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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063311
Ensembl Protein ID ENSMUSP00000040321.6
UniProt Accession Q925E7; Q6ZPN5; 2ABD_MOUSE
Genbank Protein ID AAK53703.1; BAC98196.2; AAH66022.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta
Genbank Nucleotide ID AF366393; AK129386; BC066022
Gene Name Ppp2r2d; D7Ertd753e; Kiaa1541
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041769.13 ENSMUST00000041097.12 ENSMUSP00000040321.6
ENSMUSG00000041769.13 ENSMUST00000148453.7 ENSMUSP00000119183.1
ENSMUSG00000041769.13 ENSMUST00000136824.7 ENSMUSP00000133380.1
ENSMUSG00000041769.13 ENSMUST00000172764.1 ENSMUSP00000133810.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-10 42.4 101 130
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf...sd.tllvsGsdDgtikvWDl 30
           +++ +++   ++  +++ +++D+tik+W +
   Q: 101  KINKIRWlpqQNaAHFLLSTNDKTIKLWKI 130
           79999***986677788889********85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
 B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Protein Sequence
(Fasta)
MAGAGGGGCP AGGNDFQWCF SQVKGAVDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 60
FQREQENKGR AHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063311|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCCTTCGA GCATCCAGTC CAGCCGGCCG CAGAAGAAAG TCTGAGGCCT TAAGAACGTA 60
GAGGGCGTCG CGTCCTAGCC TTGACACGAC TCGAGAAGGC CGCCTCTATC TGCCAGCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063311|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0051301--P:cell division
GO:0032502--P:developmental process
GO:0010458--P:exit from mitosis
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0070262--P:peptidyl-serine dephosphorylation
KEGG mmu:52432
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001982 Ailuropoda melanoleuca 97.39 0.00e+00 823.00
IUUC-Atr-002520 Amborella trichopoda 51.00 1.00e-127 449.00
IUUC-Aca-004276 Anolis carolinensis 96.82 0.00e+00 864.00
IUUC-Ath-007621 Arabidopsis thaliana 51.34 2.00e-133 469.00
IUUC-Acl-008202 Aspergillus clavatus 56.37 1.00e-132 466.00
IUUC-Afl-008646 Aspergillus flavus 56.03 2.00e-133 469.00
IUUC-Afu-009027 Aspergillus fumigatus 56.37 1.00e-133 469.00
IUUC-Ani-009191 Aspergillus nidulans 56.68 6.00e-135 474.00
IUUC-Ang-009769 Aspergillus niger 56.41 5.00e-136 477.00
IUUC-Ate-010549 Aspergillus terreus 56.40 1.00e-132 466.00
IUUC-Bci-013801 Botrytis cinerea 55.00 3.00e-138 484.00
IUUC-Cja-019573 Callithrix jacchus 97.14 0.00e+00 797.00
IUUC-Cfa-021111 Canis familiaris 98.10 0.00e+00 830.00
IUUC-Cpo-022206 Cavia porcellus 98.86 0.00e+00 881.00
IUUC-Cre-022876 Chlamydomonas reinhardtii 53.26 3.00e-133 468.00
IUUC-Csv-026097 Ciona savignyi 78.85 0.00e+00 705.00
IUUC-Cgl-026750 Colletotrichum gloeosporioides 54.89 3.00e-134 471.00
IUUC-Dno-028876 Dasypus novemcinctus 95.91 0.00e+00 861.00
IUUC-Dor-030390 Dipodomys ordii 92.14 0.00e+00 771.00
IUUC-Dse-031305 Dothistroma septosporum 56.57 8.00e-136 477.00
IUUC-Dme-032131 Drosophila melanogaster 80.18 0.00e+00 724.00
IUUC-Fal-037650 Ficedula albicollis 90.91 0.00e+00 821.00
IUUC-Fox-037988 Fusarium oxysporum 55.93 8.00e-134 470.00
IUUC-Fso-038460 Fusarium solani 55.27 1.00e-134 473.00
IUUC-Gmo-039380 Gadus morhua 93.86 0.00e+00 843.00
IUUC-Ggr-039883 Gaeumannomyces graminis 55.56 8.00e-136 477.00
IUUC-Gga-040518 Gallus gallus 97.05 0.00e+00 865.00
IUUC-Gac-042418 Gasterosteus aculeatus 94.09 0.00e+00 841.00
IUUC-Ggo-044426 Gorilla gorilla 97.38 0.00e+00 800.00
IUUC-Hsa-045992 Homo sapiens 97.27 0.00e+00 843.00
IUUC-Itr-048097 Ictidomys tridecemlineatus 96.91 0.00e+00 821.00
IUUC-Lch-050206 Latimeria chalumnae 95.45 0.00e+00 858.00
IUUC-Loc-052535 Lepisosteus oculatus 95.68 0.00e+00 857.00
IUUC-Lma-053162 Leptosphaeria maculans 55.31 1.00e-133 469.00
IUUC-Laf-054373 Loxodonta africana 96.90 0.00e+00 823.00
IUUC-Mcc-054713 Macaca mulatta 97.50 0.00e+00 843.00
IUUC-Meu-056756 Macropus eugenii 89.76 0.00e+00 746.00
IUUC-Mor-057270 Magnaporthe oryzae 55.60 2.00e-135 476.00
IUUC-Mpo-057327 Magnaporthe poae 55.77 5.00e-136 477.00
IUUC-Mla-059127 Melampsora laricipopulina 56.92 3.00e-149 521.00
IUUC-Mga-059678 Meleagris gallopavo 96.67 0.00e+00 821.00
IUUC-Mmr-061468 Microcebus murinus 97.50 0.00e+00 874.00
IUUC-Mac-065244 Musa acuminata 50.92 1.00e-127 449.00
IUUC-Mpu-066766 Mustela putorius furo 95.95 0.00e+00 818.00
IUUC-Mlu-066933 Myotis lucifugus 96.82 0.00e+00 864.00
IUUC-Nfi-068532 Neosartorya fischeri 56.37 1.00e-133 469.00
IUUC-Ncr-068905 Neurospora crassa 56.28 9.00e-137 480.00
IUUC-Nle-069157 Nomascus leucogenys 97.62 0.00e+00 798.00
IUUC-Ont-072224 Oreochromis niloticus 94.55 0.00e+00 847.00
IUUC-Oba-075715 Oryza barthii 51.22 6.00e-134 471.00
IUUC-Opu-083739 Oryza punctata 52.23 6.00e-136 477.00
IUUC-Olu-087882 Ostreococcus lucimarinus 50.51 2.00e-128 452.00
IUUC-Oga-088573 Otolemur garnettii 96.67 0.00e+00 821.00
IUUC-Ptr-090847 Pan troglodytes 97.38 0.00e+00 800.00
IUUC-Pan-092846 Papio anubis 97.50 0.00e+00 842.00
IUUC-Psi-093292 Pelodiscus sinensis 97.26 0.00e+00 865.00
IUUC-Pma-094603 Petromyzon marinus 88.66 6.00e-100 356.00
IUUC-Pno-094992 Phaeosphaeria nodorum 56.63 8.00e-136 477.00
IUUC-Pfo-097231 Poecilia formosa 94.55 0.00e+00 848.00
IUUC-Pab-098445 Pongo abelii 97.62 0.00e+00 800.00
IUUC-Pte-104403 Pyrenophora teres 55.65 2.00e-135 475.00
IUUC-Pyt-104776 Pyrenophora triticirepentis 55.99 3.00e-134 471.00
IUUC-Rno-105189 Rattus norvegicus 99.77 0.00e+00 889.00
IUUC-Sce-106284 Saccharomyces cerevisiae 56.32 1.00e-119 423.00
IUUC-Sha-107195 Sarcophilus harrisii 95.07 0.00e+00 789.00
IUUC-Sja-107757 Schizosaccharomyces japonicus 57.62 9.00e-139 486.00
IUUC-Spo-108186 Schizosaccharomyces pombe 56.96 7.00e-136 477.00
IUUC-Smo-109077 Selaginella moellendorffii 53.04 2.00e-134 472.00
IUUC-Tru-118028 Takifugu rubripes 94.32 0.00e+00 845.00
IUUC-Tni-119681 Tetraodon nigroviridis 94.32 0.00e+00 845.00
IUUC-Tre-122188 Trichoderma reesei 56.26 3.00e-133 468.00
IUUC-Tvi-122271 Trichoderma virens 56.00 1.00e-134 473.00
IUUC-Tae-124558 Triticum aestivum 50.71 5.00e-131 461.00
IUUC-Tbe-127340 Tupaia belangeri 93.33 0.00e+00 781.00
IUUC-Ttr-129227 Tursiops truncatus 94.76 0.00e+00 808.00
IUUC-Vda-130007 Verticillium dahliae 55.23 1.00e-134 473.00
IUUC-Xma-133068 Xiphophorus maculatus 94.77 0.00e+00 849.00
Created Date 25-Jun-2017

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