iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044622

UUCD1 version

UUC-GoG-00861

Ensembl Protein ID

ENSGGOP00000023560.1

UniProt Accession

G3S653; G3S653_GORGO

Protein Name

Uncharacterized protein

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000025562.1	ENSGGOT00000033241.1	ENSGGOP00000023560.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.70e-06	27.8	234	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 234  CKICAESNKD-VKIEPCGHLLCSRCLAAW-----QHSDSQTCPFCR 273
           99********.******************.....6889999****8 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

RRQLAKLAII FSHMHAELHA LFPGGKYCGH MYQLTKAPAH TFWRESCGAR CVLPWAEFES 60
LLGTCHPVEP GCTALALRTT IDLTCSGHVS IFEFDVFTRL FQPWPTLLKN WQLLAVNHPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGACAGC TGGCCAAGCT GGCCATCATC TTCAGCCACA TGCACGCGGA GCTGCACGCA 60
CTCTTCCCCG GGGGAAAGTA CTGTGGACAC ATGTACCAGC TCACCAAGGC CCCCGCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	84.69	9.00e-156	543.00
IUUC-Bta-012705	Bos taurus	86.27	8.00e-160	556.00
IUUC-Cja-019179	Callithrix jacchus	92.72	0.00e+00	657.00
IUUC-Cfa-020593	Canis familiaris	80.44	4.00e-149	521.00
IUUC-Cpo-021289	Cavia porcellus	80.07	5.00e-145	507.00
IUUC-Csa-023966	Chlorocebus sabaeus	94.05	0.00e+00	631.00
IUUC-Dor-030246	Dipodomys ordii	85.11	3.00e-94	338.00
IUUC-Eca-033921	Equus caballus	68.26	2.00e-124	438.00
IUUC-Fca-035747	Felis catus	77.57	9.00e-147	513.00
IUUC-Hsa-045735	Homo sapiens	98.60	0.00e+00	689.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	83.77	1.00e-151	529.00
IUUC-Laf-053983	Loxodonta africana	85.86	9.00e-153	533.00
IUUC-Mmr-061310	Microcebus murinus	82.28	9.00e-154	536.00
IUUC-Mmu-064155	Mus musculus	78.50	3.00e-149	521.00
IUUC-Mpu-066655	Mustela putorius furo	84.62	2.00e-148	519.00
IUUC-Mlu-067929	Myotis lucifugus	85.50	2.00e-136	478.00
IUUC-Nle-070065	Nomascus leucogenys	77.87	1.00e-144	505.00
IUUC-Ocu-074049	Oryctolagus cuniculus	77.03	4.00e-133	467.00
IUUC-Oga-087952	Otolemur garnettii	83.66	7.00e-166	576.00
IUUC-Oar-089382	Ovis aries	81.96	7.00e-155	540.00
IUUC-Ptr-090579	Pan troglodytes	83.75	8.00e-160	556.00
IUUC-Pan-092075	Papio anubis	94.68	0.00e+00	673.00
IUUC-Pab-098100	Pongo abelii	85.15	1.00e-164	572.00
IUUC-Pva-102714	Pteropus vampyrus	77.78	6.00e-120	424.00
IUUC-Rno-105348	Rattus norvegicus	78.50	1.00e-148	519.00
IUUC-Sha-107138	Sarcophilus harrisii	65.62	3.00e-123	434.00
IUUC-Ssc-116424	Sus scrofa	84.64	2.00e-153	535.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence