iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ogu-078844

Ensembl Protein ID

OGLUM03G38890.1

UniProt Accession

A0A0D9ZF17; A0A0D9ZF17_9ORYZ

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
OGLUM03G38890	OGLUM03G38890.1	OGLUM03G38890.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.20e-104	349.4	16	506

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD+++ve+s+++++FL++ae  g+s+A++++ +l+eln+ vn++++e
   Q: 16   YDRQLRIWGDQGQAALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDGSKVEQSDMGNNFLLDAECLGQSRAKSVCSFLQELNDAVNAKFVE 109
           ********************************************************************************************** PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn... 181
           es+  l ++++ Ff++f+vV++++ ++ + +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++ +P+++lk++     
   Q: 110  ESPLVLIDTNPsFFSQFTVVIATQLPERSLLKLDDICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHNPWVELKQFAKsid 203
           *****************************************************************************************88899 PP
   S: 182  ......aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtks 268
                 +++++++++v++  l+e++a +++++ +++++ek e+k ++++ + + deen++ea+e + k   +  i++ i+q++++ + ++v++s
   Q: 204  indkdpVVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKNEFKALIREHMLNLDEENYKEAVESSYKVSVTPGISDeIRQIIDD-SSAEVNSS 296
           999999******************************************************************************9.78899*** PP
   S: 269  kspfwv...........................................................................sfcsnaealq... 284
           +s+fwv                                                                           +fc+na++l+   
   Q: 297  SSDFWVlvaalkefianegngelplegtipdmtslteyyvslqkiyqakaesdclalehhvkdilkridrdpdsisrayikTFCKNARKLRvcr 390
           *******************************************************************************************666 PP
   S: 285  ........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagn 364
                   + +   + +++++++++     +y+llra++r++++++r pg ++ e d+d +++l+taa +  ++++g+++ +l++dli+e++++
   Q: 391  yrsmeeefSSPVLSEVQKYFTDEDYcfvmnFYVLLRAVDRLAANYNRCPGIFESEIDED-VPRLKTAAVSV-MSEMGMNGaPLSEDLITEMCRF 482
           666555543366666677777777799999*******************9999999999.9****988875.6********************* PP
   S: 365  iipaiattnavvgGlaaqEviKvv 388
           + ++i++++a++gG+a+qEviK +
   Q: 483  GGAEIHPVAAFIGGVASQEVIKWI 506
           **********************87 PP

Organism

Oryza glumaepatula

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAATAAAFA EPKTKYDRQL RIWGDQGQAA LEKASICLLT CGPTGTEAMK NLVLGGVGSV 60
TVVDGSKVEQ SDMGNNFLLD AECLGQSRAK SVCSFLQELN DAVNAKFVEE SPLVLIDTNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCACGATCCC CTTCTCCTTG CTCCGCCTCC ACTTAGCTTG AGACCGCTTT ATTCCTCGCT 60
CAGGGAGGAG AAGGAGAAGG CGAAGGCGAA GCAAAGCAAA ACCTCGGAAG AGCGGCAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	87.05	0.00e+00	879.00
IUUC-Aml-002333	Ailuropoda melanoleuca	43.74	4.00e-122	431.00
IUUC-Atr-002644	Amborella trichopoda	70.62	0.00e+00	710.00
IUUC-Apl-003446	Anas platyrhynchos	42.86	5.00e-113	400.00
IUUC-Aca-004450	Anolis carolinensis	41.72	2.00e-115	409.00
IUUC-Aly-005466	Arabidopsis lyrata	66.20	0.00e+00	702.00
IUUC-Ath-006692	Arabidopsis thaliana	66.80	0.00e+00	702.00
IUUC-Ago-007900	Ashbya gossypii	28.01	8.00e-35	140.00
IUUC-Acl-008333	Aspergillus clavatus	31.80	4.00e-60	225.00
IUUC-Afl-008529	Aspergillus flavus	32.13	6.00e-64	238.00
IUUC-Afu-009071	Aspergillus fumigatus	31.49	9.00e-59	220.00
IUUC-Ani-009443	Aspergillus nidulans	31.93	1.00e-54	207.00
IUUC-Ang-009669	Aspergillus niger	30.87	1.00e-61	230.00
IUUC-Aor-009914	Aspergillus oryzae	31.64	7.00e-62	231.00
IUUC-Ate-010450	Aspergillus terreus	31.45	5.00e-61	228.00
IUUC-Ame-011183	Astyanax mexicanus	40.52	5.00e-114	404.00
IUUC-Bgr-012111	Blumeria graminis	31.25	3.00e-52	198.00
IUUC-Bta-012583	Bos taurus	44.11	3.00e-123	434.00
IUUC-Bci-013892	Botrytis cinerea	30.69	2.00e-49	189.00
IUUC-Bdi-014592	Brachypodium distachyon	87.73	0.00e+00	885.00
IUUC-Bol-016401	Brassica oleracea	65.99	0.00e+00	697.00
IUUC-Bra-017506	Brassica rapa	65.33	0.00e+00	682.00
IUUC-Cel-018456	Caenorhabditis elegans	29.59	7.00e-64	237.00
IUUC-Cja-020007	Callithrix jacchus	44.25	6.00e-122	430.00
IUUC-Cfa-020324	Canis familiaris	43.91	2.00e-123	435.00
IUUC-Cpo-022248	Cavia porcellus	40.17	1.00e-68	253.00
IUUC-Csa-023149	Chlorocebus sabaeus	41.50	6.00e-96	344.00
IUUC-Cho-024537	Choloepus hoffmanni	36.28	8.00e-81	293.00
IUUC-Cin-025763	Ciona intestinalis	41.19	6.00e-103	367.00
IUUC-Csv-026113	Ciona savignyi	38.95	5.00e-94	337.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.26	8.00e-49	187.00
IUUC-Cne-026884	Cryptococcus neoformans	30.26	2.00e-59	222.00
IUUC-Dre-028140	Danio rerio	41.85	4.00e-118	417.00
IUUC-Dno-030033	Dasypus novemcinctus	43.29	3.00e-111	395.00
IUUC-Dor-030513	Dipodomys ordii	36.51	6.00e-38	151.00
IUUC-Dse-031536	Dothistroma septosporum	29.49	1.00e-54	207.00
IUUC-Dme-031683	Drosophila melanogaster	38.23	9.00e-90	323.00
IUUC-Ete-032420	Echinops telfairi	38.38	3.00e-103	368.00
IUUC-Eca-033992	Equus caballus	42.04	9.00e-94	336.00
IUUC-Eeu-034713	Erinaceus europaeus	33.97	6.00e-30	124.00
IUUC-Fca-036548	Felis catus	43.71	3.00e-123	434.00
IUUC-Fal-037600	Ficedula albicollis	42.00	1.00e-110	393.00
IUUC-Fox-038037	Fusarium oxysporum	30.06	3.00e-58	219.00
IUUC-Fso-038387	Fusarium solani	30.08	2.00e-58	219.00
IUUC-Gmo-038562	Gadus morhua	40.48	5.00e-111	394.00
IUUC-Ggr-040005	Gaeumannomyces graminis	30.84	2.00e-55	209.00
IUUC-Gga-041129	Gallus gallus	42.91	4.00e-114	404.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.32	2.00e-114	405.00
IUUC-Gma-043610	Glycine max	69.35	0.00e+00	703.00
IUUC-Ggo-045611	Gorilla gorilla	43.65	5.00e-121	427.00
IUUC-Hsa-046563	Homo sapiens	43.91	5.00e-122	430.00
IUUC-Hvu-047790	Hordeum vulgare	87.12	0.00e+00	635.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	44.31	4.00e-122	431.00
IUUC-Kpa-049309	Komagataella pastoris	35.05	2.00e-70	259.00
IUUC-Lch-050038	Latimeria chalumnae	42.43	2.00e-115	408.00
IUUC-Lpe-051535	Leersia perrieri	90.69	0.00e+00	875.00
IUUC-Loc-051917	Lepisosteus oculatus	38.21	1.00e-98	352.00
IUUC-Lma-053112	Leptosphaeria maculans	32.02	3.00e-62	232.00
IUUC-Laf-053690	Loxodonta africana	44.71	1.00e-124	439.00
IUUC-Mcc-055117	Macaca mulatta	43.56	6.00e-120	424.00
IUUC-Meu-056761	Macropus eugenii	35.98	1.00e-86	313.00
IUUC-Mor-057230	Magnaporthe oryzae	31.02	6.00e-60	224.00
IUUC-Mpo-057514	Magnaporthe poae	34.02	1.00e-52	200.00
IUUC-Mtr-058551	Medicago truncatula	66.21	0.00e+00	678.00
IUUC-Mla-059183	Melampsora laricipopulina	33.85	3.00e-78	285.00
IUUC-Mga-060144	Meleagris gallopavo	42.17	2.00e-110	392.00
IUUC-Mvi-060221	Microbotryum violaceum	34.01	1.00e-59	224.00
IUUC-Mmr-061325	Microcebus murinus	43.06	5.00e-119	421.00
IUUC-Mdo-062532	Monodelphis domestica	43.71	1.00e-121	429.00
IUUC-Mmu-063956	Mus musculus	43.31	3.00e-121	428.00
IUUC-Mac-064521	Musa acuminata	72.27	0.00e+00	753.00
IUUC-Mpu-066716	Mustela putorius furo	43.72	4.00e-120	424.00
IUUC-Mlu-067459	Myotis lucifugus	44.42	6.00e-124	437.00
IUUC-Nfi-068245	Neosartorya fischeri	32.07	4.00e-59	221.00
IUUC-Ncr-068910	Neurospora crassa	30.43	2.00e-55	209.00
IUUC-Nle-070034	Nomascus leucogenys	42.42	7.00e-115	407.00
IUUC-Opr-070552	Ochotona princeps	39.76	4.00e-98	351.00
IUUC-Ont-071426	Oreochromis niloticus	41.43	8.00e-117	413.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.26	3.00e-81	295.00
IUUC-Ocu-074911	Oryctolagus cuniculus	44.51	1.00e-123	436.00
IUUC-Oba-075437	Oryza barthii	98.79	0.00e+00	946.00
IUUC-Obr-076684	Oryza brachyantha	92.93	0.00e+00	841.00
IUUC-Ogl-077170	Oryza glaberrima	98.79	0.00e+00	946.00
IUUC-Oin-079105	Oryza indica	98.99	0.00e+00	950.00
IUUC-Olo-080943	Oryza longistaminata	95.39	0.00e+00	912.00
IUUC-Oni-082891	Oryza nivara	95.77	0.00e+00	916.00
IUUC-Opu-083457	Oryza punctata	97.79	0.00e+00	934.00
IUUC-Oru-084960	Oryza rufipogon	95.39	0.00e+00	912.00
IUUC-Osa-085358	Oryza sativa	98.59	0.00e+00	944.00
IUUC-Ola-086420	Oryzias latipes	39.49	4.00e-70	257.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.77	3.00e-55	209.00
IUUC-Oga-088810	Otolemur garnettii	44.11	2.00e-122	432.00
IUUC-Oar-089196	Ovis aries	43.85	2.00e-121	429.00
IUUC-Ptr-090617	Pan troglodytes	43.91	3.00e-122	431.00
IUUC-Pan-092761	Papio anubis	44.11	3.00e-123	434.00
IUUC-Psi-093191	Pelodiscus sinensis	40.85	9.00e-115	406.00
IUUC-Pma-094380	Petromyzon marinus	40.85	2.00e-109	388.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.49	6.00e-53	202.00
IUUC-Ppa-095798	Physcomitrella patens	55.29	1.00e-165	575.00
IUUC-Pfo-096467	Poecilia formosa	41.58	7.00e-113	400.00
IUUC-Pab-098255	Pongo abelii	45.29	4.00e-107	381.00
IUUC-Pop-099722	Populus trichocarpa	69.82	0.00e+00	734.00
IUUC-Pca-100807	Procavia capensis	52.41	3.00e-53	201.00
IUUC-Ppe-101280	Prunus persica	68.81	0.00e+00	722.00
IUUC-Pva-102333	Pteropus vampyrus	42.46	3.00e-116	411.00
IUUC-Pgr-103401	Puccinia graminis	29.29	1.00e-61	230.00
IUUC-Ptt-103889	Puccinia triticina	26.32	1.00e-52	200.00
IUUC-Pte-104355	Pyrenophora teres	31.51	3.00e-60	225.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.02	2.00e-61	229.00
IUUC-Rno-105810	Rattus norvegicus	43.11	8.00e-120	423.00
IUUC-Sce-106397	Saccharomyces cerevisiae	29.47	9.00e-31	127.00
IUUC-Sha-106770	Sarcophilus harrisii	49.23	5.00e-71	260.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.80	3.00e-74	271.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.60	5.00e-75	274.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.55	5.00e-51	194.00
IUUC-Smo-109296	Selaginella moellendorffii	54.55	7.00e-158	550.00
IUUC-Sit-110157	Setaria italica	87.73	0.00e+00	903.00
IUUC-Sly-111660	Solanum lycopersicum	67.81	0.00e+00	708.00
IUUC-Stu-112469	Solanum tuberosum	68.04	0.00e+00	716.00
IUUC-Sar-113083	Sorex araneus	33.74	2.00e-79	289.00
IUUC-Sbi-113813	Sorghum bicolor	88.53	0.00e+00	910.00
IUUC-Sre-115058	Sporisorium reilianum	33.63	1.00e-63	237.00
IUUC-Tgu-116772	Taeniopygia guttata	42.63	3.00e-110	391.00
IUUC-Tru-118686	Takifugu rubripes	40.64	2.00e-115	408.00
IUUC-Tsy-119111	Tarsius syrichta	45.25	2.00e-62	233.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.41	2.00e-101	362.00
IUUC-Tca-121491	Theobroma cacao	69.56	0.00e+00	692.00
IUUC-Tre-122103	Trichoderma reesei	31.58	3.00e-63	235.00
IUUC-Tvi-122672	Trichoderma virens	30.91	4.00e-58	218.00
IUUC-Tae-125316	Triticum aestivum	87.93	0.00e+00	885.00
IUUC-Tur-126487	Triticum urartu	86.41	0.00e+00	856.00
IUUC-Tme-127097	Tuber melanosporum	33.90	5.00e-71	261.00
IUUC-Ttr-128465	Tursiops truncatus	40.67	7.00e-107	380.00
IUUC-Uma-129645	Ustilago maydis	32.13	3.00e-61	229.00
IUUC-Vda-129989	Verticillium dahliae	27.91	6.00e-41	161.00
IUUC-Vpa-130529	Vicugna pacos	41.67	6.00e-112	397.00
IUUC-Vvi-131059	Vitis vinifera	70.36	0.00e+00	733.00
IUUC-Xtr-132002	Xenopus tropicalis	43.34	1.00e-119	423.00
IUUC-Xma-133930	Xiphophorus maculatus	41.92	2.00e-116	412.00
IUUC-Yli-134505	Yarrowia lipolytica	33.40	3.00e-73	268.00
IUUC-Zma-135619	Zea mays	87.93	0.00e+00	858.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence