-Dre-027449	Danio rerio	93.71	3.00e-80	290.00
IUUC-Dno-029130	Dasypus novemcinctus	92.86	1.00e-69	253.00
IUUC-Dor-030450	Dipodomys ordii	95.45	2.00e-61	225.00
IUUC-Ete-032397	Echinops telfairi	86.50	4.00e-84	302.00
IUUC-Eca-033312	Equus caballus	94.41	3.00e-80	289.00
IUUC-Eeu-034931	Erinaceus europaeus	89.51	3.00e-75	273.00
IUUC-Fca-035425	Felis catus	93.01	1.00e-79	287.00
IUUC-Fal-037043	Ficedula albicollis	93.71	3.00e-80	290.00
IUUC-Gmo-039645	Gadus morhua	93.71	2.00e-80	290.00
IUUC-Gga-040236	Gallus gallus	93.71	3.00e-80	289.00
IUUC-Gac-041661	Gasterosteus aculeatus	93.71	2.00e-80	290.00
IUUC-Ggo-045507	Gorilla gorilla	91.45	1.00e-83	300.00
IUUC-Hsa-046767	Homo sapiens	93.71	3.00e-80	290.00
IUUC-Itr-048197	Ictidomys tridecemlineatus	92.86	8.00e-70	254.00
IUUC-Lch-050322	Latimeria chalumnae	87.12	5.00e-84	302.00
IUUC-Loc-052673	Lepisosteus oculatus	93.71	7.00e-81	291.00
IUUC-Laf-054416	Loxodonta africana	94.41	3.00e-80	289.00
IUUC-Mcc-055072	Macaca mulatta	93.71	3.00e-80	290.00
IUUC-Meu-056590	Macropus eugenii	92.96	4.00e-79	285.00
IUUC-Mga-059436	Meleagris gallopavo	94.41	3.00e-80	289.00
IUUC-Mmr-060629	Microcebus murinus	93.71	3.00e-80	290.00
IUUC-Mdo-063010	Monodelphis domestica	94.41	3.00e-80	289.00
IUUC-Mmu-063733	Mus musculus	93.71	9.00e-81	291.00
IUUC-Mpu-065789	Mustela putorius furo	94.41	3.00e-80	289.00
IUUC-Mlu-067897	Myotis lucifugus	93.71	3.00e-80	290.00
IUUC-Nle-069421	Nomascus leucogenys	93.71	3.00e-80	290.00
IUUC-Opr-070917	Ochotona princeps	90.35	3.00e-57	211.00
IUUC-Ont-071325	Oreochromis niloticus	93.71	1.00e-80	291.00
IUUC-Oan-073006	Ornithorhynchus anatinus	92.86	2.00e-69	253.00
IUUC-Ocu-074055	Oryctolagus cuniculus	91.45	1.00e-83	300.00
IUUC-Ola-086636	Oryzias latipes	91.61	1.00e-78	285.00
IUUC-Olu-087783	Ostreococcus lucimarinus	80.00	7.00e-67	244.00
IUUC-Oga-088760	Otolemur garnettii	94.41	3.00e-80	289.00
IUUC-Oar-089803	Ovis aries	87.12	2.00e-84	303.00
IUUC-Ptr-090914	Pan troglodytes	91.45	1.00e-83	300.00
IUUC-Pan-092142	Papio anubis	94.41	3.00e-80	289.00
IUUC-Psi-093471	Pelodiscus sinensis	94.41	3.00e-80	289.00
IUUC-Pma-094642	Petromyzon marinus	89.68	7.00e-67	244.00
IUUC-Ppa-095789	Physcomitrella patens	76.43	2.00e-69	253.00
IUUC-Pfo-097071	Poecilia formosa	93.01	2.00e-79	286.00
IUUC-Pab-098017	Pongo abelii	93.71	3.00e-80	290.00
IUUC-Pop-099024	Populus trichocarpa	62.94	1.00e-55	207.00
IUUC-Pca-100467	Procavia capensis	94.41	3.00e-80	289.00
IUUC-Pva-102561	Pteropus vampyrus	93.71	3.00e-80	290.00
IUUC-Rno-105518	Rattus norvegicus	87.12	2.00e-84	303.00
IUUC-Sha-106897	Sarcophilus harrisii	93.01	6.00e-80	288.00
IUUC-Smo-108957	Selaginella moellendorffii	70.47	2.00e-61	227.00
IUUC-Sar-113672	Sorex araneus	94.41	3.00e-80	289.00
IUUC-Ssc-116298	Sus scrofa	91.16	6.00e-80	288.00
IUUC-Tgu-116892	Taeniopygia guttata	94.41	3.00e-80	289.00
IUUC-Tru-118527	Takifugu rubripes	83.73	1.00e-79	288.00
IUUC-Tsy-119046	Tarsius syrichta	94.41	5.00e-80	289.00
IUUC-Tni-120349	Tetraodon nigroviridis	92.31	2.00e-78	284.00
IUUC-Tca-121777	Theobroma cacao	61.11	6.00e-53	199.00
IUUC-Tbe-127690	Tupaia belangeri	94.41	9.00e-80	288.00
IUUC-Ttr-128358	Tursiops truncatus	93.71	3.00e-80	290.00
IUUC-Vpa-130232	Vicugna pacos	92.20	4.00e-76	276.00
IUUC-Vvi-131190	Vitis vinifera	61.07	9.00e-54	201.00
IUUC-Xtr-132173	Xenopus tropicalis	94.41	4.00e-80	290.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence