iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000008536.1	ENSAMET00000009427.1	ENSAMEP00000009042.1
ENSAMEG00000008536.1	ENSAMET00000009430.1	ENSAMEP00000009045.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.70e-23	79.7	544	582
UBD/Beta-Prp	2.30e-40	138.7	412	582

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 544  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 582
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 412  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 499
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 500  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 582
           88888888999*********************************9.********************************997443 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

HQQQVVQAVE RAKQVTMAEL NAIIGQQLQA QHLSHGHGLP VPLTPHPSGL QPPAIPPIGS 60
SASLLALSSA LGGQSHLPIK DEKKHHDNDH QRDRDSIKSS SVSPSASFRG AEKHRNSTDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCAGCAAC AAGTGGTGCA GGCTGTGGAA CGGGCCAAGC AGGTGACCAT GGCCGAACTG 60
AACGCCATCA TTGGGGTACG TGGCCTTTCC ATTTTAGCTC TGATCTTAGT GTGTGTCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018361	Caenorhabditis elegans	58.99	3.00e-122	432.00
IUUC-Cho-024590	Choloepus hoffmanni	91.85	0.00e+00	1168.00
IUUC-Dor-030533	Dipodomys ordii	93.87	0.00e+00	1098.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	662.00
IUUC-Ete-032887	Echinops telfairi	89.05	0.00e+00	1081.00
IUUC-Eeu-035237	Erinaceus europaeus	92.13	0.00e+00	1097.00
IUUC-Ggo-045633	Gorilla gorilla	98.39	0.00e+00	1231.00
IUUC-Hsa-046461	Homo sapiens	98.39	0.00e+00	1233.00
IUUC-Mcc-055766	Macaca mulatta	98.54	0.00e+00	1234.00
IUUC-Mmr-061317	Microcebus murinus	97.08	0.00e+00	1207.00
IUUC-Mpu-066410	Mustela putorius furo	93.14	0.00e+00	1147.00
IUUC-Opr-070645	Ochotona princeps	95.18	0.00e+00	1174.00
IUUC-Oar-090347	Ovis aries	90.96	0.00e+00	1145.00
IUUC-Pan-091973	Papio anubis	93.00	0.00e+00	1148.00
IUUC-Psi-093586	Pelodiscus sinensis	91.87	0.00e+00	1125.00
IUUC-Pab-097539	Pongo abelii	98.54	0.00e+00	1230.00
IUUC-Pca-101137	Procavia capensis	96.21	0.00e+00	1216.00
IUUC-Pva-103037	Pteropus vampyrus	96.14	0.00e+00	1204.00
IUUC-Sar-113267	Sorex araneus	92.76	0.00e+00	683.00
IUUC-Tsy-118884	Tarsius syrichta	91.07	0.00e+00	1087.00
IUUC-Tbe-128013	Tupaia belangeri	92.99	0.00e+00	1144.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence