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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046371
Ensembl Protein ID ENSP00000384290.3
UniProt Accession Q8WVS4; Q9NW58; WDR60_HUMAN
Genbank Protein ID AAH14491.2; BAA91528.1
Protein Name WD repeat-containing protein 60
Genbank Nucleotide ID AC004863; AK001162
Gene Name WDR60
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000126870.15 ENST00000407559.7 ENSP00000384290.3
ENSG00000126870.15 ENST00000444851.5 ENSP00000392608.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.70e-06 28.2 696 729
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWDlrtg 33
           ++ vtc+++      ll +G+  g++ vWDlr++
   Q: 696  ESQVTCCCLspLKaFLLFAGTAHGSVVVWDLRED 729
           5789**99975223469**************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in ciliogenesis.
 May play a role in ciliogenesis.
Protein Sequence
(Fasta)
MEPGKRRTKD DTWKADDLRK HLWAIQSGGS KEERKHREKK LRKESEMDLP EHKEPRCRDP 60
DQDARSRDRV AEVHTAKESP RGERDRDRQR ERRRDAKDRE KEKLKEKHRE AEKSHSRGKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046371|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGGGCAGTG CTTCTGGGCC CTCTGCTGCT CCTGCTTGTC GGTTGCTAGG CGCTGGGACG 60
CGCCTCCCGA AGGGTGCGGG GCACAGGTGG CCTCTTCGGG GTGGACCGCG CCTGGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046371|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
SMART

SM00320--WD40
Gene Ontology

GO:0097546--C:ciliary base
GO:0097542--C:ciliary tip
GO:0005929--C:cilium
GO:0005868--C:cytoplasmic dynein complex
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000242--C:pericentriolar material
GO:0045503--F:dynein light chain binding
GO:0060271--P:cilium assembly
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0035735--P:intraciliary transport involved in cilium assembly
KEGG hsa:55112
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001741 Ailuropoda melanoleuca 73.43 0.00e+00 1386.00
IUUC-Apl-003689 Anas platyrhynchos 46.33 0.00e+00 855.00
IUUC-Aca-004966 Anolis carolinensis 58.33 0.00e+00 756.00
IUUC-Ame-011562 Astyanax mexicanus 43.42 1.00e-76 281.00
IUUC-Bta-013100 Bos taurus 65.71 0.00e+00 1255.00
IUUC-Cja-019521 Callithrix jacchus 85.71 0.00e+00 1541.00
IUUC-Cfa-020943 Canis familiaris 70.19 0.00e+00 1287.00
IUUC-Cho-024500 Choloepus hoffmanni 82.76 0.00e+00 632.00
IUUC-Dre-028530 Danio rerio 47.05 3.00e-180 625.00
IUUC-Dno-029442 Dasypus novemcinctus 72.62 0.00e+00 1280.00
IUUC-Eca-033951 Equus caballus 73.75 0.00e+00 1352.00
IUUC-Fca-036542 Felis catus 71.63 0.00e+00 1254.00
IUUC-Fal-037079 Ficedula albicollis 57.49 0.00e+00 752.00
IUUC-Gac-041396 Gasterosteus aculeatus 48.54 3.00e-163 569.00
IUUC-Ggo-045638 Gorilla gorilla 90.12 0.00e+00 1665.00
IUUC-Itr-049031 Ictidomys tridecemlineatus 72.25 0.00e+00 1231.00
IUUC-Lch-049862 Latimeria chalumnae 51.59 0.00e+00 705.00
IUUC-Loc-052637 Lepisosteus oculatus 52.23 1.00e-173 604.00
IUUC-Laf-053470 Loxodonta africana 79.51 0.00e+00 1088.00
IUUC-Mcc-055753 Macaca mulatta 94.16 0.00e+00 1677.00
IUUC-Mga-059230 Meleagris gallopavo 52.98 0.00e+00 751.00
IUUC-Mmr-061703 Microcebus murinus 70.10 0.00e+00 1212.00
IUUC-Mmu-064346 Mus musculus 80.36 0.00e+00 1106.00
IUUC-Mpu-066650 Mustela putorius furo 68.18 0.00e+00 1149.00
IUUC-Nle-069413 Nomascus leucogenys 94.29 0.00e+00 1684.00
IUUC-Opr-071033 Ochotona princeps 78.06 0.00e+00 1108.00
IUUC-Ont-071388 Oreochromis niloticus 48.66 4.00e-177 615.00
IUUC-Oan-072714 Ornithorhynchus anatinus 54.75 0.00e+00 1025.00
IUUC-Ocu-074557 Oryctolagus cuniculus 78.40 0.00e+00 1280.00
IUUC-Oga-088938 Otolemur garnettii 76.08 0.00e+00 1352.00
IUUC-Oar-090053 Ovis aries 63.23 0.00e+00 877.00
IUUC-Pan-091852 Papio anubis 87.12 0.00e+00 1531.00
IUUC-Psi-093781 Pelodiscus sinensis 62.00 0.00e+00 799.00
IUUC-Pfo-096078 Poecilia formosa 46.36 9.00e-150 524.00
IUUC-Pab-097947 Pongo abelii 96.16 0.00e+00 1734.00
IUUC-Rno-105970 Rattus norvegicus 66.92 0.00e+00 1176.00
IUUC-Tgu-117448 Taeniopygia guttata 58.40 0.00e+00 732.00
IUUC-Tni-120297 Tetraodon nigroviridis 46.06 4.00e-159 555.00
IUUC-Xtr-132946 Xenopus tropicalis 52.64 0.00e+00 666.00
Created Date 25-Jun-2017

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