iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035396

Ensembl Protein ID

ENSFCAP00000008142.2

UniProt Accession

M3WA82; M3WA82_FELCA

Genbank Protein ID

ENSFCAP00000008142

Protein Name

Presenilin

Genbank Nucleotide ID

AANG02112935

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000008781.2	ENSFCAT00000008783.2	ENSFCAP00000008142.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.30e-08	33.4	284	322

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 284  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 322
           89********************************99986 PP

Organism

Felis catus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

ASRGRAMLTF MASDSEEEVC DERASLMSAE SPPPRCCQED RQGLEDGEGA DQWRGQDSED 60
DFDEDPDHYV CGGVPGQPSG LEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGGTGATT TTCCCTCCAG GGATTTCAGA GTTGCATCAG GCTTCAGTTC CGACTGAGAA 60
ACCGGAGGAG TGTCTCCCTG CTGCTGTGTT CTCCAGGAGC CAGGTAAAAA GGGGGGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	90.29	0.00e+00	646.00
IUUC-Apl-003959	Anas platyrhynchos	76.02	3.00e-161	561.00
IUUC-Aca-005160	Anolis carolinensis	73.87	3.00e-161	561.00
IUUC-Aly-005455	Arabidopsis lyrata	56.18	4.00e-18	85.90
IUUC-Ame-010686	Astyanax mexicanus	76.35	1.00e-149	522.00
IUUC-Bta-013097	Bos taurus	94.42	0.00e+00	711.00
IUUC-Bra-017580	Brassica rapa	34.91	8.00e-27	114.00
IUUC-Cja-018824	Callithrix jacchus	93.38	0.00e+00	725.00
IUUC-Cfa-020253	Canis familiaris	97.76	0.00e+00	758.00
IUUC-Cpo-021401	Cavia porcellus	94.43	0.00e+00	733.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.72	9.00e-30	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	94.63	0.00e+00	731.00
IUUC-Dre-028526	Danio rerio	70.02	5.00e-145	507.00
IUUC-Dor-031127	Dipodomys ordii	89.73	0.00e+00	675.00
IUUC-Ete-033081	Echinops telfairi	83.99	6.00e-94	337.00
IUUC-Eca-034387	Equus caballus	94.04	0.00e+00	691.00
IUUC-Eeu-034846	Erinaceus europaeus	79.13	1.00e-147	516.00
IUUC-Fal-037457	Ficedula albicollis	75.65	5.00e-160	557.00
IUUC-Gmo-038550	Gadus morhua	82.33	3.00e-105	375.00
IUUC-Gga-040706	Gallus gallus	76.65	2.00e-159	555.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.46	3.00e-131	461.00
IUUC-Ggo-045338	Gorilla gorilla	94.92	0.00e+00	743.00
IUUC-Hsa-046455	Homo sapiens	94.92	0.00e+00	743.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.08	0.00e+00	735.00
IUUC-Lch-049638	Latimeria chalumnae	67.97	1.00e-145	509.00
IUUC-Loc-052427	Lepisosteus oculatus	74.05	9.00e-158	549.00
IUUC-Laf-053758	Loxodonta africana	88.44	0.00e+00	716.00
IUUC-Mcc-054755	Macaca mulatta	94.48	0.00e+00	736.00
IUUC-Mtr-058392	Medicago truncatula	33.25	8.00e-31	127.00
IUUC-Mmr-060890	Microcebus murinus	93.51	0.00e+00	715.00
IUUC-Mdo-062197	Monodelphis domestica	80.13	4.00e-177	613.00
IUUC-Mmu-063823	Mus musculus	93.29	0.00e+00	723.00
IUUC-Mac-064858	Musa acuminata	43.27	5.00e-23	101.00
IUUC-Mpu-066181	Mustela putorius furo	96.87	0.00e+00	750.00
IUUC-Nle-069596	Nomascus leucogenys	94.18	0.00e+00	682.00
IUUC-Opr-070344	Ochotona princeps	92.49	0.00e+00	745.00
IUUC-Ont-071867	Oreochromis niloticus	70.50	4.00e-134	471.00
IUUC-Oan-073378	Ornithorhynchus anatinus	72.05	4.00e-151	527.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.16	0.00e+00	702.00
IUUC-Obr-076302	Oryza brachyantha	36.96	5.00e-17	82.40
IUUC-Ola-086707	Oryzias latipes	68.73	8.00e-105	372.00
IUUC-Oga-088560	Otolemur garnettii	93.78	0.00e+00	684.00
IUUC-Oar-089200	Ovis aries	92.86	0.00e+00	686.00
IUUC-Ptr-090569	Pan troglodytes	94.63	0.00e+00	729.00
IUUC-Pan-091742	Papio anubis	94.85	0.00e+00	731.00
IUUC-Pma-094612	Petromyzon marinus	77.25	6.00e-127	447.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	2.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	94.63	0.00e+00	731.00
IUUC-Pca-101120	Procavia capensis	90.73	0.00e+00	704.00
IUUC-Pva-102934	Pteropus vampyrus	84.33	0.00e+00	686.00
IUUC-Rno-106052	Rattus norvegicus	92.84	0.00e+00	739.00
IUUC-Sha-106876	Sarcophilus harrisii	78.80	1.00e-174	605.00
IUUC-Ssc-115380	Sus scrofa	95.97	0.00e+00	762.00
IUUC-Tgu-117280	Taeniopygia guttata	75.86	4.00e-161	560.00
IUUC-Tbe-127632	Tupaia belangeri	93.64	2.00e-179	621.00
IUUC-Ttr-129008	Tursiops truncatus	94.00	0.00e+00	728.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence