iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037638.5	ENSMUST00000174780.1	ENSMUSP00000134028.1
ENSMUSG00000037638.5	ENSMUST00000169593.1	ENSMUSP00000133152.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.50e-14	53.7	24	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +D+++ vg+ +f+ah++vLaa+S +F+ lf+ + + s  +++v ++ d v   +f+ ll+F+Y g+ld+
   Q: 24   CDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDQPASS-RDTVRLNgDiVTVPAFSRLLDFMYEGRLDL 90
           8*************************8.7778888775.9******87*******************97 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.

Protein Sequence
(Fasta)

MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDQPASS 60
RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HNLPVEDVLA AASYLHMYDI VKVCKGRLRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGCGCCGT CCGGGTCCCC GCGCCCTCCC GGCCGGGGCG CGCCGCCCCC AGTTCGGTGC 60
GGTCCGAGCT GCACGGGAAA GCTTGCAGAA CGAGCGGAGA GCCGCGCGTG CGGCGAAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:382639

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001524	Ailuropoda melanoleuca	61.00	1.00e-121	429.00
IUUC-Bta-012405	Bos taurus	66.67	4.00e-119	421.00
IUUC-Cpo-022380	Cavia porcellus	67.75	6.00e-138	483.00
IUUC-Csa-023915	Chlorocebus sabaeus	74.70	6.00e-159	553.00
IUUC-Dre-027378	Danio rerio	51.68	1.00e-107	383.00
IUUC-Hsa-046421	Homo sapiens	75.18	1.00e-159	556.00
IUUC-Itr-049050	Ictidomys tridecemlineatus	78.01	6.00e-174	603.00
IUUC-Mcc-055433	Macaca mulatta	73.29	3.00e-156	545.00
IUUC-Mdo-062104	Monodelphis domestica	53.66	1.00e-108	386.00
IUUC-Oga-088319	Otolemur garnettii	61.18	1.00e-115	409.00
IUUC-Ptr-090524	Pan troglodytes	75.41	2.00e-160	558.00
IUUC-Pan-092721	Papio anubis	63.06	6.00e-118	417.00
IUUC-Pab-098701	Pongo abelii	60.76	2.00e-111	395.00
IUUC-Rno-105978	Rattus norvegicus	94.05	0.00e+00	740.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence